LOCUS       NM_029293                583 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus phosphohistidine phosphatase 1 (Phpt1), transcript
            variant 2, mRNA.
ACCESSION   NM_029293 XM_203853
VERSION     NM_029293.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 583)
  AUTHORS   Srivastava,S., Li,Z., Soomro,I., Sun,Y., Wang,J., Bao,L.,
            Coetzee,W.A., Stanley,C.A., Li,C. and Skolnik,E.Y.
  TITLE     Regulation of KATP Channel Trafficking in Pancreatic beta-Cells by
            Protein Histidine Phosphorylation
  JOURNAL   Diabetes 67 (5), 849-860 (2018)
   PUBMED   29440278
  REMARK    GeneRIF: PHPT-1(-/-) mice exhibited neonatal hyperinsulinemic
            hypoglycemia due to impaired trafficking of KATP channels to the
            plasma membrane in pancreatic beta-cells in response to low glucose
            and leptin and resembled patients with congenital hyperinsulinism
            (CHI).
REFERENCE   3  (bases 1 to 583)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 583)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 583)
  AUTHORS   Xu,A., Hao,J., Zhang,Z., Tian,T., Jiang,S., Hao,J., Liu,C.,
            Huang,L., Xiao,X. and He,D.
  TITLE     14-kDa phosphohistidine phosphatase and its role in human lung
            cancer cell migration and invasion
  JOURNAL   Lung Cancer 67 (1), 48-56 (2010)
   PUBMED   19344975
REFERENCE   6  (bases 1 to 583)
  AUTHORS   Zhang,X.Q., Sundh,U.B., Jansson,L., Zetterqvist,O. and Ek,P.
  TITLE     Immunohistochemical localization of phosphohistidine phosphatase
            PHPT1 in mouse and human tissues
  JOURNAL   Ups J Med Sci 114 (2), 65-72 (2009)
   PUBMED   19396692
REFERENCE   7  (bases 1 to 583)
  AUTHORS   Krieglstein,J., Lehmann,M., Maurer,A., Gudermann,T., Pinkenburg,O.,
            Wieland,T., Litterscheid,S. and Klumpp,S.
  TITLE     Reduced viability of neuronal cells after overexpression of protein
            histidine phosphatase
  JOURNAL   Neurochem Int 53 (5), 132-136 (2008)
   PUBMED   18656514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732590.7.
            
            On Nov 17, 2006 this sequence version replaced NM_029293.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY705916.1, AK005756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AL732590.7         69320-69508         c
            190-314             AL732590.7         68825-68949         c
            315-583             AL732590.7         68068-68336         c
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.44 cM"
     gene            1..583
                     /gene="Phpt1"
                     /gene_synonym="1700008C22Rik; PHP; Php14"
                     /note="phosphohistidine phosphatase 1"
                     /db_xref="GeneID:75454"
                     /db_xref="MGI:MGI:1922704"
     exon            1..189
                     /gene="Phpt1"
                     /gene_synonym="1700008C22Rik; PHP; Php14"
                     /inference="alignment:Splign:2.1.0"
     exon            190..314
                     /gene="Phpt1"
                     /gene_synonym="1700008C22Rik; PHP; Php14"
                     /inference="alignment:Splign:2.1.0"
     exon            315..583
                     /gene="Phpt1"
                     /gene_synonym="1700008C22Rik; PHP; Php14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggggccca gagatcgagc gcttcgggga acatggcggc ggacctcggt cagattcctg
       61 atgtagacat tgattcggat ggcgtcttca agtatgtgct gattcgagtc cacttagcag
      121 agccttctgg ggatccggcg aaggagtgca aggaaatcgt gcgtggctac aaatgggctg
      181 agtaccacgc ggacatctat gacaaagtgt caggcgagct gcaaaggaat ggctatgact
      241 gtgagtgcct aggcggcggg cgcatctccc atcagagcca ggacaggaag atacacgtgt
      301 atggctactc tatgggttac ggtcgtgccc agcactctgt ttcaactgag aagatcaaag
      361 ccaagtatcc tgactatgag gtcacctggg ctgacgatgg ctactgaagc tctgccccac
      421 cccccacccc ccggactaag tcaggtctct gctcttgctg tgttctgttt tgaggggctg
      481 gccctgtgct ttccttttgt accttaggca gcatagcacc tgccaggcct tagaggccag
      541 accaatctgg tccataggaa ttaaaagcat tgatatgcct act
//
