LOCUS       NP_766041                637 aa            linear   ROD 08-JUN-2024
DEFINITION  ATP-dependent DNA helicase PIF1 isoform 1 [Mus musculus].
ACCESSION   NP_766041
VERSION     NP_766041.2
DBSOURCE    REFSEQ: accession NM_172453.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 637)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 637)
  AUTHORS   Belmonte,F.R., Dedousis,N., Sipula,I., Desai,N.A., Singhi,A.D.,
            Chu,Y., Zhang,Y., Bannwarth,S., Paquis-Flucklinger,V.,
            Harrington,L., Shiva,S., Jurczak,M.J., O'Doherty,R.M. and
            Kaufman,B.A.
  TITLE     Petite Integration Factor 1 (PIF1) helicase deficiency increases
            weight gain in Western diet-fed female mice without increased
            inflammatory markers or decreased glucose clearance
  JOURNAL   PLoS One 14 (5), e0203101 (2019)
   PUBMED   31136580
  REMARK    GeneRIF: They also support a role for Pif1 in weight gain
            resistance and liver metabolic dysregulation during nutrient
            stress.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 637)
  AUTHORS   Rue,L., Banez-Coronel,M., Creus-Muncunill,J., Giralt,A.,
            Alcala-Vida,R., Mentxaka,G., Kagerbauer,B., Zomeno-Abellan,M.T.,
            Aranda,Z., Venturi,V., Perez-Navarro,E., Estivill,X. and Marti,E.
  TITLE     Targeting CAG repeat RNAs reduces Huntington's disease phenotype
            independently of huntingtin levels
  JOURNAL   J Clin Invest 126 (11), 4319-4330 (2016)
   PUBMED   27721240
REFERENCE   4  (residues 1 to 637)
  AUTHORS   Bannwarth,S., Berg-Alonso,L., Auge,G., Fragaki,K., Kolesar,J.E.,
            Lespinasse,F., Lacas-Gervais,S., Burel-Vandenbos,F., Villa,E.,
            Belmonte,F., Michiels,J.F., Ricci,J.E., Gherardi,R., Harrington,L.,
            Kaufman,B.A. and Paquis-Flucklinger,V.
  TITLE     Inactivation of Pif1 helicase causes a mitochondrial myopathy in
            mice
  JOURNAL   Mitochondrion 30, 126-137 (2016)
   PUBMED   26923168
  REMARK    GeneRIF: pif1-/- animals develop a mitochondrial myopathy with
            respiratory chain deficiency.
REFERENCE   5  (residues 1 to 637)
  AUTHORS   Kazak,L., Reyes,A., Duncan,A.L., Rorbach,J., Wood,S.R.,
            Brea-Calvo,G., Gammage,P.A., Robinson,A.J., Minczuk,M. and
            Holt,I.J.
  TITLE     Alternative translation initiation augments the human mitochondrial
            proteome
  JOURNAL   Nucleic Acids Res 41 (4), 2354-2369 (2013)
   PUBMED   23275553
REFERENCE   6  (residues 1 to 637)
  AUTHORS   Reynolds,G.E., Gao,Q., Miller,D., Snow,B.E., Harrington,L.A. and
            Murnane,J.P.
  TITLE     PIF1 disruption or NBS1 hypomorphism does not affect chromosome
            healing or fusion resulting from double-strand breaks near
            telomeres in murine embryonic stem cells
  JOURNAL   DNA Repair (Amst) 10 (11), 1164-1173 (2011)
   PUBMED   21945094
  REMARK    GeneRIF: murine cells have evolved mechanisms to ensure the
            functional redundancy of Pif1 or Nbs1 in the regulation of
            chromosome healing.
REFERENCE   7  (residues 1 to 637)
  AUTHORS   Snow,B.E., Mateyak,M., Paderova,J., Wakeham,A., Iorio,C.,
            Zakian,V., Squire,J. and Harrington,L.
  TITLE     Murine Pif1 interacts with telomerase and is dispensable for
            telomere function in vivo
  JOURNAL   Mol Cell Biol 27 (3), 1017-1026 (2007)
   PUBMED   17130244
  REMARK    GeneRIF: Murine telomere homeostasis or genetic stability does not
            depend on mPif1.
REFERENCE   8  (residues 1 to 637)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135108.3.
            
            On May 20, 2019 this sequence version replaced NP_766041.1.
            
            Transcript Variant: This variant (1) represents the longest
            protein-coding transcript. Variants 1-3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY498715.1, AK049353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..637
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.4 cM"
     Protein         1..637
                     /product="ATP-dependent DNA helicase PIF1 isoform 1"
                     /EC_number="3.6.4.12"
                     /note="DNA helicase-like protein; ATP-dependent DNA
                     helicase PIF1; Pif1/Rrm3 DNA helicase-like protein; PIF1
                     homolog; PIF1 5'-to-3' DNA helicase homolog; DNA repair
                     and recombination helicase PIF1"
                     /calculated_mol_wt=69451
     Region          203..500
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Site            order(207,225..232,302,342)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350795"
     Region          <544..589
                     /region_name="SF1_C_RecD"
                     /note="C-terminal helicase domain of RecD family
                     helicases; cd18809"
                     /db_xref="CDD:350196"
     Site            555
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350196"
     CDS             1..637
                     /gene="Pif1"
                     /gene_synonym="4631410M14"
                     /coded_by="NM_172453.5:676..2589"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23295.1"
                     /db_xref="GeneID:208084"
                     /db_xref="MGI:MGI:2143057"
ORIGIN      
        1 mpssteaatd ecddaelrcr vaveelspgg qprkrqalra aelslgrner relmlrlqap
       61 gptgrprcfp lravrlftrf aatgrstlrl ptdgvpgags vqlllsdcpp erlrrflrtl
      121 rlklavapgp gpasaraqll gprprdfvti spvqpeelqr aaatkapdsa lekrpmesqt
      181 steaprwplp vkklrmpstk pklseeqaav lrmvlkgqsi fftgsagtgk syllkhilgs
      241 lpptgtvata stgvaachig gttlhafagi gsgqaplaqc malanrpgvr qgwlncqrlv
      301 ideismvead ffdkleavar avrqqkkpfg giqliicgdf lqlppvtkgs qqpqfcfqak
      361 swrrcvpvil eltevwrqad qtfisllqav rlgrcsdevt rqlrataahk vgrdgivatr
      421 lcthqddval tnekwlkalp gdvhsfeaid sdpelsrtld aqcpvsrvlq lklgaqvmlv
      481 knlavsrglv ngargvvvgf esegrglprv rflcgitevi rtdrwtvqvt ggqylsrqql
      541 plqlawaisi hksqgmsldc veislgrvfa sgqayvalsr arslqglrvl dfdptvvrcd
      601 srvlhfyatl rqgrglsles qddeeansdl enmdpnl
//
