LOCUS       NM_153412               5496 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pleckstrin homology like domain, family B, member 2
            (Phldb2), transcript variant 2, mRNA.
ACCESSION   NM_153412 XM_489563
VERSION     NM_153412.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5496)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5496)
  AUTHORS   Xie,M.J., Yagi,H., Iguchi,T., Yamazaki,H., Hanamura,K.,
            Matsuzaki,H., Shirao,T. and Sato,M.
  TITLE     Phldb2 is essential for regulating hippocampal dendritic spine
            morphology through drebrin in an adult-type isoform-specific manner
  JOURNAL   Neurosci Res 185, 1-10 (2022)
   PUBMED   36162735
  REMARK    GeneRIF: Phldb2 is essential for regulating hippocampal dendritic
            spine morphology through drebrin in an adult-type isoform-specific
            manner.
REFERENCE   3  (bases 1 to 5496)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5496)
  AUTHORS   Xie,M.J., Ishikawa,Y., Yagi,H., Iguchi,T., Oka,Y., Kuroda,K.,
            Iwata,K., Kiyonari,H., Matsuda,S., Matsuzaki,H., Yuzaki,M.,
            Fukazawa,Y. and Sato,M.
  TITLE     PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA
            receptor density and PSD95 turnover
  JOURNAL   Sci Rep 9 (1), 4305 (2019)
   PUBMED   30867511
  REMARK    GeneRIF: PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA
            and AMPA receptor density and PSD95 turnover.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5496)
  AUTHORS   Lim,B.C., Matsumoto,S., Yamamoto,H., Mizuno,H., Kikuta,J., Ishii,M.
            and Kikuchi,A.
  TITLE     Prickle1 promotes focal adhesion disassembly in cooperation with
            the CLASP-LL5beta complex in migrating cells
  JOURNAL   J Cell Sci 129 (16), 3115-3129 (2016)
   PUBMED   27378169
REFERENCE   6  (bases 1 to 5496)
  AUTHORS   Basu,S., Sladecek,S., Martinez de la Pena y Valenzuela,I.,
            Akaaboune,M., Smal,I., Martin,K., Galjart,N. and Brenner,H.R.
  TITLE     CLASP2-dependent microtubule capture at the neuromuscular junction
            membrane requires LL5beta and actin for focal delivery of
            acetylcholine receptor vesicles
  JOURNAL   Mol Biol Cell 26 (5), 938-951 (2015)
   PUBMED   25589673
  REMARK    GeneRIF: A transport system, organized by agrin through PI3 kinase,
            GSK3beta, CLASP2, and LL5beta, for precise delivery of
            acetylcholine receptor vesicles from subsynaptic nuclei to
            overlying synaptic membrane was identified at neuromuscular
            junction membrane.
REFERENCE   7  (bases 1 to 5496)
  AUTHORS   Hiepen,C., Benn,A., Denkis,A., Lukonin,I., Weise,C.,
            Boergermann,J.H. and Knaus,P.
  TITLE     BMP2-induced chemotaxis requires PI3K p55gamma/p110alpha-dependent
            phosphatidylinositol (3,4,5)-triphosphate production and LL5beta
            recruitment at the cytocortex
  JOURNAL   BMC Biol 12, 43 (2014)
   PUBMED   24885555
  REMARK    GeneRIF: These results provide evidence for an important
            contribution of the BMP2-PI3K (p55gamma/p110alpha)- PIP3-LL5beta
            signalling axis in mesenchymal progenitor cell chemotaxis.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5496)
  AUTHORS   Kishi,M., Kummer,T.T., Eglen,S.J. and Sanes,J.R.
  TITLE     LL5beta: a regulator of postsynaptic differentiation identified in
            a screen for synaptically enriched transcripts at the neuromuscular
            junction
  JOURNAL   J Cell Biol 169 (2), 355-366 (2005)
   PUBMED   15851520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164979.2 and AC166572.1.
            
            On Nov 15, 2011 this sequence version replaced NM_153412.3.
            
            Transcript Variant: This variant (2) lacks an exon and uses an
            alternate splice site in the coding region, but maintains the
            reading frame, compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF506821.1, SRR10223970.18611.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC164979.2         40575-40745         c
            172-1508            AC164979.2         21126-22462         c
            1509-1892           AC164979.2         4493-4876           c
            1893-2036           AC166572.1         801-944
            2037-2174           AC166572.1         2011-2148
            2175-2303           AC166572.1         14523-14651
            2304-2459           AC166572.1         22183-22338
            2460-2570           AC166572.1         23274-23384
            2571-2660           AC166572.1         25838-25927
            2661-2804           AC166572.1         28553-28696
            2805-2945           AC166572.1         31365-31505
            2946-3045           AC166572.1         32869-32968
            3046-3250           AC166572.1         40526-40730
            3251-3341           AC166572.1         45433-45523
            3342-3488           AC166572.1         46395-46541
            3489-3708           AC166572.1         52075-52294
            3709-3794           AC166572.1         54828-54913
            3795-5496           AC166572.1         55709-57410
FEATURES             Location/Qualifiers
     source          1..5496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.08 cM"
     gene            1..5496
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /note="pleckstrin homology like domain, family B, member
                     2"
                     /db_xref="GeneID:208177"
                     /db_xref="MGI:MGI:2444981"
     exon            1..171
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            172..1508
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3935
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein LL5-beta"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family B member
                     2 isoform 2"
                     /protein_id="NP_700461.2"
                     /db_xref="CCDS:CCDS28202.1"
                     /db_xref="GeneID:208177"
                     /db_xref="MGI:MGI:2444981"
                     /translation="MAEDSHMQKQLEFQNGSLEEGFVVRSLENEPQNMMESLSPRKYS
                     SSLKFKANGDYSGSYLTLSQPVSAKRSPSPMGTSVRSSPSLAKIQGSKQFCDGIDKNI
                     SMKPPISFLSSAASLGGYPLGKADLDHYTGRDSERSTRLSEKPPYSRYSSRNKSHDSV
                     YFLGGLEGRKTSGSLLTMWNGNSLSCTGSSPISRSGAASMPSSPKQVRKMNLQDHSTL
                     QPRLSRHKEPASENVSVRTRKYSGSSLSNMGAYSRSLPRLYKATDNQMSPLSLPPRSS
                     LGNSRRGQLGEKDLPHSLVDSDNYLNFSSLSSGASPYKTCLSEGNPYVSSALSVPASP
                     RVARKMLLASTSSDDFDRASYSGTSPSHSFISGEPDRVLVARRNFSCGSMELDDSDLE
                     SLRQSSETPQPVLRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL
                     SLCAEYTKPEGRRLSAGTTVADVQKINKELEKLQLSDEESVFEDALVCPDARYRCHRK
                     GSLQDVDVAGFGNLGHSASFLAPRGSRSDELLGDLTRTPPSSSAAFLKATNESSYLSI
                     LPKTPEDIGEEQRTQELAAMEDARMVILNNLEELEQKIKDINDQMDESSRELDMECAL
                     LDGEQKSETAELMKEKEILDHLNRKITELEKNIVGEKTKEKVKLDAEREKLERLQELY
                     SEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLT
                     QQLLREVAEYQRNIVARKEKISALKKQASHIVQQAQREQDHFVKEKNNLIMMLQREKE
                     NLCNLEKKYSSLTGGKGFPINPNTLKEGYISVNEINESCGNSTNLSPSTQFPADADAA
                     VTEPALAVPVSQPQSSEHFRSLEERKKQHKEGLYLSDTLPRKKTTPSLSPHFSSATMG
                     RSTTPKAHLPLGQSNSCGSVLPHSLATMTKDSESRRMLRGYNHQQMSEGQRQKPEFYS
                     RTASESNVYLNSFHYPDRSYKDQAYDTLSLDSSDSMETSISACSPDNISSASTSNIAR
                     IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLI
                     EKEVKIREKQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCFHVSITEKTCRGYL
                     IKMGGKIKTWKKRWFVFDRNKRTFSYYADKHEAKLKGVIYFQAIEEVYYDHLKNANKS
                     PNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL"
     exon            1509..1892
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2036
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2174
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2303
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2459
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2570
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2660
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2804
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2945
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3045
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3250
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3341
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3488
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3708
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3794
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..5496
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5466..5471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /note="hexamer: ATTAAA"
     polyA_site      5483
                     /gene="Phldb2"
                     /gene_synonym="C820004H04Rik; LL5b; LL5beta"
                     /note="major polyA site"
ORIGIN      
        1 gggaggggcg cccggagtgc gcggtgtgcg gcggcagggt ctggctgcag cctgcggcag
       61 cggcggggac cggactagga cacagggaga gagggagggc ggaggcaagg gacaggccca
      121 agggcagcgg gacccgagga gagagttgca gttccagaga aagatgagct ggatccagcc
      181 atattatggc agaagatagc cacatgcaaa agcagctgga attccaaaat ggtagcttag
      241 aggaaggatt tgtggtacgt tccctggaga acgagcccca aaacatgatg gagagcctaa
      301 gcccgaggaa atactcatca agtctgaagt ttaaagccaa cggggactat tctggctcct
      361 atttaaccct ctcccaaccg gtgtctgcca agagaagccc ttctccaatg ggcaccagcg
      421 tcaggagcag tccctccttg gccaaaatcc agggaagcaa acagttctgc gatggaattg
      481 ataaaaatat ttccatgaaa cctcctattt ctttcctcag ttctgcagcc tctcttggcg
      541 gctatcctct tgggaaagca gatttggatc attatactgg tcgagacagt gagaggtcca
      601 ccaggctctc agagaagcct ccctattcca gatacagctc taggaataaa tctcatgaca
      661 gtgtctactt tctagggggg ctggaaggaa gaaaaacctc tggctcgctc ctgaccatgt
      721 ggaacggaaa ttccttgagc tgcactggct cgtcacccat cagcaggtct ggggcagcga
      781 gcatgccttc aagtccaaag caagtcagga agatgaacct tcaggaccac tcgacacttc
      841 agcccaggtt aagcaggcac aaggagccgg cctcagaaaa cgtcagtgtg agaacaagga
      901 aatactcagg gagcagtctg agtaatatgg gtgcctacag ccgatcgctt cccaggttgt
      961 ataaagccac agacaaccag atgtcgcctc tcagcctgcc tccaagaagt tccctgggca
     1021 attccagaag aggtcagtta ggagaaaagg atctacctca tagcctagtg gatagtgaca
     1081 attaccttaa cttttcttct ctaagctcag gggcttcacc ctataaaacc tgtctgtcag
     1141 agggaaatcc ttacgtaagc tccgccctca gtgttcctgc cagtcctcgt gtggctcgga
     1201 agatgctcct ggcctccacc tcctctgatg actttgatag ggcttcatac tcagggacca
     1261 gcccaagtca ttccttcatt tctggagagc cagaccgagt gcttgtggcc aggaggaact
     1321 tctcttgtgg atcaatggag cttgatgact ctgatctgga aagcctaaga cagtcgtcag
     1381 aaactccgca gccggtcctt cgagaaagga aaagtagcat tagctccatc tcgggacgcg
     1441 acgacctgat ggattatcac cgaagacaga gggaggagag actcagggag caggagatgg
     1501 agcgactgga gcggcagcgg ctggagacca tcctcagtct ctgtgctgag tatacaaagc
     1561 ctgaaggtcg ccgcctgtcc gctggcacca cggtggctga tgtgcagaaa atcaacaagg
     1621 agcttgagaa gctgcagctg tcggatgagg agtctgtgtt cgaggacgct ctggtgtgcc
     1681 ccgatgccag gtacaggtgc caccggaagg gctctctcca ggatgttgac gttgctggct
     1741 tcgggaacct tggtcacagt gccagcttcc tggcccccag gggcagcagg agcgatgaac
     1801 tgcttggtga cctcactagg acgcccccat catcctcagc cgcgtttctg aaagcaacca
     1861 atgagtcctc ctacctcagt atccttccga agaccccaga ggatataggt gaggaacaga
     1921 ggactcaaga gttggctgca atggaagacg cccggatggt gattctgaac aaccttgagg
     1981 aacttgagca gaaaatcaaa gatataaatg accaaatgga tgaatcttcc agagagttgg
     2041 atatggaatg cgctcttttg gatggagaac agaaatccga gacggctgag ctcatgaagg
     2101 aaaaggagat tctagatcat ctaaaccgga aaatcacgga actagaaaag aacatcgtag
     2161 gcgagaagac taaggagaag gtaaagcttg atgctgagag ggaaaagcta gagaggcttc
     2221 aggagctgta ctccgagcag aagacccagc tggacaattg tcctgagtcc atgagggagc
     2281 agttacagca acaactcaag agggatgccg acctgttgga tgttgagagc aaacactttg
     2341 aagacttgga attccagcag cttgagcatg agagccgcct agatgaggaa aaggagaact
     2401 tgactcaaca gctcctgcgg gaggtggcag agtatcagcg gaacatcgtg gctaggaagg
     2461 aaaaaatttc tgcattgaaa aagcaagcca gtcacatcgt tcagcaggct cagagggaac
     2521 aagatcactt tgtgaaagag aagaacaatc taataatgat gctccaaaga gaaaaagaga
     2581 atctttgcaa tttggaaaag aaatactcca gtctcactgg tgggaaaggg ttccctatta
     2641 accccaatac tctgaaagag ggctatatca gtgtaaatga gattaatgag tcatgtggca
     2701 attccacgaa tctatcccct tccactcagt tccctgctga tgctgatgct gctgtcactg
     2761 agcctgcctt ggctgtgccg gtgagccagc cccagagttc agagcacttt agaagcctgg
     2821 aagaaaggaa aaagcagcac aaagaaggcc tctacctgag tgacactctg cctcgaaaga
     2881 aaaccacccc ttccctgtcc ccacacttca gcagtgccac aatggggagg agcaccaccc
     2941 cgaaggctca cctccctctg gggcagagca atagctgtgg cagtgtgctc cctcactcac
     3001 tggcgaccat gaccaaagac tctgagtctc ggaggatgct cagaggttat aatcaccaac
     3061 agatgagtga aggacaaaga cagaaacccg aattttacag ccgcacagca tctgagtcaa
     3121 acgtctactt gaatagtttc cattacccag atcgcagcta caaggatcag gcctatgaca
     3181 cgttgagcct ggacagctct gacagcatgg agaccagcat ctctgcctgt tcaccggaca
     3241 atatatcaag tgccagcaca tccaatattg ccagaataga agaaatggag agactcttga
     3301 aacaggcgca cgcggagaag actcggctgc ttgagtccag ggaacgggaa atggaagcca
     3361 aaaaacgagc tctggaagaa gaaaaacgac gccgggaaat cctggaaaaa cgattgcaag
     3421 aagaaaccag ccagaggcag aagttaatag aaaaagaagt caaaataaga gagaaacaaa
     3481 gggcacaggc tcgtcccctg actcgctatc tgccagtgcg gaaggaagac ttcgacttgc
     3541 ggagtcacgt ggagactgca ggccacaata ttgacacctg ttttcatgtg tcaatcacag
     3601 agaagacctg ccgaggatac ctcatcaaaa tgggtgggaa aattaaaacg tggaaaaaac
     3661 gctggtttgt ttttgaccgg aataagcgaa cattttctta ctatgcagac aagcatgagg
     3721 ctaaattgaa aggcgtgata tactttcaag ccattgaaga agtgtattat gatcacctca
     3781 agaacgctaa taagagccct aatccattac tcacctttag cgtcaagaca catgacagaa
     3841 tctattacat ggtggctcct tcaccagagg ccatgcggat ctggatggac gttatagtga
     3901 ctggagcaga aggatatacc cacttcctgt tgtagtgaac tttggccatg gtccacttca
     3961 gggaagactg caatagtttc ttacaagagt gaagccatat ccagtctcag atggaaagga
     4021 ctaacagacc catcccttta gttgtgtgca ctcagaactc tttttataat ggagagcctt
     4081 tcatacaaaa ggaagcaggg cccatagtgg taggactgga gctcctacga caaaaacaaa
     4141 aacaaaacac tattttgata aaagcatcat ttagatacac actcttattt ttatcagctg
     4201 gtgttggtta aatgaactga acagtttaca caatatctgt aaatatgtac ttagaaatac
     4261 aagattattt tagaacgcaa ctcattgccc ttgatgatca cctgccatct ttgtaggaag
     4321 tagaatttta taaaagtaga caaataatga cttagaaggc aacaggtttt agacatcttg
     4381 ccttagtttt taaatactgc acccaaacca aagacccggc ttgactcctg tttaacatca
     4441 gagttgctct ctaaatagtc tttaaaatgg gattttgatg ttaattctgt agtatccacc
     4501 ctcccaacaa gctactgtgc ctatataata aaccactttc ttaaaagaat aaaaaccaaa
     4561 acaaacaaac aaacaaacaa aaccctcctt gttttaagaa aaggccatct cagacaacag
     4621 acccctgcaa catcaggcag tttaaattaa ggagaatatt tagtgtgggg atcctgttct
     4681 gtggaaaatt tgtccattct cagtgctgag aatgaaagca agtagtagcc actttcctcc
     4741 agactgctgg attcctctta tgaagtgaac atgttattgg caccctcacg tggcataact
     4801 atgaaatctg tttcactgaa aatctgagca attaaagtat cttttttttt ttcaaaagac
     4861 aaccaaaact caaattacca ttctctatgc tatatctttt tccatgtatc tttacaaatg
     4921 gcctttgttt ttagagctaa tgtttgttga atgaaatgac ttcaggcaag tcttttttta
     4981 taatcatttt tcaagtgcca tttgtgtgtg cgtgtgtgtt ctgtgtttgt aagtatgaac
     5041 aaattatttc ctaaaacatg ccaaatggat agaagtagaa aacaatgttt agaaatgtgt
     5101 ccataaaact gtcaagccaa ctgggcacaa cttaaaagaa acttacagtg tactcttata
     5161 tctttataca tgtttccaaa aataagattt ttgcaactgg atgatgcaag ggtttacttg
     5221 aacaatgaag gaccgagatc atgaccgtag gaggtattat ttcttgtctg tgatttttgc
     5281 agaggttccc cttcaatgtt agtgatctta aacattaaaa tgcaattgtt aagatttggt
     5341 tgcttgatgt aaagatacaa tttgtctgta ctgtactttc ttcataggat tgtaagggtg
     5401 ttctaatcac tttgcatgtc ataaatcttt tagatatgta tgtgggttaa atgtatgaag
     5461 tttggattaa agcgttgacc tcattcacag tggaaa
//
