LOCUS       NP_064419               1101 aa            linear   ROD 17-DEC-2022
DEFINITION  GPI ethanolamine phosphate transferase 3 isoform 1 [Mus musculus].
ACCESSION   NP_064419
VERSION     NP_064419.2
DBSOURCE    REFSEQ: accession NM_020035.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1101)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   2  (residues 1 to 1101)
  AUTHORS   Shishioh N, Hong Y, Ohishi K, Ashida H, Maeda Y and Kinoshita T.
  TITLE     GPI7 is the second partner of PIG-F and involved in modification of
            glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 280 (10), 9728-9734 (2005)
   PUBMED   15632136
REFERENCE   3  (residues 1 to 1101)
  AUTHORS   Hong Y, Maeda Y, Watanabe R, Inoue N, Ohishi K and Kinoshita T.
  TITLE     Requirement of PIG-F and PIG-O for transferring phosphoethanolamine
            to the third mannose in glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 275 (27), 20911-20919 (2000)
   PUBMED   10781593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092394.1 and BU708685.1.
            
            [WARNING] On Jul 26, 2023 this sequence was replaced by
            NP_064419.3.
            
            On Jun 16, 2009 this sequence version replaced NP_064419.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092394.1, AB038560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     Protein         1..1101
                     /product="GPI ethanolamine phosphate transferase 3 isoform
                     1"
                     /note="GPI ethanolamine phosphate transferase 3;
                     phosphatidylinositol-glycan biosynthesis class O protein"
                     /calculated_mol_wt=119941
     Region          72..352
                     /region_name="GPI_EPT_3"
                     /note="GPI ethanolamine phosphate transferase 3, PIG-O;
                     cd16023"
                     /db_xref="CDD:293747"
     Site            order(84,139,243,285..286)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:293747"
     Site            order(84,139,243,286)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:293747"
     CDS             1..1101
                     /gene="Pigo"
                     /gene_synonym="PIG-O"
                     /coded_by="NM_020035.3:678..3983"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS18088.1"
                     /db_xref="GeneID:56703"
                     /db_xref="MGI:MGI:1861452"
ORIGIN      
        1 mnilfsprmr kvsvllflaw vcflfyagia lftsgflltr leltnqsscq elpgpgplpw
       61 gshgkpgacw mpsrfsrvvl vlidalrfdf aqpqrshvpg eppvsvpflg klgslqrile
      121 sqphhgrlyr sqvdpptttm qrlkalttgs lptfidagsn fashaivedn viqqlnsagr
      181 rvvfmgddtw rdlfpgafsq afffssfnvr dlhtvdngil ehlyptldgg swdvliahfl
      241 gvdhcghkhg phhpemakkl sqmdqviqgl ierlendtll vvagdhgmtm ngdhggdsel
      301 evsaalflys ptalfpsvpp eepevipqvs lvptlalllg lpipfgntge vmaelfsggs
      361 dsshphssal aqvsalhina qqvsrflhty saatqdlqvk elhrlqtlfs kasaryqhfl
      421 rdpqeaeaal stltaefqqf lrgaralcie swarfslvrm aggaallaaa cllcllasql
      481 avapgflfrp lllipvawgl twtilyagvs vttgskidlv vlgavaaags llpflwkawv
      541 srgskrplap llpvprpvli lllirlatff sdsfvvaear atpfllgslv fflvaqlhwe
      601 gqllppkplt msrlgssapt apprhsgaha lwlgiglllf trlaglfhrc peetpacrss
      661 pwlsplasmv ggraknlwyg acvgalvall vvvrlwlrry gnlkspeppv lfvrwgmplm
      721 vlgtaaywal asgaeeappr lralvagasa vlpravmgla alglvlllwr pvtvlvkaga
      781 atsrtrtilt pfsgpptsqa dldyvvpqiy rhmqeefqgr lertkaqgpi tvaayqlgsv
      841 ysaamvtall llafplmllh vervslvfll lflqsflllh llaagtpvat pgpftvlwqa
      901 vsawvllatq tfystghqpv fsaihwhaaf vgfpdghgss twlpallvga ntfashllfa
      961 vgcpllllwp flcerqgpkr rqplpgsese arvrpeeeee lqeplmemrl rdapnhfnaa
     1021 llqlglkylf ilgaqilaca laasilrrhl mvwkvfapkf ifeavgfivs svglllgial
     1081 vmrvdvavss wfkklvlaqq r
//
