LOCUS       NM_001159618             852 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphatidylinositol glycan anchor biosynthesis, class
            P (Pigp), transcript variant 2, mRNA.
ACCESSION   NM_001159618
VERSION     NM_001159618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Lukacs,M., Roberts,T., Chatuverdi,P. and Stottmann,R.W.
  TITLE     Glycosylphosphatidylinositol biosynthesis and remodeling are
            required for neural tube closure, heart development, and cranial
            neural crest cell survival
  JOURNAL   Elife 8, e45248 (2019)
   PUBMED   31232685
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Liu,C., Morishima,M., Yu,T., Matsui,S., Zhang,L., Fu,D., Pao,A.,
            Costa,A.C., Gardiner,K.J., Cowell,J.K., Nowak,N.J., Parmacek,M.S.,
            Liang,P., Baldini,A. and Yu,Y.E.
  TITLE     Genetic analysis of Down syndrome-associated heart defects in mice
  JOURNAL   Hum Genet 130 (5), 623-632 (2011)
   PUBMED   21442329
  REMARK    Erratum:[Hum Genet. 2011 Nov;130(5):633. Nowak, Normal J [corrected
            to Nowak, Norma J]]
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   4  (bases 1 to 852)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   5  (bases 1 to 852)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   6  (bases 1 to 852)
  AUTHORS   Choi,D.K., Suzuki,Y., Yoshimura,S., Togashi,T., Hida,M.,
            Taylor,T.D., Wang,Y., Sugano,S., Hattori,M. and Sakaki,Y.
  TITLE     Molecular cloning and characterization of a gene expressed in mouse
            developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down
            syndrome Critical Region gene 5)
  JOURNAL   Mamm Genome 12 (5), 347-351 (2001)
   PUBMED   11331941
REFERENCE   7  (bases 1 to 852)
  AUTHORS   Watanabe,R., Murakami,Y., Marmor,M.D., Inoue,N., Maeda,Y., Hino,J.,
            Kangawa,K., Julius,M. and Kinoshita,T.
  TITLE     Initial enzyme for glycosylphosphatidylinositol biosynthesis
            requires PIG-P and is regulated by DPM2
  JOURNAL   EMBO J 19 (16), 4402-4411 (2000)
   PUBMED   10944123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX511452.1, AF216307.1 and BC096569.1.
            
            Transcript Variant: This variant (2), also known as DCRC-2,
            represents use of an alternate promoter and uses an alternate
            translation start site, compared to variant 6. The resulting
            isoform (b) has a shorter and distinct N-terminus, compared to
            isoform e.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX511452.1, SRR7345562.808787.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               BX511452.1         2-135
            135-500             AF216307.1         33-398
            501-852             BC096569.1         429-780
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.18 cM"
     gene            1..852
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class P"
                     /db_xref="GeneID:56176"
                     /db_xref="MGI:MGI:1860433"
     exon            1..185
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..606
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /EC_number="2.4.1.198"
                     /note="isoform b is encoded by transcript variant 2;
                     phosphatidylinositol N-acetylglucosaminyltransferase
                     subunit P; PIG-P; down syndrome critical region protein 5
                     homolog; phosphatidylinositol-glycan biosynthesis class P
                     protein; Down syndrome critical region gene c; Down
                     syndrome critical region homolog 5"
                     /codon_start=1
                     /product="phosphatidylinositol
                     N-acetylglucosaminyltransferase subunit P isoform b"
                     /protein_id="NP_001153090.1"
                     /db_xref="CCDS:CCDS49919.1"
                     /db_xref="GeneID:56176"
                     /db_xref="MGI:MGI:1860433"
                     /translation="MRGQDSGPLSSPGPFLASEGPRLSKATGKMVENSPSPLPERAIY
                     GFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVIGYVLL
                     FGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVNKMFFLGAKELN
                     T"
     exon            186..289
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            290..362
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            363..481
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            482..817
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      619..624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /note="hexamer: TATAAA"
     polyA_site      641
                     /gene="Pigp"
                     /gene_synonym="Dcrc; Dscr5"
                     /note="major polyA site"
ORIGIN      
        1 tgcgcattgg actgagtggg gctgaagggt ggggacgggt gggcgtcggt gctcgcagga
       61 ctcaaggtcc cgggcctcct gtttcctctg agcctcacga aggctgggac agggcccatc
      121 atgagagggc aggactcggg gcctctgtcc agcccgggcc ccttcctcgc ctcagagggt
      181 ccgagattgt ctaaagccac agggaagatg gtggaaaatt caccgtcgcc attgccagaa
      241 agagcgattt atggctttgt tcttttccta agctcacaat ttggcttcat actttatctt
      301 gtgtgggctt tcgttcccga atcttggtta aactccttag gcttaactta ctggcctcaa
      361 aaatactggg cggttgcatt gcccgtctac ctccttatca cagttgtaat tggttatgtg
      421 ctcttatttg gaatcaacat gatgagtacc tctccacttg actccattca tacgatcaca
      481 gataactatg ctaaaaacca acagaggaaa aactaccaag aggatgccat cccagcattg
      541 agagatgtcc ccattagtga agtaaacaaa atgtttttcc taggagccaa agaactcaat
      601 acctaaaact gagctgtgta taaacatcct aaaaccagtc atttacagtt gtgggctgaa
      661 taattttgag cataattata ttgattgtcc ttttaatacc caatattgac atgtaaaaac
      721 atgacagttg attccttaga ttaagttcaa ttggtattgt aaatattttc aactgagttt
      781 ttaattgaca ataaataaaa taccacatta tactataaaa aaaaaaaaaa aaaaaaaaaa
      841 aaaaaaaaaa aa
//
