LOCUS       NM_029988               2376 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus phosphatidylinositol glycan anchor biosynthesis, class
            H (Pigh), mRNA.
ACCESSION   NM_029988 XM_127026
VERSION     NM_029988.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Wergedal,J.E., Ackert-Bicknell,C.L., Beamer,W.G., Mohan,S.,
            Baylink,D.J. and Srivastava,A.K.
  TITLE     Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J
            intercross and a combined intercross involving NZB/B1NJ, RF/J,
            MRL/MpJ, and SJL/J mouse strains
  JOURNAL   J Lipid Res 48 (8), 1724-1734 (2007)
   PUBMED   17496333
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Seldin,M.F., Hirohata,S. and Apte,S.S.
  TITLE     Chromosomal mapping of Adam9, Adam15 and Adam21
  JOURNAL   Matrix Biol 19 (2), 185-187 (2000)
   PUBMED   10842103
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Ware,R.E., Howard,T.A., Kamitani,T., Chang,H.-M., Yeh,E.T.H. and
            Seldin,M.F.
  TITLE     Chromosomal assignment of genes involved in
            glycosylphosphatidylinositol anchor biosynthesis: implications for
            the pathogenesis of paroxysmal nocturnal hemoglobinuria
  JOURNAL   Blood 83 (12), 3753-3757 (1994)
   PUBMED   8204896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY779412.1 and BC086806.1.
            
            [WARNING] On Apr 2, 2024 this sequence was replaced by NM_029988.3.
            
            On Sep 26, 2005 this sequence version replaced NM_029988.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086806.1, AK167892.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY779412.1         1-49
            50-2376             BC086806.1         1-2327
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..2376
                     /gene="Pigh"
                     /gene_synonym="2210416H01Rik; A930028P05Rik; PIG-H"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class H"
                     /db_xref="GeneID:110417"
                     /db_xref="MGI:MGI:99463"
     exon            1..231
                     /gene="Pigh"
                     /gene_synonym="2210416H01Rik; A930028P05Rik; PIG-H"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..618
                     /gene="Pigh"
                     /gene_synonym="2210416H01Rik; A930028P05Rik; PIG-H"
                     /EC_number="2.4.1.198"
                     /note="phosphatidylinositol-glycan biosynthesis class H
                     protein; phosphatidylinositol glycan, class H"
                     /codon_start=1
                     /product="phosphatidylinositol
                     N-acetylglucosaminyltransferase subunit H"
                     /protein_id="NP_084264.1"
                     /db_xref="CCDS:CCDS26006.1"
                     /db_xref="GeneID:110417"
                     /db_xref="MGI:MGI:99463"
                     /translation="MEDEKSFSDICGGRLALRCRYYSPYCREFGLSSARLSLCSLTAV
                     TCAVWLAAYGLFTLCENSMVLSATIFITILGLLGYLHFVKIDQETLLIIDSLGIQMTS
                     SYASGKESTTFIEMDKVKDIIINEAIYMQKVIYYLCILLKEPGKPHEISRVVPVFQSA
                     KPRLDCLIEVYRSCQEVLAHQKATATSL"
     exon            232..441
                     /gene="Pigh"
                     /gene_synonym="2210416H01Rik; A930028P05Rik; PIG-H"
                     /inference="alignment:Splign:2.1.0"
     exon            442..525
                     /gene="Pigh"
                     /gene_synonym="2210416H01Rik; A930028P05Rik; PIG-H"
                     /inference="alignment:Splign:2.1.0"
     exon            526..2353
                     /gene="Pigh"
                     /gene_synonym="2210416H01Rik; A930028P05Rik; PIG-H"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgagcctc cgggtgggct agagcggcgc gacattcagg tgtgtgcggc catggaggac
       61 gagaagagct tctccgatat ctgcggcggc cgcctagccc tgcggtgccg ctactactca
      121 ccgtactgcc gcgagttcgg cctcagctcg gctcggctgt cgctgtgctc gctcaccgcg
      181 gtcacctgcg cggtgtggct ggcggcctac gggctcttca ccctgtgcga gaatagcatg
      241 gtcctctctg ccaccatctt catcaccatc ttaggcctgc ttggttacct ccattttgtg
      301 aagattgacc aggagactct actaatcatc gactcacttg gcatccagat gacttcatct
      361 tatgcatcgg gcaaagaaag taccaccttc atagagatgg acaaggtcaa ggacattatc
      421 attaacgagg ctatctacat gcagaaggtc atttactacc tctgcatttt actgaaggag
      481 ccggggaagc cacacgagat ctctcgagta gttcctgtct tccagagtgc caagccccgg
      541 ttggactgct tgattgaagt atacagaagc tgccaggagg ttctggcaca ccagaaagcc
      601 acagcaacaa gcttatgagg ctcagcattc aaaggccagt attgtcttta tggagaggac
      661 tcctagactg tagtggccgg tttattttcc atactgtaaa aaccatcagg acacagtcct
      721 gggaatcaga atggatgagt agatctcaga accacagagg aggggctgga acttgattca
      781 tgttcataat gttccctgta taatacagtt ttttctatac tacgaatcaa ggggagacct
      841 taaggatttt gacatgtcaa aaggcggcca ggcatagtgg cacatgcctt tagtcccagc
      901 actcaagagg cagaagcagg tgatctcttg agtttaaggc cattctgagc tacatagtaa
      961 gtatcctcca cccaaaagta ttgtccaaaa agaacactga aaactttaag taccttcatg
     1021 tttgtgttaa aatctgtgaa gtattaagac tggtaccaga tttcacaaga aaaatgtaat
     1081 ttccatctgt atagactctt gtctaaaagt tagggaaaat aagtcacatt tttatgtatg
     1141 agttagcagg aataaaatgc ctaaagggct agcctctatc cacccagctc ctaagatctg
     1201 tgcaggatca tgactccttc atccacaatt tagctaggga tggtgtggat gcttgtaatc
     1261 ccagctctca gaagctgtca acaggaggat tgaaagtttg aggccagcct gggcttcgtg
     1321 atgagacact gtctcaaacc ccaagataaa tatccacaac acacagttat tgtctggttc
     1381 actgacagtt ttattgacaa acatacatag catttcagcc atgggtgtca agcatgagag
     1441 tacctttctg ttaatatttt ctattgctca aaagctgttt ggctaagagg gcttaggtga
     1501 agagtgagag attaaatgtt ggttcccaga catgagcctg tcacattaaa ggatgaggaa
     1561 gccagttgac agaagccttt gtttcagagg tggttcctta gatgctaaag atcaggaagg
     1621 agaaaaggcg ctggactggg cagaactcgc ctttaacccc agcactgcag aggcagaggc
     1681 aggcggatct ctgagtttga ggccagcctg gtctacatag tgagttccag gacagccagg
     1741 tctgcatagt gaaaccctat ctcaaaaaga gagcaagaga aaggaaaaaa aaaagcagca
     1801 gcacagcagc agtagctaat cagaccttca agtcttacaa acagttgcat tagctggaat
     1861 tctgtttaca aaacaaaaac aacctgagag cagactacat ccttactggc tttaaggccc
     1921 ttgggatgta aaccaagaac tgcattctct gcccttcacc tagccttgaa ggagctgtcc
     1981 aggggcctat agcaatgtga cttgaggtag acctgtctcc tctagaaccc caaatctggg
     2041 gtgggagttg gggttcaaac agaaatggct ataaagctgc ctggcttgca agtcaagctc
     2101 tttttaaggg gcagactctt gtgccttttt aaagtcaggc ttgtcagttc aaaggatgag
     2161 ggattacagc agctgaggca ttcagattaa actaattttt ggccttgcag tttcttgtgg
     2221 tgtacaacac acacattgtt gggttaaagg cttatttctt gatattcctc ttatccccta
     2281 gtctatgtta ctgaaaaata ataaaactgc cttaaagcta cacaataaag cttatttttt
     2341 atatgttgga aaaaaaaaaa aaaaaaaaaa aaaaaa
//
