LOCUS       NM_009434                737 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus pleckstrin homology like domain, family A, member 2
            (Phlda2), mRNA.
ACCESSION   NM_009434
VERSION     NM_009434.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 737)
  AUTHORS   Yang,X., Wang,Z., Samovich,S.N., Kapralov,A.A., Amoscato,A.A.,
            Tyurin,V.A., Dar,H.H., Li,Z., Duan,S., Kon,N., Chen,D., Tycko,B.,
            Zhang,Z., Jiang,X., Bayir,H., Stockwell,B.R., Kagan,V.E. and Gu,W.
  TITLE     PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct
            ferroptotic response during tumor suppression
  JOURNAL   Cell Metab 36 (4), 762-777 (2024)
   PUBMED   38309267
  REMARK    GeneRIF: PHLDA2-mediated phosphatidic acid peroxidation triggers a
            distinct ferroptotic response during tumor suppression.
REFERENCE   2  (bases 1 to 737)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   3  (bases 1 to 737)
  AUTHORS   Angiolini,E., Sandovici,I., Coan,P.M., Burton,G.J., Sibley,C.P.,
            Fowden,A.L. and Constancia,M.
  TITLE     Deletion of the Imprinted Phlda2 Gene Increases Placental Passive
            Permeability in the Mouse
  JOURNAL   Genes (Basel) 12 (5), 639 (2021)
   PUBMED   33922969
  REMARK    GeneRIF: Deletion of the Imprinted Phlda2 Gene Increases Placental
            Passive Permeability in the Mouse.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 737)
  AUTHORS   Manti,M., Pui,H.P., Edstrom,S., Risal,S., Lu,H., Lindgren,E.,
            Ohlsson,C., Jerlhag,E., Benrick,A., Deng,Q. and Stener-Victorin,E.
  TITLE     Excess of ovarian nerve growth factor impairs embryonic development
            and causes reproductive and metabolic dysfunction in adult female
            mice
  JOURNAL   FASEB J 34 (11), 14440-14457 (2020)
   PUBMED   32892421
REFERENCE   5  (bases 1 to 737)
  AUTHORS   Imaizumi,Y., Furutachi,S., Watanabe,T., Miya,H., Kawaguchi,D. and
            Gotoh,Y.
  TITLE     Role of the imprinted allele of the Cdkn1c gene in mouse
            neocortical development
  JOURNAL   Sci Rep 10 (1), 1884 (2020)
   PUBMED   32024956
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 737)
  AUTHORS   Salas,M., John,R., Saxena,A., Barton,S., Frank,D., Fitzpatrick,G.,
            Higgins,M.J. and Tycko,B.
  TITLE     Placental growth retardation due to loss of imprinting of Phlda2
  JOURNAL   Mech Dev 121 (10), 1199-1210 (2004)
   PUBMED   15327781
  REMARK    GeneRIF: Phlda2 gene is imprinted, with preferential expression
            from the maternal allele in placenta. It acts as a rheostat for
            placental growth, with overgrowth after gene deletion and growth
            retardation after loss of imprinting.
REFERENCE   7  (bases 1 to 737)
  AUTHORS   Paulsen,M., Davies,K.R., Bowden,L.M., Villar,A.J., Franck,O.,
            Fuermann,M., Dean,W.L., Moore,T.F., Rodrigues,N., Davies,K.E.,
            Hu,R.J., Feinberg,A.P., Maher,E.R., Reik,W. and Walter,J.
  TITLE     Syntenic organization of the mouse distal chromosome 7 imprinting
            cluster and the Beckwith-Wiedemann syndrome region in chromosome
            11p15.5
  JOURNAL   Hum Mol Genet 7 (7), 1149-1159 (1998)
   PUBMED   9618174
REFERENCE   8  (bases 1 to 737)
  AUTHORS   Dao,D., Frank,D., Qian,N., O'Keefe,D., Vosatka,R.J., Walsh,C.P. and
            Tycko,B.
  TITLE     IMPT1, an imprinted gene similar to polyspecific transporter and
            multi-drug resistance genes
  JOURNAL   Hum Mol Genet 7 (4), 597-608 (1998)
   PUBMED   9499412
REFERENCE   9  (bases 1 to 737)
  AUTHORS   Qian,N., Frank,D., O'Keefe,D., Dao,D., Zhao,L., Yuan,L., Wang,Q.,
            Keating,M., Walsh,C. and Tycko,B.
  TITLE     The IPL gene on chromosome 11p15.5 is imprinted in humans and mice
            and is similar to TDAG51, implicated in Fas expression and
            apoptosis
  JOURNAL   Hum Mol Genet 6 (12), 2021-2029 (1997)
   PUBMED   9328465
REFERENCE   10 (bases 1 to 737)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF615806.1, Y15443.1 and
            CF617643.1.
            
            On Jan 15, 2005 this sequence version replaced NM_009434.1.
            
            Summary: This gene is one of several genes in the imprinted gene
            domain on chromosome 7. Studies using knockout mice have shown that
            the product of this gene regulates placental growth. Transcripts
            from this gene are most abundant in placenta and yolk sac, and are
            almost entirely transcribed from the maternal allele. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF615806.1, AK131929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 15327781
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CF615806.1         753-766             c
            15-588              Y15443.1           1-574
            589-737             CF617643.1         559-707
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6 x DBA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.23 cM"
     gene            1..737
                     /gene="Phlda2"
                     /gene_synonym="Ipl; Tssc3"
                     /note="pleckstrin homology like domain, family A, member
                     2"
                     /db_xref="GeneID:22113"
                     /db_xref="MGI:MGI:1202307"
     exon            1..468
                     /gene="Phlda2"
                     /gene_synonym="Ipl; Tssc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..469
                     /gene="Phlda2"
                     /gene_synonym="Ipl; Tssc3"
                     /note="protein 50C15; imprinted in placenta and liver
                     protein; tumor-suppressing subchromosomal transferable
                     fragment 3"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family A member
                     2"
                     /protein_id="NP_033460.1"
                     /db_xref="CCDS:CCDS22042.1"
                     /db_xref="GeneID:22113"
                     /db_xref="MGI:MGI:1202307"
                     /translation="MASKIVMSSKTVKTSDEILCEGELEKRSDSLFQVWKKKRCVLTA
                     DRLRLFSGKTSPAKELFFHSILKVDCVEHTSKYVYFTIVTNYYKEIDFRCTVESCWNA
                     AITMALIDFQNRRALQDFPRYRYQRSESEMPSEPGEQSALGP"
     exon            469..737
                     /gene="Phlda2"
                     /gene_synonym="Ipl; Tssc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      709..714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phlda2"
                     /gene_synonym="Ipl; Tssc3"
                     /note="hexamer: AATAAA"
     polyA_site      737
                     /gene="Phlda2"
                     /gene_synonym="Ipl; Tssc3"
                     /note="major polyA site"
ORIGIN      
        1 agcagagcga gcgcatttgg tgcaaccttt cgaaatggct tcgaaaatcg tgatgtcttc
       61 gaaaaccgtg aagacctccg acgagatcct ttgcgagggc gagctggaga agcgaagcga
      121 cagcctgttc caggtatgga agaagaagcg ctgcgtgctc accgccgacc gcctgcgcct
      181 cttctccggg aaaaccagcc ccgccaagga gctgtttttc cactccatcc tcaaggtgga
      241 ctgcgtggag cacacctcta agtacgtgta cttcaccatc gtcaccaact attacaagga
      301 gatcgacttc cgctgcacgg tggagagctg ctggaacgcg gccatcacca tggcgctgat
      361 cgacttccag aaccgtcggg cgctgcaaga ctttccccgc taccggtatc agcgctctga
      421 gtctgaaatg ccttccgagc cgggagagca gagcgctctg ggtccgtgaa acgcacggga
      481 ccagttgagc cgggaaccag cccacgctgc cgcatcagac aggagcccag gagcccaggg
      541 gatgccccgg gtgacgccgc cgctgctctt caccgaagat attcccgtgc ttgctgagcc
      601 ttgccccgct gtgcgggtgc gctaacttat tggaccgtat ttatattggt tacctgcttc
      661 caacccacca ttccgtgtta atatttttta taccatattt tcattccaaa taaacaatgt
      721 cacttttctt tttttaa
//
