LOCUS       NM_001413454            5099 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pleckstrin homology like domain, family B, member 1
            (Phldb1), transcript variant 37, mRNA.
ACCESSION   NM_001413454 XM_036154536
VERSION     NM_001413454.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5099)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5099)
  AUTHORS   Zhou,Q.L., Jiang,Z.Y., Mabardy,A.S., Del Campo,C.M.,
            Lambright,D.G., Holik,J., Fogarty,K.E., Straubhaar,J., Nicoloro,S.,
            Chawla,A. and Czech,M.P.
  TITLE     A novel pleckstrin homology domain-containing protein enhances
            insulin-stimulated Akt phosphorylation and GLUT4 translocation in
            adipocytes
  JOURNAL   J Biol Chem 285 (36), 27581-27589 (2010)
   PUBMED   20587420
  REMARK    GeneRIF: PHLDB1 is a novel modulator of Akt protein kinase
            activation by insulin.
REFERENCE   3  (bases 1 to 5099)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5099)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   5  (bases 1 to 5099)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human LL5A gene and mouse
            Ll5a gene in silico
  JOURNAL   Int J Oncol 23 (5), 1477-1483 (2003)
   PUBMED   14532993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151971.3.
            
            On Nov 1, 2022 this sequence version replaced XM_036154536.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.11182.1,
                                           SRR10223971.9111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC151971.3         1356-1506
            152-277             AC151971.3         4377-4502
            278-1629            AC151971.3         6111-7462
            1630-1911           AC151971.3         10854-11135
            1912-2052           AC151971.3         11488-11628
            2053-2190           AC151971.3         11716-11853
            2191-2346           AC151971.3         14736-14891
            2347-2457           AC151971.3         18605-18715
            2458-2547           AC151971.3         18884-18973
            2548-2688           AC151971.3         23080-23220
            2689-2791           AC151971.3         23327-23429
            2792-2836           AC151971.3         23905-23949
            2837-3131           AC151971.3         24556-24850
            3132-3255           AC151971.3         24934-25057
            3256-3402           AC151971.3         26593-26739
            3403-3519           AC151971.3         28286-28402
            3520-3622           AC151971.3         28645-28747
            3623-3708           AC151971.3         34074-34159
            3709-5099           AC151971.3         35078-36468
FEATURES             Location/Qualifiers
     source          1..5099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..5099
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /note="pleckstrin homology like domain, family B, member
                     1"
                     /db_xref="GeneID:102693"
                     /db_xref="MGI:MGI:2143230"
     exon            1..151
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            152..277
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..3849
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /note="isoform 33 is encoded by transcript variant 37;
                     protein LL5-alpha"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family B member
                     1 isoform 33"
                     /protein_id="NP_001400383.1"
                     /db_xref="GeneID:102693"
                     /db_xref="MGI:MGI:2143230"
                     /translation="MLCLGQSTFLRFNHPAEAKWMKSMIPAGVRAPGPTYNPGSAESE
                     SLVNGNHTAQPATRAPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPL
                     SPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPS
                     VPPLVPARSSSYHLALQPPQSRPSGSRSSDSPRLGRKGGHERPPSPGLRGLLTDSPAA
                     TVLAEARRTTESPRLGGQLPVVAISLSEYPSSGARSQPASIPGSPKFQSPVPAPRNKI
                     GTLQDRPPSPFREPPGTERVLTSSPSRQLVGRTFSDGLAATRTLQPPESPRLGRRGLD
                     SMRELPPLSPSLSRRALSPLPARTAPDPKLSREVAESPRPRRWAAHGTSPEDFSLTLG
                     ARGRRTRSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPRAQRKLSSGDLR
                     VPIPRERKNSITEISDNEDELLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSR
                     ADGGPETGELPSIGEATAALALAGRRPSRGLAGAIVVSGRCGEESGGASQRLWESMER
                     SDEENLKEECSSTESTQQEHEDAPGAKHQGEVLAVEEERAQVLGRVEQLKIRVKELEQ
                     QLQEAAREAEMERALLQGEREAERASLQKEQRAVDQLQEKLVALETGIQKDRDKEADA
                     LETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSVSKRKERLAVLDSQA
                     GQIRAQAVQESERLAREKNAALQLLQKEKEKLNVLERRYHSLTGGRPFPKTTSTLKEV
                     YRSKMDSDAASPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLAQNGTSSL
                     PRNLAATLQDIETKRQLALQQKVELPPAEPLPPEDPAGHQVIEEQRRRLAELKQKAAA
                     EAQCQWDALHGAGPFSAGPSGFPALMHHSILHHLPAGRERGEEGEHAYDTLSLESSDS
                     METSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKSRLMESRVRLTGARR
                     QQVEREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKLREKQFSQARPLTR
                     YLPNRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLIKMGGKIKSWKKRWFVFDR
                     LKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMV
                     APSAEAMRIWMDVIVTGAEGYTQFMN"
     exon            278..1629
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1911
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2052
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2190
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2346
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2457
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2547
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2688
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2791
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2836
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..3131
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3255
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3402
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3519
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3622
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3708
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..5099
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5077..5082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /note="hexamer: AATAAA"
     polyA_site      5099
                     /gene="Phldb1"
                     /gene_synonym="D330037A14Rik; Ll5a; Ll5alpha"
                     /note="major polyA site"
ORIGIN      
        1 attggcggct gctcgctccc tggctgctcg caccgcgcct ggagccggcg gcgcgggagg
       61 tcggcccgcc ccctcaaagg cccagggcgg gcgggcgacc tgcagggccc gggctggtag
      121 gagcgaacag tccggaggtc ctggttcagc ggctgcatgt tgtgtctggg tcaatccacc
      181 ttcctgcgct ttaaccatcc agccgaagcc aagtggatga aaagtatgat tccagcaggg
      241 gtccgggccc cagggcccac ctacaaccct ggctctgctg aatcggagag cctggtcaat
      301 gggaaccaca cagcacaacc tgcaacccgg gcaccgtcag cctgtgccag ccacagttcc
      361 ctggtgagct ctattgaaaa ggacctgcag gaaatcatgg attcattggt gctagaggag
      421 cctggagctg caggcaagaa gcctgctgcc acatccccat tgtcgccaat ggctaacggc
      481 gggcgctacc tgttgtcccc tccaaccagc cccggtgcca tgtctgtggg ctccagctat
      541 gagaacacct ctccagcctt ctctccactt tcctcaccag ccagcagcgg aagctgtgct
      601 agccattcac caagtgggca ggagccagga ccctctgtgc ccccattggt gcctgcccgc
      661 tcctctagct accatttggc tctgcaacct ccacagtctc gcccaagtgg ttcccgctcc
      721 tctgacagtc cccggctggg cagaaaaggg ggtcatgaga gacctcccag ccctggtctc
      781 cggggtcttc tgacggacag tcctgccgct accgtcttgg ctgaggcccg cagaaccact
      841 gagagtcccc ggctaggtgg gcagttacct gtggtggcta tcagcctgag tgaataccca
      901 tcttccggtg cccgcagcca acccgccagt attcctggca gccccaagtt ccagtctcca
      961 gtgcctgctc cccgaaacaa gatcggcaca ctccaggacc gccctcccag tcctttccgt
     1021 gagcccccag gcacagagcg ggtactaaca agcagcccct ctcgacaact ggtgggcaga
     1081 acattttcgg atgggttagc agcaactcgt accctccagc cgcctgagag tccccgcctg
     1141 ggccggaggg gcctggacag tatgcgggaa ctgcccccgt tgagtccatc tctgtctcga
     1201 agggctctgt ccccactgcc agcccggact gccccagatc ccaagctaag cagggaagtg
     1261 gccgagagtc cccggccccg gcgctgggca gcccacggga cttcacctga ggacttctcc
     1321 ctgactctag gagcacgggg tcgcaggact cggagtccct cgcccaccct cggggagtcc
     1381 ctggcacctc gcaagggtag cttcagtggc aggctgagcc cagcttacag tctgggctct
     1441 cttactgggg cttcacctcg tcagagcccc cgtgctcagc ggaagctctc cagtggggac
     1501 ttgcgggtac ccattccaag ggagaggaaa aacagcatca cggagatcag cgacaatgag
     1561 gacgaacttc tggagtacca ccgtcggcag cgccaagagc ggctccggga gcaggagatg
     1621 gagaggctgg aacgccagcg cctggagacc atcctgaacc tgtgtgctga gtacagccga
     1681 gctgacgggg gacctgagac tggggagctg cccagtattg gagaggccac ggcagcgctg
     1741 gccttggcag gcaggaggcc ctcaagaggc ttggcaggag ccatagtagt ctccggaagg
     1801 tgcggcgagg agtctggagg tgcctcccag cgcctgtggg agagcatgga gcgctctgat
     1861 gaagagaatc tcaaagagga atgcagcagc accgagagca cccagcagga gcatgaagac
     1921 gctcctggcg cgaagcacca aggcgaggtg ctggctgtgg aagaggagcg ggctcaggtt
     1981 ctggggcgag tagaacagct gaagatccga gtgaaggagc tggaacagca gctgcaggag
     2041 gcagcccgag aggccgagat ggagagagca ctgctgcagg gggagcggga ggcagagcga
     2101 gcctcgctgc agaaggaaca aagggcggtg gaccagctgc aggagaagtt ggtggccttg
     2161 gagacaggca tccagaagga cagggacaag gaggcagacg ctctagagac tgagacaaag
     2221 ctctttgagg acctggagtt ccagcagctg gagcgtgaga gtcgcgtgga ggaggagcgg
     2281 gagctggccg gccaagggct gctgcggagc aaggctgagt tgctgcgcag tgtgagcaag
     2341 aggaaggagc gcctagctgt actggacagt caggctgggc agatccgggc ccaggcagta
     2401 caggagtcag agcgtctggc ccgggaaaag aatgctgccc tgcagctact gcaaaaggag
     2461 aaggagaagc tgaatgtcct tgagaggaga taccattcgc tcacgggggg caggcctttt
     2521 ccgaagacca cctccaccct caaagaggtt taccgctcca agatggatag tgatgcggcc
     2581 agccccctgc ccaggacccg tagcggccct ctcccctcct cctcaggctc ctcctcctcc
     2641 tcttcacagc tcagcgtggc taccctgggc cgtagtcctt ccccaaagag tgctctgctc
     2701 gcccagaatg gcaccagtag ccttcctcgc aacctggcag ccacactgca ggacattgag
     2761 accaagcgcc agctggccct acagcaaaag gtcgagttac ctcctgccga gcccctccca
     2821 cctgaagacc cagcaggaca ccaagtgatc gaggagcaac ggaggagact ggcggagctg
     2881 aagcagaagg cggcggcaga ggctcagtgc cagtgggatg ccttgcatgg tgcagggccc
     2941 ttttcagcag gcccttcagg cttccctgca ctcatgcatc attccatcct gcatcacctg
     3001 ccagctggcc gggagcgtgg agaggagggc gagcacgctt acgacaccct gagcctggag
     3061 agttcagaca gcatggagac cagcatctct acaggcggca actctgcctg ttccccggac
     3121 aacatgtcca gcgccagtgg tctggacatg ggcaagatcg aggaaatgga gaagatgcta
     3181 aaggaagctc acgcagagaa gagccggctc atggagtcca gggtgaggct gactggagcc
     3241 aggaggcagc aggtggagcg ggagatggag cttcggaggc aggccctgga ggaggaacgg
     3301 aggaggcggg agcaagtgga gcggcggctg cagagtgaga gcgcccgcag gcagcagctg
     3361 gtggagaaag aagtcaagct ccgggaaaag cagttctccc aggcacggcc tcttacacgt
     3421 taccttccca accggaagga ggactttgat ctgaagaccc acatagagtc atcaggccac
     3481 ggggtggaca cctgcctaca tgtggtgctt agcagcaagg tgtgccgtgg ctacctgatc
     3541 aagatgggtg gcaagattaa atcgtggaag aagcgctggt ttgtctttga tcggctgaag
     3601 cgcacccttt cctattacgt ggacaaacat gagacgaagc tgaagggggt catctatttc
     3661 caggccatcg aggaagtgta ctatgaccac ctgcgcagcg cagccaagag tccgaatccg
     3721 gccctcacct tctgtgtgaa gacccatgac cggttgtact acatggtggc cccgtctgca
     3781 gaggccatgc gcatctggat ggatgtcatc gtcacggggg ccgagggcta cactcaattc
     3841 atgaactaac taccctgcac ctcctgggtt ccccagctca gccccaggac tccgtgccct
     3901 gccacctgcc actctgcttg tccctgggga cagtggcaca ttgggcacgg ggctgcaaag
     3961 gatcgggatg tagttgagta cctcggggct tttgtgcaag aagacaaatt gtgttatgag
     4021 gagtttggtg cttgggaatt gagctccagt ccctaaagag ccagcagaga ggaaaggaag
     4081 agggagaggc cttgtcggtc ctgggagtcc agaagttcag gttccctcct gggtccagca
     4141 ggctgaagag gctgctgagc tgcgctctcg gctctgtccc ggcacccacc caccccagct
     4201 tgttttctct ttgtaaagga caaactatgg taccagaatc tgccaaagat ccccttctca
     4261 tctcatcccc tctgcagggg ctgggagggg tcctgagcag agccacgtgc agagctgggg
     4321 agcggctcag gccccaaccc catctgcctc ctcctcttct tcctcttcct cctcctccca
     4381 cctcccactt gtcactactc agctcaagga ccagagacct caagtgtcac tttcgaggtc
     4441 cagccccatc atcctgttac aagcccgtca tccttgtctc catggtgacc gcttcatcac
     4501 catggttaca cactaattgc catggccact ctgtggcttt gcccactgct tctggctgtg
     4561 ggccacatga gggtacgtgc catcatctct ccaacccagg cctgggggca tgtcacatgg
     4621 tgggaggaga tggaattcct cccggctgca gtgtgtctcc agcccccagc ccagcccctc
     4681 tcccttttac tgtgccttgc ttagagccag aagggatgat gtcctgggat ccaagaccag
     4741 agggacagca tcactgaggg gagaggaagc tgagaggtct gccctcccat tctaacagga
     4801 ctagttccca gtgaggaaca agggtagctc agagtgcctg caaagaagcc tgagttgggg
     4861 ctggggcggg cagaagcaga ggccctgagc tgtggtaatc tcccttcagt ttcccaaagg
     4921 tgatgggaaa ggagaacgga ggataagtct ccagctggct ggcctcagcc ttgcgcctta
     4981 acactaagcc accttccctg ccctccccag cactgggccc ttagttgctg ggcctggttg
     5041 ggtgttttgc agtatttgta agcatttcag cagaacaata aaagcatttt gactatgta
//
