LOCUS       NM_010726               1474 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phytanoyl-CoA hydroxylase (Phyh), mRNA.
ACCESSION   NM_010726
VERSION     NM_010726.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Ferdinandusse,S., Zomer,A.W., Komen,J.C., van den Brink,C.E.,
            Thanos,M., Hamers,F.P., Wanders,R.J., van der Saag,P.T.,
            Poll-The,B.T. and Brites,P.
  TITLE     Ataxia with loss of Purkinje cells in a mouse model for Refsum
            disease
  JOURNAL   Proc Natl Acad Sci U S A 105 (46), 17712-17717 (2008)
   PUBMED   19004801
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Huyghe,S., Casteels,M., Janssen,A., Meulders,L., Mannaerts,G.P.,
            Declercq,P.E., Van Veldhoven,P.P. and Baes,M.
  TITLE     Prenatal and postnatal development of peroxisomal
            lipid-metabolizing pathways in the mouse
  JOURNAL   Biochem J 353 (Pt 3), 673-680 (2001)
   PUBMED   11171065
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Lee,Z.H., Kim,H., Ahn,K.Y., Seo,K.H., Kim,J.K., Bae,C.S. and
            Kim,K.K.
  TITLE     Identification of a brain specific protein that associates with a
            refsum disease gene product, phytanoyl-CoA alpha-hydroxylase
  JOURNAL   Brain Res Mol Brain Res 75 (2), 237-247 (2000)
   PUBMED   10686344
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Jansen,G.A., Ofman,R., Denis,S., Ferdinandusse,S., Hogenhout,E.M.,
            Jakobs,C. and Wanders,R.J.
  TITLE     Phytanoyl-CoA hydroxylase from rat liver. Protein purification and
            cDNA cloning with implications for the subcellular localization of
            phytanic acid alpha-oxidation
  JOURNAL   J Lipid Res 40 (12), 2244-2254 (1999)
   PUBMED   10588950
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Mihalik,S.J., Morrell,J.C., Kim,D., Sacksteder,K.A., Watkins,P.A.
            and Gould,S.J.
  TITLE     Identification of PAHX, a Refsum disease gene
  JOURNAL   Nat Genet 17 (2), 185-189 (1997)
   PUBMED   9326939
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Iwano,M., Ueno,S., Miyazaki,M., Harada,T., Nagai,Y., Hirano,M.,
            Dohi,Y., Akai,Y., Kurioka,H. and Dohi,K.
  TITLE     Molecular cloning and expression of a novel peptide (LN1) gene:
            reduced expression in the renal cortex of lupus nephritis in
            MRL/lpr mouse
  JOURNAL   Biochem Biophys Res Commun 229 (1), 355-360 (1996)
   PUBMED   8954131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY139974.1, AK146753.1 and BY369819.1.
            
            On Dec 11, 2007 this sequence version replaced NM_010726.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.59382.1, AK146753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               BY139974.1         1-209
            210-1455            AK146753.1         195-1440
            1456-1474           BY369819.1         422-440
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.06 cM"
     gene            1..1474
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /note="phytanoyl-CoA hydroxylase"
                     /db_xref="GeneID:16922"
                     /db_xref="MGI:MGI:891978"
     exon            1..149
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1091
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /EC_number="1.14.11.18"
                     /note="lupus nephritis-associated peptide 1; phytanoyl-CoA
                     dioxygenase, peroxisomal; phytanic acid oxidase;
                     phytanoyl-CoA alpha-hydroxylase"
                     /codon_start=1
                     /product="phytanoyl-CoA dioxygenase, peroxisomal
                     precursor"
                     /protein_id="NP_034856.1"
                     /db_xref="CCDS:CCDS15660.1"
                     /db_xref="GeneID:16922"
                     /db_xref="MGI:MGI:891978"
                     /translation="MNLTRAGARLQVLLGHLGRPSAPTIVAQPVSGLASPASFQPEQF
                     QYTLDNNVLTLEQRKFYEENGFLVIKNLVSDDDIQRFRAEFERICREEVKPPGIVIMR
                     DVALAKQDYMPSDRMVSKIQDFQEDEELFRYCLLPEILKYVECFTGPNIMALHGMLIN
                     KPPDVGKKTSRHPLHQDLHYFPFRPSNLIVCAWTAMEHIDRNNGCLVVLPGTHKGTLK
                     PHDYPKWEGGVNKMYHGIQDYDPNSPRVHLVMEKGDTVFFHPLLIHGSGRNKTQGFRK
                     AISCHFGSSDCQCIDVSGTSQENIAREVVEMAEKKYGFQGVMDFKDTWIFRSRLVKGE
                     RINI"
     exon            150..208
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     exon            209..319
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     exon            320..488
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     exon            489..570
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     exon            571..752
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     exon            753..902
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1037
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1474
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /note="hexamer: AATAAA"
     polyA_site      1461
                     /gene="Phyh"
                     /gene_synonym="Lnap1; PAHX"
                     /note="major polyA site"
ORIGIN      
        1 tctactagga ggcggggcct tgccgtaagt taagtgtgac ctgggcgcag cagtttcgtc
       61 tgctggcccc caccatgaat cttacgcgcg ccggcgcccg gctgcaggtc cttctgggac
      121 acctcggccg accctcggcc ccaacgattg tagcccagcc tgtatcaggg ttggcttccc
      181 ctgccagttt ccagcctgaa caattccagt atactctgga taataatgtc ctcaccctgg
      241 agcagagaaa attttatgaa gaaaatgggt ttctcgtcat taagaatctg gtatctgatg
      301 atgacattca acgttttcga gcagagtttg aaagaatctg cagagaggag gtgaaaccac
      361 cagggatcgt tataatgaga gatgtggccc ttgcaaaaca ggattatatg ccaagtgata
      421 ggatggtttc aaagatccag gatttccaag aagatgagga gctcttcaga tactgccttc
      481 tccccgagat tctgaagtat gtggagtgtt tcactggacc caatattatg gctctgcatg
      541 ggatgctgat caacaagcct ccagatgttg gcaagaagac atcccggcat cccttgcatc
      601 aggatctgca ctatttcccc ttccgaccta gcaacctaat tgtttgtgct tggacagcca
      661 tggagcacat tgacagaaac aacggttgtc tggttgtgct cccaggtacc cacaaaggca
      721 ctctgaagcc acatgattac cccaagtggg agggaggtgt taacaaaatg taccatggca
      781 tccaagacta tgaccccaac agcccccggg tccacctagt gatggaaaag ggcgatactg
      841 ttttcttcca ccctctgctc atccatggat ctggtcggaa caaaactcaa ggcttccgga
      901 aagcaatttc ctgccacttc ggcagctctg actgccagtg tatcgatgtg agcggcacca
      961 gtcaagaaaa tattgcaagg gaagttgtcg agatggcaga gaaaaagtat ggattccaag
     1021 gagtcatgga ctttaaggac acttggatat ttcgaagccg acttgtgaaa ggagaaagaa
     1081 taaacatttg aaacagccct tcaagagtga ggtactggga tgatagtctg agacaggagc
     1141 atcgagagtt cgagtacagc ctgagctaca cagaaggatg ctatctcctc ctctttcccc
     1201 cataaacaaa atgaaaagag ttagctcttc cttataattc ctttaaagag gacatcaaag
     1261 caaagaaaga catctaagga aaaaaatttt taactgagat gatgttctct ttttatcacc
     1321 tgttaacaag atcaagatgc acgtattggg gattcatgaa tttaattaat gtggtactat
     1381 tgtcttaatg gagtgaaata ttactgtttt aagaaaaact aacctagggt gtaactaata
     1441 aaggtgactg agtataatgt aggcatatta agtc
//
