LOCUS       NM_001252523            4028 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus phosphatidylinositol binding clathrin assembly protein
            (Picalm), transcript variant 5, mRNA.
ACCESSION   NM_001252523
VERSION     NM_001252523.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4028)
  AUTHORS   Azarnia Tehran D, Kochlamazashvili G, Pampaloni NP, Sposini S,
            Shergill JK, Lehmann M, Pashkova N, Schmidt C, Lowe D, Napieczynska
            H, Heuser A, Plested AJR, Perrais D, Piper RC, Haucke V and
            Maritzen T.
  TITLE     Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's
            disease risk factor CALM bidirectionally controls synaptic
            plasticity
  JOURNAL   Sci Adv 8 (21), eabl5032 (2022)
   PUBMED   35613266
REFERENCE   2  (bases 1 to 4028)
  AUTHORS   Ando K, De Decker R, Vergara C, Yilmaz Z, Mansour S, Suain V,
            Sleegers K, de Fisenne MA, Houben S, Potier MC, Duyckaerts C,
            Watanabe T, Buee L, Leroy K and Brion JP.
  TITLE     Picalm reduction exacerbates tau pathology in a murine tauopathy
            model
  JOURNAL   Acta Neuropathol 139 (4), 773-789 (2020)
   PUBMED   31925534
  REMARK    GeneRIF: Picalm reduction exacerbates tau pathology in a murine
            tauopathy model.
REFERENCE   3  (bases 1 to 4028)
  AUTHORS   Nakano Y, Wiechert S and Banfi B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 4028)
  AUTHORS   Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T and Tomita T.
  TITLE     Partial loss of CALM function reduces Abeta42 production and
            amyloid deposition in vivo
  JOURNAL   Hum Mol Genet 25 (18), 3988-3997 (2016)
   PUBMED   27466196
REFERENCE   5  (bases 1 to 4028)
  AUTHORS   Xu W, Tan L and Yu JT.
  TITLE     The Role of PICALM in Alzheimer's Disease
  JOURNAL   Mol Neurobiol 52 (1), 399-413 (2015)
   PUBMED   25186232
  REMARK    Review article
REFERENCE   6  (bases 1 to 4028)
  AUTHORS   Rinchik EM and Carpenter DA.
  TITLE     N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the
            Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557
            gametes and deletion mapping and complementation analysis of 31
            mutations
  JOURNAL   Genetics 152 (1), 373-383 (1999)
   PUBMED   10224267
REFERENCE   7  (bases 1 to 4028)
  AUTHORS   Potter MD, Shinpock SG, Popp RA, Godfrey V, Carpenter DA, Bernstein
            A, Johnson DK and Rinchik EM.
  TITLE     Mutations in the murine fitness 1 gene result in defective
            hematopoiesis
  JOURNAL   Blood 90 (5), 1850-1857 (1997)
   PUBMED   9292517
REFERENCE   8  (bases 1 to 4028)
  AUTHORS   Holdener BC, Thomas JW, Schumacher A, Potter MD, Rinchik EM, Sharan
            SK and Magnuson T.
  TITLE     Physical localization of eed: a region of mouse chromosome 7
            required for gastrulation
  JOURNAL   Genomics 27 (3), 447-456 (1995)
   PUBMED   7558026
REFERENCE   9  (bases 1 to 4028)
  AUTHORS   Potter MD, Klebig ML, Carpenter DA and Rinchik EM.
  TITLE     Genetic and physical mapping of the fitness 1 (fit1) locus within
            the Fes-Hbb region of mouse chromosome 7
  JOURNAL   Mamm Genome 6 (2), 70-75 (1995)
   PUBMED   7767008
REFERENCE   10 (bases 1 to 4028)
  AUTHORS   Rinchik EM, Carpenter DA and Selby PB.
  TITLE     A strategy for fine-structure functional analysis of a 6- to
            11-centimorgan region of mouse chromosome 7 by high-efficiency
            mutagenesis
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 896-900 (1990)
   PUBMED   2300582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130210.4, BK001028.1, AK220291.1 and AC158781.4.
            
            [WARNING] On May 2, 2023 this sequence was replaced by
            NM_001252523.3.
            
            On Feb 16, 2018 this sequence version replaced NM_001252523.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057683.1, SRR3224858.7454.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC130210.4         67806-67824         c
            20-303              BK001028.1         1-284
            304-1618            AK220291.1         1-1315
            1619-2163           AK220291.1         1466-2010
            2164-4028           AC158781.4         47856-49720
FEATURES             Location/Qualifiers
     source          1..4028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.47 cM"
     gene            1..4028
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /note="phosphatidylinositol binding clathrin assembly
                     protein"
                     /db_xref="GeneID:233489"
                     /db_xref="MGI:MGI:2385902"
     exon            1..490
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2178
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /note="isoform 5 is encoded by transcript variant 5;
                     clathrin assembly lymphoid myeloid leukemia"
                     /codon_start=1
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform 5"
                     /protein_id="NP_001239452.1"
                     /db_xref="CCDS:CCDS85337.1"
                     /db_xref="GeneID:233489"
                     /db_xref="MGI:MGI:2385902"
                     /translation="MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDY
                     LIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNT
                     LFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMN
                     TEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINL
                     LEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLD
                     ALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQAR
                     LKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPND
                     LLDLQQPTFHPSVHAMSAAPQGASTWGGFSPSPVAQPHSSAGLNVDFESVFGNKSTNV
                     AVDSGGGLLKPTVASQNQSLPVAKLPPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVS
                     WSQPGEKKLTGGSNWQPKVAPTTAWSAATMNGMHFPQYAPPVMAYPATTPTGMIGYGI
                     PPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM"
     exon            491..633
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            634..709
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            710..812
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            813..906
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1018
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1125
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1167
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1253
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1377
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1514
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1618
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1726
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1843
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1874
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1974
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..1998
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2058
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2163
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..4028
                     /gene="Picalm"
                     /gene_synonym="CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgaccta ggggcagccc ggaaagctcc gaggaggagc ctggcgccgc cattttcctg
       61 cagctgcctg gccctcttac ccggtcgggc tccagctgac cagggaaggg gtgggccgag
      121 gctgaggcgc gggacccggg agtggccccg acttggtgtg ggagcccgcc gggggaacac
      181 gcgagccggg gctctcggag cgggtggcgg cgcgcggccc tgagccccgc cccaggccgg
      241 caggcgggcg gggagccggt gggggtaggg ggtgcggtgg ggggtgggga ccctcgggcg
      301 cttgggggtc ccaggccccg ccggctgcgg agcggaaggg gtggcggacg agccgcagag
      361 atgtctggcc agagcctgac ggaccgaatc accgcggccc agcacagtgt cactggctcc
      421 gcggtatcta agacagtatg caaggccacg acccacgaga tcatgggccc caagaaaaag
      481 cacctggact acttaattca gtgtacaaat gagatgaatg tgaacatccc acagttggcg
      541 gacagtttgt ttgaaagaac tactaacagt agttgggtgg tggtcttcaa atcactcatt
      601 acaactcatc atttgatggt gtatggaaat gagcgtttca ttcagtattt ggcttcaaga
      661 aacacattgt ttaacttaag caattttttg gataaaagtg gattgcaagg atatgatatg
      721 tctacattta ttagacggta tagtagatac ttaaatgaaa aagcagtttc atacagacaa
      781 gttgcattcg atttcacaaa agtgaagaga ggagctgatg gagttatgag aacaatgaac
      841 acagaaaaac tcttaaaaac tgtaccaatt atccaaaatc aaatggatgc acttcttgat
      901 tttaatgtta atagtaatga acttacaaat ggggtaataa atgctgcctt catgctcctc
      961 ttcaaagatg ccattagact atttgcagca tacaatgaag gaattattaa tttattggaa
     1021 aaatattttg atatgaaaaa gaaccagtgc aaagaaggtc ttgacatcta taagaagttt
     1081 ctgactagga tgacaagaat ctcagagttt ctgaaagttg cagagcaagt tggaattgac
     1141 agaggagata ttccagatct ttcacaggcc cccagcagtc ttcttgatgc tttagaacaa
     1201 catttagctt ccttggaagg aaagaaaatc aaagattcca cagctgcaag cagggctaca
     1261 acactttcca atgcagtctc ttctttggca agcactggcc tatctctgac caaagtggat
     1321 gaaagggaaa aacaggcagc attagaggaa gaacaggctc gtttaaaagc attaaaggaa
     1381 cagcgtctaa aagaacttgc aaagaaaccg catacctctc taacaactgc agcctctccg
     1441 gtgtccacct cagcaggggg aataatgact gcaccagcca ttgacatatt ttctacccct
     1501 agttcttcta acagcacatc taagctgcca aatgacctgc ttgacttgca gcagccaacc
     1561 tttcacccgt ctgtccacgc catgtcggct gctcctcagg gagcgagtac atggggagga
     1621 ttcagtcctt ctccagttgc acagccacat tcttcagctg gccttaatgt tgactttgaa
     1681 tctgtgtttg gaaataaatc tacgaatgtt gctgtagatt ctggtggtgg acttctcaaa
     1741 ccaacagtgg cctcccagaa ccagagtctt cctgttgcca aacttccgcc taacaaatta
     1801 gtgtctgacg acttggattc atctttagcc aaccttgtgg gcaatcttgg cattggaaat
     1861 ggaaccacta agaatgatgt aagttggagt caaccaggtg aaaagaagtt aactggagga
     1921 tctaactggc aaccaaaggt tgcaccaaca actgcctgga gcgctgcaac aatgaatggc
     1981 atgcattttc cacaatacgc gccccctgta atggcctatc ctgctactac accaacgggc
     2041 atgataggat atggaattcc tcctcagatg ggaagtgtac ctgtaatgac acaaccaacc
     2101 ttaatataca gccagcctgt catgagacca ccaaacccct ttggccctgt atcaggagca
     2161 cagatacagt ttatgtaact agatggaaga gaatggaatt actccaagaa tacaagtgca
     2221 caggcggcaa ctccttactt ccagcaaaat tgaaactgct gtctctgaaa ctcttcctcc
     2281 attagagcgc tccagtaacc catgaaggcc cacagcggga tgggactagt ttataggaga
     2341 gcgttgtcaa taccacttat aaagccaaga attgccatga tttaagacta agatctgtct
     2401 ttttggtgac taacacttca gttctttcaa ctcctattaa tacccataat cagtaaccta
     2461 ccaagaaaag cccgtatttg gaaagtgtgg agtttgtgtt ggaaaagctg cctggagaga
     2521 agagttgtgt cctttaccat agcaacagga ttcattgggg gatcaaaatc ataattttaa
     2581 attatgcatt atatttcttt tctccactcc tcacatatac agaaaccata attgaagtta
     2641 acttttcttt ttaaaaaaaa tttatattca gtttgcagta gacattcctt aagtatttgt
     2701 atttatttat gattatcaat tttacataac attaatatta tatcagacct ccttaagaaa
     2761 atgagtatgg atgttcacag tatgtttgat ttttatccac aagaatgaat ctgattcaga
     2821 atgcttttca gctgacatac agagcactaa atactttacg gcaaatccat aggtctgaat
     2881 ctcttaagaa ttctcagtct ctctgggatg tagggcgcat tataaatgca ttaatcctta
     2941 tagtcaatcc tgtgcctagg attttgcaag ggaacagttc actgactagg aaaagcacta
     3001 catttaaaac tcagcattag tgcattggga aggatcttta ctgctttgtg cttggcatgt
     3061 cgttattttc catttgacat tagggccttt ccaaatgaat gtgaggagtt gctttcactt
     3121 caagactgtc cttcttttca gtaaaacttt aggagatgtt atggggaaag ggagggaaca
     3181 gaaatccttg aactttttat ttggcgtgtg ccatgttatg atcatgtacc ttttcaataa
     3241 ggggagatag tatctttaaa gtcaatgtct agccaagagt ttagttaatg aagaattaaa
     3301 ctgcactgtt gatcggtgct ttctgtaaat acatcttatc gcttgggttg agaggggcct
     3361 taagaaggac agttcattgt aggaaagcaa ttctgtacat gagttaagca tacttgttgc
     3421 attgtctctg cagattctat ttttgtttac aatattaaaa tgtatgttag caaatgggtg
     3481 gattttcaaa taaaatgcag cttccacaaa acatgttacg gtgttctggt ttgaggtgtg
     3541 ttctcctttt tccttccttt tttttttttt tttttttttt tattattatt attatcagtc
     3601 tcatcagttt tttgctaata aaattatgcc caggaggtta ttatatcgac tggtcaaata
     3661 aaatgtaaaa tttgtttaac tatacaaaaa gaataatgtc tgaattcttg ttaccgtctg
     3721 gactcgctta gacacattac ttgcacttgt tcactttcct tcctgagggg acgccgtcag
     3781 tcaggtaagt taagggagaa agtacttgct cgtcagtgcg taagactgtg tttgctaaag
     3841 aatgtctgta tcatatagtg tagtggataa taaacgagca tcagagtgca tcaaagagag
     3901 atcaaaagct gtatactgct aagtgtttgt tctggtatgg aaaaaaatca cagtttttag
     3961 ccattgtgtt tttgttaatg actgattttc aaatttcgct attattaaaa tgtttccata
     4021 tgaactga
//
