LOCUS       NM_001122594            7854 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PH domain and leucine rich repeat protein phosphatase
            2 (Phlpp2), mRNA.
ACCESSION   NM_001122594 XM_146511 XM_916673
VERSION     NM_001122594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7854)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7854)
  AUTHORS   Wang,L., Wang,C., Sun,Z., Du,A., Shan,F. and Sun,Z.
  TITLE     Knockdown of Mmu-circ-0001380 Attenuates Myocardial
            Ischemia/Reperfusion Injury via Modulating miR-106b-5p/Phlpp2 Axis
  JOURNAL   J Cardiovasc Transl Res 16 (5), 1064-1077 (2023)
   PUBMED   37474690
  REMARK    GeneRIF: Knockdown of Mmu-circ-0001380 Attenuates Myocardial
            Ischemia/Reperfusion Injury via Modulating miR-106b-5p/Phlpp2 Axis.
REFERENCE   3  (bases 1 to 7854)
  AUTHORS   Sharma,M. and Dey,C.S.
  TITLE     PHLPP isoforms differentially regulate Akt isoforms and AS160
            affecting neuronal insulin signaling and insulin resistance via
            Scribble
  JOURNAL   Cell Commun Signal 20 (1), 179 (2022)
   PUBMED   36376971
  REMARK    GeneRIF: PHLPP isoforms differentially regulate Akt isoforms and
            AS160 affecting neuronal insulin signaling and insulin resistance
            via Scribble.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7854)
  AUTHORS   Li,D.F., Chang,X., Zhao,J.L., Chen,X.M., Xu,Z.L., Zhang,D.G.,
            Wu,B.H., Wang,L.S., Bai,Y. and Yao,J.
  TITLE     Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial
            Pyroptosis by Activating the NF-kappaB Signaling Pathway
  JOURNAL   Oxid Med Cell Longev 2021, 5570731 (2021)
   PUBMED   34394827
  REMARK    GeneRIF: Colonic Epithelial PHLPP2 Deficiency Promotes Colonic
            Epithelial Pyroptosis by Activating the NF-kappaB Signaling
            Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7854)
  AUTHORS   Lupse,B., Annamalai,K., Ibrahim,H., Kaur,S., Geravandi,S.,
            Sarma,B., Pal,A., Awal,S., Joshi,A., Rafizadeh,S., Madduri,M.K.,
            Khazaei,M., Liu,H., Yuan,T., He,W., Gorrepati,K.D.D., Azizi,Z.,
            Qi,Q., Ye,K., Oberholzer,J., Maedler,K. and Ardestani,A.
  TITLE     Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells
            in diabetes
  JOURNAL   Cell Rep 36 (5), 109490 (2021)
   PUBMED   34348155
  REMARK    GeneRIF: Inhibition of PHLPP1/2 phosphatases rescues pancreatic
            beta-cells in diabetes.
REFERENCE   6  (bases 1 to 7854)
  AUTHORS   Lai,M., Gonzalez-Martin,A., Cooper,A.B., Oda,H., Jin,H.Y.,
            Shepherd,J., He,L., Zhu,J., Nemazee,D. and Xiao,C.
  TITLE     Regulation of B-cell development and tolerance by different members
            of the miR-17 approximately 92 family microRNAs
  JOURNAL   Nat Commun 7, 12207 (2016)
   PUBMED   27481093
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7854)
  AUTHORS   Wen,Y.A., Li,X., Goretsky,T., Weiss,H.L., Barrett,T.A. and Gao,T.
  TITLE     Loss of PHLPP protects against colitis by inhibiting intestinal
            epithelial cell apoptosis
  JOURNAL   Biochim Biophys Acta 1852 (10 Pt A), 2013-2023 (2015)
   PUBMED   26187040
REFERENCE   8  (bases 1 to 7854)
  AUTHORS   Nowak,D.G., Cho,H., Herzka,T., Watrud,K., DeMarco,D.V., Wang,V.M.,
            Senturk,S., Fellmann,C., Ding,D., Beinortas,T., Kleinman,D.,
            Chen,M., Sordella,R., Wilkinson,J.E., Castillo-Martin,M.,
            Cordon-Cardo,C., Robinson,B.D. and Trotman,L.C.
  TITLE     MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to
            IL6 Secretion and AKT Suppression via PHLPP2
  JOURNAL   Cancer Discov 5 (6), 636-651 (2015)
   PUBMED   25829425
REFERENCE   9  (bases 1 to 7854)
  AUTHORS   Li,X., Stevens,P.D., Liu,J., Yang,H., Wang,W., Wang,C., Zeng,Z.,
            Schmidt,M.D., Yang,M., Lee,E.Y. and Gao,T.
  TITLE     PHLPP is a negative regulator of RAF1, which reduces colorectal
            cancer cell motility and prevents tumor progression in mice
  JOURNAL   Gastroenterology 146 (5), 1301-12 (2014)
   PUBMED   24530606
  REMARK    GeneRIF: PHLPP is a negative regulator of RAF1, which reduces
            colorectal cancer cell motility and prevents tumor progression in
            mice.
REFERENCE   10 (bases 1 to 7854)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048472.1, AC122807.3 and AI481772.1.
            
            On Apr 23, 2010 this sequence version replaced NM_001122594.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117961.1, AK048260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1683              AK048472.1         2-1684
            1684-1740           AC122807.3         43470-43526         c
            1741-1896           AC122807.3         40476-40631         c
            1897-2097           AC122807.3         37726-37926         c
            2098-2260           AC122807.3         33088-33250         c
            2261-2391           AC122807.3         32292-32422         c
            2392-2502           AC122807.3         31638-31748         c
            2503-2697           AC122807.3         30718-30912         c
            2698-2929           AC122807.3         29138-29369         c
            2930-7442           AC122807.3         22115-26627         c
            7443-7854           AI481772.1         1-412               c
FEATURES             Location/Qualifiers
     source          1..7854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.33 cM"
     gene            1..7854
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /note="PH domain and leucine rich repeat protein
                     phosphatase 2"
                     /db_xref="GeneID:244650"
                     /db_xref="MGI:MGI:2444928"
     exon            1..115
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..4084
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /EC_number="3.1.3.16"
                     /note="GTPase activating protein and VPS9 domains 1"
                     /codon_start=1
                     /product="PH domain leucine-rich repeat-containing protein
                     phosphatase 2"
                     /protein_id="NP_001116066.2"
                     /db_xref="CCDS:CCDS57644.1"
                     /db_xref="GeneID:244650"
                     /db_xref="MGI:MGI:2444928"
                     /translation="MGEVEPVPAGPLEPPEPPEAAAPRRPGGIRVLKRNMKHNGSRTC
                     LNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTSSSSSSSSSSDLHLVLCTVE
                     TPASEICAGEGRESLYLQLHGDLVRRLEPSERPLQIVYDYLSRLGFEDPVRIQEEATN
                     PDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSV
                     KDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQAS
                     KVVSQRMSTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLHKFSQLK
                     GLNLSHNKLGLFPVLLCEISTLTELSLSCNGFHDLPSQIGKLLNLQTLSLDGNGLTAL
                     PDELGNLRQLTSLGISFNDFRHIPEVLEKLTMLDKVAMAGNRLEVLNLGALTRMSQVK
                     HVDLRMNHLKTVITENMEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELT
                     LSGFSLRTLYASWNRLTAVNVYPVPSLLTSLELSQNLLECVPDWACEAKKLEILDISH
                     NLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDIQHNTLSRLPDTLFSK
                     ALNLRYLNASANSLESLPSACAGEESLSVLQLLYLTSNLLTDQCIPVLVGHPHLRVLH
                     LANNQLQTFPASKLNKLEQLEELNLSGNKLTAIPTTIANCKRLHTLVAHANNISIFPE
                     ILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDMFSHITALK
                     IDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLCVSALAMDNFAEGVGAVYGMFDGDRN
                     EELPRLLQCTMADVLLEEVQHSTNDTVFMTNTFLVSHRKLGMAGQKLGSSALLCYIRP
                     DTADPTSSFSLTVANVGMCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITED
                     NKVNGVTCCTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKALWEHLSYLEAVN
                     AVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFA
                     STAALKDTPKPTTPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNTVGLEASLLPRP
                     ERRCSLHPASSAGVFQRQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIH
                     CCRGREPESSPPLPKNSSNACSEERARGAGFGIRRQNSVNSGILLPANRDKMELQKSP
                     STSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFVVPRDLE
                     EEVKEQMKQHQEGRPEPEPRGEERTEPLEEFDTAL"
     exon            116..396
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            397..530
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            531..721
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            722..847
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1002
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1149
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1380
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1583
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1644
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1740
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1896
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2097
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2260
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2391
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2502
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2697
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2929
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..7847
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7809..7814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /note="hexamer: AATAAA"
     polyA_site      7836
                     /gene="Phlpp2"
                     /gene_synonym="C130044A18Rik; Phlppl"
                     /note="major polyA site"
ORIGIN      
        1 aaatccttgg ccgccaatgg gggaggtgga gcccgtgccc gcgggcccgc tggagccccc
       61 ggagccacct gaagcggcgg cgcctcgccg gcccggaggg attcgggtcc taaagagaaa
      121 tatgaaacac aatgggagca gaacttgttt gaatagaaga agtaggtttg gttcccgaga
      181 aagagactgg ctaagagaag atgtgaagag aggctgtgtt tacctttatg gagcagacac
      241 gaccactgcc actacaacca cctcctcctc ctcctcctcc tcctcctctt ctgatttaca
      301 tcttgtcctt tgcacagtag agacaccagc gtcagaaata tgtgctggag agggaagaga
      361 aagcctctat ctacagcttc atggagatct ggtcaggaga ctggagccct ctgaacggcc
      421 tctccagatt gtttacgatt acttatccag gctggggttt gaagatcccg tgcgcataca
      481 ggaggaggct acgaaccctg acctcagctg tatgattcga ttttatggtg aaaaaccatg
      541 ccagatggat catctggatc gaatcctact gtctggcatc tataatgtac gcaaaggaaa
      601 aacccagctg cacaaatggg ctgagcgcct cgttgttctc tgtggtacct gccttattgt
      661 ttcctcagtg aaggattgtc aaactggaaa gatgcacatt ttgccgctgg ttgggggaaa
      721 gatagaagaa gtgaagcgcc ggcagcactc ccttgctttc agctcagctg gagcccaagc
      781 tcagacctat catgtcagct ttgagacttt ggctgagtac cagagatggc aacggcaggc
      841 gtctaaggtg gtgtcgcagc ggatgagcac tgtggacctc tcatgctaca gccttgaaga
      901 ggttcctgag catctcttct acagccaaga catcacctac ctcaacctgc ggcacaactt
      961 catgcagcta gaaagaccag ggggccttga cacactccac aaattttctc aactgaaggg
     1021 cctgaacttg tcccataata aacttggact gtttcctgtg ctgctgtgtg agatttctac
     1081 cctgactgag ctcagccttt cttgtaatgg atttcatgac ttgccaagtc agattggtaa
     1141 attgctaaat cttcagaccc tcagcctcga cggcaacggc ctcacggctc tgccagatga
     1201 gttgggaaac ctgcggcagc tcacttctct gggaatttcc ttcaacgatt ttcgtcacat
     1261 ccctgaagtt ttggagaaac ttaccatgtt agataaagtg gctatggcag gaaaccgttt
     1321 ggaggtcctg aacctggggg cactgaccag gatgagccag gtcaagcacg tggatctgag
     1381 gatgaaccac ttgaaaacgg tgattactga aaatatggaa ggaaataaac atatcacgca
     1441 catggatttg cgggacaatc agttgactga tttggacctt agctccttat gtagcttgga
     1501 gcagctgcac tgtgagcgga accagctgag ggagctgaca ctcagcggct tctcccttcg
     1561 aaccctctac gccagttgga acaggctgac ggcagtgaat gtgtacccag tgcccagcct
     1621 gctcacttct ttggagctct cccaaaactt gctggagtgt gtccctgact gggcctgtga
     1681 agcaaaaaag ctggaaatac tagacataag ccacaatctt cttacagagg tccccatgag
     1741 aattctgagt agtctgagtc ttcggaaact gatggtagga cacaatcaca tccatgtcct
     1801 tcctgcactg gtggagcaca ttcccctcga ggtcctggat atccagcata acactctctc
     1861 caggctgccg gacacgctct tctccaaggc cttaaatctc aggtacttga atgcatctgc
     1921 aaatagtctg gagtccttgc cttctgcgtg tgctggagag gagagtctga gtgtgctgca
     1981 gctgctgtac ctgaccagca accttctgac agatcagtgc ataccagttt tggtcgggca
     2041 cccacacctg cgagttctgc accttgcaaa caaccagctc cagaccttcc ctgcaagcaa
     2101 gctaaataaa ctggagcagc tggaagagct gaatctaagt gggaacaaac ttacagctat
     2161 ccccacaacc atagccaact gcaaaaggct gcacaccctt gtcgcccatg ccaacaacat
     2221 cagcatcttc ccagagatcc tgcagctgcc tcagattcag tttgtagacc tgagttgcaa
     2281 tgacttgaca gaaatcctaa ttccagaagc tctgcctgct actttacaag accttgatct
     2341 gacaggaaat acaaatctgg tcctggaaca taagactttg gacatgttta gccacatcac
     2401 agccctgaag attgatcaga agcctttgcc agccacagac tctgcagtta catcaacctt
     2461 ctggagccat ggcctggccg agatggcagg gcagaggaat aaactctgtg tgtctgccct
     2521 ggctatggat aactttgcag agggtgtggg agctgtctac ggcatgtttg atggggaccg
     2581 gaatgaagaa ctccctcgtc tgctgcagtg tacaatggca gatgtgcttt tggaagaagt
     2641 acagcactca acaaatgaca cagttttcat gaccaatacc ttcttggtat ctcacaggaa
     2701 attaggaatg gctggccaga agctgggttc ttcggctctc ctgtgctata ttcgacctga
     2761 cactgccgac ccaacaagta gctttagctt gactgtagcc aatgttggca tgtgccaagc
     2821 tgtcctgtgc cgaggtggga agccagtacc tctttctaaa gtcttcagct tggagcatga
     2881 cccagaggag gctcagaggg tgaaagacca gaaagccatc ataacagagg acaacaaggt
     2941 gaacggagta acctgctgca cccggctgct ggggtgcaca tacctctacc catggatcct
     3001 ccccaagccc cacatagctt ccactccact taccattcaa gatgaattgc tgattttggg
     3061 aaacaaagca ctgtgggaac acttgtcata tctagaagct gtcaatgcag tacgtcacgt
     3121 gcaagaccca ctagctgctg ctaagaagct gtgcacatta gcccagagct acggttgtca
     3181 ggacaacgtg ggggcaatgg tggtttattt gaatattggt gaagaaggct gtacctgtga
     3241 aatgaatggg ctcacccttc caggccctgt gggatttgct tcaactgcag ccctcaagga
     3301 tactcccaag ccaaccactc cctcctccag tagtgggatt gcctccgagt tcagcagtga
     3361 gatgtccacc tcagaggtga gcagtgaagt gggctccacg gcctcggatg agcacaacac
     3421 tgtgggcctg gaggcgagct tgctgcccag gccagagagg cgctgcagtc tgcacccagc
     3481 gtcctccgca ggggtgttcc agcgccagcc ttcttgtgct actttttcca gcaatcagtc
     3541 tgacaatggc ctggacagtg acgatgacca gcctgttgaa ggagtcataa ccaacggcag
     3601 cagggttgaa gtagaggtag acatccattg ctgccgaggc agagagccag agagctcccc
     3661 tccgctcccg aagaactctt ccaacgcctg ttcagaggag cgtgctagag gggcggggtt
     3721 tgggatccga agacagaaca gtgtcaacag tggtatactt ctgccagcga acagagacaa
     3781 gatggagctg cagaagtctc cctccacttc ttgtctgtat ggaaagaaac tctccaatgg
     3841 ctccattgtg cccctagagg acagcctgaa cctcattgag gtggccacag aagcacccaa
     3901 aaggaaaact ggctactttg ctgcccccac tcagctggaa ccagaggatc agtttgtcgt
     3961 ccctcgagac ctggaagagg aagtgaagga gcagatgaag cagcaccagg agggcaggcc
     4021 tgagcccgag ccccggggag aggagcggac agagcccctg gaggagtttg atacagcact
     4081 gtgattgtac ctctcgtgtg gacgcagcct gagggagggc tgtgtggtat tggggaaggg
     4141 accttcagga gatatttgcc tcagtgtttc aaaccataga taatatggag tagaatttgg
     4201 agccaaaaag ttgagcacta gcagggtctg gctcttgatg ggctcggacc gccatcagtg
     4261 ttaagcttca cattggacct tggttggact cccagcgttg ctgggagaca gcagatgttc
     4321 tgtgtcagtc ctgccacctg ccattaaccc tttctctcct aggatcattt gagaaattgc
     4381 ctgcctgggc aggaaaggga ctatttctgt ggaggaagta actgaaggtt gattcccttt
     4441 actaattgct gctgatggat ctctgtgaca agagaaatca ccttatctct cagactaact
     4501 agtgggatgt gatgtgacta gtcacatggc tttttattct ctaggagaat acagcctatc
     4561 aaatgtctac tggagataca gaaccaatca agcaggtgac ttatgtatgt aatgttgtgt
     4621 aacgagagca cttttcattg actgtgaacc ttttattttt gaatctgcac tcggagccaa
     4681 tcttcttaga ggcagcccag ctcctttgtc cctaggtaga agtcattgag cattggagcc
     4741 tctttgaggg tgcttgggag ggtcctggaa gttgatgtgc tggatgtcag actgggaaag
     4801 ctcctgagaa acttggggtg ggtgggtggg gatttataag atgggggagg agtgagaact
     4861 aagtcaagtc aaagagactc agccttggat aagctgaccc ctgctaggaa ctaggatccc
     4921 aaggcaggga cttgtgggtt tgcctctttt ccttaatgtg gtagacttgg cagctagcca
     4981 gcctcttgac aggtgggctg actccttgaa ttatagcaag tgagtacaac aggagaccag
     5041 ctaggaacat atatgggcag ccagatctca caagttagac ttgctcccct ctctctctct
     5101 ctctctctct ctctcttctt actcttcttt ctcttctctt ctcttccctc cttctcttcc
     5161 ctccttccct cccttcctcc ttccctccct ccctctctca ggatgttttc tagaatgttg
     5221 tagtgagtgt gttgtttggc actgtgccct tctgaatatt gctgagtccc ctgacatggt
     5281 gacatggttc aaagtgctgg cctcaacaca gaggaagaaa gactattcaa ctgagcgatt
     5341 gctaaactta cagaaaacct gtaatttttt tttcacattc ctcttaactc tagcaagtga
     5401 ccacttcttg tgtatttctg ttgctctttc cgtaggttac taaggaaact cattcctatt
     5461 tattgatgta aattttggca ttgcttgatt ttactcagtt gaaaaatgtg ctttgaattt
     5521 ttagaatatt gcacaactaa aaaaatagat tggggcattt ttaaaaattt tcctttatag
     5581 aaacaaattg ttaaatataa gattgaaagt gtctattttt cctttgtttt tgaggaggaa
     5641 gtttttgttt aaagcaatac tgaaaagcag acagataatt ctgtcctcag aggccctgtg
     5701 ctcatgtgca cagggttagt ggttacactg ggggtggggt ggggtggagg atgctctatc
     5761 actgcagcag ctgcctaata attcagttct caagaatctg aacgtgagcc cccaagtcgg
     5821 caacactcag cttccttctg tcagttactg tcagttactg ggaaacatta gaactcaggt
     5881 gcttgatttg agatggggac ccagcggctt atacagattg taggtgtact gcagggagga
     5941 gagaccatgg caccaccttg tgttcccacc ttatttttat atgggaaact tgaagaaaaa
     6001 aaaaagaaag aaaatgagag tgaaggaaaa acacaaggtg aggatgctgc agagagcctc
     6061 ctgctcagca gagcctttga gctgaagaac gagaggtggt gattatgaga aaccagttat
     6121 gtggaaaagc agcacttcgg tagtcttaga acaattgtct ttttattata tgtgatctgt
     6181 tttcttatcc tctgtttgtt tacctcccca ttcactaaag tcgcctcaaa actcagttct
     6241 aaacggatct tgacaaacat gaacgtactt cccttctggt tagcagaact ctggggtgca
     6301 gggtcctttg tgggggttca gggttcctta ggttgtgttg agaaacctca gtgtaggcca
     6361 aaccaaaatg gatggttctg gttttgtaat tgtctttctt tcatgtccta ttatactctg
     6421 tattaaaaaa cagagggtta aaaggccata gtccatttcc caaaacgtaa tacacgcctc
     6481 ttgtaacagt gaggtgattt gctgatgttt ttatctgagt aggctgtcag gtgagtgtga
     6541 ttcctttccc gtacccagag ggtacattct ccaggtggcc agaggacagg ttccttctta
     6601 cacagagcct gccctccctc tatatgattc ttggtctctg cccacatctc ccgttcagtt
     6661 aatttaaaca aatctctgag gccaggtgtg gtggcacagt ggctcacacc tgcaaatctg
     6721 cacgcacatg ggaggttaaa gcaggagaat cagggatgag ggttagcctt ggctacagag
     6781 agttcaaatc cagtctggta tacatgagtc ccagcctcaa aaccaaacaa acaggatttc
     6841 tgaagaaaga gcactcggct gttgggtgtg gttcaggaag ctcactggca gagagtgtct
     6901 gtggccccag tcaaggtttt tacccagtga cagataactg gaaatgacaa tgttgatagg
     6961 aaataaagtg tggtgccacc atggagtcat ccctggccac tcccgacaca agcgaggctt
     7021 gactatacta ctgtggagta tacacgtgca ataatcagtg aactcaatcc ctggtggaca
     7081 gaagagccgc ccaagctgcg tgtaatctct gggtgctatc acagtgcgtt tcacgagtgc
     7141 tgtttccagg cagttaggtt gggctgaact tgtgagtatc aaacagtgct cttctttctg
     7201 tgtagacctt cagcaaaagc aggtacttgg aaaccacagg ctcaccttct ctatctattc
     7261 agtaattatt aacaaagaga cctccataag ggagcacttg gctgttactg ataatgtacc
     7321 aattgctaaa gaacccgtct ccaagccatc cggtgatgtg tgcagcatca ctgtagaact
     7381 gtcccgtgcc gctcttcact tccctttggg tggagccttt tcgactcccc atggcaggct
     7441 aatctttctc tccaggtagt aacttggccc cgaggttggg caagtactcc ccagactgag
     7501 agaagcggct gcgtcacatc tgctgtgttc cgtcattggt gatcagccag tcagcattcg
     7561 ctccctgtgt ctaactctct ctctcgcacc tctcccagat gctatctatc gggttttctc
     7621 actgttgcca gtggatgtca tccaaacagt gggctcatat cttatggttt ttgtgcaatc
     7681 attgtcgtat tgtagtccta agactcatta tagtgtattt ttgatatttt tgaaatgtgt
     7741 taaatttttt aattcaataa tatgagccag agcatgttgc agcaaatcta ttgtttgtaa
     7801 aaaataataa taaacaataa ataaaataaa atgggatatc ttttccaaaa aaaa
//
