LOCUS       NM_029320               3297 bp    mRNA    linear   ROD 16-OCT-2021
DEFINITION  Mus musculus progesterone immunomodulatory binding factor 1
            (Pibf1), mRNA.
ACCESSION   NM_029320
VERSION     NM_029320.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3297)
  AUTHORS   Pallinger E, Bognar Z, Bogdan A, Csabai T, Abraham H and
            Szekeres-Bartho J.
  TITLE     PIBF+ extracellular vesicles from mouse embryos affect IL-10
            production by CD8+ cells
  JOURNAL   Sci Rep 8 (1), 4662 (2018)
   PUBMED   29549351
  REMARK    GeneRIF: Data suggest, that PIBF transported by the extracellular
            vesicles( EVs) from the embryo to maternal lymphocytes might induce
            increased IL-10 production by the latter, this way contributing to
            the Th2 dominant immune responses described during pregnancy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3297)
  AUTHORS   Huang B, Faucette AN, Pawlitz MD, Pei B, Goyert JW, Zhou JZ,
            El-Hage NG, Deng J, Lin J, Yao F, Dewar RS 3rd, Jassal JS, Sandberg
            ML, Dai J, Cols M, Shen C, Polin LA, Nichols RA, Jones TB, Bluth
            MH, Puder KS, Gonik B, Nayak NR, Puscheck E, Wei WZ, Cerutti A,
            Colonna M and Chen K.
  TITLE     Interleukin-33-induced expression of PIBF1 by decidual B cells
            protects against preterm labor
  JOURNAL   Nat Med 23 (1), 128-135 (2017)
   PUBMED   27918564
  REMARK    GeneRIF: B cell deficiency in mice resulted in a lower uterine
            level of active progesterone-induced blocking factor 1 (PIBF1), and
            susceptibility to preterm labor after inflammation. B cells are a
            significant producer of PIBF1 in mouse uterus in late gestation.
REFERENCE   3  (bases 1 to 3297)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 3297)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3297)
  AUTHORS   Sung,Y.H., Baek,I.J., Kim,D.H., Jeon,J., Lee,J., Lee,K., Jeong,D.,
            Kim,J.S. and Lee,H.W.
  TITLE     Knockout mice created by TALEN-mediated gene targeting
  JOURNAL   Nat Biotechnol 31 (1), 23-24 (2013)
   PUBMED   23302927
REFERENCE   6  (bases 1 to 3297)
  AUTHORS   Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M,
            Hoodless PA, Jones SJ, Marra MA and Helgason CD.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 3297)
  AUTHORS   Eickhoff H, Schuchhardt J, Ivanov I, Meier-Ewert S, O'Brien J,
            Malik A, Tandon N, Wolski EW, Rohlfs E, Nyarsik L, Reinhardt R,
            Nietfeld W and Lehrach H.
  TITLE     Tissue gene expression analysis using arrayed normalized cDNA
            libraries
  JOURNAL   Genome Res 10 (8), 1230-1240 (2000)
   PUBMED   10958641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017107.1, AK030385.1, AK006060.1 and AL361753.1.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_029320.4.
            
            On Oct 22, 2013 this sequence version replaced NM_029320.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1279              AK017107.1         2-1280
            1280-2215           AK030385.1         761-1696
            2216-3280           AK006060.1         190-1254
            3281-3297           AL361753.1         375-391
FEATURES             Location/Qualifiers
     source          1..3297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 49.27 cM"
     gene            1..3297
                     /gene="Pibf1"
                     /note="progesterone immunomodulatory binding factor 1"
                     /db_xref="GeneID:52023"
                     /db_xref="MGI:MGI:1261910"
     exon            1..706
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..979
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             728..2998
                     /gene="Pibf1"
                     /note="progesterone-induced blocking factor 1"
                     /codon_start=1
                     /product="progesterone-induced-blocking factor 1"
                     /protein_id="NP_083596.2"
                     /db_xref="CCDS:CCDS36997.1"
                     /db_xref="GeneID:52023"
                     /db_xref="MGI:MGI:1261910"
                     /translation="MSRKIAKEPKKVNISSSLESEDISLETTIHTDDVSSSEEREGKV
                     KITRQLIERKEILHNIQLLKIELSQKNMMIDNLKMDYLTKIEELEEKLNDALHQKQLL
                     TLRLDNQLTIQQKDAKKYQELMKQEMETILLRQKQLEETNHQLREKAGDVRRNLRDFE
                     LTEEQYVKLKSFPEDQLSIPEYVSIRFYELVNPLRKEVCELQVKKSELSEELSTSKGQ
                     LKQLTETYEEDRRNNAELLIRCQRLTLELADTKQLVQQGDYRQENYDKVKSERDALEQ
                     DVLELRRKHEVLEASHIAQAKERNELSKEVSSLQQTVTLLQKDKDYLNRQNMELSVRC
                     AHEEDRLERLQVQLEDTKKAREEMYEKYVTSRDHYKTEYENKLHDELEQIKLKTNLEI
                     DQLRSASREMYERENRNLREARDNALAEKNRAVAAEKDALGKHEQLLDRYRELQLSTE
                     SKVSEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQTS
                     SEKRITELEAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERILYSYGYGANV
                     PTTAKRRLKQSVHLARRVLQLEKQNSLILKDLDHQKNQVRQLSQELDRANSLLNQTQQ
                     PYRYLIESVRQRDAKIDSLMKSTAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLSHR
                     EEFAAMKQIIINMCSKHSENNLFLTKMESKSVTENQAKTLNMPREHEENIFIPKPTLF
                     TKKEAQEWPKSQKMKT"
     exon            980..1080
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1279
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1399
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1533
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1642
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1824
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1950
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2049
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2215
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2366
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2457
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2560
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2691
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2776
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2947
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3281
                     /gene="Pibf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcggcccc gcgtccacgc acctggtgca gcagcacatt ggtgtccggc agaaggtagt
       61 gcggccacgg gcagaggctg ctcgcctggt cccggggctg cagctccagg gccgggcccg
      121 cgtgcgcccc gccgcaggcc gagcaagccg gcgcgccgca gccgatgtca tcccgcaggt
      181 agtgctcgcg cacgatcttc accacgccgc ccgcgcgggt cttcttcaag aacgtcttgg
      241 acctgagcat ctcgcctcgc ggcgtgggat cccggccgtc agctaagaaa ccgaggcgcg
      301 gccacgcgca ttcccgcttt tgcccgctgg ctggtgaggt cactctcgcg agaaaacacg
      361 aaggcgcgtt cgttccccga cggtcgcggt gattgggcga gtgttggttg tttcctcccg
      421 ccggtgggcg gggctttcct ctggactaca gctcccagcc tgcaccgctt ccgactggct
      481 tccgggaagg agtgagcttg ggtacctgcg caccccaggt tcttccgact tcttctgggg
      541 cacggcgtgt ggttgtcttg gtgaccgatc ctaacggtcc ggtagccccg agatacctgt
      601 tgaggggtgg cagcctgagc tgctgactga agacgccatt ggttcttcca agagtccggg
      661 tgaagctggt gttatcctta tatgcggagt tactgaccat tgagagaaga ttgattcaaa
      721 taataaaatg tctcgcaaaa ttgccaagga accaaaaaaa gtaaatatct ctagttctct
      781 ggagtctgaa gatattagtt tggaaacaac cattcataca gatgatgtct catcatcaga
      841 ggagcgagaa ggtaaagtca aaatcaccag gcagttaatc gaaagaaaag agatacttca
      901 taatattcag ttactgaaaa tcgagctatc ccagaaaaac atgatgatcg acaacttgaa
      961 aatggattat cttacaaaga ttgaggagct agaggaaaaa cttaatgacg cccttcacca
     1021 gaagcagctg ctaactttgc gattagacaa tcagttgact attcaacaga aagatgccaa
     1081 aaaatatcaa gaactaatga aacaagaaat ggaaaccatt ttattgcgac agaagcaact
     1141 ggaagaaaca aaccatcagc tgagagaaaa ggctggagat gttcgccgaa atctgcgaga
     1201 ctttgagctg acagaagagc agtatgtgaa gctaaaatct tttcctgaag atcaactctc
     1261 tattcctgaa tatgtatcta ttcgcttcta tgagctcgtg aacccattaa gaaaggaagt
     1321 ctgtgagcta caggtgaaga agagtgaact ctctgaagaa ctgagtacaa gtaaaggcca
     1381 actgaagcag ctgacggaga catatgaaga agatcgaaga aacaacgctg aacttctaat
     1441 tcgatgtcaa cgtttgacct tagaattagc agacacaaaa cagttagttc agcaaggtga
     1501 ttaccgtcaa gagaactatg acaaagtgaa gagtgaacgc gatgctctgg aacaggacgt
     1561 actcgagctt agaagaaaac acgaagtact tgaagcctct cacatagctc aagctaagga
     1621 aaggaatgaa ttatcaaagg aggtcagcag cctgcagcag acagtcaccc tgctgcagaa
     1681 ggataaagac tacctcaatc gccaaaacat ggaactcagt gtacgctgtg cccatgagga
     1741 ggatcggctg gaaaggctgc aagttcaact ggaagacacc aaaaaggcta gagaagagat
     1801 gtatgagaaa tatgtcacgt ccagagacca ttataaaaca gaatatgaaa ataaactaca
     1861 tgatgaactg gaacaaatca aattgaaaac taatctagaa attgatcagc ttcgaagtgc
     1921 ctctagggaa atgtatgaac gagaaaacag aaatctccgt gaagcaaggg ataatgcact
     1981 cgctgaaaag aaccgagcag tggcagcgga aaaggacgct ctgggaaagc atgagcagct
     2041 cctagacagg tacagagaac tccagctcag tacagagagc aaggtatctg agtttctcca
     2101 tcagagcaag ttgaagtcct ttgaaagtga gcgtgttcaa ctcctgcaag aggaaactgc
     2161 aagaaatctc acgcagtgcc agttggagtg tgaaaaatat cagaagaaat tggaggtttt
     2221 aactaaagaa ttttatagtc tccaaacttc ttctgaaaaa cgcattaccg aactcgaggc
     2281 acagaactca gagcatcagg caaggttaga catttacgag aagttggaaa aggagcttga
     2341 tgagataata atgcaaacag cagaaattga aaatgaagat gaggctgaaa gaattcttta
     2401 ttcctatggt tatggtgcta atgttcccac aacagctaaa agacgactaa agcaaagtgt
     2461 ccacttggca agaagagttc ttcagttaga aaaacaaaat tcattaattt taaaagatct
     2521 ggaccatcaa aagaaccaag taagacagct ttcacaagag cttgacagag ccaattcact
     2581 gttgaatcag actcagcagc cctacagata cctcatagag tctgtgcgac agagagatgc
     2641 caagattgac tcactgatga agtctacagc tcaacttgag aaagatgtca gcaacttaaa
     2701 taaagagaag tcagccctgc tgcagacgaa gaaccagatg gcactggatc tggagcagct
     2761 cctcagtcac cgcgaggaat ttgcagctat gaagcagatc atcattaata tgtgtagtaa
     2821 acattctgag aacaacttat ttcttacgaa aatggaatca aaaagtgtga cagaaaatca
     2881 agcaaagact ttgaatatgc caagagaaca tgaagagaat atatttatac ccaagccaac
     2941 gctctttact aaaaaggaag cacaagagtg gcccaagagt cagaagatga agacctagtg
     3001 tttggtgttg aagaaagctg gagcctaacc cagccaggcc ctcggctctc cattggaaca
     3061 ggcctgtgtt atcatgtact cctgaagtgc aatgtctgtt ggggagaaag gctcacttca
     3121 atcatgtact tgatattttc aaatataagt aacttaatgt ttattttaac taatgttaaa
     3181 ttaacaaatt ttagtatagt cagcatataa ggtacaaata gtcatacttt atatgtggtt
     3241 ttatgtattt tgttataaaa taaattactc tcatctcctg aaaaaaaaaa aaaaaaa
//
