LOCUS       NM_146194               4193 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus phosphatidylinositol binding clathrin assembly protein
            (Picalm), transcript variant 1, mRNA.
ACCESSION   NM_146194
VERSION     NM_146194.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Azarnia Tehran D, Kochlamazashvili G, Pampaloni NP, Sposini S,
            Shergill JK, Lehmann M, Pashkova N, Schmidt C, Lowe D, Napieczynska
            H, Heuser A, Plested AJR, Perrais D, Piper RC, Haucke V and
            Maritzen T.
  TITLE     Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's
            disease risk factor CALM bidirectionally controls synaptic
            plasticity
  JOURNAL   Sci Adv 8 (21), eabl5032 (2022)
   PUBMED   35613266
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Ando K, De Decker R, Vergara C, Yilmaz Z, Mansour S, Suain V,
            Sleegers K, de Fisenne MA, Houben S, Potier MC, Duyckaerts C,
            Watanabe T, Buee L, Leroy K and Brion JP.
  TITLE     Picalm reduction exacerbates tau pathology in a murine tauopathy
            model
  JOURNAL   Acta Neuropathol 139 (4), 773-789 (2020)
   PUBMED   31925534
  REMARK    GeneRIF: Picalm reduction exacerbates tau pathology in a murine
            tauopathy model.
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Nakano Y, Wiechert S and Banfi B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 4193)
  AUTHORS   Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T and Tomita T.
  TITLE     Partial loss of CALM function reduces Abeta42 production and
            amyloid deposition in vivo
  JOURNAL   Hum Mol Genet 25 (18), 3988-3997 (2016)
   PUBMED   27466196
REFERENCE   5  (bases 1 to 4193)
  AUTHORS   Xu W, Tan L and Yu JT.
  TITLE     The Role of PICALM in Alzheimer's Disease
  JOURNAL   Mol Neurobiol 52 (1), 399-413 (2015)
   PUBMED   25186232
  REMARK    Review article
REFERENCE   6  (bases 1 to 4193)
  AUTHORS   Rinchik EM and Carpenter DA.
  TITLE     N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the
            Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557
            gametes and deletion mapping and complementation analysis of 31
            mutations
  JOURNAL   Genetics 152 (1), 373-383 (1999)
   PUBMED   10224267
REFERENCE   7  (bases 1 to 4193)
  AUTHORS   Potter MD, Shinpock SG, Popp RA, Godfrey V, Carpenter DA, Bernstein
            A, Johnson DK and Rinchik EM.
  TITLE     Mutations in the murine fitness 1 gene result in defective
            hematopoiesis
  JOURNAL   Blood 90 (5), 1850-1857 (1997)
   PUBMED   9292517
REFERENCE   8  (bases 1 to 4193)
  AUTHORS   Holdener BC, Thomas JW, Schumacher A, Potter MD, Rinchik EM, Sharan
            SK and Magnuson T.
  TITLE     Physical localization of eed: a region of mouse chromosome 7
            required for gastrulation
  JOURNAL   Genomics 27 (3), 447-456 (1995)
   PUBMED   7558026
REFERENCE   9  (bases 1 to 4193)
  AUTHORS   Potter MD, Klebig ML, Carpenter DA and Rinchik EM.
  TITLE     Genetic and physical mapping of the fitness 1 (fit1) locus within
            the Fes-Hbb region of mouse chromosome 7
  JOURNAL   Mamm Genome 6 (2), 70-75 (1995)
   PUBMED   7767008
REFERENCE   10 (bases 1 to 4193)
  AUTHORS   Rinchik EM, Carpenter DA and Selby PB.
  TITLE     A strategy for fine-structure functional analysis of a 6- to
            11-centimorgan region of mouse chromosome 7 by high-efficiency
            mutagenesis
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 896-900 (1990)
   PUBMED   2300582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130210.4, BK001028.1, BY160265.1 and AC158781.4.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_146194.6.
            
            On Feb 16, 2018 this sequence version replaced NM_146194.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144960.1, AY206701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC130210.4         67806-67824         c
            20-1481             BK001028.1         1-1462
            1482-1523           BY160265.1         338-379
            1524-2328           BK001028.1         1505-2309
            2329-4193           AC158781.4         47856-49720
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.47 cM"
     gene            1..4193
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /note="phosphatidylinositol binding clathrin assembly
                     protein"
                     /db_xref="GeneID:233489"
                     /db_xref="MGI:MGI:2385902"
     exon            1..490
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2343
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clathrin assembly lymphoid myeloid leukemia"
                     /codon_start=1
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform 1"
                     /protein_id="NP_666306.2"
                     /db_xref="CCDS:CCDS52307.1"
                     /db_xref="GeneID:233489"
                     /db_xref="MGI:MGI:2385902"
                     /translation="MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDY
                     LIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNT
                     LFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMN
                     TEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINL
                     LEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLD
                     ALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQAR
                     LKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPND
                     LLDLQQPTFHPSVHAMSAAPQGASTWGDPFSATLDAVEDAIPSLNPFLTKSSGDVHLP
                     IASDVSTFTTRTPTHEMFVGFSPSPVAQPHSSAGLNVDFESVFGNKSTNVAVDSGGFD
                     ELGGLLKPTVASQNQSLPVAKLPPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVSWSQ
                     PGEKKLTGGSNWQPKVAPTTAWSAATMNGMHFPQYAPPVMAYPATTPTGMIGYGIPPQ
                     MGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM"
     exon            491..633
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            634..709
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            710..812
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            813..906
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1018
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1125
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1167
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1253
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1377
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1514
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1618
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1768
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1876
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2008
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2039
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2139
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2163
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2223
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2328
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..4193
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgaccta ggggcagccc ggaaagctcc gaggaggagc ctggcgccgc cattttcctg
       61 cagctgcctg gccctcttac ccggtcgggc tccagctgac cagggaaggg gtgggccgag
      121 gctgaggcgc gggacccggg agtggccccg acttggtgtg ggagcccgcc gggggaacac
      181 gcgagccggg gctctcggag cgggtggcgg cgcgcggccc tgagccccgc cccaggccgg
      241 caggcgggcg gggagccggt gggggtaggg ggtgcggtgg ggggtgggga ccctcgggcg
      301 cttgggggtc ccaggccccg ccggctgcgg agcggaaggg gtggcggacg agccgcagag
      361 atgtctggcc agagcctgac ggaccgaatc accgcggccc agcacagtgt cactggctcc
      421 gcggtatcta agacagtatg caaggccacg acccacgaga tcatgggccc caagaaaaag
      481 cacctggact acttaattca gtgtacaaat gagatgaatg tgaacatccc acagttggcg
      541 gacagtttgt ttgaaagaac tactaacagt agttgggtgg tggtcttcaa atcactcatt
      601 acaactcatc atttgatggt gtatggaaat gagcgtttca ttcagtattt ggcttcaaga
      661 aacacattgt ttaacttaag caattttttg gataaaagtg gattgcaagg atatgatatg
      721 tctacattta ttagacggta tagtagatac ttaaatgaaa aagcagtttc atacagacaa
      781 gttgcattcg atttcacaaa agtgaagaga ggagctgatg gagttatgag aacaatgaac
      841 acagaaaaac tcttaaaaac tgtaccaatt atccaaaatc aaatggatgc acttcttgat
      901 tttaatgtta atagtaatga acttacaaat ggggtaataa atgctgcctt catgctcctc
      961 ttcaaagatg ccattagact atttgcagca tacaatgaag gaattattaa tttattggaa
     1021 aaatattttg atatgaaaaa gaaccagtgc aaagaaggtc ttgacatcta taagaagttt
     1081 ctgactagga tgacaagaat ctcagagttt ctgaaagttg cagagcaagt tggaattgac
     1141 agaggagata ttccagatct ttcacaggcc cccagcagtc ttcttgatgc tttagaacaa
     1201 catttagctt ccttggaagg aaagaaaatc aaagattcca cagctgcaag cagggctaca
     1261 acactttcca atgcagtctc ttctttggca agcactggcc tatctctgac caaagtggat
     1321 gaaagggaaa aacaggcagc attagaggaa gaacaggctc gtttaaaagc attaaaggaa
     1381 cagcgtctaa aagaacttgc aaagaaaccg catacctctc taacaactgc agcctctccg
     1441 gtgtccacct cagcaggggg aataatgact gcaccagcca ttgacatatt ttctacccct
     1501 agttcttcta acagcacatc taagctgcca aatgacctgc ttgacttgca gcagccaacc
     1561 tttcacccgt ctgtccacgc catgtcggct gctcctcagg gagcgagtac atggggagat
     1621 cctttctctg ctactctaga tgctgttgag gatgccattc caagcttaaa ccctttcctc
     1681 acaaaaagta gtggtgatgt tcacctgccc attgcttcag atgtatccac ttttactact
     1741 aggacaccta ctcatgagat gtttgttgga ttcagtcctt ctccagttgc acagccacat
     1801 tcttcagctg gccttaatgt tgactttgaa tctgtgtttg gaaataaatc tacgaatgtt
     1861 gctgtagatt ctggtggctt tgatgaacta ggtggacttc tcaaaccaac agtggcctcc
     1921 cagaaccaga gtcttcctgt tgccaaactt ccgcctaaca aattagtgtc tgacgacttg
     1981 gattcatctt tagccaacct tgtgggcaat cttggcattg gaaatggaac cactaagaat
     2041 gatgtaagtt ggagtcaacc aggtgaaaag aagttaactg gaggatctaa ctggcaacca
     2101 aaggttgcac caacaactgc ctggagcgct gcaacaatga atggcatgca ttttccacaa
     2161 tacgcgcccc ctgtaatggc ctatcctgct actacaccaa cgggcatgat aggatatgga
     2221 attcctcctc agatgggaag tgtacctgta atgacacaac caaccttaat atacagccag
     2281 cctgtcatga gaccaccaaa cccctttggc cctgtatcag gagcacagat acagtttatg
     2341 taactagatg gaagagaatg gaattactcc aagaatacaa gtgcacaggc ggcaactcct
     2401 tacttccagc aaaattgaaa ctgctgtctc tgaaactctt cctccattag agcgctccag
     2461 taacccatga aggcccacag cgggatggga ctagtttata ggagagcgtt gtcaatacca
     2521 cttataaagc caagaattgc catgatttaa gactaagatc tgtctttttg gtgactaaca
     2581 cttcagttct ttcaactcct attaataccc ataatcagta acctaccaag aaaagcccgt
     2641 atttggaaag tgtggagttt gtgttggaaa agctgcctgg agagaagagt tgtgtccttt
     2701 accatagcaa caggattcat tgggggatca aaatcataat tttaaattat gcattatatt
     2761 tcttttctcc actcctcaca tatacagaaa ccataattga agttaacttt tctttttaaa
     2821 aaaaatttat attcagtttg cagtagacat tccttaagta tttgtattta tttatgatta
     2881 tcaattttac ataacattaa tattatatca gacctcctta agaaaatgag tatggatgtt
     2941 cacagtatgt ttgattttta tccacaagaa tgaatctgat tcagaatgct tttcagctga
     3001 catacagagc actaaatact ttacggcaaa tccataggtc tgaatctctt aagaattctc
     3061 agtctctctg ggatgtaggg cgcattataa atgcattaat ccttatagtc aatcctgtgc
     3121 ctaggatttt gcaagggaac agttcactga ctaggaaaag cactacattt aaaactcagc
     3181 attagtgcat tgggaaggat ctttactgct ttgtgcttgg catgtcgtta ttttccattt
     3241 gacattaggg cctttccaaa tgaatgtgag gagttgcttt cacttcaaga ctgtccttct
     3301 tttcagtaaa actttaggag atgttatggg gaaagggagg gaacagaaat ccttgaactt
     3361 tttatttggc gtgtgccatg ttatgatcat gtaccttttc aataagggga gatagtatct
     3421 ttaaagtcaa tgtctagcca agagtttagt taatgaagaa ttaaactgca ctgttgatcg
     3481 gtgctttctg taaatacatc ttatcgcttg ggttgagagg ggccttaaga aggacagttc
     3541 attgtaggaa agcaattctg tacatgagtt aagcatactt gttgcattgt ctctgcagat
     3601 tctatttttg tttacaatat taaaatgtat gttagcaaat gggtggattt tcaaataaaa
     3661 tgcagcttcc acaaaacatg ttacggtgtt ctggtttgag gtgtgttctc ctttttcctt
     3721 cctttttttt tttttttttt ttttttatta ttattattat cagtctcatc agttttttgc
     3781 taataaaatt atgcccagga ggttattata tcgactggtc aaataaaatg taaaatttgt
     3841 ttaactatac aaaaagaata atgtctgaat tcttgttacc gtctggactc gcttagacac
     3901 attacttgca cttgttcact ttccttcctg aggggacgcc gtcagtcagg taagttaagg
     3961 gagaaagtac ttgctcgtca gtgcgtaaga ctgtgtttgc taaagaatgt ctgtatcata
     4021 tagtgtagtg gataataaac gagcatcaga gtgcatcaaa gagagatcaa aagctgtata
     4081 ctgctaagtg tttgttctgg tatggaaaaa aatcacagtt tttagccatt gtgtttttgt
     4141 taatgactga ttttcaaatt tcgctattat taaaatgttt ccatatgaac tga
//
