LOCUS       NM_008888               2856 bp    mRNA    linear   ROD 19-DEC-2023
DEFINITION  Mus musculus paired-like homeobox 2b (Phox2b), mRNA.
ACCESSION   NM_008888
VERSION     NM_008888.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Soto-Perez J, Cleary CM, Sobrinho CR, Mulkey SB, Carroll JL,
            Tzingounis AV and Mulkey DK.
  TITLE     Phox2b-expressing neurons contribute to breathing problems in Kcnq2
            loss- and gain-of-function encephalopathy models
  JOURNAL   Nat Commun 14 (1), 8059 (2023)
   PUBMED   38052789
  REMARK    GeneRIF: Phox2b-expressing neurons contribute to breathing problems
            in Kcnq2 loss- and gain-of-function encephalopathy models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Vermeiren S, Cabochette P, Dannawi M, Desiderio S, San Jose AS,
            Achouri Y, Kricha S, Sitte M, Salinas-Riester G, Vanhollebeke B,
            Brunet JF and Bellefroid EJ.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Laddach A, Chng SH, Lasrado R, Progatzky F, Shapiro M, Erickson A,
            Sampedro Castaneda M, Artemov AV, Bon-Frauches AC, Amaniti EM,
            Kleinjung J, Boeing S, Ultanir S, Adameyko I and Pachnis V.
  TITLE     A branching model of lineage differentiation underpinning the
            neurogenic potential of enteric glia
  JOURNAL   Nat Commun 14 (1), 5904 (2023)
   PUBMED   37737269
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Jones AA, Marino GM, Spears AR and Arble DM.
  TITLE     The Molecular Circadian Clock of Phox2b-expressing Cells Drives
            Daily Variation of the Hypoxic but Not Hypercapnic Ventilatory
            Response in Mice
  JOURNAL   Function (Oxf) 4 (4), zqad023 (2023)
   PUBMED   37342417
  REMARK    GeneRIF: The Molecular Circadian Clock of Phox2b-expressing Cells
            Drives Daily Variation of the Hypoxic but Not Hypercapnic
            Ventilatory Response in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2856)
  AUTHORS   McCoy ME and Kamitakahara AK.
  TITLE     Ontogeny and Trophic Factor Sensitivity of Gastrointestinal
            Projecting Vagal Sensory Cell Types
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   36973009
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2856)
  AUTHORS   Young HM, Hearn CJ, Ciampoli D, Southwell BR, Brunet JF and
            Newgreen DF.
  TITLE     A single rostrocaudal colonization of the rodent intestine by
            enteric neuron precursors is revealed by the expression of Phox2b,
            Ret, and p75 and by explants grown under the kidney capsule or in
            organ culture
  JOURNAL   Dev Biol 202 (1), 67-84 (1998)
   PUBMED   9758704
REFERENCE   7  (bases 1 to 2856)
  AUTHORS   Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, Goridis C and
            Guillemot F.
  TITLE     The bHLH protein NEUROGENIN 2 is a determination factor for
            epibranchial placode-derived sensory neurons
  JOURNAL   Neuron 20 (3), 483-494 (1998)
   PUBMED   9539123
REFERENCE   8  (bases 1 to 2856)
  AUTHORS   Hirsch MR, Tiveron MC, Guillemot F, Brunet JF and Goridis C.
  TITLE     Control of noradrenergic differentiation and Phox2a expression by
            MASH1 in the central and peripheral nervous system
  JOURNAL   Development 125 (4), 599-608 (1998)
   PUBMED   9435281
REFERENCE   9  (bases 1 to 2856)
  AUTHORS   Pattyn A, Morin X, Cremer H, Goridis C and Brunet JF.
  TITLE     Expression and interactions of the two closely related homeobox
            genes Phox2a and Phox2b during neurogenesis
  JOURNAL   Development 124 (20), 4065-4075 (1997)
   PUBMED   9374403
REFERENCE   10 (bases 1 to 2856)
  AUTHORS   Patorska-Mach,E.
  TITLE     [Effect of experimental ornithosis on the morphology of neurons in
            the central nervous system and on the activity of acid and alkaline
            phosphatase]
  JOURNAL   Pol Tyg Lek 32 (42), 1625-1628 (1977)
   PUBMED   200898
  REMARK    GeneRIF: Phox2b-variants (wt and neuroblastoma related) affect
            proliferation of cultured sympathetic precursors. Phox2b variants
            directly interact with the bHLH transcription factor Hand2.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079610.1.
            
            [WARNING] On Jan 16, 2024 this sequence was replaced by
            NM_008888.4.
            
            On May 7, 2009 this sequence version replaced NM_008888.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079610.1, Y14493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2349              BC079610.1         1-2349
            2350-2856           BC079610.1         2351-2857
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 35.95 cM"
     gene            1..2856
                     /gene="Phox2b"
                     /gene_synonym="Dilp1; NBPhox; Pmx2b; Px2b"
                     /note="paired-like homeobox 2b"
                     /db_xref="GeneID:18935"
                     /db_xref="MGI:MGI:1100882"
     exon            1..426
                     /gene="Phox2b"
                     /gene_synonym="Dilp1; NBPhox; Pmx2b; Px2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1130
                     /gene="Phox2b"
                     /gene_synonym="Dilp1; NBPhox; Pmx2b; Px2b"
                     /note="neuroblastoma Phox; PHOX2B homeodomain protein;
                     dilated pupils 1; GENA 269; paired mesoderm homeobox 2b"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 2B"
                     /protein_id="NP_032914.1"
                     /db_xref="CCDS:CCDS19316.1"
                     /db_xref="GeneID:18935"
                     /db_xref="MGI:MGI:1100882"
                     /translation="MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQY
                     NPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIR
                     TTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAA
                     AAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGP
                     SPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPG
                     PGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF"
     exon            427..614
                     /gene="Phox2b"
                     /gene_synonym="Dilp1; NBPhox; Pmx2b; Px2b"
                     /inference="alignment:Splign:2.1.0"
     exon            615..2840
                     /gene="Phox2b"
                     /gene_synonym="Dilp1; NBPhox; Pmx2b; Px2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctagagac ctcagacaag gcatctcaca ggaggctttt tcataaaact aggctcggct
       61 ggtagtaagg aggccagtgt ggaggcaggc gttgagcagt gcacatctcc ccactccagc
      121 caccgtctcc acatccatct tttatttcat ttttccactt ggctgagcca tccagaacct
      181 tttcaatgta taaaatggaa tattcttacc tcaattcctc tgcctacgag tcctgtatgg
      241 ccgggatgga tacctccagc ttggcttcag catatgcaga cttcagttcc tgcagccagg
      301 ccagtggctt ccagtataac ccgataagga ccacttttgg ggccacgtcc ggttgcccgt
      361 ccctcacgcc gggatcctgc agcctgggca ccctcaggga ccaccagagc agtccgtacg
      421 ccgcagttcc atacaaactc ttcaccgacc acggcggcct caacgagaaa cgcaagcagc
      481 ggcgcatccg caccaccttc acaagcgcgc agctcaaaga gttggagagg gtcttcgctg
      541 agacgcacta ccctgacatc tacaccaggg aagagctagc actgaagatc gacctcaccg
      601 aggcgagagt ccaggtgtgg ttccagaacc gccgggctaa gtttcgcaag caggagcgcg
      661 cagccgccgc tgctgccgcc gccgccaaaa acggctcctc cgggaagaag tctgactcct
      721 cccgggacga cgagagcaaa gaggccaaga gcactgatcc cgacagcact gggggcccgg
      781 gacccaaccc caacccgacc cccagctgtg gggcaaatgg cggcggtggc ggagggccca
      841 gcccagccgg agctccgggg gcggcgggcc cggggggccc gggaggcgaa cccggcaagg
      901 gcggtgcggc tgcggctgct gctgcagctg cagcggctgc agcggcggct gcggctgcgg
      961 cggcgggagg cctggctgcg gccggaggcc ccggacaagg ctgggctcct ggcccgggcc
     1021 ccatcacctc catcccagat tctcttgggg ggcccttcgc cagcgtctta tcttcgctcc
     1081 aaagacccaa cggtgccaaa gccgccttag tgaagagcag tatgttctga tctgcgatct
     1141 gcggcggcgg cgggcgagcc cggggcccgg gctggcgagt gggcgagtgg gtagacccaa
     1201 ggctagtgtc gctgctgtca gtggcttttt tttttttttt catcgaaggc ctaaaatgat
     1261 cgcgattcga aaaaacaacg agaaaatgac gtcgctccat ttcaacccca ctcctacccc
     1321 tttcctcacc cccaaacaaa gcaaaacaaa acaaacaaaa atcttcacct gccttgggct
     1381 gcgcatagga cagggctcca cctgctgccc aagggatgtg agcttggact tcggggcact
     1441 ctcagggggc tgtgtctgag tgacgggtgt atgtctgtct cagagaatgt gtgtctgtgg
     1501 ccccaagtag gtgataggga gagacggggg caccacaacc aactcagtga cttcttagga
     1561 aaaaaaagtt ggaaagcagc aaagatacaa aaggaaaatg aaataaatta caaaaagttt
     1621 ttttaaaaga tccaaatgga gggaataatt tgaaaataca aaggagacga gggaggactg
     1681 tggctggcgc tgaggttttg gtcttgcgaa cccctaaatt ctctcgctca cgactgcaca
     1741 gactgtcttg cggctcctct ataggaaaga gtactgatgc ctgtccggcc ccggttcccc
     1801 tcaggtccct gtgctctggt cattgcagtg atggctcact cagactgtcc tggcagccaa
     1861 agtgactttc tggagctctg cttgcctgtc cccacctcgc tggaaaccat ctcgccatta
     1921 gcgcaactga tttcccacac tctgctctgg cctgaaccct aatcttcgca gccgcttggc
     1981 cctgagagat gatgccctgt acaggagatc ccttctcacc ctccagctct gcaaaccgtg
     2041 tctcatgttt cacagcgttc ctgttttttc tctcccgcca cccccaccgg catttccttc
     2101 ttccaccagc tttaatggaa ctttttttgg cactgctttg cattggagtc agttgtagtc
     2161 cacatagctg gctgcagaga aatcagtctt acccagcaag gggaaggcac acacaagttt
     2221 gcagaaagtg tctcagatcg cgtttctgat tgagtgatcc gagctggact cctcctgtag
     2281 ggtggacaga ctgtatattg ataattcctt ctatgcgcag tttagacatc tctgttgggc
     2341 ttttttttta aatttttatt ttaaaaggca caaaactata gatattagtt gaatgttgag
     2401 gctttaactt tttcggtgtc tttctacagc tgtgttctgt gactcaattg tatcgtgtta
     2461 ctctcagtac agaccgtctc ctctacgtga ccgtataatg ttttttctcc tcttgtagtc
     2521 tttatggtgt gtctttatga cgtaataagg ttctcacggg ttcgattcct ttgtgtttag
     2581 agagaccagg ttcagacaat ggtatatatt tttgttatca ggtgcatgtc tgtctgattt
     2641 ccttttcttc tcgttgggac tatgtttgtg aacatgagcg tcataagtta tgtttcagat
     2701 tttcaaattt atttatacgt gttataatga atgcttctat ttaaagggga aatatttcta
     2761 catgtgcata tagttttcca agagtgtacc attaacttga ttgttgataa taaaaagaaa
     2821 aagcaagtct aagcaagtaa aaaaaaaaaa aaaaaa
//
