LOCUS       NM_001039485           10742 bp    mRNA    linear   ROD 20-NOV-2023
DEFINITION  Mus musculus piezo-type mechanosensitive ion channel component 2
            (Piezo2), mRNA.
ACCESSION   NM_001039485 XM_001478778 XM_001480289
VERSION     NM_001039485.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10742)
  AUTHORS   Zhu Y, Garcia-Sanchez J, Dalal R, Sun Y, Kapiloff MS, Goldberg JL
            and Liu WW.
  TITLE     Differential expression of PIEZO1 and PIEZO2 mechanosensitive
            channels in ocular tissues implicates diverse functional roles
  JOURNAL   Exp Eye Res 236, 109675 (2023)
   PUBMED   37820892
  REMARK    GeneRIF: Differential expression of PIEZO1 and PIEZO2
            mechanosensitive channels in ocular tissues implicates diverse
            functional roles.
REFERENCE   2  (bases 1 to 10742)
  AUTHORS   Lam RM, von Buchholtz LJ, Falgairolle M, Osborne J, Frangos E,
            Servin-Vences MR, Nagel M, Nguyen MQ, Jayabalan M, Saade D,
            Patapoutian A, Bonnemann CG, Ryba NJP and Chesler AT.
  TITLE     PIEZO2 and perineal mechanosensation are essential for sexual
            function
  JOURNAL   Science 381 (6660), 906-910 (2023)
   PUBMED   37616369
  REMARK    GeneRIF: PIEZO2 and perineal mechanosensation are essential for
            sexual function.
REFERENCE   3  (bases 1 to 10742)
  AUTHORS   Villarino NW, Hamed YMF, Ghosh B, Dubin AE, Lewis AH, Odem MA, Loud
            MC, Wang Y, Servin-Vences MR, Patapoutian A and Marshall KL.
  TITLE     Labeling PIEZO2 activity in the peripheral nervous system
  JOURNAL   Neuron 111 (16), 2488-2501 (2023)
   PUBMED   37321223
REFERENCE   4  (bases 1 to 10742)
  AUTHORS   Servin-Vences MR, Lam RM, Koolen A, Wang Y, Saade DN, Loud M,
            Kacmaz H, Frausto S, Zhang Y, Beyder A, Marshall KL, Bonnemann CG,
            Chesler AT and Patapoutian A.
  TITLE     PIEZO2 in somatosensory neurons controls gastrointestinal transit
  JOURNAL   Cell 186 (16), 3386-3399 (2023)
   PUBMED   37541196
REFERENCE   5  (bases 1 to 10742)
  AUTHORS   Wolfson RL, Abdelaziz A, Rankin G, Kushner S, Qi L, Mazor O, Choi
            S, Sharma N and Ginty DD.
  TITLE     DRG afferents that mediate physiologic and pathologic
            mechanosensation from the distal colon
  JOURNAL   Cell 186 (16), 3368-3385 (2023)
   PUBMED   37541195
REFERENCE   6  (bases 1 to 10742)
  AUTHORS   Poole K, Herget R, Lapatsina L, Ngo HD and Lewin GR.
  TITLE     Tuning Piezo ion channels to detect molecular-scale movements
            relevant for fine touch
  JOURNAL   Nat Commun 5, 3520 (2014)
   PUBMED   24662763
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 10742)
  AUTHORS   Eijkelkamp N, Linley JE, Torres JM, Bee L, Dickenson AH, Gringhuis
            M, Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ, Cox
            JJ and Wood JN.
  TITLE     A role for Piezo2 in EPAC1-dependent mechanical allodynia
  JOURNAL   Nat Commun 4, 1682 (2013)
   PUBMED   23575686
  REMARK    GeneRIF: data indicate that the Epac1-Piezo2 axis has a role in the
            development of mechanical allodynia during neuropathic pain
REFERENCE   8  (bases 1 to 10742)
  AUTHORS   Dubin AE, Schmidt M, Mathur J, Petrus MJ, Xiao B, Coste B and
            Patapoutian A.
  TITLE     Inflammatory signals enhance piezo2-mediated mechanosensitive
            currents
  JOURNAL   Cell Rep 2 (3), 511-517 (2012)
   PUBMED   22921401
  REMARK    GeneRIF: piezo2 sensitization may contribute to PKA- and
            PKC-mediated mechanical hyperalgesia.
REFERENCE   9  (bases 1 to 10742)
  AUTHORS   Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A,
            Reuter K, Munier FL, Carroll P, Lewin GR and Birchmeier C.
  TITLE     The transcription factor c-Maf controls touch receptor development
            and function
  JOURNAL   Science 335 (6074), 1373-1376 (2012)
   PUBMED   22345400
REFERENCE   10 (bases 1 to 10742)
  AUTHORS   Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin
            AE and Patapoutian A.
  TITLE     Piezo1 and Piezo2 are essential components of distinct mechanically
            activated cation channels
  JOURNAL   Science 330 (6000), 55-60 (2010)
   PUBMED   20813920
  REMARK    GeneRIF: overexpression of Piezo1 or Piezo2 induced 2 kinetically
            distinct mechanically activated (MA) currents; Piezos are expressed
            in several tissues; propose that Piezos are components of MA cation
            channels
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053702.1, HQ215521.1, AC140554.3 and BC075677.1.
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_001039485.5.
            
            On Apr 14, 2011 this sequence version replaced NM_001039485.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ215521.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-914               AK053702.1         1-914
            915-5893            HQ215521.1         1-4979
            5894-5894           AC140554.3         184819-184819       c
            5895-6601           HQ215521.1         4981-5687
            6602-6607           AC140554.3         174318-174323       c
            6608-9389           HQ215521.1         5688-8469
            9390-10742          BC075677.1         2481-3833
FEATURES             Location/Qualifiers
     source          1..10742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 35.95 cM"
     gene            1..10742
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /note="piezo-type mechanosensitive ion channel component
                     2"
                     /db_xref="GeneID:667742"
                     /db_xref="MGI:MGI:1918781"
     exon            1..978
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             915..9389
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /note="family with sequence similarity 38, member B2"
                     /codon_start=1
                     /product="piezo-type mechanosensitive ion channel
                     component 2"
                     /protein_id="NP_001034574.4"
                     /db_xref="CCDS:CCDS29296.2"
                     /db_xref="GeneID:667742"
                     /db_xref="MGI:MGI:1918781"
                     /translation="MASEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLF
                     SEPTKATMQGHTGRLLQSLCITSLSFLLLHIIFHITLASLEAQHRITPAYNCSTWEKT
                     FRQIGFESLKGADAGNGIRVFVPDIGMFIASLTIWLVCRTIVKKPDTEEIAQLNSECE
                     NEELAGGEKMDSEEALIYEEDLDGEEGMEGELEESTKLKILRRFASVASKLKEFIGNM
                     ITTAGKVVVTILLGSSGMMLPSLTSAVYFFVFLGLCTWWSWCRTFDPLLFGCLCVLLA
                     IFTAGHLIGLYLYQFQFFQEAVPPNDYYARLFGIKSVIQTDCASTWKIIVNPDLSWYH
                     HANPILLLVMYYTLATLIRIWLQEPLVQEEMAKEDEGALDCSSNQNTAERRRSLWYAT
                     QYPTDERKLLSMTQDDYKPSDGLLVTVNGNPVDYHTIHPSLPIENGPAKTDLYTTPQY
                     RWEPSEESSEKKEEEEDKREDSEGEGSQEEKRSVRMHAMVAVFQFIMKQSYICALIAM
                     MAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYANLLLVLQYIWSFELP
                     EIKKVPGFLEKKEPGELASKILFTITFWLLLRQHLTEQKALREKEALLSEVKIGSQEL
                     EEKEDEELQDVQVEGEPTEKEEEEEEEIKEERHEVKKEEEEEVEEDDDQDIMKVLGNL
                     VVALFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYF
                     WMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIP
                     TSFLLVCILHLHYFHDRFLELTDLKSIPSKEDNTIYSHAKVNGRVYLIINRLAHPEGS
                     LPDLAIMNMTASLDKPEVQKLAESGEERPEECVKKTEKGEAGKDSDESEEEEDEEEES
                     EEEESSDLRNKWHLVIDRLTVLFLKFLEYFHKLQVFMWWILELHIIKIVSSYIIWVTV
                     KEVSLFNYVFLISWAFALPYAKLRRAASSVCTVWTCVIIVCKMLYQLQTIKPENFSVN
                     CSLPNENQTNIPLHELNKSLLYSAPVDPTEWVGLRKSSPLLVYLRNNLLMLAILAFEV
                     TVYRHQEYYRGRNNLTAPVSKTIFHDITRLHLDDGLINCAKYFVNYFFYKFGLETCFL
                     MSVNVIGQRMDFYAMIHACWLIGVLYRRRRKAIAEVWPKYCCFLACIITFQYFVCIGI
                     PPAPCRDYPWRFKGAYFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFED
                     ENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRSYLDMSKVIIFSYLFWFVLT
                     IIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKN
                     ILSIGACGYIGALVRNSCWLIQAFSLACTVKGYQMPEDDSRCKLPSGEAGIIWDSICF
                     AFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQL
                     KRQMDRIKARQQKYKKGKERMLSLTQESGEGQDIQKVSEEDDEREADKQKAKGKKKQW
                     WRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEEPPRKSAFQFVYQAWITDPKTA
                     LRQRRKEKKKLAREEQKERRKGSGDGPVEWEDREDEPVKKKSDGPDNIIKRIFNILKF
                     TWVLFLATVDSFTTWLNSISREHIDISTVLRIERCMLTREIKKGNVPTRESIHMYYQN
                     HIMNLSRESGLDTIDEHSGAGSRAQAAHRMDSLDSRDSISSCYTEATLLISRQSTLDD
                     LDGQDPVPKTSERARPRLRKMFSLDMSSSSADSGSVASSEPTQCTMLYSRQGTTETIE
                     EVEAEAEEEVVEGLEPELHDAEEKEYAAEYEAGVEEISLTPDEELPQFSTDDCDVEAP
                     PSYSKAVSFEHLSFASQDDSGAKNHMVVSPDDSRTDKLESSILPPLTHELTASDLLMS
                     KMFHDDELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLL
                     LPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKERPYF
                     PPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDIVDSNTDKEGSDDELSL
                     DQGRRGSSDSLKSINLAASVESVHVTFPEQPAAIRRKRSCSSSQISPRSSFSSNRSKR
                     GSTSTRNSSQKGSSVLSLKQKSKRELYMEKLQEHLIKAKAFTIKKTLQIYVPIRQFFY
                     DLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFL
                     VMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVA
                     QLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAV
                     MDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMI
                     IVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDN
                     SKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDP
                     NSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVT
                     IEKIYPYYVKAPSDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLNLTGSRI
                     FNQGSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMF
                     EELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREKTN"
     exon            979..1074
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1200
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1243
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1406
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1617
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1831
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1994
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2114
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2153
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2292
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2441
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2672
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2796
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..3095
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3244
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3418
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3460
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3675
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3836
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..4013
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            4014..4139
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4340
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4545
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            4546..4647
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            4648..4813
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..5057
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5154
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5314
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5315..5404
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5405..5526
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5527..5598
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5599..5705
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5706..5820
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5821..5880
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            5881..6047
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            6048..6214
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            6215..6382
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            6383..6790
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            6791..7049
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            7050..7232
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            7233..7485
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            7486..7618
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            7619..7766
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            7767..7981
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            7982..8140
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            8141..8288
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            8289..8477
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            8478..8570
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            8571..8743
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            8744..8872
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            8873..8952
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            8953..9136
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
     exon            9137..10724
                     /gene="Piezo2"
                     /gene_synonym="5930434P17; 9030411M15Rik; 9430028L06Rik;
                     Fam38b; Fam38b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgagagc ttgcaaagtt tcattgaagg tggaggagct cgcgccctcc ggggagcccg
       61 ggctgcttgg ctcgggagag gctgctccgt tggggacgcg gggacctctg cagggctcct
      121 gggctttctt ttctcactaa agtcgcggtg gtagcgccgc gcgctccgcg tctgggtctt
      181 ggttccggcc cagactcgca cagctcctca cggggaggac tggactcgca tccccgcggg
      241 ctggcagcgc gaccccgccg ggtcgggaat gtttctccgc gccctgcaac tggcgcccgg
      301 ctctccctgg cctgaagctt gggggcgctg aggctgagcg gagcagcaat tcagcgatcc
      361 gcccggaggc tggggctcca ggacgcggct tccagggcgc ccggcgggtc tttagcgcac
      421 cgggagcgcc tcagtccgcg tggactcgga gcccgggctg cgccgcccag actcacttac
      481 ttcggaaggg ttcagctaga aactctcggc catcccggaa cgccgcctcc agagcaggca
      541 gaggacagct atcctcctcc atcccctctc ctcaccgccc ccattcttct ccactcccag
      601 agtgtccctc ccttggctcc ttcccaggcg acccctggag ccgctgccgc tggattccga
      661 ttccacactt catgggcggg ccacaggggc tcgggcgcct ggttaggtgg ctgcctggag
      721 ccccgtgagc tgagcggctc ccgcccgtcg agcgcgccct cggggcagag agcgccgcgc
      781 cagccgacgc gatgccaggg tggctacgag cagccgggcg cacgaggccc taggtagaca
      841 tgggcctgac atcccagctc taggaacccc tgagcgtcgc cctactgctc ggactagcaa
      901 ggtcccacga cacgatggct tcggaagtgg tgtgcgggct gatcttcagg ctgctgcttc
      961 ccatctgcct ggcagtagca tgtgcgttcc ggtacaatgg gctctccttt gtctacctta
     1021 tctacctctt gctcattcct ctgttctcag aaccaaccaa agcaacgatg caaggacaca
     1081 cagggcggtt gctacagtcc ctgtgcatca ccagcctctc atttctgctg cttcacatca
     1141 ttttccacat cacactggcc agtctggaag ctcaacaccg catcacacct gcttacaact
     1201 gctcaacatg ggaaaagacc ttccggcaga ttggctttga aagcttgaag ggagctgatg
     1261 ccggcaatgg catcagggta tttgtgcctg atatcgggat gttcattgca agtctgacca
     1321 tctggctggt ctgcagaacc attgttaaga aaccagacac agaagaaata gcccaattga
     1381 attctgagtg tgaaaatgaa gaattggctg gaggagaaaa gatggattca gaggaggcgc
     1441 tgatttatga agaggactta gatggagaag aaggcatgga aggagagcta gaagaaagca
     1501 caaaactaaa aatacttcgc aggttcgcct ctgtcgcctc caaactgaag gagttcattg
     1561 gcaatatgat caccacggcg ggcaaggtcg tggtgaccat cctactgggc tcctcgggca
     1621 tgatgctgcc atctttgacc tcggctgtgt acttctttgt atttctgggc ctgtgtacct
     1681 ggtggtcctg gtgccgaact ttcgacccat tgctgttcgg ctgcctctgt gtcctgctgg
     1741 caatcttcac tgctgggcac ctgattggac tttatctgta ccagttccaa ttcttccaag
     1801 aagcggtccc gcccaatgac tactatgcaa ggttgtttgg gatcaagtcc gttatccaga
     1861 cagactgtgc cagcacctgg aagatcatag taaacccaga cctgtcctgg tatcaccatg
     1921 ccaaccccat cctcctgctg gtgatgtact atacgctggc cacgctgatt cgcatctggc
     1981 tacaagagcc tcttgtgcaa gaggagatgg cgaaggaaga tgagggtgcc ctggattgca
     2041 gctccaatca gaacacggca gagaggaggc ggagcctgtg gtatgcaacc cagtacccaa
     2101 cagatgagag aaaactttta tccatgaccc aagatgacta caaaccatct gatggcctgc
     2161 tggtgaccgt gaatggcaac cctgtggact accacaccat ccacccaagc ctgcccatag
     2221 agaatggccc tgccaagacg gacctgtaca ccactcccca gtaccggtgg gagccttcgg
     2281 aggagtcctc agaaaagaaa gaggaagaag aggacaagag agaagactcc gaaggggaag
     2341 ggagccagga ggagaaaagg agtgtgagaa tgcacgccat ggtcgccgtg ttccagttca
     2401 tcatgaagca gagttacatc tgtgccctca tcgccatgat ggcatggagc atcacctacc
     2461 acagctggct gactttcgtg ctgttgatct ggtcctgcac cctctggatg attcgcaaca
     2521 ggaggaagta tgccatgatc agttctcctt tcatggtcgt ctatgcgaat ctgctgctgg
     2581 tgctgcagta catatggagc ttcgagctcc ccgagattaa gaaggtcccc gggtttctag
     2641 aaaagaaaga gccgggagaa cttgcttcaa agattctctt caccatcacg ttctggctgc
     2701 tcctgaggca gcatctcaca gagcagaagg ccctgaggga aaaggaagca cttctttctg
     2761 aagtcaaaat tggaagtcaa gaacttgaag aaaaggaaga tgaggagctc caagatgtac
     2821 aagtggaagg ggagcccaca gagaaggaag aagaagagga agaggaaata aaggaagaaa
     2881 ggcatgaggt aaagaaggaa gaggaagagg aagtggagga agatgatgac caggacatca
     2941 tgaaggtgct gggtaatctg gtggtggccc tcttcatcaa gtattggatc tacgtctgcg
     3001 ggggcatgtt cttttttgtc agctttgagg ggaaaatcgt catgtacaaa atcatctaca
     3061 tggtgctgtt cctgttctgc gtggccttgt accaggtgca ctacgagtgg tggaggaaga
     3121 tcctgaagta cttctggatg tcggtggtca tttataccat gttggtgctc atcttcatat
     3181 acacttacca gtttgaaaac ttcccaggcc tgtggcaaaa catgaccgga ttaaagaaag
     3241 aaaagctcga ggacctcggc ctgaagcagt tcacggtcgc tgaactgttc actcgcatat
     3301 tcatccccac ctcctttcta ctcgtctgca tcctacacct ccactacttc cacgatcggt
     3361 tcctggaact tacagacctc aagtccatcc ccagcaaaga agacaacacc atctacagcc
     3421 atgccaaagt caatggtcgc gtgtacctaa taataaatag gttggcccac cctgaaggaa
     3481 gtcttccaga cttagccatc atgaatatga cggccagcct tgataagcct gaggtgcaga
     3541 agttggcaga gtctggggag gagaggccag aagagtgtgt caagaagacg gagaagggtg
     3601 aggctgggaa agacagtgat gagtctgagg aggaggaaga tgaagaagag gaatccgagg
     3661 aagaagaaag ctcagacctc aggaacaagt ggcacctggt gattgaccgg ctcactgtgc
     3721 tctttctaaa attcctggag tatttccaca agttgcaggt gtttatgtgg tggatcttgg
     3781 agctgcacat catcaaaatc gtctcatcgt acattatctg ggtgactgtg aaagaggtgt
     3841 ctctgttcaa ctatgtattt ttgatttctt gggcatttgc tctgccatat gccaaactcc
     3901 gtcgtgcggc ttccagtgtc tgcactgtct ggacatgtgt gatcatcgtc tgcaaaatgt
     3961 tgtaccagct gcaaaccatt aaacctgaga acttttctgt caactgctcc ttgcccaatg
     4021 aaaatcaaac caacattccc cttcatgagt tgaacaagtc tcttctctac agtgcccctg
     4081 ttgatcccac tgagtgggta ggcctgagga agtcctctcc tttgctcgtc tacctgagga
     4141 acaacctcct gatgctggcg attttggcct ttgaagtcac cgtttaccgc catcaggagt
     4201 actatcgagg ccgaaacaac ctgactgctc cagtgtctaa aactatcttt catgacatca
     4261 caaggttaca tctagatgat gggcttatca attgtgccaa atattttgta aattacttct
     4321 tctacaagtt tggcctagag acctgtttcc taatgtccgt gaatgtaatt ggacagcgaa
     4381 tggacttcta cgccatgatt catgcctgtt ggttgatcgg tgtcttgtat cgacgcagaa
     4441 gaaaagccat tgccgaggtc tggcccaagt actgctgctt cctggcttgc atcatcacct
     4501 tccagtactt cgtctgcatc ggcatccccc ctgccccttg ccgagattat ccatggagat
     4561 ttaagggagc ctacttcaat gataacatta tcaagtggct gtacttcccg gatttcattg
     4621 tgcggcccaa ccccgtgttt cttgtctatg acttcatgct gctcctgtgt gcttccttac
     4681 aacgacagat ctttgaggac gaaaacaagg cagccgtgcg catcatggcc ggggacaatg
     4741 tcgagatctg catgaacctt gatgcagcct cgttcagcca gcataaccct gtgccagatt
     4801 tcattcactg cagatcttac ttggacatgt ccaaagtgat catcttcagc tacctcttct
     4861 ggttcgtcct caccatcatc ttcattacgg gaacaaccag gatcagcata ttttgcatgg
     4921 gctacttggt ggcctgtttc tatttcctgc tctttggagg ggatctgctg ctgaagccca
     4981 tcaagagcat ccttcgttac tgggactggc tgattgcata caacgtgttt gtgatcacca
     5041 tgaagaatat actgtcaata ggagcctgtg gatacattgg cgcactagta agaaacagct
     5101 gctggttgat ccaagcgttc agcctggcct gcaccgtgaa aggctatcag atgcctgaag
     5161 atgactccag atgcaagctg cccagtgggg aggcagggat catctgggac agcatctgct
     5221 ttgcgtttct gctgctgcag aggagagtct tcatgagcta ctacttcctg catgtcgtgg
     5281 ctgacattaa agcatcccag atcctggcat ccagaggggc cgaacttttc caggctacaa
     5341 ttgtgaaagc tgtaaaggca agaattgaag aagagaaaaa atccatggac cagctgaaga
     5401 gacagatgga tcgcatcaaa gcccggcaac aaaagtacaa aaagggtaag gagaggatgc
     5461 tgagcttgac ccaggagtca ggggaaggcc aggacatcca gaaagtctca gaagaagatg
     5521 atgaaagaga agcagacaaa cagaaagcca agggcaaaaa aaagcagtgg tggcggcctt
     5581 gggttgatca tgcttccatg gtcaggagtg gagattatta tttgtttgaa acggatagtg
     5641 aagaggagga agaagaggaa cttaaaaagg aggatgaaga acccccacgg aagtcagcat
     5701 tccagttcgt ctaccaagcc tggattactg atcctaaaac ggcactccga cagaggagga
     5761 aagagaagaa aaagttggcc agagaagagc agaaggagag acgcaaagga tctggggacg
     5821 gtccagtgga atgggaagat cgagaggatg agccagtcaa aaagaaatct gatggaccag
     5881 ataatatcat caagaggata tttaatatcc tgaagttcac atgggttctg ttcctggcca
     5941 cagtggatag tttcaccact tggctcaact ccatctcaag ggaacacatc gacatatcca
     6001 cagtcctgcg gattgaaaga tgcatgctga ctcgagagat aaaaaagggc aatgttccaa
     6061 cacgggaaag catccacatg tactaccaga accacattat gaacctttcc cgagaatccg
     6121 gcctggacac aatcgacgag cactcggggg ctggctccag ggcccaggca gcacatagga
     6181 tggatagctt agattcccgg gacagtatct ccagctgcta cactgaagcg accctgctga
     6241 tctcaaggca gtccaccctt gatgatttag atggacaaga ccccgttcct aaaacaagcg
     6301 agcgtgctcg gcctaggctc cgtaaaatgt tcagcctgga catgtcctct tcgtcagctg
     6361 acagtggcag tgtagcatca agcgagccca cacagtgtac catgctgtat tcgcgccaag
     6421 gaactacgga aaccatcgag gaggtggagg ctgaagctga ggaggaggtg gtagaaggtc
     6481 tggagcctga gctccatgat gcagaagaaa aggaatacgc agctgaatat gaagcagggg
     6541 tagaggagat cagcctcact ccagatgagg aattgcctca gttctctaca gatgactgtg
     6601 atgtggaggc gccgccctct tacagcaagg ctgtcagctt tgagcatcta tcgtttgcgt
     6661 cgcaagatga ctctggggcc aagaaccaca tggtggtcag tcctgatgac agccgtacag
     6721 acaagctgga gtcaagcatc ttaccacctc tgactcatga gctgacagcc agcgatctgc
     6781 tgatgagcaa gatgttccat gatgatgagc ttgaggagtc tgagaagttc tacgtggacc
     6841 agccccggtt tttgctgcta ttctatgcca tgtataacac cctggtggcc cgctcagaaa
     6901 tggtgtgcta tttcgtgatt atcctgaacc acatgacctc tgcctccatc atcactctcc
     6961 tgttgcccat cttgatcttc ctctgggcca tgctgtctgt tcccaggccc agccgacgct
     7021 tctggatgat ggccatcgtc tacactgagg tggcgatcgt agtgaaatac ttcttccagt
     7081 tcggcttctt tccctggaat aaggacttgg aaatatacaa ggaaaggccc tactttccac
     7141 cgaacatcat cggggtggag aagaaggagg gctatgttct ttatgacctc attcagctgc
     7201 tggctctatt cttccatcgc tccattctga agtgtcatgg tctatgggac gaggatgaca
     7261 ttgttgacag taacacagac aaggaaggat cggatgacga gctgtccctc gatcagggca
     7321 gaagaggctc ctcagactca ctgaagtcta tcaacctggc tgcctctgta gagtctgtcc
     7381 acgtgacctt ccccgagcag ccagcggcca tcaggagaaa acgctcctgc agtagctctc
     7441 agatctcccc acggtccagc ttctcttcaa ataggtccaa aagaggcagc acaagcaccc
     7501 ggaacagtag ccagaaagga agcagtgttt taagccttaa acagaaaagc aaacgagaac
     7561 tttacatgga aaagcttcaa gagcatttaa tcaaagcaaa ggcgtttacc ataaagaaga
     7621 ctctacagat ctatgtcccc attcggcaat tcttctatga cctcatccac ccagactaca
     7681 gtgctgtgac tgatgtatac gtgctgatgt ttctggctga cactgtagac ttcattatca
     7741 tcgtctttgg attctgggcc tttgggaaac actcggcagc tgcagatatc acctcttctc
     7801 tatcagaaga ccaggtcccc gggccattcc tggtgatggt cctcattcag tttggaacca
     7861 tggtggtgga ccgtgcactc tacctcagga agactgtgct gggcaaggtc atcttccagg
     7921 tcatcctcgt gtttgggatt cacttctgga tgttcttcat cttacccggt gtgactgaga
     7981 ggaaattcag ccagaacctg gtggcacagc tttggtactt tgtgaagtgt gtgtactttg
     8041 ggctgtctgc ctatcaaatc cgctgtggct acccaacccg tgtgctcggg aacttcctca
     8101 caaagagcta caattacgtc aacctcttct tgtttcaagg gttccgcctg gtcccatttc
     8161 tgactgagct gcgggctgtg atggattggg tgtggacaga tacaaccctg agcctctcca
     8221 gctggatttg tgtggaggac atttacgcgc acatttttat cttaaagtgc tggcgagagt
     8281 cggaaaagag ataccctcaa cccaggggtc agaagaagaa gaaagccgtg aagtacggca
     8341 tgggcggcat gatcatcgtc cttctcatct gtatcgtctg gtttcctctg ctcttcatgt
     8401 ctttgatcaa atctgtcgca ggggttatca accaacccct ggatgtgtcc gtcacaatta
     8461 ccctgggagg ttatcagcct atcttcacaa tgagcgccca gcaaagccag ctgaaagtta
     8521 tggataattc aaagtataat gaatttctaa aatctttcgg ccccaacagt ggcgcaatgc
     8581 aatttctgga gaactatgaa agggaagacg taacagtagc agaactggaa gggaactcga
     8641 attctttgtg gaccatcagc cctcccagta agcagaaaat gatacaggag ctcaccgacc
     8701 ccaatagttg cttctctgtt gttttttcat ggagtatcca gagaaacatg actttgggtg
     8761 caaaagccga aatagcaacg gataagcttt ctttccctct tgcggtcgca acacggaata
     8821 gcatagctaa aatgattgct ggcaatgaca cagaaagttc aaacacgcca gtgacaatag
     8881 agaagatcta cccatactat gtgaaggcac ccagcgattc aaactcaaag cctataaaac
     8941 agcttctgtc tgaaaataat ttcatgaata tcaccatcat tttgttcaga gacaatgtca
     9001 caaagtccaa tagtgagtgg tgggttctca acctgaccgg aagtaggata ttcaaccagg
     9061 ggtcccaagc cttggaactg gtggtcttca atgacaaagt cagccctcca agtctaggct
     9121 tcttggctgg ctatggtatc atgggattgt atgcatctgt tgtccttgta attgggaaat
     9181 ttgttcgtga gttcttcagt gggatctctc attccatcat gtttgaagag cttccaaatg
     9241 tggacagaat cttgaagttg tgcacagata tattcctcgt gagggagaca ggggagttgg
     9301 aactggagga agacctctac gccaagttga tattcctgta caggtcacca gaaaccatga
     9361 tcaagtggac tagagaaaaa acaaactgat cacttaagac ctggactgca aataaagcta
     9421 acatttgaat tttttttttt ttaagaaaag cacaatactc taagagctaa gcatttctag
     9481 ttgggcggca accatttctc ttctgacagg tggctgaaag aagttgattt tcttgttcat
     9541 gcaagtcacc tcacacaaga aggcgctgtt gaagttctcc gtactcccat gtctctgaaa
     9601 tcagggctca ttgcttttag agttttggtt ttttgttttt tgggtttttg ttttgttttg
     9661 tttttgtttg tttgtttgtt tttagtcaag agtatcttgc attcttaatc agttatggga
     9721 aaggttccag tagtgtccct tcccttggag aaaggcacct gtgtctaact ctgcagggtc
     9781 ctcacctttc ctggcgtcat ggtcaacgtg caacacatag ctcttctcac cgctggggca
     9841 actgctgagc agagacccca cgaaccctca gcacactcca gatgtgcagc agcaatagga
     9901 ggcagcagca ctgcctgagt ttcaagagga aagaggggac cctggaccca gaagatgtgg
     9961 ctggaaggac aagcctcatt ctaagcaaaa agataacatt agtgatactc ctactgcctt
    10021 atctcaactg aagactggta agaaatcttt ctattgaaca ccagtgactt ctcaggaaaa
    10081 aaaaaaaaac actcagcaaa gcaactacgt ggacacctct gcttgtgagg tcgggtggta
    10141 accactctag gtagtggtga tcattctgct tcggatggct cctgttgcca cagcaacagg
    10201 acagcagtga tcagctaagc ctgatgggaa cacctcggct ttgtaacttc agtgactgag
    10261 gccacagggc tcttctgcct ctccccatcg cccctcccca cctctcccca tcccctcatg
    10321 cttcctccca tttccatgat ttaaggcagt ggttttttcc agtgtgtgac attttccttg
    10381 ctgtttttca ggcatatcaa agagtttaca tattccgatt cacattttta catctaagac
    10441 gggtttttta agttcataat tatgaaagaa atatgtatat cgagcttggg gaaataaaat
    10501 aatgatggcc ttttttctta aattattatc attgggaata caacctcttc attgagatag
    10561 cattgtagca tgaaaattta tgattgaaat gtacttttca ttcaatatta aaaaaaatgc
    10621 tgtttctgag aagaatcatt gaatgggcta gactatgtca aaaaccactc ctgtgtactc
    10681 tgggttcagg actgacttaa aataaagcac atcttgcaaa gtcaaaaaaa aaaaaaaaaa
    10741 aa
//
