LOCUS       NM_001045558            1984 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus protein interacting with C kinase 1 (Pick1),
            transcript variant 2, mRNA.
ACCESSION   NM_001045558
VERSION     NM_001045558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1984)
  AUTHORS   Fadahunsi,N., Petersen,J., Metz,S., Jakobsen,A., Vad Mathiesen,C.,
            Silke Buch-Rasmussen,A., Kurgan,N., Kjaergaard Larsen,J.,
            Andersen,R.C., Topilko,T., Svendsen,C., Apuschkin,M., Skovbjerg,G.,
            Hendrik Schmidt,J., Houser,G., Elgaard Jager,S., Bach,A.,
            Deshmukh,A.S., Kilpelainen,T.O., Stromgaard,K., Madsen,K.L. and
            Clemmensen,C.
  TITLE     Targeting postsynaptic glutamate receptor scaffolding proteins
            PSD-95 and PICK1 for obesity treatment
  JOURNAL   Sci Adv 10 (9), eadg2636 (2024)
   PUBMED   38427737
  REMARK    GeneRIF: Targeting postsynaptic glutamate receptor scaffolding
            proteins PSD-95 and PICK1 for obesity treatment.
REFERENCE   2  (bases 1 to 1984)
  AUTHORS   Jin,J., Li,K., Du,Y., Gao,F., Wang,Z. and Li,W.
  TITLE     Multi-omics study identifies that PICK1 deficiency causes male
            infertility by inhibiting vesicle trafficking in Sertoli cells
  JOURNAL   Reprod Biol Endocrinol 21 (1), 114 (2023)
   PUBMED   38001535
  REMARK    GeneRIF: Multi-omics study identifies that PICK1 deficiency causes
            male infertility by inhibiting vesicle trafficking in Sertoli
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1984)
  AUTHORS   Birmingham,E.A., Wickens,M.M., Kirkland,J.M., Knouse,M.C.,
            McGrath,A.G. and Briand,L.A.
  TITLE     Circulating ovarian hormones interact with protein interacting with
            C kinase (PICK1) within the medial prefrontal cortex to influence
            cocaine seeking in female mice
  JOURNAL   Horm Behav 155, 105408 (2023)
   PUBMED   37541099
  REMARK    GeneRIF: Circulating ovarian hormones interact with protein
            interacting with C kinase (PICK1) within the medial prefrontal
            cortex to influence cocaine seeking in female mice.
REFERENCE   4  (bases 1 to 1984)
  AUTHORS   Bygrave,A.M., Sengupta,A., Jackert,E.P., Ahmed,M., Adenuga,B.,
            Nelson,E., Goldschmidt,H.L., Johnson,R.C., Zhong,H., Yeh,F.L.,
            Sheng,M. and Huganir,R.L.
  TITLE     Btbd11 supports cell-type-specific synaptic function
  JOURNAL   Cell Rep 42 (6), 112591 (2023)
   PUBMED   37261953
REFERENCE   5  (bases 1 to 1984)
  AUTHORS   Ramsakha,N., Ojha,P., Pal,S., Routh,S., Citri,A. and
            Bhattacharyya,S.
  TITLE     A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis
  JOURNAL   J Biol Chem 299 (6), 104837 (2023)
   PUBMED   37209824
  REMARK    GeneRIF: A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis.
REFERENCE   6  (bases 1 to 1984)
  AUTHORS   Takeya,R., Takeshige,K. and Sumimoto,H.
  TITLE     Interaction of the PDZ domain of human PICK1 with class I
            ADP-ribosylation factors
  JOURNAL   Biochem Biophys Res Commun 267 (1), 149-155 (2000)
   PUBMED   10623590
REFERENCE   7  (bases 1 to 1984)
  AUTHORS   Dev,K.K., Nishimune,A., Henley,J.M. and Nakanishi,S.
  TITLE     The protein kinase C alpha binding protein PICK1 interacts with
            short but not long form alternative splice variants of AMPA
            receptor subunits
  JOURNAL   Neuropharmacology 38 (5), 635-644 (1999)
   PUBMED   10340301
REFERENCE   8  (bases 1 to 1984)
  AUTHORS   Torres,R., Firestein,B.L., Dong,H., Staudinger,J., Olson,E.N.,
            Huganir,R.L., Bredt,D.S., Gale,N.W. and Yancopoulos,G.D.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   9  (bases 1 to 1984)
  AUTHORS   Staudinger,J., Lu,J. and Olson,E.N.
  TITLE     Specific interaction of the PDZ domain protein PICK1 with the COOH
            terminus of protein kinase C-alpha
  JOURNAL   J Biol Chem 272 (51), 32019-32024 (1997)
   PUBMED   9405395
REFERENCE   10 (bases 1 to 1984)
  AUTHORS   Staudinger,J., Zhou,J., Burgess,R., Elledge,S.J. and Olson,E.N.
  TITLE     PICK1: a perinuclear binding protein and substrate for protein
            kinase C isolated by the yeast two-hybrid system
  JOURNAL   J Cell Biol 128 (3), 263-271 (1995)
   PUBMED   7844141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU698586.1, AK090155.1, AI893973.1 and AI385692.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048788.1, SRR1660815.40779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BU698586.1         209-217
            10-1231             AK090155.1         2-1223
            1232-1441           AI893973.1         55-264
            1442-1984           AI385692.1         1-543               c
FEATURES             Location/Qualifiers
     source          1..1984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..1984
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /note="protein interacting with C kinase 1"
                     /db_xref="GeneID:18693"
                     /db_xref="MGI:MGI:894645"
     exon            1..189
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            190..293
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1503
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /note="protein kinase C-alpha-binding protein; protein
                     that interacts with C kinase 1"
                     /codon_start=1
                     /product="PRKCA-binding protein"
                     /protein_id="NP_001039023.1"
                     /db_xref="CCDS:CCDS27635.1"
                     /db_xref="GeneID:18693"
                     /db_xref="MGI:MGI:894645"
                     /translation="MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYC
                     PCLYIVQVFDNTPAALDGTVAAGDEITGVNGKSIKGKTKVEVAKMIQEVKGEVTIHYN
                     KLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTA
                     ELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIE
                     KFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYS
                     CIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQL
                     QRFVSTMSKYYNDCYAVLQDADVFPIEVDLAHTTLAYGPNQGSFTDGEEEDEEEEDGA
                     AREVSKDACGATGPTDKGGSWCDS"
     exon            294..405
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            406..534
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            535..601
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..691
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            692..745
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            746..808
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            809..942
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1035
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1086
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1231
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1977
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /note="hexamer: AATAAA"
     polyA_site      1977
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /note="major polyA site"
ORIGIN      
        1 tgacgcgaca gtcgcggtcg ccgccaggtg gaacggcagg tgggttcagg tgccagcctg
       61 gcccgggcct ggcagtggga ccgactctct cggtgagcga ctgaagcggc tcccaaggct
      121 ctggagaccg tggggcgggc tccagaatcc gagcccgtcg ccctggcctg gggtcctccc
      181 ctgtaccaaa cccagtttcc tattcccctc ccgagctggg cagttagcca gtcggcccca
      241 actctcggaa ccatgtttgc agacttagac tatgacatcg aagaggataa attaggaatc
      301 cccactgtgc ctgggaaggt caccctacag aaggatgccc agaacctgat tgggatcagc
      361 atcggaggag gggcccaata ctgtccttgt ctctatatcg tccaggtatt tgataacacg
      421 cctgcagcct tggatggcac tgtggcagct ggtgacgaga tcactggggt caatggcaag
      481 tcaatcaaag gaaaaaccaa ggtagaggtg gcgaagatga ttcaggaagt gaagggggag
      541 gtgaccatcc attacaacaa gctgcaggcg gaccctaagc agggcatgtc cctggacatt
      601 gtgttgaaga aagtcaagca ccggctggta gaaaacatga gttcaggcac agctgatgcc
      661 ctgggcctaa gccgcgccat cctgtgtaac gatggcttgg taaagcggct ggaggagctg
      721 gaacgcactg ctgagctgta caaagggatg acggaacaca ccaagaatct cctacgggcc
      781 ttttatgagc tgtcgcagac ccaccgggcc tttggggacg tgttctctgt gattggggtg
      841 cgggagccgc agccagcagc aagtgaagca tttgtgaagt ttgcagacgc acaccgcagc
      901 attgagaagt tcggcattcg gctactgaaa accatcaaac cgatgctgac ggacctgaac
      961 acgtacctca ataaagccat ccctgataca cgcctcacca tcaagaagta cctggatgtg
     1021 aagtttgagt acctgtcgta ctgtctaaag gtgaaggaga tggatgacga ggaatacagc
     1081 tgcattgccc taggcgagcc gctataccga gtgagcacag gcaactatga gtaccgcctc
     1141 attctgcgct gccgccagga ggctcgagcc cgcttctccc agatgcgcaa agatgttctg
     1201 gagaagatgg agctgctgga ccagaagcac gtccaggaca tcgtgttcca gctgcagcgc
     1261 ttcgtatcca ccatgtccaa gtactataat gactgctatg cagtgctgca ggacgccgac
     1321 gtcttcccca ttgaggtgga cctggcacac accactctag cctatggccc taaccaaggc
     1381 agcttcactg atggagagga ggaggatgaa gaggaggagg atggggcagc tagggaagtg
     1441 tccaaggacg catgtggggc cactgggcct acggacaagg gcggaagctg gtgtgactcc
     1501 tgagtgcccc ctcaagtgga cctggggggc agggtagtgg gaggaccgca gtgggagtgg
     1561 ggcgggacca ctgtaggaca gcgaaggcat atagtggcgc ataaaagcct gctggctcgg
     1621 ggcgcctgcc tccctgctcc tctgtcctca aacagtgaac ccaggctgca gcctgagacc
     1681 tggactctag cccccatcca tccttcccat ctcccagcta gagggagagc tgggctttgg
     1741 acagaaaaga gaaggggctg gagcagacag agcacaggac ctgtccctgt gagcgcctcg
     1801 gtggtgccaa gcctgcaggg agtgggagcc gggtggacat ctgaggctgg ggccagtgta
     1861 ccagggcagc ccctgagtcc acatgcacac ctcagcagcc tatatttatt tgtttctggt
     1921 ttagcctcaa gggctggaag ctgggcctgt attgaataaa cagaaaccca gacagaaaaa
     1981 aaaa
//
