LOCUS       NP_035212                771 aa            linear   ROD 09-FEB-2025
DEFINITION  polymeric immunoglobulin receptor precursor [Mus musculus].
ACCESSION   NP_035212
VERSION     NP_035212.2
DBSOURCE    REFSEQ: accession NM_011082.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 771)
  AUTHORS   Donald,K., Serapio-Palacios,A., Gerbec,Z., Bozorgmehr,T.,
            Holani,R., Cruz,A.R., Schnupf,P. and Finlay,B.B.
  TITLE     Secretory IgA in breast milk protects against asthma through
            modulation of the gut microbiota
  JOURNAL   Cell Rep 43 (10), 114835 (2024)
   PUBMED   39368092
REFERENCE   2  (residues 1 to 771)
  AUTHORS   Hendrikx,T., Lang,S., Rajcic,D., Wang,Y., McArdle,S., Kim,K.,
            Mikulski,Z. and Schnabl,B.
  TITLE     Hepatic pIgR-mediated secretion of IgA limits bacterial
            translocation and prevents ethanol-induced liver disease in mice
  JOURNAL   Gut 72 (10), 1959-1970 (2023)
   PUBMED   36690432
  REMARK    GeneRIF: Hepatic pIgR-mediated secretion of IgA limits bacterial
            translocation and prevents ethanol-induced liver disease in mice.
REFERENCE   3  (residues 1 to 771)
  AUTHORS   Umemoto,S., Nakahashi-Ouchida,R., Yuki,Y., Kurokawa,S., Machita,T.,
            Uchida,Y., Mori,H., Yamanoue,T., Shibata,T., Sawada,S.I.,
            Ishige,K., Hirano,T., Fujihashi,K., Akiyoshi,K., Kurashima,Y.,
            Tokuhara,D., Ernst,P.B., Suzuki,M. and Kiyono,H.
  TITLE     Cationic-nanogel nasal vaccine containing the ectodomain of
            RSV-small hydrophobic protein induces protective immunity in
            rodents
  JOURNAL   NPJ Vaccines 8 (1), 106 (2023)
   PUBMED   37488116
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 771)
  AUTHORS   Torow,N., Li,R., Hitch,T.C.A., Mingels,C., Al Bounny,S., van
            Best,N., Stange,E.L., Simons,B., Maie,T., Ruttger,L.,
            Gubbi,N.M.K.P., Abbott,D.A., Benabid,A., Gadermayr,M., Runge,S.,
            Treichel,N., Merhof,D., Rosshart,S.P., Jehmlich,N., Hand,T.W., von
            Bergen,M., Heymann,F., Pabst,O., Clavel,T., Tacke,F., Lelouard,H.,
            Costa,I.G. and Hornef,M.W.
  TITLE     M cell maturation and cDC activation determine the onset of
            adaptive immune priming in the neonatal Peyer's patch
  JOURNAL   Immunity 56 (6), 1220-1238 (2023)
   PUBMED   37130522
REFERENCE   5  (residues 1 to 771)
  AUTHORS   Lin,H., Lin,J., Pan,T., Li,T., Jiang,H., Fang,Y., Wang,Y., Wu,F.,
            Huang,J., Zhang,H., Chen,D. and Chen,Y.
  TITLE     Polymeric immunoglobulin receptor deficiency exacerbates autoimmune
            hepatitis by inducing intestinal dysbiosis and barrier dysfunction
  JOURNAL   Cell Death Dis 14 (1), 68 (2023)
   PUBMED   36709322
  REMARK    Erratum:[Cell Death Dis. 2023 May 2;14(5):300. doi:
            10.1038/s41419-023-05816-x.. PMID: 37130832]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 771)
  AUTHORS   Martin,M.G., Wang,J., Li,T.W., Lam,J.T., Gutierrez,E.M.,
            Solorzano-Vargas,R.S. and Tsai,A.H.
  TITLE     Characterization of the 5'-flanking region of the murine polymeric
            IgA receptor gene
  JOURNAL   Am J Physiol 275 (4), G778-G788 (1998)
   PUBMED   9756509
REFERENCE   7  (residues 1 to 771)
  AUTHORS   Sato,T.
  TITLE     Mapping of mouse polymeric immunoglobulin receptor (PIgR) gene
            using simple sequence length polymorphism markers
  JOURNAL   Genes Genet Syst 73 (4), 271-273 (1998)
   PUBMED   9880925
REFERENCE   8  (residues 1 to 771)
  AUTHORS   Kushiro,A. and Sato,T.
  TITLE     Polymeric immunoglobulin receptor gene of mouse: sequence,
            structure and chromosomal location
  JOURNAL   Gene 204 (1-2), 277-282 (1997)
   PUBMED   9434194
REFERENCE   9  (residues 1 to 771)
  AUTHORS   Martin,M.G., Gutierrez,E.M., Lam,J.T., Li,T.W. and Wang,J.
  TITLE     Genomic cloning and structural analysis of the murine polymeric
            receptor (pIgR) gene and promoter region
  JOURNAL   Gene 201 (1-2), 189-197 (1997)
   PUBMED   9409786
REFERENCE   10 (residues 1 to 771)
  AUTHORS   Piskurich,J.F., Blanchard,M.H., Youngman,K.R., France,J.A. and
            Kaetzel,C.S.
  TITLE     Molecular cloning of the mouse polymeric Ig receptor. Functional
            regions of the molecule are conserved among five mammalian species
  JOURNAL   J Immunol 154 (4), 1735-1747 (1995)
   PUBMED   7836758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142656.1 and AC165322.12.
            
            On Jun 19, 2003 this sequence version replaced NP_035212.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142656.1, AK128944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     Protein         1..771
                     /product="polymeric immunoglobulin receptor precursor"
                     /note="poly-Ig receptor; phosphatidylinositol glycan,
                     class R"
                     /calculated_mol_wt=82970
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2047
     mat_peptide     19..771
                     /product="Polymeric immunoglobulin receptor.
                     /id=PRO_0000014902"
                     /note="propagated from UniProtKB/Swiss-Prot (O70570.1)"
                     /calculated_mol_wt=82970
     mat_peptide     19..611
                     /product="Secretory component. /id=PRO_0000014903"
                     /note="propagated from UniProtKB/Swiss-Prot (O70570.1)"
                     /calculated_mol_wt=65810
     Region          24..126
                     /region_name="IgV_pIgR_like"
                     /note="Immunoglobulin (Ig)-like domain in the polymeric Ig
                     receptor (pIgR) and similar proteins; cd05716"
                     /db_xref="CDD:409381"
     Region          24..40
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          27..32
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409381"
     Region          34..41
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409381"
     Region          41..51
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          51..56
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409381"
     Site            51..53
                     /site_type="other"
                     /note="CDR1-dIgA binding residues [polypeptide binding]"
                     /db_xref="CDD:409381"
     Region          52..56
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          57..75
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          65..69
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          73..75
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          81..112
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          81..87
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409381"
     Site            90
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Region          91..99
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409381"
     Region          105..112
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409381"
     Region          113..120
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          120..126
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409381"
     Region          120..126
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409381"
     Region          134..227
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            147
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Region          148..152
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          162..166
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            170
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Region          203..207
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Site            206
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Region          217..222
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..330
                     /region_name="IgV_pIgR_like"
                     /note="Immunoglobulin (Ig)-like domain in the polymeric Ig
                     receptor (pIgR) and similar proteins; cd05716"
                     /db_xref="CDD:409381"
     Region          240..257
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          244..249
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409381"
     Region          251..258
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409381"
     Region          258..266
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          266..271
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409381"
     Site            266..268
                     /site_type="other"
                     /note="CDR1-dIgA binding residues [polypeptide binding]"
                     /db_xref="CDD:409381"
     Region          267..271
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          272..289
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          279..283
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          287..289
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          295..326
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          295..301
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409381"
     Region          305..313
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409381"
     Region          319..326
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409381"
     Region          352..456
                     /region_name="IgV_pIgR_like"
                     /note="Immunoglobulin (Ig)-like domain in the polymeric Ig
                     receptor (pIgR) and similar proteins; cd05716"
                     /db_xref="CDD:409381"
     Region          352..370
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          352..354
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409381"
     Region          357..362
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409381"
     Region          364..371
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409381"
     Region          371..379
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          379..384
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409381"
     Site            379..381
                     /site_type="other"
                     /note="CDR1-dIgA binding residues [polypeptide binding]"
                     /db_xref="CDD:409381"
     Region          380..384
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          385..405
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          395..399
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          403..405
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          411..442
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          411..417
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409381"
     Site            420
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Region          421..429
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409381"
     Region          435..442
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409381"
     Region          443..451
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          451..456
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409381"
     Region          451..456
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409381"
     Region          467..562
                     /region_name="IgV_pIgR_like"
                     /note="Immunoglobulin (Ig)-like domain in the polymeric Ig
                     receptor (pIgR) and similar proteins; cd05716"
                     /db_xref="CDD:409381"
     Region          467..484
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          471..476
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409381"
     Site            471
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Region          478..485
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409381"
     Region          485..493
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          493..498
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409381"
     Site            493..495
                     /site_type="other"
                     /note="CDR1-dIgA binding residues [polypeptide binding]"
                     /db_xref="CDD:409381"
     Region          494..498
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          499..514
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          506..510
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          512..514
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          517..548
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          517..523
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409381"
     Region          527..535
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409381"
     Region          541..548
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409381"
     Region          549..557
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          557..562
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409381"
     Region          557..562
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409381"
     Region          622..641
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70570.1)"
     Site            646..668
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70570.1)"
     Site            680
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15083; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Site            689
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Site            696
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15083; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (O70570.1)"
     CDS             1..771
                     /gene="Pigr"
                     /coded_by="NM_011082.3:181..2496"
                     /db_xref="CCDS:CCDS15260.1"
                     /db_xref="GeneID:18703"
                     /db_xref="MGI:MGI:103080"
ORIGIN      
        1 mrlylftllv tvfsgvstks pifgpqevss iegdsvsitc yypdtsvnrh trkywcrqga
       61 sgmcttliss ngylskeysg ranlinfpen ntfvinieql tqddtgsykc glgtsnrgls
      121 fdvslevsqv pelpsdthvy tkdigrnvti ecpfkrenap skkslckktn qscelvidst
      181 ekvnpsyigr aklfmkgtdl tvfyvnishl thndaglyic qagegpsadk knvdlqvlap
      241 epellykdlr ssvtfecdlg revaneakyl crmnketcdv iintlgkrdp dfegrilitp
      301 kddngrfsvl itglrkedag hyqcgahssg lpqegwpiqt wqlfvneest ipnrrsvvkg
      361 vtggsvaiac pynpkesssl kywcrwegdg nghcpvlvgt qaqvqeeyeg rlalfdqpgn
      421 gtytvilnql ttedagfywc ltngdsrwrt tielqvaeat repnlevtpq natavlgetf
      481 tvschypckf ysqekywckw snkgchilps hdegarqssv scdqssqlvs mtlnpvsked
      541 egwywcgvkq gqtygettai yiaveertrg sshvnptdan arakvaleee vvdssiseke
      601 nkaipnpgpf anereiqnvg dqaqenrasg dagsadgqsr sssskvlfst lvplglvlav
      661 gaiavwvarv rhrknvdrms issyrtdism adfknsrdlg gndnmgaspd tqqtviegkd
      721 eivtttecta epeeskkakr sskeeadmay safllqssti aaqvhdgpqe a
//
