LOCUS       NM_175696               2246 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus PILR alpha associated neural protein (Pianp),
            transcript variant 1, mRNA.
ACCESSION   NM_175696
VERSION     NM_175696.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2246)
  AUTHORS   Zietek,M.M., Jaszczyk,A., Stankiewicz,A.M. and Sampino,S.
  TITLE     Prenatal gene-environment interactions mediate the impact of
            advanced maternal age on mouse offspring behavior
  JOURNAL   Sci Rep 14 (1), 31733 (2024)
   PUBMED   39738558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2246)
  AUTHORS   Winkler,M., Biswas,S., Berger,S.M., Kuchler,M., Preisendorfer,L.,
            Choo,M., Fruh,S., Rem,P.D., Enkel,T., Arnold,B., Komljenovic,D.,
            Sticht,C., Goerdt,S., Bettler,B., von Bohlen Und Halbach,O.,
            Bartsch,D. and Geraud,C.
  TITLE     Pianp deficiency links GABAB receptor signaling and hippocampal and
            cerebellar neuronal cell composition to autism-like behavior
  JOURNAL   Mol Psychiatry 25 (11), 2979-2993 (2020)
   PUBMED   31511635
  REMARK    GeneRIF: Pianp deficiency links GABAB receptor signaling and
            hippocampal and cerebellar neuronal cell composition to autism-like
            behavior.
REFERENCE   3  (bases 1 to 2246)
  AUTHORS   Dinamarca,M.C., Raveh,A., Schneider,A., Fritzius,T., Fruh,S.,
            Rem,P.D., Stawarski,M., Lalanne,T., Turecek,R., Choo,M.,
            Besseyrias,V., Bildl,W., Bentrop,D., Staufenbiel,M., Gassmann,M.,
            Fakler,B., Schwenk,J. and Bettler,B.
  TITLE     Complex formation of APP with GABAB receptors links axonal
            trafficking to amyloidogenic processing
  JOURNAL   Nat Commun 10 (1), 1331 (2019)
   PUBMED   30902970
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2246)
  AUTHORS   Biswas,S., Adrian,M., Weber,J., Evdokimov,K., Winkler,M. and
            Geraud,C.
  TITLE     Posttranslational proteolytic processing of Leda-1/Pianp involves
            cleavage by MMPs, ADAM10/17 and gamma-secretase
  JOURNAL   Biochem Biophys Res Commun 477 (4), 661-666 (2016)
   PUBMED   27349870
  REMARK    GeneRIF: Thus, Leda-1/Pianp is constitutively processed by
            proprotein convertases, sheddases including MMPs and ADAM10/17 and
            intramembrane protease gamma-secretase.
REFERENCE   5  (bases 1 to 2246)
  AUTHORS   Biswas,S., Adrian,M., Evdokimov,K., Schledzewski,K., Weber,J.,
            Winkler,M., Goerdt,S. and Geraud,C.
  TITLE     Counter-regulation of the ligand-receptor pair Leda-1/Pianp and
            Pilralpha during the LPS-mediated immune response of murine
            macrophages
  JOURNAL   Biochem Biophys Res Commun 464 (4), 1078-1083 (2015)
   PUBMED   26188512
  REMARK    GeneRIF: demonstrate that counter-regulation of the ligand-receptor
            pair Leda-1/Pianp and Pilralpha is part of the complex innate
            immune response of macrophages and its genetically determined
            strain-specific modulation
REFERENCE   6  (bases 1 to 2246)
  AUTHORS   Evdokimov,K., Biswas,S., Adrian,M., Weber,J., Schledzewski,K.,
            Winkler,M., Goerdt,S. and Geraud,C.
  TITLE     Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein
            convertases precedes its plasma membrane localization
  JOURNAL   Biochem Biophys Res Commun 434 (1), 22-27 (2013)
   PUBMED   23558288
  REMARK    GeneRIF: Furin-like proprotein convertase-dependent processing
            precedes the plasma membrane localization of LEDA-1/PIANP that is
            required for functional receptor-ligand interactions in vitro and
            in vivo.
REFERENCE   7  (bases 1 to 2246)
  AUTHORS   Kogure,A., Shiratori,I., Wang,J., Lanier,L.L. and Arase,H.
  TITLE     PANP is a novel O-glycosylated PILRalpha ligand expressed in neural
            tissues
  JOURNAL   Biochem Biophys Res Commun 405 (3), 428-433 (2011)
   PUBMED   21241660
  REMARK    GeneRIF: These results suggest that PANP is involved in immune
            regulation as a ligand of the PILRalpha.
REFERENCE   8  (bases 1 to 2246)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082984.1, BB868634.1 and BC065170.1.
            
            On Mar 21, 2009 this sequence version replaced NM_175696.3.
            
            Transcript Variant: This variant (1) is the longest transcript.
            Variants 1-3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082984.1, SRR7652917.458026.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AK082984.1         3-61
            60-91               BB868634.1         88-119
            92-360              AK082984.1         94-362
            361-1526            BC065170.1         190-1355
            1527-1714           AK082984.1         1531-1718
            1715-2246           BC065170.1         1542-2073
FEATURES             Location/Qualifiers
     source          1..2246
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..2246
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /note="PILR alpha associated neural protein"
                     /db_xref="GeneID:319352"
                     /db_xref="MGI:MGI:2441908"
     exon            1..220
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /inference="alignment:Splign:2.1.0"
     exon            221..280
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /inference="alignment:Splign:2.1.0"
     exon            281..786
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /inference="alignment:Splign:2.1.0"
     exon            787..868
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1090
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..2224
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /note="hexamer: AATAAA"
     polyA_site      2224
                     /gene="Pianp"
                     /gene_synonym="C530028O21Rik; Panp"
                     /note="major polyA site"
ORIGIN      
        1 ccggccgagc ccagccgagc ccagccgaag cgagcgtctc ccgccgccgc cgccgccgcc
       61 gccgccccgc gccccgggcg cccgcccccc tccggctcca gctcctcgct gccagccaaa
      121 cctcccgacc atgcccggcg ccccacccgt ttctgcgacc ccccagcccc gcgtagctcc
      181 gagcgcctgc agtcgtcgcg ccgccacacc aggcatgcag taaaggccaa aaatctgggt
      241 cacagctgag gaagatctca gatccagagt gcagaatgtg gtctgctcaa ctgctgtccc
      301 aactcctccc tctctggcca ctgctgttgc tgtccgtatt accacctgct cagggctcct
      361 cccatcgatc cccaccagcc ccagcccgcc ccccctgcgt ccggggtggg ccctcagccc
      421 ctcgccatgt gtgtgtttgg gagcgggcgc ctccgccaag ccgatcccca cgggtcccaa
      481 gatcacgtcg gcaggttgtg ccaggcactg cccctcctgc taccccatca ggctttgaag
      541 aggggcctcc ctcatctcag tacccttggg ctatagtgtg gggtcccaca gtatctcggg
      601 aggatggagg ggaccccaac tcggtcaatc ctggatttct gcctctggac tatggttttg
      661 cagccccaca tgggctggct actccgcacc ctaactcaga ctccatgcgg gatgacggag
      721 acgggctcat ccttggggaa acacctgcta ccttgaggcc cttcctgttt ggagggcgtg
      781 gagaaggtgt ggaccctcag ctttatgtca cgatcaccat atccatcatc atcgttcttg
      841 tggctaccgg catcatcttc aagttctgct gggaccgtag ccagaagcgg cgcaggccct
      901 cagggcagca aggtgccctg aggcaggagg agagtcagca accactgaca gacctgtctc
      961 ctgctggagt cactgtgctg ggggcttttg gggactcgcc tacccccacc cctgaccatg
     1021 aggaaccccg agggggaccc cggcctggga tgccccagcc taagggggct ccagccttcc
     1081 agttgaaccg gattcccctg gtgaatctgt gatgcccccc catgttgggg tgctgccaag
     1141 caggaggcca agtggccagc atagccacca tccactgagg gtggggcaac cctggggaat
     1201 tggggccatg gtggggggct cctagctcct gtccttgcac acaacctggg acactcacta
     1261 atcccatggg caagcccaag cgtttgtcct ccagtgactg gggtctccca ttcccaccct
     1321 tgcacattca catgaaagcc ttgcacactc acccacaccc tcacaggcca tagcacagtc
     1381 acgctctcca cgctgctcct ctgccgtgtc cccattcacg tctgctcagc cggctcctag
     1441 ctctctccct cgtgttgcct atgtcctgcc ccctttacat tctctgtgcc catctcagac
     1501 tgggcacgag catttctggc tccaatatat ggcatagtgt gcccactctg cctcatcagc
     1561 acccactggt ctagcttctg tggcccttgc atgctgccct agaggtgggt gggaggtgag
     1621 ctaggggctc cttgtaccat ttgtcatggc cccattcaca tctgtgtctt tccattccat
     1681 tccaaggatg ctggtattac tgagggctcc cccacaggaa cgggggtagt gaggcccagt
     1741 tgttaaactc tgtcatcaga agtctgggtt tgggggagtc tcctgctgca ctacatgaga
     1801 agggactccc atgtcctccc ttccctccca agtcccttgt tttgtcggtc ctggctgtct
     1861 gtgtgtatgt gtctgtatgg aattcggagc cccctcaaca ggtcctccat ctcccaccct
     1921 cccctaaggc ctcccttaat gtacctaggc tgccaggaac tgaagccagc tggttcaagg
     1981 ccattgggag ctctgcctcc atatccaccc ttctctccct gagcccctca cgttccctcc
     2041 tcccctctcc cttttccgtt ttttcagatt cttccagttt ctcgctcacc tctccagctc
     2101 ccttctccct cttacctggc tcctatgctg tgatatatat ttttgtatta tctctttctt
     2161 cttgtggtga taatcttgtg ggatgtaagt ttcaaaattt tcaaataaag cctttgcaag
     2221 ataaaaaaaa aaaaaaaaaa aaaaaa
//
