LOCUS       NM_175356               3786 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus phosphatidylinositol 4-kinase beta (Pi4kb), transcript
            variant 2, mRNA.
ACCESSION   NM_175356
VERSION     NM_175356.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3786)
  AUTHORS   Zhao,H., Kong,F., Yu,W., Zhao,H., Zhang,J., Zhou,J. and Meng,X.
  TITLE     Locational and functional characterization of PI4KB in the mouse
            embryo
  JOURNAL   J Cell Physiol 239 (4), e31195 (2024)
   PUBMED   38230579
  REMARK    GeneRIF: Locational and functional characterization of PI4KB in the
            mouse embryo.
REFERENCE   2  (bases 1 to 3786)
  AUTHORS   Sang,Y., Niu,C., Xu,J., Zhu,T., You,S., Wang,J., Zhang,L., Du,X.
            and Zhang,H.
  TITLE     PI4KIIIbeta-Mediated Phosphoinositides Metabolism Regulates
            Function of the VTA Dopaminergic Neurons and Depression-Like
            Behavior
  JOURNAL   J Neurosci 44 (11), e0555232024 (2024)
   PUBMED   38267258
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3786)
  AUTHORS   Baba,T., Alvarez-Prats,A., Kim,Y.J., Abebe,D., Wilson,S.,
            Aldworth,Z., Stopfer,M.A., Heuser,J. and Balla,T.
  TITLE     Myelination of peripheral nerves is controlled by PI4KB through
            regulation of Schwann cell Golgi function
  JOURNAL   Proc Natl Acad Sci U S A 117 (45), 28102-28113 (2020)
   PUBMED   33106410
  REMARK    GeneRIF: Myelination of peripheral nerves is controlled by PI4KB
            through regulation of Schwann cell Golgi function.
REFERENCE   4  (bases 1 to 3786)
  AUTHORS   Chang,J., Lee,S. and Blackstone,C.
  TITLE     Spastic paraplegia proteins spastizin and spatacsin mediate
            autophagic lysosome reformation
  JOURNAL   J Clin Invest 124 (12), 5249-5262 (2014)
   PUBMED   25365221
REFERENCE   5  (bases 1 to 3786)
  AUTHORS   Dooley,R., Angibaud,E., Yusef,Y.R., Thomas,W. and Harvey,B.J.
  TITLE     Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via
            protein kinase D1-phosphatidylinositol 4-kinaseIIIbeta trans Golgi
            signalling in M1 cortical collecting duct cells
  JOURNAL   Mol Cell Endocrinol 372 (1-2), 86-95 (2013)
   PUBMED   23541637
  REMARK    GeneRIF: oijbih iuhg iugh uh jkgh uib
REFERENCE   6  (bases 1 to 3786)
  AUTHORS   Wuttke,A., Sagetorp,J. and Tengholm,A.
  TITLE     Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in
            secretagogue-stimulated beta-cells
  JOURNAL   J Cell Sci 123 (Pt 9), 1492-1502 (2010)
   PUBMED   20375060
REFERENCE   7  (bases 1 to 3786)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3786)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ443265.1, AK157918.1 and AC087062.25.
            
            On Jun 17, 2014 this sequence version replaced NM_175356.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079846.1, AK157918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               BQ443265.1         1-209
            210-3692            AK157918.1         2-3484
            3693-3786           AC087062.25        168269-168362
FEATURES             Location/Qualifiers
     source          1..3786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..3786
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /note="phosphatidylinositol 4-kinase beta"
                     /db_xref="GeneID:107650"
                     /db_xref="MGI:MGI:1334433"
     exon            1..355
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1292
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..2789
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /EC_number="2.7.1.67"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosphatidylinositol 4-kinase, catalytic, beta
                     polypeptide; ptdIns 4-kinase beta"
                     /codon_start=1
                     /product="phosphatidylinositol 4-kinase beta isoform 2"
                     /protein_id="NP_780565.2"
                     /db_xref="CCDS:CCDS17599.1"
                     /db_xref="GeneID:107650"
                     /db_xref="MGI:MGI:1334433"
                     /translation="MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVID
                     PEVAQKACQEVLEKVKLLHGGVAISSKGTPLELVNGDGVDNEIRCLDDPPAQIREEED
                     EMGAGVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYI
                     GNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGA
                     YSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSK
                     SDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKT
                     QRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECE
                     NFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIG
                     ELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKR
                     DPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQ
                     LQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHG
                     SYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSS
                     PRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQ
                     QGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTN
                     GIM"
     exon            1293..1520
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1748
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1858
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1963
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2087
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2353
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2486
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2607
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..3786
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3452..3457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /note="hexamer: AATAAA"
     polyA_site      3472
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /note="major polyA site"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /note="hexamer: AATAAA"
     polyA_site      3780
                     /gene="Pi4kb"
                     /gene_synonym="ESTM41; PI4K-beta; PI4Kbeta; Pik4cb"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcact cgactcagat tacgatggca tcagtagtgt cctgacaccg ggaagcagga
       61 aagcaatctc ccggaagaaa ggctcgggcc caggggactc ttacatcgga acccgccaag
      121 gaattgttat tttgtgtcct gctagtgggg tccggtccaa cttgaagttg cgtgaaggcc
      181 ccttcaggcg gcgccgcggg cagccccgca gccggggcct ggagcagccg ccgcggccgc
      241 tgtcagggaa gcgcaggcgg ccaatggaac ccgggagcgg ccgctgctgc tgaggcggcg
      301 gtgtcggcag tccgaccccg accgcctgca ccccctccgc gagggttccc cggagcttgg
      361 aagctcgaag tctggctgta gccatgggag acatggtagt ggagcctgcc accctgaagc
      421 caacttctga gcctactcct agcccatcag ggaataatgg gggctcccta ctaagcgtca
      481 tcacggaggg ggtcggggaa ctgtcagtga ttgaccctga ggtggcccag aaggcctgcc
      541 aggaggtact ggagaaagtc aagcttttgc atggaggtgt agccatctct agcaaaggca
      601 ccccgctgga gttggttaat ggggatggtg tggacaatga aatccgttgc ctagatgatc
      661 cacctgccca gatcagggag gaagaagatg agatgggggc tggtgtggcc tctggcacag
      721 ccaaaggagc aagacgacga cgacagaaca actcagccaa acagtcttgg ctcctgaggc
      781 tgtttgagtc aaaactattt gacatctcta tggctatttc atacttgtat aactccaagg
      841 agcctggagt gcaagcctac attggcaacc ggctcttcta ctttcgcaat gaggatgtgg
      901 acttctattt gccccagttg cttaacatgt atatccacat ggatgaggat gtgggcgatg
      961 ccattaagcc ctacatagtc caccgctgtc gccagagcat caacttttcc ctccagtgtg
     1021 ccctgttgct tggggcctac tcttcagaca tgcacatttc cactcagcga cactcgcgag
     1081 ggaccaagtt acggaagcta atcctctcag atgagctgaa gccagctcac cgaaagaggg
     1141 agctgccgac attaagccca gcccctgaca cagggctgtc tccctctaaa aggactcacc
     1201 agcgttctaa gtcagatgct acggccagca taagtctcag cagcaacctg aaacgaacag
     1261 ccagcaaccc taaagtggag aatgaggatg agcctgtccg gctggcccct gagcgagaat
     1321 tcatcaagtc tttgatggca atcggcaaac ggctggccac gctccccact aaagagcaaa
     1381 aaacacaaag gctgatctca gagctttccc tgctcaacca taagctccct gcccgagtct
     1441 ggctgcccac ggctggcttt gaccaccacg tggtccgtgt gccccacaca caagctgttg
     1501 ttctcaattc caaggataag gctccctacc tgatctacgt ggaagttctc gaatgtgaaa
     1561 actttgacac aactagtgtt cctgcccgga ttcctgaaaa ccgaattcgg agtacacggt
     1621 ctgtagagaa cctgcctgaa tgtggtatca ctcatgagca gcgagctggc agcttcagca
     1681 ctgtgcccaa ttatgacaat gatgatgaag cctggtcagt ggatgatata ggcgagctgc
     1741 aagtggagct ccctgaagtg cacaccaaca gctgtgacaa catctcccag ttctcggtgg
     1801 acagcatcac cagccaggag agcaaggagc ctgtgttcat tgcagcaggg gacatccgac
     1861 ggcgcctttc agaacagctg gctcatactc ctacagcctt caaacgagac cctgaagacc
     1921 cttctgcagt tgccctcaaa gagccctggc aggagaaagt gcggaggatc agagaaggtt
     1981 ccccgtatgg ccatcttccc aattggcgac tcctttcagt cattgtcaag tgtggagatg
     2041 accttcgcca ggagctgctg gctttccagg tgttgaaaca actgcagtcc atttgggaac
     2101 aggagcgagt gcctctttgg atcaagccat ataagattct tgtgatttca gctgacagtg
     2161 gcatgattga accagtagtc aacgctgtgt ccatccacca ggtgaagaaa cagtcacagc
     2221 tctccttgct cgattacttc ctacaggaac atggcagtta taccactgag gcattcctca
     2281 gtgcccagcg caattttgtg caaagctgtg ctggctactg cttggtctgc tacctattgc
     2341 aagtcaagga caggcacaac gggaacatcc ttctggacgc agaaggtcac atcatccaca
     2401 tcgactttgg cttcatcctt tccagctcac cccgaaacct gggcttcgag acatcagcct
     2461 ttaagctgac cacagaattt gtggatgtaa tgggtggcct gaacggtgat atgttcaact
     2521 actacaagat gctcatgctg caagggctga ttgctgctcg gaagcacatg gacaaggtgg
     2581 tacagattgt ggagatcatg cagcaaggtt ctcagcttcc ttgcttccat ggctccagca
     2641 ccattcgcaa cctcaaagag aggttccaca tgagcatgac tgaggagcag ctgcagctgc
     2701 tggtggagca gatggtggac ggcagcatga ggtccatcac caccaaactc tacgatggct
     2761 tccagtacct caccaatggc atcatgtgac accattttca ggcctagaag tggtgggact
     2821 gaaggcatcc tccttagaag gacccttgcc taagaaaacc caaatcacaa aaccccacct
     2881 acctaaccac ctacccaagg gaaatggaag gcaagaaata caaaggatca tgtggtaacc
     2941 atgagagctt gccagagggt aggagagcca accttggggt ccagacttgc tggggcttcc
     3001 ccacctcttg ctgtgtcagt attaccacct gacagatccc aggactcact gccctccaga
     3061 gaacagaggt gatgaacatg aggaggactg gagtcttctt cccctcaggg gtctcagagg
     3121 ttttctacaa accatctttt attttccctg ggtcccagta aactgggagg agtaggttct
     3181 tggtacttag gacttaatcc tatgtttggc catgctgctg cctaactcag tcccctcctg
     3241 ggggctgacc cctggcccac attcccgaca agtgggtcct gcacttgctg aggtccccat
     3301 catgggggta aggaagggag aactgacaaa accctctgat gtattgaggg tactggctta
     3361 gccatgggga aatttcttac cctgatcctt tcctcacatc cagggaaaca gctttttttt
     3421 tttttttttt ttttttttaa tttttgtttg aaataaaatc cttagttagc catctgtctt
     3481 gttgcttctg ggggaggagt gcttggaaag ggttaagtcc agcatacaaa aggcaccaaa
     3541 cacacaagat gaaggaagat tgctttttcc atctgtcttc gtcaatactg cctcttccct
     3601 gagaagggct tccccagttc tgactcgccc ctccctatga gtacacatta tccaactcac
     3661 ataaaaagaa aagcctgaat ggggattaaa ccacaagcag ttttaatggt ctggttttct
     3721 ccctcctgtt tctcccactg ttagtattac tactactaca agaataaagg attcctgaga
     3781 gcctgt
//
