LOCUS       NM_153104               1910 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphatase, orphan 1 (Phospho1), mRNA.
ACCESSION   NM_153104
VERSION     NM_153104.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Houston,D.A., Stephen,L.A., Jayash,S.N., Myers,K., Little,K.,
            Hopkinson,M., Pitsillides,A.A., MacRae,V.E., Millan,J.L.,
            Staines,K.A. and Farquharson,C.
  TITLE     Increased PHOSPHO1 and alkaline phosphatase expression during the
            anabolic bone response to intermittent parathyroid hormone delivery
  JOURNAL   Cell Biochem Funct 41 (2), 189-201 (2023)
   PUBMED   36540015
  REMARK    GeneRIF: Increased PHOSPHO1 and alkaline phosphatase expression
            during the anabolic bone response to intermittent parathyroid
            hormone delivery.
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Hsu,S.N., Stephen,L.A., Dillon,S., Milne,E., Javaheri,B.,
            Pitsillides,A.A., Novak,A., Millan,J.L., MacRae,V.E., Staines,K.A.
            and Farquharson,C.
  TITLE     Increased PHOSPHO1 expression mediates cortical bone mineral
            density in renal osteodystrophy
  JOURNAL   J Endocrinol 254 (3), 153-167 (2022)
   PUBMED   35900032
  REMARK    GeneRIF: Increased PHOSPHO1 expression mediates cortical bone
            mineral density in renal osteodystrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Peng,Y., Yue,F., Chen,J., Xia,W., Huang,K., Yang,G. and Kuang,S.
  TITLE     Phosphatase orphan 1 inhibits myoblast proliferation and promotes
            myogenic differentiation
  JOURNAL   FASEB J 35 (1), e21154 (2021)
   PUBMED   33140469
  REMARK    GeneRIF: Phosphatase orphan 1 inhibits myoblast proliferation and
            promotes myogenic differentiation.
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Jiang,M., Chavarria,T.E., Yuan,B., Lodish,H.F. and Huang,N.J.
  TITLE     Phosphocholine accumulation and PHOSPHO1 depletion promote adipose
            tissue thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 117 (26), 15055-15065 (2020)
   PUBMED   32554489
  REMARK    GeneRIF: Phosphocholine accumulation and PHOSPHO1 depletion promote
            adipose tissue thermogenesis.
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Roberts,S., Narisawa,S., Harmey,D., Millan,J.L. and Farquharson,C.
  TITLE     Functional involvement of PHOSPHO1 in matrix vesicle-mediated
            skeletal mineralization
  JOURNAL   J Bone Miner Res 22 (4), 617-627 (2007)
   PUBMED   17227223
  REMARK    GeneRIF: PHOSPHO1 localization is restricted to mineralizing
            regions of bone and growth plate
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Wang,M., Zhang,Z., Zhang,Z., Vikis,H., Yan,Y., Wang,Y. and You,M.
  TITLE     Fine mapping and candidate gene analyses of pulmonary adenoma
            resistance 1, a major genetic determinant of mouse lung adenoma
            resistance
  JOURNAL   Cancer Res 67 (6), 2508-2516 (2007)
   PUBMED   17363568
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   Stewart,A.J., Roberts,S.J., Seawright,E., Davey,M.G., Fleming,R.H.
            and Farquharson,C.
  TITLE     The presence of PHOSPHO1 in matrix vesicles and its developmental
            expression prior to skeletal mineralization
  JOURNAL   Bone 39 (5), 1000-1007 (2006)
   PUBMED   16837257
REFERENCE   9  (bases 1 to 1910)
  AUTHORS   Houston,B., Stewart,A.J. and Farquharson,C.
  TITLE     PHOSPHO1-A novel phosphatase specifically expressed at sites of
            mineralisation in bone and cartilage
  JOURNAL   Bone 34 (4), 629-637 (2004)
   PUBMED   15050893
REFERENCE   10 (bases 1 to 1910)
  AUTHORS   Houston,B., Paton,I.R., Burt,D.W. and Farquharson,C.
  TITLE     Chromosomal localization of the chicken and mammalian orthologues
            of the orphan phosphatase PHOSPHO1 gene
  JOURNAL   Anim Genet 33 (6), 451-454 (2002)
   PUBMED   12464021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL593858.20.
            
            On Jul 29, 2009 this sequence version replaced NM_153104.2.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ457190.1, SRR7345562.4640307.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AL593858.20        116187-116396
            211-320             AL593858.20        120353-120462
            321-1910            AL593858.20        122238-123827
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..1910
                     /gene="Phospho1"
                     /gene_synonym="D11Moh36; Phospo1"
                     /note="phosphatase, orphan 1"
                     /db_xref="GeneID:237928"
                     /db_xref="MGI:MGI:2447348"
     exon            1..210
                     /gene="Phospho1"
                     /gene_synonym="D11Moh36; Phospo1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..320
                     /gene="Phospho1"
                     /gene_synonym="D11Moh36; Phospo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1079
                     /gene="Phospho1"
                     /gene_synonym="D11Moh36; Phospo1"
                     /EC_number="3.1.3.75"
                     /codon_start=1
                     /product="phosphoethanolamine/phosphocholine phosphatase"
                     /protein_id="NP_694744.1"
                     /db_xref="CCDS:CCDS36288.1"
                     /db_xref="GeneID:237928"
                     /db_xref="MGI:MGI:2447348"
                     /translation="MSGCFPAVGLRCLSRDGRMAAPGAPRFLLTFDFDETIVDENSDD
                     SIVRAAPGQQLPESLRATYREGYYNEYMQRVFKYLGEQGVRPRDLRAVYETIPLSPGM
                     GDLLQFIAKQGSCFEVILISDANTFGVESALRAAGHHSLFRRILSNPSGPDARGLLTL
                     RPFHTHSCSRCPANMCKHKVLSEYLRERARDGVHFERLFYVGDGANDFCPMGLLAGGD
                     VAFPRRGYPMHRLIQEAQKAEPSSFRAHVVPWETAADVRQHLQQVLKMC"
     exon            321..1910
                     /gene="Phospho1"
                     /gene_synonym="D11Moh36; Phospo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phospho1"
                     /gene_synonym="D11Moh36; Phospo1"
                     /note="hexamer: AATAAA"
     polyA_site      1910
                     /gene="Phospho1"
                     /gene_synonym="D11Moh36; Phospo1"
                     /note="major polyA site"
ORIGIN      
        1 ccgggtgctg cggctgccgc agcgcccgcc gcggctcggg ctctggctcc ccggcattta
       61 aaggggacgc ggcggcggcc ccgaggatgg ggggcaggtg gaagggacgg agcagaagca
      121 catcatccac agtccctcgg ggctggaggg attcgtgagc cggagctcag aaatccgggg
      181 gtggataaga ccgcgtaccc cccaaatccc gagctctgga tgacagctgg agaccaacag
      241 tttctaaagg tggtggttaa gataatatac tgacaatgag cgggtgtttt ccagctgttg
      301 gactacgatg cctatctagg gacggcagga tggctgcgcc gggcgcgcct cgcttcctcc
      361 tcaccttcga cttcgatgag accatcgtgg acgagaacag cgacgactcg atcgtgcgtg
      421 ccgcgccagg ccagcaactg cccgagagcc tgcgtgccac ctatcgcgag ggctactaca
      481 atgagtacat gcaacgagtc tttaagtacc tgggtgagca gggtgtacgg ccccgggacc
      541 tgcgcgctgt ctacgagacc atccccctgt cgccaggcat gggcgatttg ttgcagttca
      601 tagccaaaca gggctcctgc ttcgaggtta ttctcatttc ggatgccaac accttcggtg
      661 tggagagtgc cctgcgtgcc gctggccacc acagtttatt ccgccgcatc ctcagcaacc
      721 cgtcggggcc cgacgcgcgg ggactgctga cgctgcggcc cttccacacg cacagctgct
      781 cgcgctgccc ggccaacatg tgcaagcaca aggtgctcag cgaatacctg cgtgagcggg
      841 cccgcgacgg cgtgcacttc gagcgcctct tctacgtggg tgatggtgca aatgactttt
      901 gccccatggg gctgctggcg ggcggggacg tggccttccc gcgccgcggc taccccatgc
      961 accgcctcat ccaggaggca cagaaagctg agcccagctc cttccgcgcc cacgtggtgc
     1021 cctgggaaac agccgccgat gtgcgccaac atctgcaaca ggtgctgaag atgtgttgaa
     1081 gaccatcgcc tgccaggggt gctcgggaca accgacggag gagggacggg actggggatt
     1141 ggttaggatc acctagtttt actaccctcc tctttccttt cgctttgcta tgctcctccg
     1201 ggcatatctg gaattcagtc tgcttgtggg ctgggagcag gggttcagag ccgtccctat
     1261 ctatgcagtt aacacagctc tgctgccttc cctccaggga ggtgagcacc ccttggaagg
     1321 caggcagtgc ccctcgaact gagaggaacg ggttcctgga agttgggaga aggaacatct
     1381 cccacttact ttagctgctg taccggctgc ataacctcct ctgcccagtc tttcaaacgg
     1441 actcaggatc ccccaatccg catgccagta ccagattcct cgcggcagac ctatgatgct
     1501 ctcagaagac agctctaggt cttgatcttg cttcagccaa cgcaacccta cactaccgct
     1561 gcgctggctg cgccttgctt ccttccccct ctccaccccc accccacccc cgcccaccag
     1621 acacccccca cccacccaaa ggaagaaaaa gtcagaagga actaccgcct cctgctggta
     1681 gaacgaggta gaagaaccga ccactgacct cggagagtgt gaaaaatcct agcactccag
     1741 caagagacca gggacttcac caaagtcgtc ccctcccccc ccgcacccct ccccccttgc
     1801 attccccttt gcccttatgg aacagaaagc catgttttta agcagagcca gggaaaccca
     1861 agcccttccc ctctctggag tttcagacca ataaaggagg tgaaggggga
//
