LOCUS       NM_001411411             952 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phosphatidylinositol glycan anchor biosynthesis, class
            F (Pigf), transcript variant 12, mRNA.
ACCESSION   NM_001411411
VERSION     NM_001411411.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Li,Z., Li,D., Rao,Y., Wei,L., Liu,M., Zheng,G., Yao,Y., Hou,X.,
            Chen,Y. and Ruan,X.Z.
  TITLE     SCAP knockout in SM22alpha-Cre mice induces defective angiogenesis
            in the placental labyrinth
  JOURNAL   Biomed Pharmacother 133, 111011 (2021)
   PUBMED   33227706
REFERENCE   3  (bases 1 to 952)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 952)
  AUTHORS   Sones,J.L., Merriam,A.A., Seffens,A., Brown-Grant,D.A.,
            Butler,S.D., Zhao,A.M., Xu,X., Shawber,C.J., Grenier,J.K. and
            Douglas,N.C.
  TITLE     Angiogenic factor imbalance precedes complement deposition in
            placentae of the BPH/5 model of preeclampsia
  JOURNAL   FASEB J 32 (5), 2574-2586 (2018)
   PUBMED   29279353
REFERENCE   5  (bases 1 to 952)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 952)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (bases 1 to 952)
  AUTHORS   Hong,Y., Maeda,Y., Watanabe,R., Inoue,N., Ohishi,K. and
            Kinoshita,T.
  TITLE     Requirement of PIG-F and PIG-O for transferring phosphoethanolamine
            to the third mannose in glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 275 (27), 20911-20919 (2000)
   PUBMED   10781593
REFERENCE   8  (bases 1 to 952)
  AUTHORS   Ohishi,K., Kurimoto,Y., Inoue,N., Endo,Y., Takeda,J. and
            Kinoshita,T.
  TITLE     Cloning and characterization of the murine GPI anchor synthesis
            gene Pigf, a homologue of the human PIGF gene
  JOURNAL   Genomics 34 (3), 340-346 (1996)
   PUBMED   8786134
REFERENCE   9  (bases 1 to 952)
  AUTHORS   Ohishi,K., Inoue,N., Endo,Y., Fujita,T., Takeda,J. and Kinoshita,T.
  TITLE     Structure and chromosomal localization of the GPI-anchor synthesis
            gene PIGF and its pseudogene psi PIGF
  JOURNAL   Genomics 29 (3), 804-807 (1995)
   PUBMED   8575782
REFERENCE   10 (bases 1 to 952)
  AUTHORS   Ware,R.E., Howard,T.A., Kamitani,T., Chang,H.-M., Yeh,E.T.H. and
            Seldin,M.F.
  TITLE     Chromosomal assignment of genes involved in
            glycosylphosphatidylinositol anchor biosynthesis: implications for
            the pathogenesis of paroxysmal nocturnal hemoglobinuria
  JOURNAL   Blood 83 (12), 3753-3757 (1994)
   PUBMED   8204896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127695.3 and AC154492.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.9205038.1,
                                           SRR17253014.4187440.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC127695.3         55250-55320         c
            72-320              AC127695.3         53617-53865         c
            321-412             AC127695.3         51811-51902         c
            413-529             AC127695.3         50353-50469         c
            530-642             AC127695.3         38751-38863         c
            643-952             AC154492.2         162299-162608       c
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 56.9 cM"
     gene            1..952
                     /gene="Pigf"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class F"
                     /db_xref="GeneID:18701"
                     /db_xref="MGI:MGI:99462"
     exon            1..71
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            72..320
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..728
                     /gene="Pigf"
                     /EC_number="2.7.8.1"
                     /note="isoform 5 is encoded by transcript variant 12;
                     phosphatidylinositol-glycan biosynthesis class F protein;
                     PIG-F; phosphatidylinositol glycan, class F"
                     /codon_start=1
                     /product="phosphatidylinositol-glycan biosynthesis class F
                     protein isoform 5"
                     /protein_id="NP_001398340.1"
                     /db_xref="GeneID:18701"
                     /db_xref="MGI:MGI:99462"
                     /translation="MKDTDIKRLLYTNLLCVFSIFLSIFIPSFFVDNFSVLEAHLTWL
                     CICSASVTTVNLLSYLVVKPNVSSKRSSLSHKVTRALKCCVCFLMSCFLLHIIFVLYG
                     APLIELVLETFLFAVVLSTFTTVPCLCLLGPNLKAWLRVFSRNGVTSIWENSLQITTI
                     SSFTGAWLGAFPIPLDWERPWQVGVAHLLYTRSDLWLRGWPGYLATLDLLE"
     exon            321..412
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            413..529
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            530..642
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            643..952
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      935..940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigf"
                     /note="hexamer: AATAAA"
     polyA_site      952
                     /gene="Pigf"
                     /note="major polyA site"
ORIGIN      
        1 atgccagcct gtagcacctg agggtgggag gcggtggtgt cccccttccc ttcggcgggc
       61 gggagagtta gatagctacc caagaaaaca tcatgaaaga tactgacatc aagagacttc
      121 tgtataccaa tcttttgtgc gtattttcaa ttttcctaag cattttcatt ccgtccttct
      181 tcgtggacaa cttctcagta ttggaagctc atttgacctg gctgtgtatc tgctctgctt
      241 ctgtgaccac tgtcaatctc ttgtcgtact tagtagtgaa accgaatgtg tcctctaaaa
      301 gaagttcatt gtcacataag gtaacgcgag ctttgaaatg ctgtgtctgc ttccttatgt
      361 cttgttttct ccttcacatc atttttgttc tatatggagc accactaatc gagttggtgc
      421 tggaaacgtt tttatttgca gttgttttgt ctacttttac tacagtacct tgtctctgtt
      481 tgttaggacc aaacctcaaa gcatggctga gagttttcag tagaaatgga gttacatcta
      541 tttgggagaa tagtcttcag atcactacaa tttctagttt cacaggagcg tggcttggag
      601 catttcctat tccactggat tgggaaagac cgtggcaggt tggtgtggcc catctcctgt
      661 acactcggag cgacctttgg ctacgtggct ggcctggtta tctcgccact ctggatctac
      721 tggaatagaa agcagcttac atacaagaac aattaagagg agaaaggaga gaagttattt
      781 ctctgtgcag attccataag ggctgtgcag aagttacatg gtccaagccg ggcagtccat
      841 ttacagcact gttgttttct aaatgtcatt tcaacatgat gtgattgtag ctttttaact
      901 atgaaacccc tgagagattg taccttctag ttgaaataaa gtatttatag ta
//
