LOCUS       NP_001277954             641 aa            linear   ROD 01-MAY-2025
DEFINITION  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
            isoform 1 [Mus musculus].
ACCESSION   NP_001277954 XP_006523726 XP_006523728
VERSION     NP_001277954.1
DBSOURCE    REFSEQ: accession NM_001291025.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 641)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 641)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (residues 1 to 641)
  AUTHORS   Watanabe,R., Murakami,Y., Marmor,M.D., Inoue,N., Maeda,Y., Hino,J.,
            Kangawa,K., Julius,M. and Kinoshita,T.
  TITLE     Initial enzyme for glycosylphosphatidylinositol biosynthesis
            requires PIG-P and is regulated by DPM2
  JOURNAL   EMBO J 19 (16), 4402-4411 (2000)
   PUBMED   10944123
REFERENCE   4  (residues 1 to 641)
  AUTHORS   Hong,Y., Ohishi,K., Watanabe,R., Endo,Y., Maeda,Y. and Kinoshita,T.
  TITLE     GPI1 stabilizes an enzyme essential in the first step of
            glycosylphosphatidylinositol biosynthesis
  JOURNAL   J Biol Chem 274 (26), 18582-18588 (1999)
   PUBMED   10373468
REFERENCE   5  (residues 1 to 641)
  AUTHORS   Tiede,A., Schubert,J., Nischan,C., Jensen,I., Westfall,B.,
            Taron,C.H., Orlean,P. and Schmidt,R.E.
  TITLE     Human and mouse Gpi1p homologues restore
            glycosylphosphatidylinositol membrane anchor biosynthesis in yeast
            mutants
  JOURNAL   Biochem J 334 (Pt 3) (Pt 3), 609-616 (1998)
   PUBMED   9729469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159277.3.
            
            On or before Mar 22, 2014 this sequence version replaced
            XP_006523728.1, XP_006523726.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170431.1, ERR3363658.5615429.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.01 cM"
     Protein         1..641
                     /product="phosphatidylinositol
                     N-acetylglucosaminyltransferase subunit Q isoform 1"
                     /EC_number="2.4.1.198"
                     /note="phosphatidylinositol
                     N-acetylglucosaminyltransferase subunit Q; PIG-Q;
                     N-acetylglucosamyl transferase component GPI1;
                     phosphatidylinositol-glycan biosynthesis class Q protein"
                     /calculated_mol_wt=72413
     Site            276..298
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYT7.3)"
     Region          <370..569
                     /region_name="Gpi1"
                     /note="N-acetylglucosaminyl transferase component (Gpi1);
                     pfam05024"
                     /db_xref="CDD:461527"
     CDS             1..641
                     /gene="Pigq"
                     /gene_synonym="Gpi1; Gpi1h; Gpi1p; Gpih"
                     /coded_by="NM_001291025.2:132..2057"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS70774.1"
                     /db_xref="GeneID:14755"
                     /db_xref="MGI:MGI:1333114"
ORIGIN      
        1 mvlkvffptc casadsgllv grwvpgqssa vilavvhfpf ipiqvkella qvqkasqvpv
       61 avlgtwchrq qepqeslgnf leglgtifsh dpwlqlcrer gtrlwsckat ypqmsnpldm
      121 hpeeqvmlif ydqrklllsw lhpppvlpac qmgdttastg gladifdtva rsevlfrndq
      181 fderpvrlsh wqsegveasi lvelakrasg pvclllasll slisaasacr lwklwplsfi
      241 rsklstceql hhrlkhlsfi fstekaqnpm qlmrkanmlv svlldvalgl lllswlhsnn
      301 rigqlanalv pvadsqssvs vevlwalfcs vsadacwvcl lpgqesgaav gssqlceicg
      361 ghpsrkeele lgerrvaeel qhllqwlmga paglkmnral dqvlgrffly hihlwisyih
      421 lmspfiehil whvglsaclg ltvalsifsd iialltfhiy cfyvygarly clkiyglssl
      481 wrlfrgkkwn vlrqrvdscs ydldqlfigt llftilvfll pttalyylvf tllrllvitv
      541 qglihllvdl inslplyslg lrlcrpyrla agvkfrvlek eagrplrllm qinplsynhv
      601 mhiyrlprcg chpkhswgtl crklvfgeli ypwrqredkq d
//
