LOCUS       NM_001003948            2667 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphotyrosine interaction domain containing 1
            (Pid1), mRNA.
ACCESSION   NM_001003948 XM_129912
VERSION     NM_001003948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Fischer,A.W., Albers,K., Schlein,C., Sass,F., Krott,L.M.,
            Schmale,H., Gordts,P.L.S.M., Scheja,L. and Heeren,J.
  TITLE     PID1 regulates insulin-dependent glucose uptake by controlling
            intracellular sorting of GLUT4-storage vesicles
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1592-1603 (2019)
   PUBMED   30904610
  REMARK    GeneRIF: The data provide evidence that PID1 serves as an
            insulin-regulated retention adaptor protein controlling
            translocation of LRP1 in conjunction with GLUT4 to the plasma
            membrane of adipocytes.
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Fischer,A.W., Albers,K., Krott,L.M., Hoffzimmer,B., Heine,M.,
            Schmale,H., Scheja,L., Gordts,P.L.S.M. and Heeren,J.
  TITLE     The adaptor protein PID1 regulates receptor-dependent endocytosis
            of postprandial triglyceride-rich lipoproteins
  JOURNAL   Mol Metab 16, 88-99 (2018)
   PUBMED   30100244
  REMARK    GeneRIF: By acting as an insulin-dependent retention adaptor, PID1
            serves as a regulator of LRP1 function controlling the disposal of
            postprandial lipoproteins.
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Chen,L., Wang,X.Y., Zhu,J.G., You,L.H., Wang,X., Cui,X.W.,
            Shi,C.M., Huang,F.Y., Zhou,Y.H., Yang,L., Pang,L.X., Gao,Y.,
            Ji,C.B. and Guo,X.R.
  TITLE     PID1 in adipocytes modulates whole-body glucose homeostasis
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1861 (2), 125-132 (2018)
   PUBMED   29391195
  REMARK    GeneRIF: Results thus indicate phosphotyrosine interaction domain
            containing 1 (PID1) as a critical regulator of glucose metabolism
            in adipocytes.
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   5  (bases 1 to 2667)
  AUTHORS   Yang,L., Tong,M.L., Chi,X., Zhang,M., Zhang,C.M. and Guo,X.R.
  TITLE     Genomic DNA methylation changes in NYGGF4-overexpression 3T3-L1
            adipocytes
  JOURNAL   Int J Mol Sci 13 (12), 15575-15587 (2012)
   PUBMED   23443082
  REMARK    GeneRIF: data demonstrate that differentially methylated genes are
            significantly overrepresented in NYGGF4-overexpression adipocytes,
            providing valuable clues for further exploration of the role of
            NYGGF4 in insulin sensitivity regulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2667)
  AUTHORS   Zhao,Y.P., Zhang,C.M., Zhu,C., Chen,X.H., Wang,J.L., Ji,C.B.,
            Chi,X., Hong,Q., Peng,Y.Z. and Guo,X.R.
  TITLE     NYGGF4 homologous gene expression in 3T3-L1 adipocytes: regulation
            by FFA and adipokines
  JOURNAL   Mol Biol Rep 37 (7), 3291-3296 (2010)
   PUBMED   19894142
  REMARK    GeneRIF: The expression of NYGGF4 mRNA is affected by a variety of
            factors that are related to insulin sensitivity.[NYGGF4]
REFERENCE   7  (bases 1 to 2667)
  AUTHORS   Kajiwara,Y., Franciosi,S., Takahashi,N., Krug,L., Schmeidler,J.,
            Taddei,K., Haroutunian,V., Fried,U., Ehrlich,M., Martins,R.N.,
            Gandy,S. and Buxbaum,J.D.
  TITLE     Extensive proteomic screening identifies the obesity-related NYGGF4
            protein as a novel LRP1-interactor, showing reduced expression in
            early Alzheimer's disease
  JOURNAL   Mol Neurodegener 5, 1 (2010)
   PUBMED   20205790
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2667)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   9  (bases 1 to 2667)
  AUTHORS   Wang,B., Zhang,M., Ni,Y.H., Liu,F., Fan,H.Q., Fei,L., Pan,X.Q.,
            Guo,M., Chen,R.H. and Guo,X.R.
  TITLE     Identification and characterization of NYGGF4, a novel gene
            containing a phosphotyrosine-binding (PTB) domain that stimulates
            3T3-L1 preadipocytes proliferation
  JOURNAL   Gene 379, 132-140 (2006)
   PUBMED   16815647
REFERENCE   10 (bases 1 to 2667)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY004446.1, AK151267.1, AK083256.1 and BB370718.1.
            
            On Dec 8, 2009 this sequence version replaced NM_001003948.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The use of an alternative upstream start codon would result in a
            protein that is 14 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.196857.1, BC080290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY004446.1         1-50
            51-1077             AK151267.1         21-1047
            1078-2656           AK083256.1         999-2577
            2657-2667           BB370718.1         278-288
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.14 cM"
     gene            1..2667
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /note="phosphotyrosine interaction domain containing 1"
                     /db_xref="GeneID:98496"
                     /db_xref="MGI:MGI:2138391"
     exon            1..305
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..929
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /note="phosphotyrosine interaction domain-containing
                     protein 1"
                     /codon_start=1
                     /product="PTB-containing, cubilin and LRP1-interacting
                     protein"
                     /protein_id="NP_001003948.2"
                     /db_xref="CCDS:CCDS15104.2"
                     /db_xref="GeneID:98496"
                     /db_xref="MGI:MGI:2138391"
                     /translation="MWQPATERLQHFQTMLKSKLNVLTLKKEPIPAVLFHEPEAIELC
                     TTTPLMKARTHSGCKVTYLGKVSTTGMQFLSGCTEKPVIELWKKHTLAREDVFPANAL
                     LEIRPFQVWLHHLDHKGEATVHMDTFQVARIAYCTADHNVSPNIFAWVYREINDDLSY
                     QMDCHAVQCESKLEAKKLAHAMMEAFKKTFHSMKSDGRIHRSSSSEEASQELESDDG"
     exon            306..452
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..2667
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /note="hexamer: AATAAA"
     regulatory      2571..2576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /note="hexamer: AATAAA"
     polyA_site      2576
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /note="major polyA site"
     polyA_site      2597
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /note="major polyA site"
     regulatory      2641..2646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
                     /note="hexamer: AATAAA"
     polyA_site      2665
                     /gene="Pid1"
                     /gene_synonym="5033414K04Rik; NYGGF4; P-CLI1"
ORIGIN      
        1 agcggccgcg gcgctggggc ccgggcggag ctgcgcaatc gtctgagctg cgcaccgact
       61 ggcggccgga gcggagccca caagttgccg gcagcggagc gccgcctcgt cccgctctca
      121 gcccttgcgc ccaccgggct gcggccggcg ccaggacgct cagcctgcag acgctgaccc
      181 cagatgtgac agcgggaccg cagatctctc tccttccggg cgcaacccac agagtctcgc
      241 cagcgtctcc tctgccaaaa ccccacggct ggaagatgtg gcagccggct actgagcgcc
      301 tgcagcactt ccagaccatg ctgaagtcta agttgaatgt cctaacactg aaaaaggaac
      361 ctataccagc agtcctcttc catgagccgg aagccattga gctgtgcacc accacacccc
      421 tgatgaaggc aaggactcat agtggctgca aggttaccta tctgggaaaa gtctctacca
      481 caggcatgca gtttttgtct ggttgcaccg agaagccagt cattgagctc tggaagaaac
      541 acacactggc tcgagaagat gttttcccgg ccaacgccct cctagagatc cggccattcc
      601 aagtgtggct tcatcacctt gaccacaagg gtgaggcaac agtgcacatg gataccttcc
      661 aggtggctcg aattgcctac tgcacagctg accacaacgt gagccccaac atcttcgcct
      721 gggtgtacag agagatcaat gatgacctct cttaccagat ggactgccat gcagtgcaat
      781 gtgagagcaa gctggaggcc aagaagctgg cacacgccat gatggaggca ttcaagaaga
      841 ctttccacag tatgaagagt gatgggcgga tccataggag cagctcatct gaagaggctt
      901 cccaggaatt ggaatctgat gatggctgaa ggaacttaag atgttccagc gaaggcagca
      961 tttgggcaag gagtttcaga agctagacat gtctgcaatg attcaaattt ggtacgaaag
     1021 gactgccaac ctattggctg atcatgcttt ttaaattcag aagagtgatt ctaaatctaa
     1081 agaatcatat cattaattat gtgacattga aacctgctgc tgccgtgatc ttgaggagag
     1141 tacagatggg gaggaaggtt ccagactctc ctctcacttt ttttttcctc tcctattcca
     1201 acacttcctg ctgggagatc tccacgccta ttttcaccat tctcaggcaa atactccatg
     1261 gctgtagttt gacggactgt tccaatctgc cttatgaaat ccaacaagaa tgttagtggc
     1321 atctctgtgg tccctaggca ggcaggaggt atggggaggt gctgttggcg tggaggctgc
     1381 aggatggaag ggacacgtcc aggtgactga ctggttgctc ctcccccttg gcatgtttgc
     1441 agatcctctc ctcagtccgt gaatcagcac agcttggatt gagctttaca actaacagcg
     1501 cgctagatgg cagttaattc gcagttaaag ataatgcttt ttatttacac gaatatatca
     1561 agtagtaccc tcctattgta ttcacttctt ctattttctt agaattcttg caactaatga
     1621 ttgttcccct ccttctccca ccaccaagtt ctttgtcctt ccaacctccc ggaaagggac
     1681 aaaggctcaa catactgcag gactccaaaa gggaagaaaa taacaaatta agtaaataaa
     1741 cgatcaggaa accaaccagg aatctcagac atcagaaacc ctagtaaaga agtgaatgag
     1801 tggccaaagt ctatagaggc ttccctttag caagccctga gatatagtaa cttccttggt
     1861 tatgagtctt gttgaatgac tccttttgga aagtttaaac tctgacatgg cattgccctg
     1921 gaagtcttgc cccatcattt aacaaggaac tcaagtagga aatgagtgac atcaagtcag
     1981 tttgcctaga aatcccatgt cttcctggaa acctaaaggg aaacatgatc ttgtcctgaa
     2041 aatgatattt tagagtctga gtgacccctt tgactatcag ttctgaagag caattctcac
     2101 tggtaacttg acatctctca atttcaggat ctttgcctct cattaaaagt catggaaaat
     2161 atacacattt aaggtgaata gacacattaa ggtggcaaat gatctacttt ttcaagtaat
     2221 attgctcctt taaaaggtgt gtttttattt ctggtgatgt caggggcaac ggggtatctt
     2281 agaagcctta aatgagagct aatataatcc agacagcaat ggtgttagta tttttggtct
     2341 gtgtacccac gtgcccatgt atatgtttgt gtgtgtgtat gtgtgagtgt gtgtgtatgt
     2401 gtgtgtgtat gtaagtcccc tgtgtgggtc cagtttcaag gcatgtacaa taagcatgga
     2461 gtcgtattga tgaggactta cctcctgaag atatgcttgt tgctttatga tatatgtaaa
     2521 ctattcttta gaaaaatgca ttcactcttt aataaaagta tgtttgtgtt aataaagcca
     2581 gggcgtttca cactttatat gaacttccct ttttttaaga aatggaaatt tgacatgtaa
     2641 aataaatcaa acttggtaaa cagggca
//
