LOCUS       NM_053191               6929 bp    mRNA    linear   ROD 01-JAN-2023
DEFINITION  Mus musculus peptidase inhibitor 15 (Pi15), mRNA.
ACCESSION   NM_053191 XM_988869
VERSION     NM_053191.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6929)
  AUTHORS   Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers
            C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S,
            Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K and Betsholtz
            C.
  TITLE     Large-scale identification of genes implicated in kidney glomerulus
            development and function
  JOURNAL   EMBO J 25 (5), 1160-1174 (2006)
   PUBMED   16498405
REFERENCE   2  (bases 1 to 6929)
  AUTHORS   Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J,
            Ohara O and Seino S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   3  (bases 1 to 6929)
  AUTHORS   Smith DM, Collins-Racie LA, Marigo VA, Roberts DJ, Davis NM,
            Hartmann C, Schweitzer R, LaVallie ER, Gamer L, McCoy J and Tabin
            CJ.
  TITLE     Cloning and expression of a novel cysteine-rich secreted protein
            family member expressed in thyroid and pancreatic mesoderm within
            the chicken embryo
  JOURNAL   Mech Dev 102 (1-2), 223-226 (2001)
   PUBMED   11287197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104917.9.
            
            [WARNING] On Jul 25, 2023 this sequence was replaced by
            NM_053191.4.
            
            On Apr 22, 2022 this sequence version replaced NM_053191.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040961.1, AK030960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC104917.9         141431-141572       c
            143-450             AC104917.9         140589-140896       c
            451-569             AC104917.9         123572-123690       c
            570-702             AC104917.9         121940-122072       c
            703-818             AC104917.9         121711-121826       c
            819-6929            AC104917.9         112528-118638       c
FEATURES             Location/Qualifiers
     source          1..6929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..6929
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /note="peptidase inhibitor 15"
                     /db_xref="GeneID:94227"
                     /db_xref="MGI:MGI:1934659"
     exon            1..142
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /inference="alignment:Splign:2.1.0"
     exon            143..450
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..954
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /note="protease inhibitor 15; cysteine-rich secreted
                     protein"
                     /codon_start=1
                     /product="peptidase inhibitor 15 precursor"
                     /protein_id="NP_444421.2"
                     /db_xref="CCDS:CCDS48225.1"
                     /db_xref="GeneID:94227"
                     /db_xref="MGI:MGI:1934659"
                     /translation="MQSWRTSPSLKMIMNSAVSLVILLSLLCEAHTVVLLNPTDSSLP
                     ANNFTDTEAALSTPLESADIPKARRKRYISQNDMIAILDYHNQVRGKVFPPAANMEYM
                     VWDENLAKSAEAWAATCIWDHGPSYLLRFLGQNLSVRTGRYRSILQLVKPWYDEVKDY
                     AFPYPQDCNPRCPMRCFGPMCTHYTQMVWATSNRIGCAIHTCQNMNVWGSVWRRAVYL
                     VCNYAPKGNWIGEAPYKVGVPCSSCPPSYGGACTDNLCFPGVTTNYLYWFK"
     exon            451..569
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /inference="alignment:Splign:2.1.0"
     exon            570..702
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /inference="alignment:Splign:2.1.0"
     exon            703..818
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /inference="alignment:Splign:2.1.0"
     exon            819..6929
                     /gene="Pi15"
                     /gene_synonym="P24TI; P25TI; PI-15; SugarCrisp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagcattc aaatcttgca gactcttgca ctctgagagc ttgtaataag acatactcct
       61 cttacaagag ttgatgctac aacataacaa agaaacttac gttgttggag gagcagtgta
      121 ttcattttgg cattgtgcag agcaatgcaa agctggagga cttctccatc cctgaaaatg
      181 ataatgaact ctgcagtcag ccttgtgatt cttttgtccc ttctctgtga agcacatact
      241 gtcgttttac taaatcccac tgactcatct ctgccagcca ataacttcac tgatactgaa
      301 gccgccctca gcacaccact agagtctgcg gatatcccca aagccaggcg gaagcgttac
      361 atttctcaga atgacatgat cgccattctc gattatcata atcaagtccg gggcaaagtg
      421 ttcccaccag cagcaaacat ggaatatatg gtctgggatg aaaatcttgc aaaatcggct
      481 gaggcatggg cagcaacttg catttgggac catggacctt cttatttgct gagatttttg
      541 ggtcagaatt tgtctgtacg aactggaaga tatcgctcta tcctccagtt ggtcaagcca
      601 tggtatgatg aagtcaaaga ttatgccttt ccttaccctc aggactgcaa ccctcggtgt
      661 cccatgcgat gctttgggcc catgtgcact cattatacac agatggtttg ggccacttct
      721 aatcgaatag gatgtgcaat tcacacttgc caaaacatga acgtctgggg atctgtgtgg
      781 cgaagagcag tgtacttggt gtgcaactat gctccaaagg gtaactggat aggagaagca
      841 ccatacaaag ttggagtgcc atgttcatcg tgtcctccaa gttatggtgg agcctgtact
      901 gacaatctgt gctttccagg ggtaaccaca aactacctgt actggtttaa ataagctttt
      961 tcctttcaag gggatacaat ggtttctgga ctaataagca tatatatata tatatatata
     1021 tatatatata tatattgtga agtttgaaca tcttatattt actttattgt aatcctgttt
     1081 tcattttaat tgccaattta ctagtgttta tctagagtgt taagtcttag atacaaacaa
     1141 aacatcattt tctacttttg aacttaagtt taaattactg tatttgtagc atacacatat
     1201 gtagctatgt acccacagtt gttgcatcca attctaagac ctgcaattca gagaaattat
     1261 gttattatga ccctaaagag tgggatgtat gttcaagcta taatatatgt gtactcctat
     1321 gtatacatat ataaagatat gctcacatat atgatgtgtg atatgacaca taggtaataa
     1381 tatgatgtgg tcgttaacag gggaaaatta aaaatatact tgaggtcatg agacattttc
     1441 aggacaactt ctataattcc catgaatgta taatttgcaa ctcagtgata tttggaaata
     1501 acttaattaa gcaattgttg aattcattct ggagatactt tatttgggtc tacaaagtga
     1561 atgttcaatt tatgtaagtt tccataacac accttttgct tggtttcatt ttggttttga
     1621 attagtaagc atgtttagtg tttactgtga ctaatttact ttgctggtta tggtctgata
     1681 attacattta attcttgcct ttgagaagct atcagatgtc cctaaaataa taattttgct
     1741 ataaaattat ttttattaga tattttcttt ttttcacatt tcaaatgtta tccccttttc
     1801 ttgtttgccc ccctgaaaac cccgtataac atcttccctc cccctgctca ctaacctacc
     1861 cactcccagt tccctgttct ggcattcccc tacactgggg cattgagcct tcacaggatc
     1921 aagggcctct cctcccattg atatctgaca aggccatcct ctgctacata tgcagctgga
     1981 gccatgggtc cctccatgtg tactctttgg ttggtgattt agtccctgtg atctctggaa
     2041 gtattagttg gttcatattg ttgttcctcc tatgaggctg aaaacccctc agctcctggg
     2101 tcctttctct agctcctcca ttggggaccc tgtgctcagt ccaatggttg gttgagagca
     2161 tccacctctc tatttgtcag acactggcag agcctctcag gaaatagcta tatcaggctt
     2221 ctgtcagcaa gcacttgttg gcattcacaa tagtatctgg gtttggtaac tgtatatggg
     2281 atgaataccc aagtggggaa gtctctgagt ggccgtttct tcagtctctg ctccaaactt
     2341 tgtccttcca taggtatttt gtttcccctt ataagaagga ccaaagtatg cacactttgg
     2401 tctcccttct tcttgagctt catgtgttct gtgaattgta tcttgggtat actgagcttc
     2461 tgggctaata tccacttatc agtgagtgca taccatgtgt gttcttttgt gagtgggttg
     2521 taaaattatt tttagcaaat cattttttat gtgttttgag ggaacacaca tagtaaccac
     2581 atacagatag gataattggt aaactctact gtctcacatt aaagtgcctg tttcccaaga
     2641 gactccagct tcaatataca aatgagagat gtaaggtgtc ttaattatat ttttgtgaag
     2701 tgatatcatg accaatgttg ctttaaaaaa aaaacactta aaattggaga cttccctaca
     2761 ctttcagaag gctagtccat gatcatcatg gtggagagtt ggagctgttc aggcaggaag
     2821 caaggcactg gagccatagt tgagagctta tttacaggca ggaggcagag tgagtgagac
     2881 tgggcttgtc cttggctttt aaaacattta aatcaaccat ttggaaatat atgtcttaat
     2941 ttaaaaaaaa atttttaaga gaggacaata taacacctgg gtcaagacac aaaacaaatt
     3001 atatttaaaa tacgtgtgca tatgtgagtg cattcatgtg tgagcataag catagactta
     3061 gaaagtaagt aagcctggtc ctttcagagg gcaaacagga gaagaaagct acatatttaa
     3121 actccataca cagctgcagt tccttaggtg gatacattga aggatgacag ttaatttcgt
     3181 tcaattcaat aggagatata tccacaatct ggatactggg ccttcttaaa gacaaacaaa
     3241 tggtctaaaa acttttaaac actgaatatt gggactaaat gttttgttaa taagcgaccc
     3301 tgcctttgtg gaaacatata tggaccttat ttaaataagt atttaagtat tttagaaata
     3361 caatagagaa aagaaatatt acataattta gagttgatct aatttccttt tccttctttt
     3421 atttcctttg agacagtctc acataatcca ggttaaccct aaattcactg tatagtcaag
     3481 gataacctga ttcctgattc tcttgcctct aactcttaaa tgctggcttt atagatttgt
     3541 accacgtagc taaaggtagg aattttgttt tgatgacatc tgcttgactt acttaagaat
     3601 ttttttcctt aaggttactg aagtagagcc atataaacag tagtttacaa tcctcatttc
     3661 caggttactt tccagtttat atgtgtagga aggtttctca gttcaaagaa ataataatgg
     3721 tatttattat gtaggtccca gacttgccca gaaaagtcaa tctaccatat tatcagaaat
     3781 ttatgaatat taaaacaatc actcatagag cttcttcttg gcatggactc ttgtaattaa
     3841 ttgcatatat tacagcatgt tacctactgg atgtactata ataaatgttt aattcagtag
     3901 atttttcaga attagtttaa aagtctaaaa ttgtaaaagc taaagtgagc ttgccttttc
     3961 aaaacgttta aagactaaaa attctctaaa acataaaagt ttgaatataa caaatgtcca
     4021 aaaaacgtca tgcatggcat ggtactgaac ttggggtctt caagcatgca aaacaactct
     4081 ttcaaaacta cagctagaac cagtagctta tttataactt tacaagtaag ccaaaaccac
     4141 aacggatata tttgttattc tgtctgtact ttttaacatt ggtatgtaaa atgccatgtg
     4201 aaatattctc tttcctgggc cattgcaaat gatactttgc ttgtatcaat atagtgtctt
     4261 acatttgcat gggggtgcta ggtttttgga tttgcactgt aattctcaga gatggaacag
     4321 gcctggctat aaactgtgtc acacaggcaa ctttaagtca tcagcattaa agatattatt
     4381 ttgaaaggtt tcatcaaaaa tatgactaac agtattgatt tctcccaata atatttattt
     4441 aggggaaaag taacatgttg ctacaatatc attttttaac cttcacataa gggaaaaaat
     4501 aaatatgaaa ttgctgcact acttactaga aatgtgtgta aactgtgcag gtgtggtctt
     4561 agcattcttg taatgacaga caagcttgat ttaataacac agaagccaag atgattagca
     4621 ctattatttt tgcttttaac ccatcaaagc ttctctagaa cttttatcta gctctgctgt
     4681 tatctgcact tgagatgttc atgaaaattt tatttctaat ttttatacag tcttgataca
     4741 gtatactctg aatattttaa tcaaaaataa tatatttctc atatttttga attaaacaaa
     4801 cccataaagt ttacactatg aatccagtgc atatttatac tactttaagt atttcactta
     4861 aaggttcact ccttgcttgg taaataatgc aaaaataaat ggatgagatg aaagttttcc
     4921 taaaggaagg cagtactaaa accagtacta tttttcccct tggtatttag atttcacaat
     4981 atcatgcatg gaatgtgaat cttatagata gaaagattta cctactcaag tatttagggg
     5041 ataaaattat atttctagta gtagttaata ttgttttttt ttttttttac aggggttttg
     5101 tatttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgaaga tattcaaacc
     5161 tatggcaagg ccttttaaaa gttgtggcat ggctcaactt ggaattgtaa aatgctgatt
     5221 aaaatagaaa gttaaacaag tcaatggtta gtggtgctga aaaaaataca attaccatat
     5281 tgttacaatt tttgaggttt ttttgaaact acagttgtta ctattagata tgaatgagca
     5341 atagttgcct attctgctgc taaatatatg gtgctaaatg aattgttagt gtcaacagtt
     5401 ttaaaatcac ttccttttaa aatctattct tgattcagaa gtaatagcaa aactttctaa
     5461 tctttaccaa tatatgacag ttgaatctgc tttctcttta tttaacaata caatatcatt
     5521 acatgtaaat atatttcttt agaagtgacc attcttcaag tggatattgg tttttctttg
     5581 tgtgtgtgtg tttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     5641 tgtgtgagag agagagagag agagagagag agagatgtat ggcctgaaag gtaaaattac
     5701 ccgtgttaac catgctgcag gccgtggcgc cctctggtgt ttcaaaagac aaatttgtat
     5761 atttgataaa agctatttgt gcttagtgaa aatttgtttt gcactgtccc agaatttttc
     5821 accctggatc tcccaggatt aaaaccacaa gacaagcttg agtctattga catgccttct
     5881 taagagtaaa gaacccagac agtacttcat tcactttaaa aaaaaaaatg taatgtccac
     5941 tctaaggtac ttagtttcag ttttattgta ttttatttta ttggaaatga tttatcattg
     6001 catctcattt ttaagagttg ttgttttact tagctcagga catatcgtaa taggagacca
     6061 tataaaatag taactagtta catataccac ggagccatct atgctgattg catatctatc
     6121 atttgtgtgt tatgcttcat actacagaag taacactaac ttgctattat tccaataaca
     6181 gtttaactta tgacactcat gtgatgatag atttcataaa ctgtcttaaa gcatcagata
     6241 acctcaggtt attttcaaac ttgtttaaga atgggaagct cttctaggat ctaaaccaca
     6301 cacaaagctt caaaatatgg acctattctt ttcaaaccta gtgcccggaa actttattct
     6361 ttgggctgta gaatttcatt acactaaacg acattctgct aagttagtta attacccgga
     6421 tttttcctga aacaatcagt tacagaaaga acaaaatttg aaagcctaaa gtatttctgg
     6481 agttctttta cataactact ttcactctga ctgtgctggc aatctactag ttttgaaggg
     6541 aatcaaacac tgggctcatt ttgtccctgg ctgcttatta cagcatttgt gttttttttt
     6601 tttaatttta cttttaagct ggataatgaa ttaagtatgg tgcatatatg aagagtatgc
     6661 tttttaaaaa tatgttcatc tttcaagtat ttatatagtc ctaaaattga atgtatcact
     6721 tcagaaattg taagcataaa tatgacggct ggctgcaatt cattctgtag agttgcattg
     6781 gtgaacaggt gctcctttat gtagtgatac agtgttatga atgtatggat ttttaacctc
     6841 tgtacttgca gaccatagca aatgtagctt ttaaacctga ctgtgttatt tttccttcaa
     6901 taaaatatta ttcattattt tgattttga
//
