LOCUS       NM_011082               3849 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus polymeric immunoglobulin receptor (Pigr), mRNA.
ACCESSION   NM_011082
VERSION     NM_011082.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3849)
  AUTHORS   Donald,K., Serapio-Palacios,A., Gerbec,Z., Bozorgmehr,T.,
            Holani,R., Cruz,A.R., Schnupf,P. and Finlay,B.B.
  TITLE     Secretory IgA in breast milk protects against asthma through
            modulation of the gut microbiota
  JOURNAL   Cell Rep 43 (10), 114835 (2024)
   PUBMED   39368092
REFERENCE   2  (bases 1 to 3849)
  AUTHORS   Hendrikx,T., Lang,S., Rajcic,D., Wang,Y., McArdle,S., Kim,K.,
            Mikulski,Z. and Schnabl,B.
  TITLE     Hepatic pIgR-mediated secretion of IgA limits bacterial
            translocation and prevents ethanol-induced liver disease in mice
  JOURNAL   Gut 72 (10), 1959-1970 (2023)
   PUBMED   36690432
  REMARK    GeneRIF: Hepatic pIgR-mediated secretion of IgA limits bacterial
            translocation and prevents ethanol-induced liver disease in mice.
REFERENCE   3  (bases 1 to 3849)
  AUTHORS   Umemoto,S., Nakahashi-Ouchida,R., Yuki,Y., Kurokawa,S., Machita,T.,
            Uchida,Y., Mori,H., Yamanoue,T., Shibata,T., Sawada,S.I.,
            Ishige,K., Hirano,T., Fujihashi,K., Akiyoshi,K., Kurashima,Y.,
            Tokuhara,D., Ernst,P.B., Suzuki,M. and Kiyono,H.
  TITLE     Cationic-nanogel nasal vaccine containing the ectodomain of
            RSV-small hydrophobic protein induces protective immunity in
            rodents
  JOURNAL   NPJ Vaccines 8 (1), 106 (2023)
   PUBMED   37488116
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3849)
  AUTHORS   Torow,N., Li,R., Hitch,T.C.A., Mingels,C., Al Bounny,S., van
            Best,N., Stange,E.L., Simons,B., Maie,T., Ruttger,L.,
            Gubbi,N.M.K.P., Abbott,D.A., Benabid,A., Gadermayr,M., Runge,S.,
            Treichel,N., Merhof,D., Rosshart,S.P., Jehmlich,N., Hand,T.W., von
            Bergen,M., Heymann,F., Pabst,O., Clavel,T., Tacke,F., Lelouard,H.,
            Costa,I.G. and Hornef,M.W.
  TITLE     M cell maturation and cDC activation determine the onset of
            adaptive immune priming in the neonatal Peyer's patch
  JOURNAL   Immunity 56 (6), 1220-1238 (2023)
   PUBMED   37130522
REFERENCE   5  (bases 1 to 3849)
  AUTHORS   Lin,H., Lin,J., Pan,T., Li,T., Jiang,H., Fang,Y., Wang,Y., Wu,F.,
            Huang,J., Zhang,H., Chen,D. and Chen,Y.
  TITLE     Polymeric immunoglobulin receptor deficiency exacerbates autoimmune
            hepatitis by inducing intestinal dysbiosis and barrier dysfunction
  JOURNAL   Cell Death Dis 14 (1), 68 (2023)
   PUBMED   36709322
  REMARK    Erratum:[Cell Death Dis. 2023 May 2;14(5):300. doi:
            10.1038/s41419-023-05816-x. PMID: 37130832]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3849)
  AUTHORS   Martin,M.G., Wang,J., Li,T.W., Lam,J.T., Gutierrez,E.M.,
            Solorzano-Vargas,R.S. and Tsai,A.H.
  TITLE     Characterization of the 5'-flanking region of the murine polymeric
            IgA receptor gene
  JOURNAL   Am J Physiol 275 (4), G778-G788 (1998)
   PUBMED   9756509
REFERENCE   7  (bases 1 to 3849)
  AUTHORS   Sato,T.
  TITLE     Mapping of mouse polymeric immunoglobulin receptor (PIgR) gene
            using simple sequence length polymorphism markers
  JOURNAL   Genes Genet Syst 73 (4), 271-273 (1998)
   PUBMED   9880925
REFERENCE   8  (bases 1 to 3849)
  AUTHORS   Kushiro,A. and Sato,T.
  TITLE     Polymeric immunoglobulin receptor gene of mouse: sequence,
            structure and chromosomal location
  JOURNAL   Gene 204 (1-2), 277-282 (1997)
   PUBMED   9434194
REFERENCE   9  (bases 1 to 3849)
  AUTHORS   Martin,M.G., Gutierrez,E.M., Lam,J.T., Li,T.W. and Wang,J.
  TITLE     Genomic cloning and structural analysis of the murine polymeric
            receptor (pIgR) gene and promoter region
  JOURNAL   Gene 201 (1-2), 189-197 (1997)
   PUBMED   9409786
REFERENCE   10 (bases 1 to 3849)
  AUTHORS   Piskurich,J.F., Blanchard,M.H., Youngman,K.R., France,J.A. and
            Kaetzel,C.S.
  TITLE     Molecular cloning of the mouse polymeric Ig receptor. Functional
            regions of the molecule are conserved among five mammalian species
  JOURNAL   J Immunol 154 (4), 1735-1747 (1995)
   PUBMED   7836758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142656.1 and AC165322.12.
            
            On Aug 12, 2009 this sequence version replaced NM_011082.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142656.1, AK128944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3419              AK142656.1         3-3421
            3420-3849           AC165322.12        143968-144397       c
FEATURES             Location/Qualifiers
     source          1..3849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..3849
                     /gene="Pigr"
                     /note="polymeric immunoglobulin receptor"
                     /db_xref="GeneID:18703"
                     /db_xref="MGI:MGI:103080"
     exon            1..124
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            125..223
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            224..568
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            569..1222
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1555
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1888
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2081
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2209
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2341
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2400
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..3849
                     /gene="Pigr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigr"
                     /note="hexamer: ATTAAA"
     polyA_site      3849
                     /gene="Pigr"
                     /note="major polyA site"
ORIGIN      
        1 aaaacagttt cagttttgac aatagtcacc agtagtgcct tcctggaagc ttctagaagg
       61 gtacatactg gcttgcaggc tgtgcccgaa actggatcac ctggagagaa ggaagtagct
      121 aaaacattct catacaagaa gccaacctga gcggcacagc ccccctggaa gccacaagca
      181 atgaggctct acttgttcac gctcttggta actgtctttt caggggtctc cacaaaaagc
      241 cccatatttg gtccccagga ggtgagtagt atagaaggcg actctgtttc catcacgtgc
      301 tactacccag acacctctgt caaccggcac acccggaaat actggtgccg acaaggagcc
      361 agcggcatgt gcacaacgct catctcttca aatggctacc tctccaagga gtattcaggc
      421 agagccaacc tcatcaactt cccagagaac aacacatttg tgattaacat tgagcagctc
      481 acccaggacg acactgggag ctacaagtgt ggcctgggta ccagtaaccg aggcctgtcc
      541 ttcgatgtca gcctggaggt cagccaggtt cctgagttgc cgagtgacac ccacgtctac
      601 acaaaggaca taggcagaaa tgtgaccatt gaatgccctt tcaaaaggga gaatgctccc
      661 agcaagaaat ccctgtgtaa gaagacaaac cagtcctgcg aacttgtcat tgactctact
      721 gagaaggtga accccagcta tataggcaga gcaaaacttt ttatgaaagg gaccgaccta
      781 actgtattct atgtcaacat tagtcaccta acgcacaatg atgctgggct gtacatctgc
      841 caagctggag aaggtcctag tgctgataag aagaatgttg acctccaggt gctagcgcct
      901 gagccagagc tgctttataa agacctgagg tcctcagtga cttttgaatg tgacctgggc
      961 cgtgaggtgg caaacgaggc caaatatctg tgccggatga ataaggaaac ctgtgatgtg
     1021 atcattaaca ccctggggaa gagggatcca gactttgagg gcaggatcct gataaccccc
     1081 aaggatgaca atggccgctt cagtgtgttg atcacaggcc tgaggaagga ggatgcaggg
     1141 cactaccagt gtggagccca cagttctggt ttgcctcaag aaggctggcc catccagact
     1201 tggcaactct ttgtcaatga agagtctacc attcccaatc gtcgctctgt tgtgaaggga
     1261 gtcacaggag gctctgtggc catcgcctgt ccctataacc ccaaggaaag cagcagcctc
     1321 aagtactggt gtcgctggga aggggacgga aatggacatt gccccgtgct tgtggggacc
     1381 caggcccagg tgcaagaaga gtatgaaggc cgactggcac tgtttgatca gccaggcaat
     1441 ggtacttaca ctgtcatcct caaccagctc accaccgagg atgctggctt ctattggtgt
     1501 cttaccaatg gtgactctcg ctggagaacc acaatagaac tccaggttgc cgaagctaca
     1561 agggagccaa accttgaggt gacgccacag aacgcaacag cagtactagg agagaccttc
     1621 accgtttcct gccactatcc gtgcaaattc tactcccagg agaaatactg gtgcaagtgg
     1681 agcaacaagg gttgccacat cctgccaagc catgacgaag gtgcccgcca atcttctgtg
     1741 agctgcgacc agagcagcca gctggtctcc atgaccctga acccggtcag taaggaagat
     1801 gaaggctggt actggtgtgg ggtaaagcaa ggccagacct atggagaaac taccgccatc
     1861 tatatagcag ttgaagagag gaccagaggg tcatcccatg tcaacccaac agatgcaaat
     1921 gcacgtgcca aagtcgctct ggaagaagag gtagtggact cctccatcag tgaaaaagag
     1981 aacaaagcca ttccaaatcc cgggcctttt gccaacgaaa gagagataca gaatgtggga
     2041 gaccaagctc aggagaacag agcatctggg gatgctggca gtgctgatgg acaaagcagg
     2101 agctccagct ccaaagtgct gttctccacc ctggtgcccc tgggtctggt gctggcagtg
     2161 ggtgctatag ctgtgtgggt ggccagagtc cgacatcgga agaatgtaga ccgcatgtca
     2221 atcagcagct acaggacaga cattagcatg gcagacttca agaactccag agatttggga
     2281 ggcaatgaca acatgggggc ctctccagac acacagcaaa cagtcatcga aggaaaagat
     2341 gaaatcgtga ctaccacgga gtgcaccgct gagccagaag aatccaagaa agcaaaaagg
     2401 tcatccaagg aggaagctga catggcctac tcggcattcc tgcttcagtc cagcaccata
     2461 gctgcacagg tccacgatgg tccccaggaa gcctaggcag tgctgaccac ccacccttgc
     2521 ctgtgacaat caacttgaga atcacactga tctgctcgca gcccacactc acccatcacc
     2581 tccgctcttc cctcctgtcc tcagaggtgt gctggttcct tcctcggcca tggaagcctg
     2641 gcctagttac gcctgtttag gagagagtgt gaggcgttct tttctctatg aagagagtga
     2701 ggtggaaatg aggaggaggt gaacctgaga gacatctctg gaggaagagg gttcacaata
     2761 ggggctcgtt tcaggagaaa aggccatttg aatcttcttt ataaccatat gataggatgt
     2821 cagcgtaact cttctctcct ccatctctcc tttcctatcc tcttgattca aacaacacat
     2881 ctgagaactc actaggcttc agtgcctact aaatgctgag agccaggcca caatctttct
     2941 ataaatatta ctggaagaga tgccatctcc tcccagattc tgtcttttca ttaagataag
     3001 acatcattac caggcatacc tcctgcctct gtgcctcata ggcatacaca agccataagg
     3061 gcatcatgat tttcagatga gaagagatgt ttctcaagag tgcctagtga gatagactag
     3121 cgtcaaacca gatgtggcaa ctcctggctc ttggcctacg atctgtcttc aagacctctg
     3181 ctcttattag agggagaact ttagcatggg ggaaagtaag agaaaatgag ttaaaggagc
     3241 atggtggtgt gctcctgcaa tcccaatatt aagaggtaaa aataggatca gaagttcaag
     3301 gtaatccttg gctacctagg gagtttaagg ccagcctggg atacattgag acttggattc
     3361 aaagaagcag gaggagggag caggaagagg aggagtagaa agggggaaga aggagaagga
     3421 aaaaagaaga agaggaggaa gaggaggagg aggaggagga ggagaagaag gagaagaaga
     3481 agaagaagaa gaagaagaag aagaagaaga agaagaagaa gaagaagaag aagaagaaga
     3541 agaagaagaa gaagaagaag aagaagaaga aagacagaca gacaaaaaga caaatggatc
     3601 tttcctggtc tcacctttcc ccttcctgtc actcatgtgg acctcatata agggaaagat
     3661 actctcaacc tcttgtattt ggagagtttt gagcagacag gtagaagatg gagcctggga
     3721 gcagctgttt ttccaatagt caaattagga ctgtttctct ctgagctctg ttcttcaacc
     3781 agcacctata gaccgaaacc aacaaatcag aaatgtccat taataattaa agtctatgat
     3841 tgccaccaa
//
