LOCUS       NM_001411402            1332 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phosphatidylinositol glycan anchor biosynthesis, class
            F (Pigf), transcript variant 3, mRNA.
ACCESSION   NM_001411402 XM_036160403
VERSION     NM_001411402.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Li,Z., Li,D., Rao,Y., Wei,L., Liu,M., Zheng,G., Yao,Y., Hou,X.,
            Chen,Y. and Ruan,X.Z.
  TITLE     SCAP knockout in SM22alpha-Cre mice induces defective angiogenesis
            in the placental labyrinth
  JOURNAL   Biomed Pharmacother 133, 111011 (2021)
   PUBMED   33227706
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Sones,J.L., Merriam,A.A., Seffens,A., Brown-Grant,D.A.,
            Butler,S.D., Zhao,A.M., Xu,X., Shawber,C.J., Grenier,J.K. and
            Douglas,N.C.
  TITLE     Angiogenic factor imbalance precedes complement deposition in
            placentae of the BPH/5 model of preeclampsia
  JOURNAL   FASEB J 32 (5), 2574-2586 (2018)
   PUBMED   29279353
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Hong,Y., Maeda,Y., Watanabe,R., Inoue,N., Ohishi,K. and
            Kinoshita,T.
  TITLE     Requirement of PIG-F and PIG-O for transferring phosphoethanolamine
            to the third mannose in glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 275 (27), 20911-20919 (2000)
   PUBMED   10781593
REFERENCE   8  (bases 1 to 1332)
  AUTHORS   Ohishi,K., Kurimoto,Y., Inoue,N., Endo,Y., Takeda,J. and
            Kinoshita,T.
  TITLE     Cloning and characterization of the murine GPI anchor synthesis
            gene Pigf, a homologue of the human PIGF gene
  JOURNAL   Genomics 34 (3), 340-346 (1996)
   PUBMED   8786134
REFERENCE   9  (bases 1 to 1332)
  AUTHORS   Ohishi,K., Inoue,N., Endo,Y., Fujita,T., Takeda,J. and Kinoshita,T.
  TITLE     Structure and chromosomal localization of the GPI-anchor synthesis
            gene PIGF and its pseudogene psi PIGF
  JOURNAL   Genomics 29 (3), 804-807 (1995)
   PUBMED   8575782
REFERENCE   10 (bases 1 to 1332)
  AUTHORS   Ware,R.E., Howard,T.A., Kamitani,T., Chang,H.-M., Yeh,E.T.H. and
            Seldin,M.F.
  TITLE     Chromosomal assignment of genes involved in
            glycosylphosphatidylinositol anchor biosynthesis: implications for
            the pathogenesis of paroxysmal nocturnal hemoglobinuria
  JOURNAL   Blood 83 (12), 3753-3757 (1994)
   PUBMED   8204896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127695.3 and AC154492.2.
            
            On Aug 25, 2022 this sequence version replaced XM_036160403.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.528842.1,
                                           SRR17784651.386725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               AC127695.3         54866-55320         c
            456-704             AC127695.3         53617-53865         c
            705-796             AC127695.3         51811-51902         c
            797-913             AC127695.3         50353-50469         c
            914-1022            AC127695.3         38755-38863         c
            1023-1332           AC154492.2         162299-162608       c
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 56.9 cM"
     gene            1..1332
                     /gene="Pigf"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class F"
                     /db_xref="GeneID:18701"
                     /db_xref="MGI:MGI:99462"
     exon            1..455
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            456..704
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1136
                     /gene="Pigf"
                     /EC_number="2.7.8.1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     phosphatidylinositol-glycan biosynthesis class F protein;
                     PIG-F; phosphatidylinositol glycan, class F"
                     /codon_start=1
                     /product="phosphatidylinositol-glycan biosynthesis class F
                     protein isoform 1"
                     /protein_id="NP_001398331.1"
                     /db_xref="GeneID:18701"
                     /db_xref="MGI:MGI:99462"
                     /translation="MKDTDIKRLLYTNLLCVFSIFLSIFIPSFFVDNFSVLEAHLTWL
                     CICSASVTTVNLLSYLVVKPNVSSKRSSLSHKVTRALKCCVCFLMSCFLLHIIFVLYG
                     APLIELVLETFLFAVVLSTFTTVPCLCLLGPNLKAWLRVFSRNGVTSIWENSLQITTI
                     SSFTGAWLGAFPIPLDWERPWQVWPISCTLGATFGYVAGLVISPLWIYWNRKQLTYKN
                     N"
     exon            705..796
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            797..913
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1022
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1332
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pigf"
                     /note="hexamer: AATAAA"
     polyA_site      1332
                     /gene="Pigf"
                     /note="major polyA site"
ORIGIN      
        1 atgccagcct gtagcacctg agggtgggag gcggtggtgt cccccttccc ttcggcgggc
       61 gggagagtta ggtaagccgg tggcgggttg cttctcacac tcgcccgggg cgggtgcagg
      121 tcgcaccgcc gaccgctgcg gtgacttcca gggcgccacg cttccggcgg accagaggat
      181 gccctgcgct accgaccctc tgagatgccg gcgtctatca cagtctctca ggggactccg
      241 acctcaggtc accgggtcgg ccgcacgggc tctctctatg atggcgacct ccagttgccc
      301 acactgcgcc gtccgaggct gggacggagc cacctgggtg gggtggagct gcggtccgca
      361 cctgagcaaa ggctgctcag gaggagggct cgggagcagc caagccttcc gaccccgttc
      421 tcacgggatc gcgagtcccg agggcggctt cccagatagc tacccaagaa aacatcatga
      481 aagatactga catcaagaga cttctgtata ccaatctttt gtgcgtattt tcaattttcc
      541 taagcatttt cattccgtcc ttcttcgtgg acaacttctc agtattggaa gctcatttga
      601 cctggctgtg tatctgctct gcttctgtga ccactgtcaa tctcttgtcg tacttagtag
      661 tgaaaccgaa tgtgtcctct aaaagaagtt cattgtcaca taaggtaacg cgagctttga
      721 aatgctgtgt ctgcttcctt atgtcttgtt ttctccttca catcattttt gttctatatg
      781 gagcaccact aatcgagttg gtgctggaaa cgtttttatt tgcagttgtt ttgtctactt
      841 ttactacagt accttgtctc tgtttgttag gaccaaacct caaagcatgg ctgagagttt
      901 tcagtagaaa tggagttaca tctatttggg agaatagtct tcagatcact acaatttcta
      961 gtttcacagg agcgtggctt ggagcatttc ctattccact ggattgggaa agaccgtggc
     1021 aggtgtggcc catctcctgt acactcggag cgacctttgg ctacgtggct ggcctggtta
     1081 tctcgccact ctggatctac tggaatagaa agcagcttac atacaagaac aattaagagg
     1141 agaaaggaga gaagttattt ctctgtgcag attccataag ggctgtgcag aagttacatg
     1201 gtccaagccg ggcagtccat ttacagcact gttgttttct aaatgtcatt tcaacatgat
     1261 gtgattgtag ctttttaact atgaaacccc tgagagattg taccttctag ttgaaataaa
     1321 gtatttatag ta
//
