LOCUS       NM_028398               1867 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus 5-phosphohydroxy-L-lysine phospholyase (Phykpl),
            transcript variant 2, mRNA.
ACCESSION   NM_028398
VERSION     NM_028398.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Delprato,A., Bonheur,B., Algeo,M.P., Rosay,P., Lu,L., Williams,R.W.
            and Crusio,W.E.
  TITLE     Systems genetic analysis of hippocampal neuroanatomy and spatial
            learning in mice
  JOURNAL   Genes Brain Behav 14 (8), 591-606 (2015)
   PUBMED   26449520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662843.11 and AL645602.14.
            
            On May 22, 2020 this sequence version replaced NM_028398.2.
            
            Summary: This gene overlaps in a tail-to-tail orientation the gene
            encoding heterogeneous nuclear ribonucleoprotein A/B. The terminal
            exon of this gene is interspersed with exons of heterogeneous
            nuclear ribonucleoprotein A/B. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133235.1, AK013489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AL662843.11        142893-142991
            100-218             AL662843.11        143626-143744
            219-378             AL662843.11        144673-144832
            379-453             AL662843.11        149511-149585
            454-541             AL662843.11        150118-150205
            542-658             AL662843.11        150281-150397
            659-741             AL662843.11        151716-151798
            742-967             AL662843.11        152028-152253
            968-1122            AL645602.14        2471-2625
            1123-1212           AL645602.14        2846-2935
            1213-1343           AL645602.14        3661-3791
            1344-1397           AL645602.14        4764-4817
            1398-1867           AL645602.14        6990-7459
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.08 cM"
     gene            1..1867
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /note="5-phosphohydroxy-L-lysine phospholyase"
                     /db_xref="GeneID:72947"
                     /db_xref="MGI:MGI:1920197"
     exon            1..99
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1444
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /EC_number="4.2.3.134"
                     /note="isoform 2 is encoded by transcript variant 2;
                     alanine--glyoxylate aminotransferase 2-like 2;
                     5-phosphohydroxy-L-lysine phospho-lyase"
                     /codon_start=1
                     /product="5-phosphohydroxy-L-lysine phospho-lyase isoform
                     2"
                     /protein_id="NP_082674.1"
                     /db_xref="CCDS:CCDS24653.1"
                     /db_xref="GeneID:72947"
                     /db_xref="MGI:MGI:1920197"
                     /translation="MAADTRAKAVTLDLRRRLLSSSCRLFFPEDPVKIIRGQGQYLYD
                     EQGREYLDCINNVAHVGHCHPTVVQAAHEQNLVLNTNSRYLHDNIVDYAQRLSETLPE
                     QLSVFYFLNSGSEANDLALRLARQYTGHQDVVVLDHAYHGHLSSLIDISPYKFRNLGG
                     QKEWVHVAPLPDTYRGPYREDHPNPAEAYANEVKHVISSAQQKGRKIAAFFAESLPSV
                     SGQIIPPAGYFSQVAEHIHRAGGLFVADEIQVGFGRIGKHFWAFQLEGEDFVPDIVTM
                     GKSIGNGHPVACMATTQAVSRAFEATGVEYFNTFGGNPVSCAVGLAVLDVLKTEQLQA
                     HATNVGSFLLEHLTQQKAKHPIIGDVRGTGLFIGVDLIKDETLRTPATEEAEYLVSRL
                     KENYILLSIDGPGKNILKFKPPMCFNVDNAQHVVAKLDDILTDMEEKVRSCETLRIKH
                     PPEDTHPTQILLTRQQD"
     exon            100..218
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..378
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..453
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..541
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..658
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..741
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..967
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1122
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1212
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1343
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1397
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1867
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1838..1843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /note="hexamer: ATTAAA"
     polyA_site      1867
                     /gene="Phykpl"
                     /gene_synonym="2900006B13Rik; Agxt2l2"
                     /note="major polyA site"
ORIGIN      
        1 aagcgcgcag catctgggta ctggctgacc gctcggcgcc atggccgcgg acacgcgcgc
       61 caaggccgtc actctggacc tgagacgtcg gctgctcagc tcttcctgca gactcttttt
      121 tcctgaggat cctgttaaga ttatccgagg ccaagggcag tacctgtacg atgagcaagg
      181 gcgagagtac ctggactgta tcaacaacgt ggctcatgtt gggcactgcc accctaccgt
      241 ggtccaagcc gcacatgaac agaacctagt gctcaacacc aacagccgct acctgcatga
      301 caacatcgtg gactatgccc agaggctgtc ggagaccctg ccggagcagc tctctgtgtt
      361 ttacttcttg aattctgggt cagaagccaa cgacctggcc ttgagactag ctcgacagta
      421 cacgggacac caggatgtgg tggtattaga ccatgcttat catggtcacc tgagctccct
      481 gatcgacatc agtccctaca agttccggaa tctgggtggc cagaaggaat gggtccatgt
      541 ggctcctctc ccagacacct accggggccc ttacagggag gaccacccca acccagcaga
      601 ggcctatgcc aacgaggtga agcacgtcat cagcagtgca cagcagaagg gcaggaagat
      661 cgcagccttc ttcgctgagt ctctgcccag tgtgagtgga cagatcattc ctcctgctgg
      721 ctacttctcc caggtggctg agcacatcca cagagccgga gggctctttg tggcagatga
      781 gatccaggtt ggttttggcc gcataggcaa gcacttttgg gccttccagc tggagggaga
      841 agactttgtt cccgacattg tcaccatggg caagtccatc ggcaatggtc accctgttgc
      901 ctgcatggcc actacccaag ctgtgtcaag ggcatttgaa gctaccggtg tagaatactt
      961 caacacgttt ggtggcaacc ccgtatcctg tgctgtgggg ctagcagtcc tagatgtctt
     1021 gaaaacagaa cagctccagg ctcacgccac taatgtgggc agtttccttc tggagcacct
     1081 cacccagcag aaagccaagc accctatcat tggagatgtc aggggcactg gactcttcat
     1141 cggtgtggat ctcatcaaag atgagaccct gaggacacca gcaactgaag aggcggaata
     1201 tttggtctcc aggctaaagg aaaactacat tttactgagc attgatggcc ctggaaagaa
     1261 tattctgaag ttcaagcccc caatgtgctt caacgttgac aatgcacaac atgtggtagc
     1321 aaagctggat gacattctaa cagacatgga agaaaaagta agaagttgtg aaaccctgag
     1381 gatcaagcac cccccagaag atactcatcc tactcaaata ctcctaacaa gacagcaaga
     1441 ttgacaccca ccttacagat aaaacaagtg tgtgaggctt cactggattg gtgaactact
     1501 gataggcttt atttctaaat caaaacaaga cccagtcaga cttttatgcc tgaaaacttt
     1561 gaggatggtg tacatgcttc aaaagaacat gttttaaaga cagacctgac atactcccat
     1621 ttttaaaaaa aaaaaaaaaa ggtaaaaaat gagctggcca tggcacatgc ctttagtctc
     1681 atctcactgg gaggtagaaa caggcagaac tcttaagttt gagaccagcc tggttttgta
     1741 tagggcagcc agggcagcag tacggtgatc tctcaaaagg gggtggaaag ataaacttta
     1801 tctctcccta tcaagctatg acttttattt catctgaatt aaagacactg aataatttga
     1861 gtattta
//
