LOCUS       NM_022654               3357 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus p53 induced death domain protein 1 (Pidd1), transcript
            variant 1, mRNA.
ACCESSION   NM_022654 XM_006536218
VERSION     NM_022654.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3357)
  AUTHORS   Braun,V.Z., Karbon,G., Schuler,F., Schapfl,M.A., Weiss,J.G.,
            Petermann,P.Y., Spierings,D.C.J., Tijhuis,A.E., Foijer,F., Labi,V.
            and Villunger,A.
  TITLE     Extra centrosomes delay DNA damage-driven tumorigenesis
  JOURNAL   Sci Adv 10 (13), eadk0564 (2024)
   PUBMED   38552015
REFERENCE   2  (bases 1 to 3357)
  AUTHORS   Kim,J.Y., Wang,L.Q., Sladky,V.C., Oh,T.G., Liu,J., Trinh,K.,
            Eichin,F., Downes,M., Hosseini,M., Jacotot,E.D., Evans,R.M.,
            Villunger,A. and Karin,M.
  TITLE     PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent
            transition from simple steatosis to steatohepatitis
  JOURNAL   Cell Metab 34 (10), 1548-1560 (2022)
   PUBMED   36041455
REFERENCE   3  (bases 1 to 3357)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3357)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   5  (bases 1 to 3357)
  AUTHORS   Sheikh,T.I., Vasli,N., Pastore,S., Kharizi,K., Harripaul,R.,
            Fattahi,Z., Pande,S., Naeem,F., Hussain,A., Mir,A., Islam,O.,
            Girisha,K.M., Irfan,M., Ayub,M., Schwarzer,C., Najmabadi,H.,
            Shukla,A., Sladky,V.C., Braun,V.Z., Garcia-Carpio,I., Villunger,A.
            and Vincent,J.B.
  TITLE     Biallelic mutations in the death domain of PIDD1 impair caspase-2
            activation and are associated with intellectual disability
  JOURNAL   Transl Psychiatry 11 (1), 1 (2021)
   PUBMED   33414379
  REMARK    GeneRIF: Biallelic mutations in the death domain of PIDD1 impair
            caspase-2 activation and are associated with intellectual
            disability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3357)
  AUTHORS   Manzl,C., Krumschnabel,G., Bock,F., Sohm,B., Labi,V.,
            Baumgartner,F., Logette,E., Tschopp,J. and Villunger,A.
  TITLE     Caspase-2 activation in the absence of PIDDosome formation
  JOURNAL   J Cell Biol 185 (2), 291-303 (2009)
   PUBMED   19364921
  REMARK    GeneRIF: Results suggest that at least one alternative
            PIDDosome-independent mechanism of caspase-2 activation exists in
            mammals in response to DNA damage.
REFERENCE   7  (bases 1 to 3357)
  AUTHORS   Berube,C., Boucher,L.M., Ma,W., Wakeham,A., Salmena,L., Hakem,R.,
            Yeh,W.C., Mak,T.W. and Benchimol,S.
  TITLE     Apoptosis caused by p53-induced protein with death domain (PIDD)
            depends on the death adapter protein RAIDD
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14314-14320 (2005)
   PUBMED   16183742
REFERENCE   8  (bases 1 to 3357)
  AUTHORS   Tinel,A. and Tschopp,J.
  TITLE     The PIDDosome, a protein complex implicated in activation of
            caspase-2 in response to genotoxic stress
  JOURNAL   Science 304 (5672), 843-846 (2004)
   PUBMED   15073321
REFERENCE   9  (bases 1 to 3357)
  AUTHORS   Carmichael,P.L., Mills,J.J., Campbell,M., Basu,M. and Caldwell,J.
  TITLE     Mechanisms of hormonal carcinogenesis in the p53+/- hemizygous
            knockout mouse: studies with diethylstilbestrol
  JOURNAL   Toxicol Pathol 29 Suppl, 155-160 (2001)
   PUBMED   11695552
  REMARK    GeneRIF: P450 levels were higher in female DES-treated p53+/- mice
            compared to treated wild type mice.
            Review article
REFERENCE   10 (bases 1 to 3357)
  AUTHORS   Lin,Y., Ma,W. and Benchimol,S.
  TITLE     Pidd, a new death-domain-containing protein, is induced by p53 and
            promotes apoptosis
  JOURNAL   Nat Genet 26 (1), 122-127 (2000)
   PUBMED   10973264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158224.6.
            
            On or before Feb 6, 2018 this sequence version replaced
            XM_006536218.3, NM_022654.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.488501.1,
                                           SRR13948564.434985.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC158224.6         93198-93254         c
            58-443              AC158224.6         92197-92582         c
            444-857             AC158224.6         91380-91793         c
            858-1067            AC158224.6         90841-91050         c
            1068-1122           AC158224.6         90704-90758         c
            1123-1324           AC158224.6         90402-90603         c
            1325-1450           AC158224.6         90205-90330         c
            1451-1630           AC158224.6         89915-90094         c
            1631-1778           AC158224.6         89687-89834         c
            1779-1914           AC158224.6         89460-89595         c
            1915-2065           AC158224.6         89232-89382         c
            2066-2189           AC158224.6         89021-89144         c
            2190-2308           AC158224.6         88800-88918         c
            2309-2422           AC158224.6         88607-88720         c
            2423-2622           AC158224.6         88307-88506         c
            2623-3357           AC158224.6         87342-88076         c
FEATURES             Location/Qualifiers
     source          1..3357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.79 cM"
     gene            1..3357
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /note="p53 induced death domain protein 1"
                     /db_xref="GeneID:57913"
                     /db_xref="MGI:MGI:1889507"
     exon            1..57
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            58..443
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2881
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /note="isoform a is encoded by transcript variant 1;
                     p53-induced protein with a death domain; leucine-rich
                     repeat and death domain-containing protein; p53 protein
                     induced, with death domain; leucine-rich and death domain
                     containing; p53-induced death domain-containing protein 1"
                     /codon_start=1
                     /product="p53-induced death domain-containing protein 1
                     isoform a"
                     /protein_id="NP_073145.1"
                     /db_xref="CCDS:CCDS22014.1"
                     /db_xref="GeneID:57913"
                     /db_xref="MGI:MGI:1889507"
                     /translation="MAAVLEGQEPEETAAAAEDAATSTLEAVDAGPGAPFLPAGNQLN
                     LDLRPGGCHRLQYLCSQQPPQLLQVEFLRLSTHEDPQLLDDTLAKVPWSLLRLRSLVL
                     KGGQSRGALGACLHGTLTTLPAGLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLL
                     SHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRLDLSENLLDTIPSEI
                     GNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDLR
                     DNRLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLLLTSDLDSFLVT
                     PHGCSVTLACGVRLQFPAGATTTPVTIHYRLWLPEPGLVSLGPHDFLLSSVLELQPHG
                     VAFQQDVSLWLLFVPPRVRRCREVVVRTRSNNTWNDLETQLEEEAPKRLWARCQVPHF
                     SWFLVVLRPVSNTCLLPPEGALLCSSGHPGVRVTFPPGVTEEPRQVSMQVVHMAGLEL
                     RTLLEESEASVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLT
                     TTWDDITTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLI
                     ALQRRRDPEQVLLQCLPRNKVDATLSRLLVRYRGPEPSETVEMFEGEKFFAAFERGID
                     VDADRPDCVDGRICFVFYSHLKNVKEVYITTALDREAQDVRGQVSFYRGSLPVEVPAE
                     AEAARQRKGTDALWMATLPIKLPRLRGAQGSGQGTDFSLMPLNLGDAETGFLTQSNLL
                     SVASRLGPDWPAVALHLGMPYHKLQRIRHEFRDDLDGQVRHMLFSWAERQTGQPGAVG
                     HLVQALEQSDRRDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPGTSASQTPESAQ
                     A"
     exon            444..857
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1067
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1122
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1324
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1450
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1630
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1778
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1914
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2065
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2189
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2308
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2422
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2622
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..3357
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3324..3329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /note="hexamer: AATAAA"
     polyA_site      3357
                     /gene="Pidd1"
                     /gene_synonym="1200011D09Rik; Lrdd; Pidd"
                     /note="major polyA site"
ORIGIN      
        1 gccggcggga aggcagcaca gagcgcgcct agactggcgg ggagatcagc gtggcagctt
       61 ctatcagcct tgcctaagca ggcttgcttg gcaagctggg acatgtctgg tccccgagga
      121 ccttccatgg gtgatggctg cagtgttgga ggggcaggag ccggaggaaa ctgcagctgc
      181 tgcagaggat gctgcaacat ccaccttgga ggctgtggat gccgggcctg gagcaccttt
      241 tctcccggct gggaaccagt tgaacttgga cctacgccca gggggctgcc atcggctaca
      301 gtacctgtgt tcccagcagc ccccacagct gctgcaagtg gagtttttgc ggctcagcac
      361 ccatgaggac cctcagctgc tggatgacac cctagccaag gttccgtgga gtctgctgcg
      421 ccttcgctcc ctggtcctca aaggtggcca gagccggggt gccctgggtg cctgcctcca
      481 tggaaccctg accactctgc ctgctggcct gagtgatttg gcctgcctgg ctcacctaga
      541 cctgagcttc aacaggctgg agacgctgcc tacctgtgtc ccggaactgc acggcctgga
      601 tgcgttgctg ctttctcaca accatctctc agagctgccc gaggccctgg gggcactgcc
      661 cgcccttacc ttcctcaccg tgacacacaa ccgcctagaa agactacccc taacactcgg
      721 gtccctgtcc acccttcagc gtctcgatct ctctgagaac cttctagaca ccataccctc
      781 tgagattgga aacctgcgca gcctcagtga gctcaatctg gcctccaacc ggctgcagag
      841 tctcccagct tccctcgcgg ggctgcggtc cctgcggctc cttgttctgc acagcaacct
      901 cctgacctca gtgcccactg gcctggtcca cctgccactg atcactcggc ttgacctgag
      961 ggacaaccgg ctccgagacc tgcctgctga gttactagac gctccctttg tgcgcctgca
     1021 ggggaaccct ctgggcgagg cctctccagc acccccaagt cccccagaca tatcccaggt
     1081 tccagaaatg cccaggctat tgctgacctc agatttggac agcttccttg tgactcccca
     1141 tggctgttct gtgaccctgg cctgtggtgt ccgcctacag tttccagcag gagccaccac
     1201 cacgcctgtc accatccact atcgactctg gttgcccgag ccaggcctgg tctctctggg
     1261 acctcatgac ttcctgctta gtagtgtcct ggagctgcag ccccatgggg tggctttcca
     1321 gcaagatgtg agcttatggc tgctctttgt ccctccacga gtccgtcgct gtcgtgaggt
     1381 agttgtgagg acacggagta acaacacctg gaatgaccta gagacccaac tggaggaaga
     1441 ggcacccaag aggctctggg ctcgctgcca ggtgccccac ttctcctggt tcctggtcgt
     1501 tttacgccca gtatccaaca cttgcctttt gccaccagag ggagcacttc tctgctcctc
     1561 aggtcatcct ggggtcagag tcacttttcc ccctggggtt acagaagagc ctcggcaagt
     1621 ctccatgcag gtagtgcata tggctggact agagctgaga acccttctgg aagaatcaga
     1681 ggcatcagta agccctctgc tgtgcctttc acagagcggc ccccccagct tcctacaacc
     1741 tgtcactgtg cagttgcccc tgcctcctgg cgttacaggc ttcagtctag accgctccca
     1801 cctgcatctg ctctaccgaa cacccctgac aaccacctgg gatgatatca ccactcaggt
     1861 ggcactggaa ttcacccacc tgtatgcacg cttccaggtc acgcacttct cctggtactg
     1921 gctctggtat accaccaaaa cctgtgtggg gggcctggcc cggaaggcct gggaacggct
     1981 gcgactgcac cgtgtgaatc tcattgcact gcagaggcgc cgagaccctg agcaggttct
     2041 gctgcagtgc ctgccacgga acaaggtaga tgccaccctg agtcggctgc tggttcgcta
     2101 ccgtggccct gaaccctctg agactgtgga gatgtttgag ggtgagaagt tctttgcagc
     2161 ctttgagcgg ggcattgatg tagatgcaga ccgtccagac tgtgtggatg gcagaatctg
     2221 ctttgtcttc tattcacacc tgaagaacgt aaaggaggta tacatcacca cagccttgga
     2281 ccgggaagct caggatgttc gaggacaggt gtccttttat cggggttcac ttcctgtgga
     2341 ggtacctgca gaggcagagg ctgcccggca gaggaagggt acagatgcac tgtggatggc
     2401 caccttgccc atcaagctac cgagactccg gggtgcccag gggagtgggc aggggactga
     2461 cttctccttg atgcctctga acctgggtga tgcagaaact ggattcctga ctcagagcaa
     2521 cctgctgagt gtggcctcac gcctaggtcc tgactggcca gctgtggccc tgcacctagg
     2581 catgccctac cataagctac agcgtatccg gcatgaattc agggatgacc tggatggcca
     2641 ggtccgacac atgctcttct cttgggctga gcgccagact ggacagcctg gagctgtggg
     2701 acacctggta caggccttgg aacagagtga tcggcgggat gtggctgaag aggtgcgtgc
     2761 catcttggag cttggccgcc acaagtacca ggacagcatt cgacgcacag ggctggcccc
     2821 tgaggattct actctgcctg gcacctcggc ttcacagact ccagagtctg cacaggccta
     2881 ggcttacaga cttaattaag atagctttaa acttgactcg accagtgggc agagccctat
     2941 ccttctacct cacccgtgtg ctccagtgcc ccagcataca aaaacccact cactgtctag
     3001 cccaagctag cctccaactc acagtgagta catctcagag attgttttac ataaaggata
     3061 gagagcaggt tgcccatact tgctaccatg ccaggccctt ctgctaagat gggagcagag
     3121 aaggcctgga gggagagatg gctcagtagt taacaacact agctgctcct tcagggaacc
     3181 tagtttgttt cctctaccta cctgatggct catgacaatc tgtaactcca gttctgaagg
     3241 gtcagcccct tcctctggcc cccacagaca ccaggcacac atgtgtgcag acaagtatgc
     3301 aggcaaaaca tccatacaaa taaaataaaa gctatttatt gtgtgtgtga gacagaa
//
