LOCUS       NP_598540                582 aa            linear   ROD 12-JUN-2024
DEFINITION  GPI transamidase component PIG-T isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_598540 XP_918069 XP_927653 XP_927668 XP_927676 XP_927684
            XP_927692
VERSION     NP_598540.2
DBSOURCE    REFSEQ: accession NM_133779.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 582)
  AUTHORS   Li,H.L., Li,Z., Qin,L.Y., Liu,S., Lau,L.T., Han,J.S. and Yu,A.C.
  TITLE     The novel neurotrophin-regulated neuronal development-associated
            protein, NDAP, mediates apoptosis
  JOURNAL   FEBS Lett 580 (7), 1723-1728 (2006)
   PUBMED   16516892
  REMARK    GeneRIF: different regulations of NDAP expression by neurotrophins
            indicate that the expression of NDAP might be a checkpoint for
            apoptosis during neuronal development [NDAP]
REFERENCE   2  (residues 1 to 582)
  AUTHORS   Li,Z., Li,Q., Sun,C.X., Hertz,L. and Yu,A.C.
  TITLE     Cloning and identification of differentially expressed transcripts
            in primary culture of GABAergic neurons
  JOURNAL   Neurochem Res 26 (10), 1101-1105 (2001)
   PUBMED   11700951
REFERENCE   3  (residues 1 to 582)
  AUTHORS   Ohishi,K., Inoue,N. and Kinoshita,T.
  TITLE     PIG-S and PIG-T, essential for GPI anchor attachment to proteins,
            form a complex with GAA1 and GPI8
  JOURNAL   EMBO J 20 (15), 4088-4098 (2001)
   PUBMED   11483512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591478.19.
            
            On Jan 4, 2007 this sequence version replaced NP_598540.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155057.1, AK153464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.17 cM"
     Protein         1..582
                     /product="GPI transamidase component PIG-T isoform 1
                     precursor"
                     /note="GPI transamidase component PIG-T; neuronal
                     development-associated protein 7;
                     phosphatidylinositol-glycan biosynthesis class T protein"
                     /calculated_mol_wt=63185
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2538
     mat_peptide     26..582
                     /product="GPI transamidase component PIG-T.
                     /id=PRO_0000024108"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BXQ2.2)"
                     /calculated_mol_wt=63185
     Region          36..555
                     /region_name="Gpi16"
                     /note="Gpi16 subunit, GPI transamidase component;
                     pfam04113"
                     /db_xref="CDD:461180"
     Site            168
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q8BXQ2.2)"
     Site            295
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BXQ2.2)"
     Site            331
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BXQ2.2)"
     Site            526..548
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BXQ2.2)"
     CDS             1..582
                     /gene="Pigt"
                     /gene_synonym="2510012P17Rik; 4930534E15Rik; CGI-06; NDAP;
                     Ndap7"
                     /coded_by="NM_133779.3:19..1767"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS17038.2"
                     /db_xref="GeneID:78928"
                     /db_xref="MGI:MGI:1926178"
ORIGIN      
        1 maaamplglp lrllvlllvg rgccgcaegp rdslreelvi tplpsgdvaa tfqfrtrwds
       61 dlqregvshy rlfpkalgql iskyslrelh lsftqgfwrt rywgppflqa psgaelwvwf
      121 qdtvtdvdks wrelsnvlsg ifcaslnfid atntvtptas fkplglandt ddyflryavl
      181 prevvctenl tpwkkllpcs skaglsvllk adrlfhtsyh sqavhirpic rnahctsisw
      241 elrqtlsvvf dafitgqgkk dwslfrmfsr tlteacplas qslvyvditg ysqdnetlev
      301 sppptstyqd vilgtrktya vydlfdtami nnsrnlniql kwkrppdnea lpvpflhaqr
      361 yvsgyglqkg elstllynsh pyrafpvlll dvvpwylrly vhtltitskg kenkpsyihy
      421 qpaqdrqqph llemliqlpa nsvtkvsiqf erallkwtey tpdpnhgfyv spsvlsalvp
      481 svvaakpvdw egsplfntlf pvsdgssyfv rlytepllvn lptpdfsmpy nvicltctvv
      541 avcygsfynl ltrtfhieep ksgglakrla nlirrargvp pl
//
