LOCUS       NM_001165949            2938 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus protein inhibitor of activated STAT 3 (Pias3),
            transcript variant 3, mRNA.
ACCESSION   NM_001165949
VERSION     NM_001165949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2938)
  AUTHORS   Wang,B., Qian,W., Chen,K., Li,M. and Du,C.
  TITLE     Knocking Down PIAS3 Reduces H2O2-induced Oxidative Stress Injury in
            HT22 Cells
  JOURNAL   Cell Biochem Biophys 82 (2), 1381-1387 (2024)
   PUBMED   38733503
  REMARK    GeneRIF: Knocking Down PIAS3 Reduces H2O2-induced Oxidative Stress
            Injury in HT22 Cells.
REFERENCE   2  (bases 1 to 2938)
  AUTHORS   Fu,W., Liu,H., Wei,P., Xia,C., Yu,Q., Tian,K., Li,Y., Liu,E.,
            Xu,B., Miyata,M., Wang,R. and Zhao,S.
  TITLE     Genetic deficiency of protein inhibitor of activated STAT3
            suppresses experimental abdominal aortic aneurysms
  JOURNAL   Front Cardiovasc Med 10, 1092555 (2023)
   PUBMED   37008329
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2938)
  AUTHORS   Conz,A., Musi,C.A., Russo,L., Borsello,T. and Colnaghi,L.
  TITLE     Super-resolution study of PIAS SUMO E3-ligases in hippocampal and
            cortical neurons
  JOURNAL   Eur J Histochem 65 (s1), 3241 (2021)
   PUBMED   34459572
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2938)
  AUTHORS   Jiang,M., Zhang,W., Zhang,R., Liu,P., Ye,Y., Yu,W., Guo,X. and
            Yu,J.
  TITLE     Cancer exosome-derived miR-9 and miR-181a promote the development
            of early-stage MDSCs via interfering with SOCS3 and PIAS3
            respectively in breast cancer
  JOURNAL   Oncogene 39 (24), 4681-4694 (2020)
   PUBMED   32398867
  REMARK    GeneRIF: Cancer exosome-derived miR-9 and miR-181a promote the
            development of early-stage MDSCs via interfering with SOCS3 and
            PIAS3 respectively in breast cancer.
REFERENCE   5  (bases 1 to 2938)
  AUTHORS   Min,H.K., Choi,J., Lee,S.Y., Seo,H.B., Jung,K., Na,H.S., Ryu,J.G.,
            Kwok,S.K., Cho,M.L. and Park,S.H.
  TITLE     Protein inhibitor of activated STAT3 reduces peripheral arthritis
            and gut inflammation and regulates the Th17/Treg cell imbalance via
            STAT3 signaling in a mouse model of spondyloarthritis
  JOURNAL   J Transl Med 17 (1), 18 (2019)
   PUBMED   30630513
  REMARK    GeneRIF: PIAS3 could have therapeutic benefits in patients with
            Spondyloarthritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2938)
  AUTHORS   Zentner,M.D., Lin,H.H., Deng,H.T., Kim,K.J., Shih,H.M. and Ann,D.K.
  TITLE     Requirement for high mobility group protein HMGI-C interaction with
            STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial
            Na+ channel (alpha-ENaC) transcription by Ras activation in
            salivary epithelial cells
  JOURNAL   J Biol Chem 276 (32), 29805-29814 (2001)
   PUBMED   11390395
REFERENCE   7  (bases 1 to 2938)
  AUTHORS   Kotaja,N., Aittomaki,S., Silvennoinen,O., Palvimo,J.J. and
            Janne,O.A.
  TITLE     ARIP3 (androgen receptor-interacting protein 3) and other PIAS
            (protein inhibitor of activated STAT) proteins differ in their
            ability to modulate steroid receptor-dependent transcriptional
            activation
  JOURNAL   Mol Endocrinol 14 (12), 1986-2000 (2000)
   PUBMED   11117529
REFERENCE   8  (bases 1 to 2938)
  AUTHORS   Rodel,B., Tavassoli,K., Karsunky,H., Schmidt,T., Bachmann,M.,
            Schaper,F., Heinrich,P., Shuai,K., Elsasser,H.P. and Moroy,T.
  TITLE     The zinc finger protein Gfi-1 can enhance STAT3 signaling by
            interacting with the STAT3 inhibitor PIAS3
  JOURNAL   EMBO J 19 (21), 5845-5855 (2000)
   PUBMED   11060035
REFERENCE   9  (bases 1 to 2938)
  AUTHORS   Sturm,S., Koch,M. and White,F.A.
  TITLE     Cloning and analysis of a murine PIAS family member, PIASgamma, in
            developing skin and neurons
  JOURNAL   J Mol Neurosci 14 (1-2), 107-121 (2000)
   PUBMED   10854042
REFERENCE   10 (bases 1 to 2938)
  AUTHORS   Chung,C.D., Liao,J., Liu,B., Rao,X., Jay,P., Berta,P. and Shuai,K.
  TITLE     Specific inhibition of Stat3 signal transduction by PIAS3
  JOURNAL   Science 278 (5344), 1803-1805 (1997)
   PUBMED   9388184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY154092.1, BC051252.1, BE989927.1 and BB042656.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region, and uses an alternate translational start codon,
            compared to variant 1. The encoded isoform (3) has a distinct
            N-terminus and is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051252.1, SRR7345562.3943281.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BY154092.1         3-92
            91-2830             BC051252.1         1-2740
            2831-2934           BE989927.1         5-108               c
            2935-2938           BB042656.1         288-291
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.95 cM"
     gene            1..2938
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /note="protein inhibitor of activated STAT 3"
                     /db_xref="GeneID:229615"
                     /db_xref="MGI:MGI:1913126"
     exon            1..120
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1983
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /note="isoform 3 is encoded by transcript variant 3; E3
                     SUMO-protein ligase PIAS3; E3 SUMO-protein transferase
                     PIAS3; protein inhibitor of activated STAT protein 3"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS3 isoform 3"
                     /protein_id="NP_001159421.1"
                     /db_xref="CCDS:CCDS51007.1"
                     /db_xref="GeneID:229615"
                     /db_xref="MGI:MGI:1913126"
                     /translation="MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHL
                     LKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLT
                     PGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHF
                     TFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGK
                     LCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYL
                     VRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRL
                     TVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCS
                     DCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDL
                     TIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFL
                     SSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDTLGHFFQYRGTP
                     SHFLGPLAPTLGSSHRSSTPAPPPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDV
                     ISLD"
     exon            121..538
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            539..623
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            624..674
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            675..765
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            766..900
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1006
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1080
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1241
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1375
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1544
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1678
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1716
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..2938
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2811..2816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /note="hexamer: AATAAA"
     polyA_site      2830
                     /gene="Pias3"
                     /gene_synonym="Pias3l"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcggcc tttgcggccg gcgctggggc ggagagtttg cgccggtccc tgggcctgag
       61 ctccggctcg ggctggggcg cctgcgatgt ctcaagatgg cggagctggg cgagttaaag
      121 cacatggtga tgagtttccg agtgtctgag ctccaggtgc tcctcggctt cgctggcagg
      181 aacaagagtg ggcggaaaca cgagctgctg gccaaggccc tgcacctcct caagtctagc
      241 tgcgccccca gcgtccagat gaagatcaaa gaactttatc gcaggcgctt tccccggaag
      301 accctggggc cttctgatct ctccttgctt tctttgcccc ctggcacctc tcctgtaggc
      361 tcccccggcc cccttgctcc catccctccc acccttctga cccctggcac cttgctaggc
      421 cctaagcgtg aggtggacat gcatcctcct ctgccgcagc ctgtgcaccc cgatgtcacc
      481 atgaagccac tgcccttcta tgaagtctat ggggagctca tccgacccac cacccttgcg
      541 tccacctcca gccagaggtt cgaggaagcc cacttcacct tcgcgctcac tccccagcag
      601 ctgcagcaga ttctcacgtc cagggaggtt ctgccaggag ccaagtgtga ttacaccata
      661 caagtgcagc tcagattctg tctctgtgag accagctgcc ctcaggagga ctatttcccc
      721 cctaacctct ttgttaaggt taatgggaaa ctctgccccc tgccgggtta cctccctcca
      781 accaagaatg gagctgagcc caagaggccc agccgtccga tcaacatcac acccttggct
      841 cgactctcag ccactgtccc caacaccatc gtagttaatt ggtcatctga gtttggacgg
      901 aattactcct tgtccgtgta cctggtgagg caattgactg cagggaccct tctacaaaaa
      961 ctcagagcca aggggatccg gaatccagac cattcccggg cactgatcaa ggagaaactg
     1021 actgctgacc ccgacagtga agtggctact acaagtctcc gggtgtcact catgtgcccg
     1081 ctagggaaga tgcgcctgac tgtcccgtgt cgtgccctca cctgtgccca tctgcagagt
     1141 ttcgatgctg ccctttatct acagatgaat gagaagaagc cgacatggac gtgtcctgtg
     1201 tgtgacaaga aggctcccta tgagtcgctg attattgatg gtttattcat ggaaattctt
     1261 aattcctgtt cggattgtga tgagatccag ttcatggaag atggatcctg gtgtccgatg
     1321 aaacccaaga aggaggcatc agaggtttgc cccccgccag ggtatgggct ggatggtctc
     1381 cagtacagcg cagtccagga gggaattcag ccagagagta agaagagggt cgaagtcatt
     1441 gacttgacca tcgaaagctc atcagatgag gaggatttgc cccccaccaa gaagcactgc
     1501 cctgtcacct cagcggccat tccagccctt cctggaagca aaggagccct gacctctggt
     1561 caccagccat cctcggtgct gcggagccct gcaatgggca cactgggcag tgacttcctg
     1621 tctagtctcc cgctacatga gtacccacct gccttcccac tgggggctga catccaaggt
     1681 ttagatttat tttctttcct tcagactgag agtcagcact acggcccttc agttatcact
     1741 tcgctagatg aacaggacac ccttggccac ttcttccagt accggggaac cccttcccac
     1801 ttcctgggcc cactggcccc cacactgggg agctctcacc gcagctccac tccagcgccc
     1861 cctcctggtc gtgtcagcag cattgtggct cctgggagct ccttgaggga agggcatgga
     1921 ggacccctgc cttcaggtcc ctctttgact ggctgtcggt cagacgtcat ttccttggac
     1981 tgagcttttt ggattatgaa atcaatctcc attggcccca gcactgagca gatcacgttg
     2041 tgggttccga acccctggct gctctgatcc ctcaggggtc attggccaaa ggccaggcca
     2101 gagcttcatg gatacctgct tttggcctta tcgctgccta acaggccagt actcacaggg
     2161 ttaacattta acctttttat ggtggcacat tcctctgggt atggtaacct aggcagtggg
     2221 aggcagatgg gatagggact gagggatgag ggggtcctta gcctttacca gatcttcagc
     2281 ctcttgggga aaggcacttt cctgcctcct ctcccaagac tctccgttcc ctacccaaac
     2341 ccaaatatct ggtctttgac atccattccg ttctctttga ccatacagtc gggcgacagg
     2401 tcagagatgg acagagaact ctattttgga ttgcagattt cttttttgta cataaataag
     2461 aaaactccaa agcatccaaa gatgaaatcc cttgcctttc actccccagt gtgactcgag
     2521 gaggaaacaa ggccttagtt gtgattccca ggggctgggg agcaaggcgt ggcctgtctg
     2581 ctgcctgggt ctctatttat atatttaagt tcacaatgtt tttatgctaa acagccaagg
     2641 ggcgaagcgt ctagtggcct gtgttcaggc ctggattact cttgcacctt ttgtgggaca
     2701 tgggggctct gtgttctcct ccccaatact caggcccctt ccttcagggc caaggccctg
     2761 tgatgtgatt ttacttttat tcccaaagtt gtagcagagt tctcgcctac aataaaggtt
     2821 gtgaatgttc tgtgagcgtc atggagggga agggatgttg tacctcgctt tccagaccca
     2881 gggtttgtgg ggcagagggt ccatgttcca tcctttcact taaaaaaaaa aaaagaac
//
