LOCUS       NM_172992               4839 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus putative homeodomain transcription factor 2 (Phtf2),
            mRNA.
ACCESSION   NM_172992
VERSION     NM_172992.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4839)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 4839)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB245749.1, AK042382.1, AK037021.1, AK151762.1 and AK004246.1.
            
            On Nov 28, 2007 this sequence version replaced NM_172992.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052841.1, AK037021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CB245749.1         1-21
            22-1060             AK042382.1         1-1039
            1061-3771           AK037021.1         948-3658
            3772-4733           AK151762.1         524-1485
            4734-4839           AK004246.1         707-812
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.83 cM"
     gene            1..4839
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /note="putative homeodomain transcription factor 2"
                     /db_xref="GeneID:68770"
                     /db_xref="MGI:MGI:1916020"
     exon            1..169
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            170..249
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2448
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /codon_start=1
                     /product="protein PHTF2"
                     /protein_id="NP_766580.3"
                     /db_xref="CCDS:CCDS51426.1"
                     /db_xref="GeneID:68770"
                     /db_xref="MGI:MGI:1916020"
                     /translation="MASRVTDAIVWYQKKIGAYDQQIWEKSVEQREIKGLRNKPKKTA
                     HVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPFFSRWWLQVTSRVIFSW
                     LLVLYLLQVAAIVLFCSAPSPHSIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKPPLGT
                     GGKRRRKLRKAAHLEVHREGDGSSTTDNTQEGAVQSHGAGAPYSVGTVFRDLWLAAFF
                     LSGSKKAKNSIDKSTETDNGYVSLDGKRTVKSSEDGAQYHEPQCETVGPEDAAWATRT
                     PRSVPAKDTQRKITNVSDEVSSEEGPETGYPLRGHVDRTSESGLRNRKPHHYKKHYAN
                     EDAPKSGTSCSSRCSSSRQDSESTRPESETEDVLWEDLLHCAECRSSCTSETDVGNPQ
                     INPCGKKEYRDDPFHQSHLPWLHSSHPGLEKISAIVWEGNDCKKADMSVLEISGMIMN
                     RVNNHVPGIGYQVFGNAISLILGLTPFVFRLSQATDLEQLTAHSASELYVIAFGSNED
                     VMVLSMVLISFVVRVSLVWIFFFLLCVAERTYKQRLLFAKLFGHLTSARRARKSEVPH
                     FRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQLLHVHEIFL
                     DCHYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKE
                     ELTLVNNVLKLATKLLKELDSPFRLYGLTMNPLLYNITQVVILSAVSGVISDLLGFNL
                     KLWKIKS"
     exon            250..306
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            307..376
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            377..535
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            536..701
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            702..866
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1053
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1209
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1428
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1557
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1830
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1962
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2049
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2205
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2301
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2427
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..4839
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4734
                     /gene="Phtf2"
                     /gene_synonym="1110054G21Rik; 9530062N20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcccggg aggcggagcg cggtgcgggc ggcgcgagcg gcgcgagggt ggaggcagcg
       61 cgccgccggc ggcggggctg tagctctttg ggctccagcg gcggcactag ccttcgcgac
      121 tctgcgcgtc tcctagccgc ttcccagcgg cgcggcgccg gcggctacgc ttaaaatgac
      181 gaatgtgtga tctcaatgga ataaatggcg tccagagtca cagatgctat agtctggtat
      241 cagaagaaga ttggagccta tgatcaacaa atatgggaaa agtctgttga acaaagagaa
      301 atcaagggct taaggaataa accaaagaaa acagcacatg tgaaaccaga cctcatcgat
      361 gttgatcttg tgagagggtc tgcatttgct aaggcaaagc ctgaaagtcc ttggacttct
      421 ctgacaagga aagggattgt tcgagttgtc tttttccctt tcttctcccg ctggtggtta
      481 caagtaacgt ccagagtcat cttctcctgg cttcttgttc tctatcttct ccaagttgct
      541 gcaatagtat tattctgttc cgctcctagc ccacatagca tacctctaac tgaagtgatt
      601 gggccaatat ggctgatgct gcttttggga accgtgcatt gccagattgt ttcaacaaga
      661 acacccaagc ctccactagg cacaggcggt aaacgaagaa ggaaattaag aaaagcagcc
      721 catttggaag tccacaggga aggggacggt tctagcacca cagataacac acaggaggga
      781 gcggtgcaga gccacggcgc aggcgcccct tacagtgttg gcactgtctt cagagacctt
      841 tggcttgctg ctttcttctt atcagggtca aagaaggcaa agaattcaat tgataagtca
      901 accgagactg acaatggcta tgtgtccctc gatgggaaga ggactgtaaa aagcagtgag
      961 gatggagcac agtaccatga gcctcagtgt gaaactgttg gaccagaaga cgcagcctgg
     1021 gccacacgaa cgccaaggag tgttcctgcc aaagataccc aaagaaagat aacaaatgtc
     1081 tctgatgaag tatccagtga ggagggtccc gaaacaggat acccattgcg tggtcatgtg
     1141 gacagaactt ctgaaagcgg tcttcgaaat agaaagccac accattataa aaagcattat
     1201 gcaaatgagg atgcccctaa atcgggtact agttgcagct ctcgctgttc aagttccaga
     1261 caggattctg agagcacaag gccagaatct gaaaccgaag atgtattatg ggaagacttg
     1321 ttacactgtg cggaatgccg ctcatcttgt accagtgaga cagatgtggg aaaccctcag
     1381 ataaatccat gtgggaagaa agaatataga gacgaccctt ttcatcagag tcatttgccc
     1441 tggcttcata gttcccaccc aggattagaa aaaatcagtg ctatagtgtg ggaaggtaac
     1501 gactgtaaga aagcagacat gtctgtactt gaaatcagtg ggatgataat gaacagagtg
     1561 aacaaccatg tcccaggcat aggataccag gtatttggaa atgccatctc tctaatcctg
     1621 ggcttgaccc catttgtttt ccgactgtca caagcaacag acttggagca gctcacagcc
     1681 cattctgcgt cagaacttta tgtgattgcg tttggctcta acgaagatgt catggttctt
     1741 tctatggtcc tgataagttt tgtggttcga gtctctcttg tgtggatctt cttttttttg
     1801 ctgtgtgtag cagaaagaac atataagcaa cgattactct ttgcaaaact ctttggacac
     1861 ttgacgtctg caaggagagc tcgcaaatct gaggttccgc atttccggtt gaagaaagta
     1921 cagaatataa aaatgtggct gtctctgcgt tcctatctta agcgccgagg ccctcagcga
     1981 tctgtggatg tcattgtctc atcggccttc ttactgacaa tctcagttgt gtttatctgc
     2041 tgtgcacagc tgctccacgt gcacgagatc ttccttgact gtcactataa ctgggagctg
     2101 gtgatctggt gcatctcctt aacgctgttc ctcctgaggt tcgttactct tggatcagaa
     2161 accagcaaga aatacagcaa tacctcaatc ctacttacgg aacagataaa cctctacttg
     2221 aaaatggaga agaaacctaa caaaaaggag gagctgaccc ttgtgaataa tgtgttaaag
     2281 ctggctacga aactgctgaa ggaattggac agtcccttta ggttgtatgg acttacaatg
     2341 aatccgctgc tgtataacat cacccaggtt gtcatccttt cggctgtttc cggtgtcatc
     2401 agtgacttgc ttggatttaa tttaaagctg tggaagatca aatcgtgaca gttgagagaa
     2461 atggaggtgt agccgggatg ccagagcacg agcgctgatg gagctggctg gaagcagtgg
     2521 gtggctctgc tccaggagtc tactgggaaa gaagtgttta catcagaatg tattgtgcaa
     2581 ttcttatatt tattttactt gtccactggt tttgttttgt tttgtgtgtg tgtgtgtgtg
     2641 tatgtttgtt ttctttcttt ttttcctttt aaacatttag tttgttttaa gcattgaagt
     2701 ttttcattgt tgaaagggtg gcagagcgga tccagatacc tgagatcctg gtaattgttg
     2761 acgtaattga caagcagatt gtgaaaacag aagccattgc taagcactgt ttcttcatta
     2821 atgccgtgaa cttgccttac ttgaggaata cgtctttaac tctgaaatag tgcgttgtct
     2881 cagctaaaca catgtcctct ggtaaaccag ggtccgctca ggatcgctct tgaaatactt
     2941 cagaacagta ctgggatcta gactgactaa gctgcagttg aagcaccctt cagtattaat
     3001 agatggtgtt gtataacagg tcaacaagtg ctctttgata ataaaactct taatggagca
     3061 ataattgtaa atggttacca tactgtaaaa tattttgata aaaattaatt agtaataaat
     3121 gtatttattt aaaacactga gctgtttgca cagctccaac tgtgcatgct caaaatgtgc
     3181 actttttaaa atggtttctt ttggtgtata tctctatgtg gatatgttac agtgtactag
     3241 ggcataatat ggtatccttt tgagtgaggt ctatcctcat ctcacaagtg aagtgcctat
     3301 tgttattact aaataaagtg cgttacgttt actcaaaaga atttcccatg gtacactata
     3361 gcgtatgctg ttcctaccac acttaaataa agcttaagaa taaagttgtc tgattgctag
     3421 ttataaaatt tccaaatttt ccagaaggac agctccagcc taccagttct agcttccaga
     3481 tttaatctgg tgcacccctc ccctggctcc attacataag ggctattttt agatgctttt
     3541 aacgtggaaa gctagctgct ctccccttca gtaacttgtc cgtgtccggt gggagcttat
     3601 catgtttccc tttggcaaat agggcagata tgatagtccc tacatcgggc cttgattcta
     3661 agttgttacc tttgtacaat cagtagtgtt ttaagaatta catgaaacaa tgtttttgtg
     3721 attgtcttgt ttaagccaac catttggttt ttaaaacaaa gaaattattt gaaacaatct
     3781 aggattttct tggtgcaaag tcatattgaa tatattcata tttttagcat attttaaggt
     3841 ctttaaaata attaattgta aataatttat ttgattggtg cagttctaat tcgcaaatca
     3901 ctcttaaaat caggatgtgt agagaccaga gccatgtgtt aaatgttgcc cttcccattc
     3961 ctctgagcaa cctcagctaa gcctcactgg agagtgctct ctgtatagga aacggcagac
     4021 agcattgtgt tccgtctgcc tgcgctctaa tatgtccaat aatgaccaaa gtgcattctg
     4081 ggtatttttc gaggaatgta ttactggagc tttaagaaca tacttagttt ctcatgtgaa
     4141 gaattaggct ttgtctgata tgttccttcc tatattgtct aatttgaggt tgtttttagg
     4201 cactatattt tataaacttt ttcaaaataa ggtacatacc tatacagaac ttaccatttt
     4261 gcacagagta tatcaaatat attttgagaa taaaaaagta cagcatgagt tctgttagga
     4321 ataaagtgag attgttgtat cttaaaaaac ttatttcaga ttggaggtat ttttgagaaa
     4381 agtagctgag tatactgact taggaaaatg cttgctttag gttgcagctg tgtttaacgt
     4441 agagttgggg tggattgtac agtatcggcc gtgccgttaa cgtgggcagc agtagagttc
     4501 taggaggaaa atgtgctaag cagcttcata gttcacagag ccatttcaga gtagtaagtg
     4561 acatccctgc ctttaagtat accatgaatg taagaagtag aagttgtaac atatcacatc
     4621 atagagaaaa agcaacccag aggtagaatt atggcaaatg ctgtgtgctg tttctttgcc
     4681 gtgtgttttt aaaagtttga acagcaagtt taaaataaaa cattataaga ctgacttgtg
     4741 tgtgtttttt taagtgtggg ttggtttttg tgcttactgt aatataagct gtacttactg
     4801 ccctttagac aaggacggtg aaaataaagt tttaactgt
//
