LOCUS       NM_026234               7569 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphatidylinositol glycan anchor biosynthesis, class
            M (Pigm), mRNA.
ACCESSION   NM_026234
VERSION     NM_026234.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7569)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7569)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 7569)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074311.28.
            
            On Mar 1, 2008 this sequence version replaced NM_026234.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7569              AC074311.28        139928-147496
FEATURES             Location/Qualifiers
     source          1..7569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.73 cM"
     gene            1..7569
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class M"
                     /db_xref="GeneID:67556"
                     /db_xref="MGI:MGI:1914806"
     exon            1..7569
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1440
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /EC_number="2.4.1.-"
                     /note="phosphatidylinositol glycan, class M; PIG-M;
                     GPI-MT-I; GPI mannosyltransferase I;
                     phosphatidylinositol-glycan biosynthesis class M protein"
                     /codon_start=1
                     /product="GPI mannosyltransferase 1"
                     /protein_id="NP_080510.1"
                     /db_xref="CCDS:CCDS15513.1"
                     /db_xref="GeneID:67556"
                     /db_xref="MGI:MGI:1914806"
                     /translation="MSYPMHWGEWILNFRVPPAGVFGVAFLARVALVFYGVFQDRTLL
                     VRYTDIDYHVFTDAARFVTEGRSPYLRATYRYTPLLSWLLTPNVYLSELFGKFLFISC
                     DLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLSTLYF
                     IEKRLIACAAVFYGFAVHMKMYPVTYILPIALHLRPERDDDERLRQARFSFQARLYDF
                     LRRLCSWAVLLFVAVAGLTFVALSFGFYYKYGWEFLEHTYFYHLTRRDIRHNFSPYFY
                     MLYLTAESKWSFTLGIAAFLPQFILLSAASFAYYRDLVFCCFLHTSIFVTFNKVCTSQ
                     YFLWYLCLLPLVMPLVRMPWKRAVVLLLFWFIGQALWLAPAYVLEFQGKNTFLFIWLA
                     GLFFLLINCSILIQIISHYKEDRLTERIKYD"
     regulatory      7072..7077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      7095
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="major polyA site"
     regulatory      7406..7411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="hexamer: TATAAA"
     polyA_site      7428
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="major polyA site"
     regulatory      7435..7440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="hexamer: AATATA"
     polyA_site      7460
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
     regulatory      7525..7530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      7546
                     /gene="Pigm"
                     /gene_synonym="4933437L05Rik; C920011G20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggacttggg gtgccggaag tgatcattcc tcggttcttc ctgtcggtgc tgtagcagag
       61 gagatgctcc cggcggctga gaggcgtcag cccgaggacg gttagcgaga ggggcgcagt
      121 gtggacccgg ggccgggccg ggccgggcgg gtggcccgca ctcggaccat gagctacccc
      181 atgcactggg gggaatggat cctgaacttt cgggtgccgc ccgccggggt gttcggcgtg
      241 gccttcctgg cccgggtcgc cctggttttc tacggtgtct tccaggaccg gactctgctg
      301 gtgaggtaca ccgacataga ctaccacgtg ttcacggacg ccgcgcgctt cgtcacggaa
      361 gggcgctccc cgtacctgcg ggcgacctac cgctacaccc cgctcctgag ctggctcctc
      421 acccccaacg tctacctcag cgaactcttc ggcaagtttc tcttcatcag ctgcgatctc
      481 ctcaccgcct tcctcctgta ccgcctgctg ctgctcaagg ggctggggcg ccgccaagcc
      541 tgtggctact gcgtcttctg gcttctcaac cctttgccca tggcggtgtc cagccggggc
      601 aacgcggact ccatcgtcgc ctccctggtt ctctcgaccc tgtacttcat agagaaacgg
      661 ctcatcgcgt gcgccgcggt gttctatggc ttcgcggtgc acatgaagat gtacccggtg
      721 acctacatcc tccccatagc gctccatctg cggcccgagc gcgacgatga cgagcgtctc
      781 cggcaagccc ggttctcttt ccaggctcgt ttgtacgact tcctgaggag gctgtgtagc
      841 tgggcagtgc tgcttttcgt agcagttgca gggctcacgt ttgttgccct gagcttcggt
      901 ttttactata agtacggttg ggagtttttg gagcacacct acttttatca cctaactagg
      961 agggatatcc gccataattt ctctccgtac ttctatatgc tgtatttgac tgccgagagc
     1021 aagtggagtt ttactctggg gattgcggcg ttcctgccac agttcatctt gctgtcagcc
     1081 gcatctttcg cctactacag agaccttgtc ttctgctgtt tccttcatac gtccattttt
     1141 gtgactttta acaaagtctg cacctctcag tactttcttt ggtatctctg ccttctgcct
     1201 ctggtgatgc cactggtgag gatgccttgg aaaagagccg tagtcctctt actgttctgg
     1261 ttcataggac aggccttatg gctggctcct gcatatgttc tagagtttca aggaaagaac
     1321 accttcctgt ttatttggtt agccggtttg ttcttccttc tgatcaactg ttccatactg
     1381 attcagatta tttcccatta caaggaggac cgcctaacgg agagaatcaa atacgactaa
     1441 tgtgttctgg atcttctgca acattctgat tttgccgtat ggactaggag gctttggaat
     1501 ttttctcctc cctgaacatt ctaagcactc tagtgaaagt tcctttgttc caatagaaat
     1561 taaaaccagt gttggcctta tatataaagg gggcccaaga actgaggtcc atggtccatc
     1621 ctttagaagt cttagggctc atttgcttga tgagaagaaa gccattcctg tttcacagtt
     1681 gagaagccgg tgaagctaga agatgctgaa atatttttga acagtagagg aataaggtct
     1741 ctagcagcgt ttgttcctgt cacatggtgc tactgttgta ccttcagccc ctgccttttt
     1801 ttttttttcc tgcagttctg acagcggtgg aagttgacaa aatccctaaa gcacaacatt
     1861 tttacgtatt aagtattaac agttccatgc tcggttggga aagtctgaaa tttttgtagt
     1921 aagtgtgggg gcttagaaga gaactaatcc aaagaatcta aattgtgatc atgtatttgt
     1981 tttgtaattg agtttttcag tattagtacc agtggtattc attttatata aaaagattaa
     2041 atttaaactc atccactgta gacctgagtt taagaaaacg aaatggagca ttattaacat
     2101 gtatatgctt atcctttttc taactgctag gaagactttt cctctagagt ttcctctgag
     2161 agcggtgtgt tgtaaaagtg gtaaaattta gatgctaaag cctaagtttt gagtataact
     2221 tcacttgctc tcttctggtt ttatcatcta aattgttaca aaggagaaca ttgtttataa
     2281 ggcataaatc ctacactctg aaaattccag gatagaaagg aagactgctt gctgtaaagc
     2341 atgagtgctg cgtgctgtca ttggacaatc aagaggtggt aagggatttg aggaattaca
     2401 gaaatgaggc tgtgaggagc aggtctttct acttatcact tgaagtaaac acagtgaaac
     2461 tgtatgaata aactttctca actgtatgaa taaacattct aaaatatttt tagaaaacat
     2521 agagcctgtc tgtgttgagg gttttctaac attcaaagat gcagtagcaa tagatgagta
     2581 taattttttt tttaaagaat aaaattatca tctttaaatg caagttcaag agaagatagg
     2641 atttttgttt gtttgtttgt tttttttttg gtttggtagg ggttggtttt tcctttgtct
     2701 ggtttttttt gtttttttgt tttttttttt tgacccaggg tttctctgtg cagccctggc
     2761 tttcctggaa ctcactctgt aggcaaggtt gactcaaaga tctgcctgcc tctgtctcct
     2821 gagtgctggg actaaaggag tgtgtaacca cactcagcaa gaagaaagtt ttaacaggct
     2881 ttaatttatt tttactttta ataagaatgt tgattttgaa tgtttatcag ctagttctga
     2941 ttgttttatt tttctttgag atagcactcc attctacagc acaggctggc ctcaagctca
     3001 ctgcactctt cttgcctctg aagtgctagg tctacatgtc tgagccacta taactggctt
     3061 tctgattgtt acttctaaag caagatttta gggctaagag aacaactgct gaaagttgtc
     3121 ctctgacttc cacgagcatg cagtgacgtg tgcttgtgca cgtacatggg tgcacacaca
     3181 caaactaatg agtgtattct ctcaagaaag ctatttaaaa catgaaaagg tctagatgtt
     3241 ttcagatata aaataagttg tctcaatgct gatgtctaac gacttttagc aaatgtggta
     3301 gtaaacaatc acataaatat gtttttggct ttaggaaaag gactttgttt tttggagcca
     3361 aagtctcact gtggtagcct cggatgcctc agactcagtg tgcaatcccg accaacctcc
     3421 aactcatcct cctgctctag cctcttgggt cctgggatta aaaatgtgcc aggccagttt
     3481 ttactttgac tgccatatgc atatccttac catgtttttc tctttctttg taaagttcca
     3541 gcttccatgc atgtacctgg gtgacatgag aattctaaaa aaaaacaagc tagaaaatag
     3601 ttctgtctcc agcctgcata agcgtagatg gcgataatac agactctctc agtaggtcct
     3661 ctagccgctt ctgttattcc acctttgact tcgattcctc ttccagctgc ttacccagcc
     3721 tttcactctg ctccgccttc tgctggacgg catccaactc agccagggcg agctttagct
     3781 tttccttaaa gacattcttt tcggaagtca tttcctctta gagcagagca tcagagtgtc
     3841 ctttcctaag gcgctcctga aaagattcaa tgacccttcg ggttgtgctc catctccagg
     3901 tgcttatgat ggtaaaactt gagaagcaaa ctctccatga atataatttt tgtgatcatg
     3961 atgtttttgt ttttaaattg gattcttttc cagggtcagc aacaacaaaa aactcctgaa
     4021 aaataagcac tactccagaa aagtagtatt ctttccccct gtcacggcaa gcctagaaag
     4081 cctttgagga taaaatcttt ataggctggt cataattaaa aattctctta ggggcagcat
     4141 ttctttgctg gattcctttt gggattggcc ttaggaagaa gaataggtgg cttttctgtt
     4201 gcttactgta tgtgagaaaa gtggtcaatt gtagaaaaca gtgacctttc ctaaaatggc
     4261 aagatccata tttctattta gctcctaaca gcacactgct taagacagtt taagaagtgg
     4321 ctttccaatt atggtacatg aaccttttaa aattattatg gtgattgaaa cccctattct
     4381 aggcaagcag tctgccactg agtaatgtac ccagccccaa gtgaatattt gaaattgaaa
     4441 atttgagcaa ggaaagtata tattcatgtg tttttatagg cctgactttt gttgttcttt
     4501 tagacagtct tagtccaggc tggccttaaa ctttgtttgc ccaagataaa cttgaactga
     4561 tcttcatgcc tctacctcct aaagagctga gattacagtc ctgtgacact gtgcttggct
     4621 cagaaattct ttatcaaaga aatgcaagtg tttcttaagg gatgcagaag atatttgcag
     4681 ttagtctgct gcaaaccttt atttttttaa tttgctttat atgtataggt gttttgcata
     4741 tatgtctgtg caccatgtgc attcctagtg cccaaggtgg ccagaagagg gcattggatt
     4801 tctagaatag atggttctga gccaccatgt gggtgggtac taggaatcca acctgaaaat
     4861 ctccgggaag agcagctagc actcttcacc actgagccaa ctcttcagcc ccatgctgca
     4921 gagacattta gtaagttaag cggagaaaag acctgatttg atcttttggc ttttacttct
     4981 gttttgcagc ttttaaagtt ttatttgggg aagaggcaca cataccttgt cctgtgtatg
     5041 caggtcagat gcacttgtgg acggcagagg acttgtggta gtccatttcc ctctttccat
     5101 tatgctggcc ctaggatcaa acttgggttg tcagtcttgg cagctgtacc tttttacact
     5161 gcactgtctg gtcgctttgt cttttttccg tttatgatat cttttgtttc cttataagtc
     5221 cttaaataat accttaaaat tgtgtcgctc tttgacgtat tttctgtgta attctcttgt
     5281 tcttatacta cctgcattat ctttatgtca ctgtagcaaa tgcctatcat aagtcaactc
     5341 tcaggagcca taatgggaca agctaataac tagcaggtga tcatcctgaa gtggcctgcc
     5401 tcggattatt atataatctg cgacaggtgc gcccttatta agaaaggctg taagggactc
     5461 attttaggaa agatgcctgc tattaatgtg cttttcctgt tactattaaa catatataac
     5521 aatcactaag tagtagcaca cccctgtgga gcagatctct gcagatccac aaagagcttg
     5581 tcgtgttgct atatagacaa atagatgact taagtcttca tgatgatcct ataagaattc
     5641 ctaaaattat atctgtgttt attaagctct tttataacag gactgctatt aggtcctttt
     5701 ttgatagtca aagctgcaat gagaactctg cccaagtgtc cccagttaat tgctcttaga
     5761 tagtaaccag actttatcct attcagagta cactccaaga agttgtaaaa caattaacca
     5821 aaggtcataa aaagggaact aatgatttat tataggtgtt aggacagaag ataaaatatc
     5881 tattgggctt atctatacaa aacttcactg ataacttagt tatggtttta aaccttcagg
     5941 gaccctgtag agctgagaca agtgatggat gtttagccag ataattactc ctaactgtta
     6001 ggagcgtgca tgtaaacatt cactgttgta aacttctatt tcagtttatg atttgatttt
     6061 atgtgtgaac ttgtgatgaa cttgtaacat gtgatcatgt attctggaag atatataagt
     6121 actgaggaca gagagatgag gggagagaaa ggagaatttt ttccctttcc ccacttagag
     6181 aactttttcc ctttccccac tcaggatctt tttgcttaga tagctttcat aggaaacttt
     6241 tttacaactt agtaataaac tctataacca cttttctaag tgtccttttt tctccctgca
     6301 acttccaact agcaggctga aagttagagc ccagcagcaa ttcctgctgc gatagaacaa
     6361 aggctattaa cttaatcctt tgtggtttga ggaagaggtg ctaagtgcca gaaactgcag
     6421 tctctgcctc agaggatcac agaaggcagg tcagctacaa tagcatagta acttagaatt
     6481 agacaagtaa ctttttagta tatagcaacc ctaaatataa gaaccaagaa ccctccgcct
     6541 acgcgctccc cctctgctgt ctcaagaaga accaagaaga aagaacaaaa cccccaccag
     6601 agctgccccc cccaacagtc aatttataga gagaaaagat ttatttgggg ccatggatta
     6661 aaagtttaac tttgagattg gttggccttg tggccacagg cctgtagtga ggtagcacac
     6721 tgtagcatga ggacacgata aaacaaactg ttgacgttat tgtgggtgca gaagacagag
     6781 tctgagacat gggtctctga gatccttttg agggcacacc cctaatgccc taaaacctca
     6841 cactgggctg gcctaaagtt tccacagttt ccagtagtgc cgcagtcaag gaaacaagct
     6901 tttaacacct gggccttggg gagagttcag atccatacta tagcattaac tgtgtaggac
     6961 agactgactg acaggcaagc agtcatgatt agattaagaa gaatgtttct ccacacaggt
     7021 tgtgattttt ttttttttct gtaactgctt ttctgatgtc cccaaaatgt cattaaaggt
     7081 ctcaagttcc ctggattggg atcattatcg tctgttttgt tttttagttg taggagatag
     7141 ggtcttatat agctcaggct ggtctcaaac ttgttatgta acagaggctg gccttgaact
     7201 cagcctcttg agtctacctc ccaagtacta gaattaacag gtgtgctgga ccatgcctag
     7261 tgtggattag gttctttgga aaagctgtga gaaatatgta cactactggg caactcagca
     7321 aaaggattct taaaactgta gatctcagtc actgacatct cgccatctgg attttataag
     7381 ctgtataatg atgtttcata agttgtataa aacttgaact ttaatttatg gctgaatata
     7441 ttgttctttt tttctcttaa catccgttat tttatattcc tacctacact ctcttgccat
     7501 ctgtgatgta agttatcagt agaaaagaaa aacctgaaaa attctacctg tggtggtctt
     7561 tatatccaa
//
