LOCUS       NM_019663               3855 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus protein inhibitor of activated STAT 1 (Pias1), mRNA.
ACCESSION   NM_019663
VERSION     NM_019663.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3855)
  AUTHORS   Wang,L., Zeng,W., Wang,C., Lu,Y., Xiong,X., Chen,S., Huang,Q.,
            Yan,F. and Huang,Q.
  TITLE     SUMOylation and coupling of eNOS mediated by PIAS1 contribute to
            maintenance of vascular homeostasis
  JOURNAL   FASEB J 38 (1), e23362 (2024)
   PUBMED   38102979
  REMARK    GeneRIF: SUMOylation and coupling of eNOS mediated by PIAS1
            contribute to maintenance of vascular homeostasis.
REFERENCE   2  (bases 1 to 3855)
  AUTHORS   Wang,G., Zhao,Y., Zhou,Y., Jiang,L., Liang,L., Kong,F., Yan,Y.,
            Wang,X., Wang,Y., Wen,X., Zeng,X., Tian,G., Deng,G., Shi,J.,
            Liu,L., Chen,H. and Li,C.
  TITLE     PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral
            replication and virulence
  JOURNAL   PLoS Pathog 18 (4), e1010446 (2022)
   PUBMED   35377920
  REMARK    GeneRIF: PIAS1-mediated SUMOylation of influenza A virus PB2
            restricts viral replication and virulence.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3855)
  AUTHORS   Mei,L., Qv,M., Bao,H., He,Q., Xu,Y., Zhang,Q., Shi,W., Ren,Q.,
            Yan,Z., Xu,C., Tang,C., Hussain,M., Zeng,L.H. and Wu,X.
  TITLE     SUMOylation activates large tumour suppressor 1 to maintain the
            tissue homeostasis during Hippo signalling
  JOURNAL   Oncogene 40 (35), 5357-5366 (2021)
   PUBMED   34267330
REFERENCE   4  (bases 1 to 3855)
  AUTHORS   Conz,A., Musi,C.A., Russo,L., Borsello,T. and Colnaghi,L.
  TITLE     Super-resolution study of PIAS SUMO E3-ligases in hippocampal and
            cortical neurons
  JOURNAL   Eur J Histochem 65 (s1), 3241 (2021)
   PUBMED   34459572
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3855)
  AUTHORS   Robinson,N.J., Miyagi,M., Scarborough,J.A., Scott,J.G., Taylor,D.J.
            and Schiemann,W.P.
  TITLE     SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere
            maintenance through NF-kappaB and Notch signaling
  JOURNAL   Sci Signal 14 (689) (2021)
   PUBMED   34187905
  REMARK    GeneRIF: SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate
            telomere maintenance through NF-kappaB and Notch signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3855)
  AUTHORS   Tan,J.A., Hall,S.H., Hamil,K.G., Grossman,G., Petrusz,P. and
            French,F.S.
  TITLE     Protein inhibitors of activated STAT resemble scaffold attachment
            factors and function as interacting nuclear receptor coregulators
  JOURNAL   J Biol Chem 277 (19), 16993-17001 (2002)
   PUBMED   11877418
  REMARK    GeneRIF: Protein inhibitors of activated STAT resemble scaffold
            attachment factors and function as interacting nuclear receptor
            coregulators.
REFERENCE   7  (bases 1 to 3855)
  AUTHORS   Megidish,T., Xu,J.H. and Xu,C.W.
  TITLE     Activation of p53 by protein inhibitor of activated Stat1 (PIAS1)
  JOURNAL   J Biol Chem 277 (10), 8255-8259 (2002)
   PUBMED   11788578
  REMARK    GeneRIF: protein inhibitor of activated Stat1 (PIAS1) interacts
            with the tetramerization and C-terminal regulatory domains of p53
            in yeast two-hybrid analyses
REFERENCE   8  (bases 1 to 3855)
  AUTHORS   Kotaja,N., Aittomaki,S., Silvennoinen,O., Palvimo,J.J. and
            Janne,O.A.
  TITLE     ARIP3 (androgen receptor-interacting protein 3) and other PIAS
            (protein inhibitor of activated STAT) proteins differ in their
            ability to modulate steroid receptor-dependent transcriptional
            activation
  JOURNAL   Mol Endocrinol 14 (12), 1986-2000 (2000)
   PUBMED   11117529
REFERENCE   9  (bases 1 to 3855)
  AUTHORS   Sturm,S., Koch,M. and White,F.A.
  TITLE     Cloning and analysis of a murine PIAS family member, PIASgamma, in
            developing skin and neurons
  JOURNAL   J Mol Neurosci 14 (1-2), 107-121 (2000)
   PUBMED   10854042
REFERENCE   10 (bases 1 to 3855)
  AUTHORS   Liu,B., Liao,J., Rao,X., Kushner,S.A., Chung,C.D., Chang,D.D. and
            Shuai,K.
  TITLE     Inhibition of Stat1-mediated gene activation by PIAS1
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10626-10631 (1998)
   PUBMED   9724754
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK075708.1.
            
            On Apr 6, 2007 this sequence version replaced NM_019663.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075708.1, SRR1660815.178947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3855              AK075708.1         2-3856
FEATURES             Location/Qualifiers
     source          1..3855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.91 cM"
     gene            1..3855
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /note="protein inhibitor of activated STAT 1"
                     /db_xref="GeneID:56469"
                     /db_xref="MGI:MGI:1913125"
     exon            1..32
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1964
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /EC_number="2.3.2.27"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1;
                     DEAD/H box-binding protein 1; protein inhibitor of
                     activated STAT protein 1; RING-type E3 ubiquitin
                     transferase PIAS1"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS1"
                     /protein_id="NP_062637.2"
                     /db_xref="CCDS:CCDS40665.1"
                     /db_xref="GeneID:56469"
                     /db_xref="MGI:MGI:1913125"
                     /translation="MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHL
                     LKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPPTLSPSTIPQLTYDGH
                     PASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDN
                     SQRFRETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPN
                     LCVKVNTKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGR
                     TYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLL
                     CPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLF
                     MEILKYCTDCDEIQFKEDGSWAPMRSKKEVQEVTASYNGVDGCLSSTLEHQVASHNQS
                     SNKNKKVEVIDLTIDSSSDEEEEEPPAKRTCPSLSPTSPLSNKGILSLPHQASPVSRT
                     PSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAAA
                     AVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPATNGSSSGSNSSLVSSNSLRES
                     HGHGVASRSSADTASIFGIIPDIISLD"
     exon            33..477
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            478..562
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            563..610
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            611..701
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            702..836
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            837..942
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1016
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1177
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1308
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1489
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1632
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1670
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..3855
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3829..3834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
                     /note="hexamer: AATAAA"
     polyA_site      3854
                     /gene="Pias1"
                     /gene_synonym="2900068C24Rik; Ddxbp1; GBP"
ORIGIN      
        1 gacgcaagat ggcggacagt gcggaactaa agcaaatggt tatgagcctt agagtttctg
       61 aactccaagt actgttgggc tacgctggga ggaacaagca cggacgcaaa cacgaacttc
      121 ttacaaaagc cctgcatttg ttaaaggctg gctgtagtcc tgctgtacaa atgaaaatta
      181 aagaactcta caggaggcgg ttccctcaga aaattatgac gcctgcggac ttgtctatcc
      241 ccaacgtaca ttcaagtcct atgcctccga ctctttctcc atccaccatt ccacagctca
      301 cttatgatgg ccaccctgca tcatccccac tactccctgt ttctcttctg ggacccaaac
      361 atgaactgga actcccacat ctcacgtcag cgctgcaccc agtccacccg gacataaagc
      421 tgcagaagct accattctat gacctgttgg atgaactgat caagcccacc agtctagctt
      481 cagacaacag ccagcgcttt cgggaaacct gttttgcatt tgccttgaca ccacaacagg
      541 tgcagcagat cagcagctcc atggatattt ctgggaccaa atgtgacttc acagtgcagg
      601 tccaattaag gttttgttta tcagaaacca gttgtccaca agaagatcac ttcccaccca
      661 acctttgtgt aaaagtgaat acaaaacctt gcagccttcc aggttacctt ccacctacta
      721 aaaacggtgt ggaaccaaag cgacctagcc gaccaattaa tatcacctca cttgtccgat
      781 tgtccacgac agtaccaaat accattgttg tttcttggac tgcagaaatt ggaagaacct
      841 attccatggc agtatatctt gtaaaacagt tgtcctcaac agttcttctt cagaggttac
      901 gagcaaaggg aataaggaat ccggatcatt ctagagcttt aattaaagag aagttaactg
      961 cagatccaga tagtgagata gctactacca gcctacgggt ttcgctgctg tgtccacttg
     1021 ggaaaatgcg actgacaatc ccctgtcggg cacttacctg ctcccacctt cagtgttttg
     1081 atgcaactct ttacattcaa atgaatgaga aaaaaccaac atgggtttgt cctgtctgtg
     1141 ataagaaggc cccatatgaa caccttatta ttgacgggtt gtttatggaa attctaaagt
     1201 actgcacaga ctgtgacgag atacagttta aggaggatgg ctcgtgggct ccaatgaggt
     1261 caaagaagga ggttcaagaa gtcactgcct cctacaatgg agttgatggt tgcttgagct
     1321 ccacattgga gcatcaggta gcgtcccaca accagtcctc aaataaaaac aagaaagtcg
     1381 aggtcattga cctaaccatt gacagctcgt cagatgaaga ggaggaagaa ccccctgcca
     1441 agaggacctg tccttccctg tctcctacgt caccactaag taataaaggc attttaagtc
     1501 ttcctcatca agcctcgcct gtgtcccgca ccccaagcct tcctgctgta gatacaagct
     1561 acatcaacac ctccctcatc caggactaca ggcacccctt ccacatgacg cctatgcctt
     1621 atgacttaca aggattagat ttctttcctt tcttatcagg agacaatcag cattacaaca
     1681 cctccctgct agccgcagct gcagcggcgg tctcagatga ccaggacctc ctgcactcct
     1741 cccggttttt cccgtatacc tcctcgcaga tgtttctcga ccagctaagt gcaggaggga
     1801 gcacatctct gccagccacc aacggaagca gtagcggcag caacagcagc cttgtgtctt
     1861 ccaacagtct gagagagagc catggccatg gtgtggccag caggagcagc gcagacacag
     1921 cgtccatctt tggcatcata ccagacatta tctcattgga ctgacgctct caccctgctg
     1981 ctcccacccc atcccagatt aaatgacttg gcagaagaga actctatgct ctgttttacc
     2041 ttatcctgtt tagaaaagta tacaagcgtg gttttttttt tccttttttt tagggaaaaa
     2101 aaaattaaaa gaaatgtaca gagaacaaaa ctatattttc agttttactt ttgtatataa
     2161 atctaagact gcctgtctga taaaacactt gtttaaaaaa aaaaaaaaga aaaaagaaaa
     2221 agaaaaaaca agcacccaca aaccttcagt tcattttttc tggattctga agacttcacc
     2281 atttgtcctg tggtttgggt tttattttac ttcaatggca ttatctttct tgcaataacg
     2341 gaaacaattg catgtatgag gtttaaattg tgggctttgt tgtggggatg ggtttgggat
     2401 agctttgatt tccatttttt aaaagtgaca gacttggatt ctgtttgtgt gtgcgtagat
     2461 tttaccagcc ttaagttatg agcctcgtct atcttactgc ataccctttg ttttcaagac
     2521 agagcttgtg tgcgtgagtg cgtgcgcgcg tgcgcgcaag agcgcctgtg tacctgtatg
     2581 tgctgttctg tcgtcactcg cccctcctcc tcagtttgca tttggttatt atcactcttg
     2641 tgtgagcatc tttctcaact ctccctaggt gcatgttctc catcccagat cctctgtgat
     2701 ctgctgtcta ccctctacga gtgtgtttcc cagaagtgct ggagcaaacg ctgcttggat
     2761 gcgcagtctg tgggcaggcc ctcgaatgac aatacacttc tgttgattct aagtctgaat
     2821 tgccagtatt ctgtatgtaa tccaaggctg tgagcacttg cattttggca acagggtaac
     2881 aagttttcct tgaggatctt cataccaaaa tgggatgtga aagaaccccc gtagccccgt
     2941 ggggtgtgga gctggcagag gtcgttccgt tccaccgaaa gaaaagaagg aaggaaggaa
     3001 ggaaagaaag aatcggttat cctaaagtta acagtacagc acagcccaca tgtggatcca
     3061 taccaaatct atctgataaa tagttgaaac tcaaaaataa ccttagttat tttggttttc
     3121 tgtctccgag tatacttcct ttcttagccg tgttcttttt tccttcacct ttagtgaaag
     3181 catgacatag gaagcctttt tttttttaaa ttcaagaacc aattggtctc acctactctc
     3241 aatagcagaa tatgtaaata tattaaaatt tgtttcagga ggtgattaag ggtcaaagga
     3301 aggaaaaaat acttctcata cttgagagtc cgcagagaag aaagcatgct ctgacagtgg
     3361 gagatagatg gcaactgatg gaggatgcag gtgtaactgc agagagccag ggcacaccat
     3421 caccagctcc tgcactggct tttatgtccc accttcatgt tttcagagtt gtggaaggac
     3481 catctttgtg tgtggtaaac ttgttttcaa gccttgcatc cataacagaa ggaccggtag
     3541 gtattaatcc aggtagaagt catgatgact gtgtcttcag ttgtataata aaggaagtgg
     3601 ttcacatgac agcgtggcat ctaaaaataa tatctatttt atagtctctc tgctactaaa
     3661 atgtcgactt gaatttttga aaaaagttgg tgttgatatg tatatgtgtg tgtgtgtgta
     3721 tatatatatg tatttataaa caagtgcgtg tgagtaacat catcgtcttc ccctacgcat
     3781 gtgtgttcca cacagaaacg gctgtgttag agtcacaaaa caattcgcaa taaaacaaga
     3841 catttgttat cagtt
//
