LOCUS       NM_021501               1676 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus protein inhibitor of activated STAT 4 (Pias4), mRNA.
ACCESSION   NM_021501
VERSION     NM_021501.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Yu,X., Chen,H., Zuo,C., Jin,X., Yin,Y., Wang,H., Jin,M., Ozato,K.
            and Xu,S.
  TITLE     Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by
            Rbp2 through interacting with Piasy for transcriptional attenuation
  JOURNAL   FASEB J 32 (2), 552-567 (2018)
   PUBMED   28970247
  REMARK    GeneRIF: study demonstrates that Piasy may prevent exaggerated
            transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of
            IFNI, avoiding excessive immune responses
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Usui,N., Araujo,D.J., Kulkarni,A., Co,M., Ellegood,J., Harper,M.,
            Toriumi,K., Lerch,J.P. and Konopka,G.
  TITLE     Foxp1 regulation of neonatal vocalizations via cortical development
  JOURNAL   Genes Dev 31 (20), 2039-2055 (2017)
   PUBMED   29138280
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Sun,L., Fan,Z., Chen,J., Tian,W., Li,M., Xu,H., Wu,X., Fang,M.,
            Xia,J. and Xu,Y.
  TITLE     Protein inhibitor of activated STAT 4 (PIAS4) regulates
            pro-inflammatory transcription in hepatocytes by repressing SIRT1
  JOURNAL   Oncotarget 7 (28), 42892-42903 (2016)
   PUBMED   27285989
  REMARK    GeneRIF: Findings indicate that protein inhibitor of activated STAT
            4 (PIAS4) mediated SIRT1 repression in response to nutrient surplus
            contributes to the pathogenesis of Nonalcoholic Steatohepatitis
            (NASH).
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Sun,L., Fan,Z., Chen,J., Tian,W., Li,M., Xu,H., Wu,X., Shao,J.,
            Bian,Y., Fang,M. and Xu,Y.
  TITLE     Transcriptional repression of SIRT1 by protein inhibitor of
            activated STAT 4 (PIAS4) in hepatic stellate cells contributes to
            liver fibrosis
  JOURNAL   Sci Rep 6, 28432 (2016)
   PUBMED   27323886
  REMARK    GeneRIF: PIAS4 mediated SIRT1 repression led to SMAD3
            hyperacetylation and enhanced SMAD3 binding to fibrogenic gene
            promoters and PIAS4 promoted hepatic stellate cells activation in a
            SIRT1-dependent manner in vitro.
            Erratum:[Sci Rep. 2016 Jul 27;6:30513. doi: 10.1038/srep30513..
            PMID: 27461716]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Subramanian,L., Benson,M.D. and Iniguez-Lluhi,J.A.
  TITLE     A synergy control motif within the attenuator domain of
            CCAAT/enhancer-binding protein alpha inhibits transcriptional
            synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3
  JOURNAL   J Biol Chem 278 (11), 9134-9141 (2003)
   PUBMED   12511558
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Sachdev,S., Bruhn,L., Sieber,H., Pichler,A., Melchior,F. and
            Grosschedl,R.
  TITLE     PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1
            activity by sequestration into nuclear bodies
  JOURNAL   Genes Dev 15 (23), 3088-3103 (2001)
   PUBMED   11731474
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   Nelson,V., Davis,G.E. and Maxwell,S.A.
  TITLE     A putative protein inhibitor of activated STAT (PIASy) interacts
            with p53 and inhibits p53-mediated transactivation but not
            apoptosis
  JOURNAL   Apoptosis 6 (3), 221-234 (2001)
   PUBMED   11388671
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Sturm,S., Koch,M. and White,F.A.
  TITLE     Genomic organization of the gene for mouse PIASgamma and analysis
            of its promoter
  JOURNAL   Gene 266 (1-2), 123-130 (2001)
   PUBMED   11290426
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Sturm,S., Koch,M. and White,F.A.
  TITLE     Cloning and analysis of a murine PIAS family member, PIASgamma, in
            developing skin and neurons
  JOURNAL   J Mol Neurosci 14 (1-2), 107-121 (2000)
   PUBMED   10854042
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC025159.1.
            
            On Oct 21, 2007 this sequence version replaced NM_021501.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025159.1, AF109174.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1676
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /note="protein inhibitor of activated STAT 4"
                     /db_xref="GeneID:59004"
                     /db_xref="MGI:MGI:2136940"
     exon            1..36
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1533
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /EC_number="2.3.2.27"
                     /note="protein inhibitor of activated STAT PIASy; protein
                     inhibitor of activated STAT protein 4; protein inhibitor
                     of activated STAT protein gamma; RING-type E3 ubiquitin
                     transferase PIAS4"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS4"
                     /protein_id="NP_067476.2"
                     /db_xref="CCDS:CCDS35992.1"
                     /db_xref="GeneID:59004"
                     /db_xref="MGI:MGI:2136940"
                     /translation="MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQ
                     LVQFDCSPELFKKIKELYETRYAKKSAEPGPQAPRPLDPLALHSMPRTPLSGPTVDYP
                     VLYGKYLNGLGRLPTKTLKPEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFA
                     LTPRQVEMIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPG
                     YYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSD
                     LLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAET
                     CAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSECEGADEIEFL
                     AEGSWRPIRAEKEPSCSPQGPILVLGTSDANGLAPASSTPGIGSGLSGPGSAGSGAGA
                     AGSLENGKTGADVVDLTLDSSSSSEDEDEDEDDDEDEDEGPRPKRRCPFQKGLVPAC"
     exon            37..442
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            443..527
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            528..569
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            570..660
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            661..789
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            790..895
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            896..969
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1130
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1261
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1673
                     /gene="Pias4"
                     /gene_synonym="Pias-gamma; Piasg; PIASY"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggccaaga tggcggcaga gctggtggag gccaaaaaca tggtgatgag cttccgagta
       61 tcagacctgc agatgctgct gggctttgta ggccggagca agagtgggct gaagcacgaa
      121 ctggtgacca gggccttgca gctggtgcag ttcgactgta gcccagagct tttcaagaag
      181 atcaaagagc tgtatgagac tcgctatgcc aagaagagtg cagagcccgg cccacaggca
      241 ccacggcccc tggatcccct ggcactacac tccatgccca ggactcccct gtcagggccc
      301 accgtggact accccgtgct gtacgggaag tacttgaatg gactggggcg cctgcccacc
      361 aagaccctta agccggaggt acgcctggtt aagctcccct tcttcaacat gctggacgaa
      421 ttgctgaagc ccactgaact ggtcccacag agtgcagaga agctgcaaga gagcccatgc
      481 atcttcgcgc taacacctcg gcaggtggag atgatccgca actccaggga gctgcagcct
      541 ggagtgaaag ctgtgcaggt ggtgctgagg atctgttact ctgataccag ctgtccgcag
      601 gaggaccaat acccacccaa catcgctgtg aaggtcaacc acagctactg ctcagtgccg
      661 ggctactatc cctccaacaa gcctggtgtg gaacctaaga ggccctgccg ccccatcaac
      721 cttacccacc tcatgtatct gtcctcggcc accaaccgca ttactgtcac ctggggcaac
      781 tatggcaaga gctactctgt ggctttgtac ctggtgcgac agctgacctc ctcagacctg
      841 ctacagaggt tgaagacgat tggggtgaag catcctgagc tgtgcaaggc tttggtcaag
      901 gagaagcttc gcctagaccc cgacagcgag atcgccacta ccggagtgcg agtgtccctc
      961 atctgcccac tggtgaagat gcgcctctcg gtgccctgcc gtgcagagac ctgcgcacac
     1021 ctgcagtgct ttgatgctgt gttctacctg caaatgaatg agaagaagcc cacctggatg
     1081 tgccctgtgt gtgacaagcc tgcagcctat gaccagctca tcatagatgg gctgctgtcg
     1141 aagatcctga gtgagtgtga gggcgcggat gagattgagt tcctggcgga aggctcatgg
     1201 cgtccaatcc gtgcagagaa ggagccaagc tgcagcccac agggccccat cctggtgcta
     1261 ggcacctcgg acgccaatgg gctcgcacca gcctccagca cccccggtat aggcagtggc
     1321 ctgagtggcc caggcagcgc cggcagcggt gcgggggcag caggcagcct ggagaatggc
     1381 aagacgggag ccgacgtggt ggacctcaca ctggacagct cgtcgtcctc ggaagatgaa
     1441 gatgaggacg aggacgacga tgaggacgag gacgagggcc cccggccgaa gcgccgctgc
     1501 ccgttccaga aaggcctggt gcccgcgtgc tgactccgct gcgggggcgc tggagggcgg
     1561 gagccgcacc cgtccatcat tccctcgccc acccctcccc ggctcccggc tcctgtacct
     1621 ctggactctc ctcttggggg gattaaaaaa agtaaaatga caaaaaaaaa aaaaaa
//
