LOCUS       NM_027040                833 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus piercer of microtubule wall 1 (Pierce1), mRNA.
ACCESSION   NM_027040 XM_130125 XM_914418 XM_976934
VERSION     NM_027040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 833)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 833)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 833)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 833)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 833)
  AUTHORS   Gui,M., Farley,H., Anujan,P., Anderson,J.R., Maxwell,D.W.,
            Whitchurch,J.B., Botsch,J.J., Qiu,T., Meleppattu,S., Singh,S.K.,
            Zhang,Q., Thompson,J., Lucas,J.S., Bingle,C.D., Norris,D.P., Roy,S.
            and Brown,A.
  TITLE     De novo identification of mammalian ciliary motility proteins using
            cryo-EM
  JOURNAL   Cell 184 (23), 5791-5806 (2021)
   PUBMED   34715025
REFERENCE   6  (bases 1 to 833)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   7  (bases 1 to 833)
  AUTHORS   Sung,Y.H., Baek,I.J., Kim,Y.H., Gho,Y.S., Oh,S.P., Lee,Y.J. and
            Lee,H.W.
  TITLE     PIERCE1 is critical for specification of left-right asymmetry in
            mice
  JOURNAL   Sci Rep 6, 27932 (2016)
   PUBMED   27305836
  REMARK    GeneRIF: This is the first report implicating a role for PIERCE1 in
            the symmetry-breaking step of left-right asymmetry specification.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 833)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   9  (bases 1 to 833)
  AUTHORS   Sung,Y.H., Kim,H.J., Devkota,S., Roh,J., Lee,J., Rhee,K., Bahk,Y.Y.
            and Lee,H.W.
  TITLE     Pierce1, a novel p53 target gene contributing to the
            ultraviolet-induced DNA damage response
  JOURNAL   Cancer Res 70 (24), 10454-10463 (2010)
   PUBMED   21159655
REFERENCE   10 (bases 1 to 833)
  AUTHORS   Sung,Y.H., Kim,H.J. and Lee,H.W.
  TITLE     Identification of a novel Rb-regulated gene associated with the
            cell cycle
  JOURNAL   Mol Cells 24 (3), 409-415 (2007)
   PUBMED   18182857
  REMARK    GeneRIF: RbEST47 was considerably down-regulated in immortalized
            cells, and showed cell cycle-dependent expression, suggesting
            important roles in S and/or G2[RbEST47]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099566.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XM_914418.2, XM_130125.6, XM_976934.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099566.1, BC048581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..833
                     /gene="Pierce1"
                     /gene_synonym="1700007K13Rik; Rbest47"
                     /note="piercer of microtubule wall 1"
                     /db_xref="GeneID:69327"
                     /db_xref="MGI:MGI:1916577"
     exon            1..291
                     /gene="Pierce1"
                     /gene_synonym="1700007K13Rik; Rbest47"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..559
                     /gene="Pierce1"
                     /gene_synonym="1700007K13Rik; Rbest47"
                     /note="pierce 1; UPF0691 protein C9orf116 homolog;
                     p53-induced expression in RB-null cells protein 1"
                     /codon_start=1
                     /product="piercer of microtubule wall 1 protein"
                     /protein_id="NP_081316.1"
                     /db_xref="CCDS:CCDS15837.1"
                     /db_xref="GeneID:69327"
                     /db_xref="MGI:MGI:1916577"
                     /translation="MSEEKPQQSAEEPEPGEPKAKPAPEEPEPGEPKAKPAPEEPEPG
                     EPKAKPAPEKTSDYYRISEKLPVRFNNPGWFHGYGTKEAVSMYRTSNQTYGSRAPTVH
                     EMPKVFYPSSNKFSRQHAAFGMFQSHNINVTLEKSLVTGPDNHITHYDRLNFHPSYNV
                     NRPSICD"
     exon            292..370
                     /gene="Pierce1"
                     /gene_synonym="1700007K13Rik; Rbest47"
                     /inference="alignment:Splign:2.1.0"
     exon            371..804
                     /gene="Pierce1"
                     /gene_synonym="1700007K13Rik; Rbest47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      781..786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pierce1"
                     /gene_synonym="1700007K13Rik; Rbest47"
                     /note="hexamer: ATTAAA"
     polyA_site      804
                     /gene="Pierce1"
                     /gene_synonym="1700007K13Rik; Rbest47"
                     /note="major polyA site"
ORIGIN      
        1 gccttgccgc agcaggcaca gacttgatct gggctagttt cctgcgggag gccaaatgtc
       61 tgaagaaaaa cctcaacagt ccgcggagga gccggagccg ggggagccca aggctaagcc
      121 cgccccagag gagccggagc cgggggagcc caaggctaag cctgccccag aggagccgga
      181 gccgggggag cccaaggcta agcctgcccc agagaagacc agcgactact accgcattag
      241 cgagaagctc ccagtcaggt tcaacaaccc ggggtggttt catggctacg ggaccaagga
      301 agctgtttcc atgtacagga ccagtaacca aacctacgga agcagagccc ccacggtgca
      361 tgagatgcca aaagtatttt atccatcttc aaataagttt tccagacaac acgcagcttt
      421 tggaatgttc cagagtcata atattaatgt caccctggag aagagcttag tgaccgggcc
      481 tgacaatcac atcacccact atgaccgttt gaactttcac cccagttaca atgtcaacag
      541 gccgtccatc tgtgactaag ggagctgggt tcctgtcctc agggctctcc tgactcaggg
      601 ctgcttcggg gagcacggat gcccttgatc cttgacaggt gccctattct aaaggcttgg
      661 atctcactgc cttctcagaa aacacttttc ctttccagag gagaaaaatg tgcaaataga
      721 gccacaatac cttgtgttct gcatttcaca caggaaagat gctgacagca tctttgtttt
      781 attaaaaagt tgccacagcc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
