LOCUS       NM_009344               1953 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus pleckstrin homology like domain, family A, member 1
            (Phlda1), mRNA.
ACCESSION   NM_009344
VERSION     NM_009344.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1953)
  AUTHORS   Platko,K., Gyulay,G., Lebeau,P.F., MacDonald,M.E., Lynn,E.G.,
            Byun,J.H., Igdoura,S.A., Holden,R.M., Roubtsova,A., Seidah,N.G.,
            Krepinsky,J.C. and Austin,R.C.
  TITLE     GDF10 is a negative regulator of vascular calcification
  JOURNAL   J Biol Chem 300 (11), 107805 (2024)
   PUBMED   39307303
REFERENCE   2  (bases 1 to 1953)
  AUTHORS   Wang,J., Gu,D., Jin,K., Shen,H. and Qian,Y.
  TITLE     Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in
            an in-vitro model of intracerebral hemorrhage
  JOURNAL   Neuroreport 35 (9), 590-600 (2024)
   PUBMED   38652514
  REMARK    GeneRIF: Egr1 promotes Nlrc4-dependent neuronal pyroptosis through
            phlda1 in an in-vitro model of intracerebral hemorrhage.
REFERENCE   3  (bases 1 to 1953)
  AUTHORS   Yousof,T.R., Bouchard,C.C., Alb,M., Lynn,E.G., Lhotak,S., Jiang,H.,
            MacDonald,M., Li,H., Byun,J.H., Makda,Y., Athanasopoulos,M.,
            Maclean,K.N., Cherrington,N.J., Naqvi,A., Igdoura,S.A.,
            Krepinsky,J.C., Steinberg,G.R. and Austin,R.C.
  TITLE     Restoration of the ER stress response protein TDAG51 in hepatocytes
            mitigates NAFLD in mice
  JOURNAL   J Biol Chem 300 (2), 105655 (2024)
   PUBMED   38237682
  REMARK    GeneRIF: Restoration of the ER stress response protein TDAG51 in
            hepatocytes mitigates NAFLD in mice.
REFERENCE   4  (bases 1 to 1953)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   5  (bases 1 to 1953)
  AUTHORS   Meng,L., Gu,T., Wang,J., Zhang,H. and Nan,C.
  TITLE     Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by
            downregulating NLRP3 inflammasome activation
  JOURNAL   Allergol Immunopathol (Madr) 51 (5), 41-47 (2023)
   PUBMED   37695229
  REMARK    GeneRIF: Knockdown of PHLDA1 alleviates sepsis-induced acute lung
            injury by downregulating NLRP3 inflammasome activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1953)
  AUTHORS   Hossain,G.S., van Thienen,J.V., Werstuck,G.H., Zhou,J., Sood,S.K.,
            Dickhout,J.G., de Koning,A.B., Tang,D., Wu,D., Falk,E., Poddar,R.,
            Jacobsen,D.W., Zhang,K., Kaufman,R.J. and Austin,R.C.
  TITLE     TDAG51 is induced by homocysteine, promotes detachment-mediated
            programmed cell death, and contributes to the cevelopment of
            atherosclerosis in hyperhomocysteinemia
  JOURNAL   J Biol Chem 278 (32), 30317-30327 (2003)
   PUBMED   12738777
  REMARK    GeneRIF: TDAG51 is induced by homocysteine, promotes
            detachment-mediated PCD, and contributes to the development of
            atherosclerosis observed in hyperhomocysteinemia
REFERENCE   7  (bases 1 to 1953)
  AUTHORS   Rho,J., Gong,S., Kim,N. and Choi,Y.
  TITLE     TDAG51 is not essential for Fas/CD95 regulation and apoptosis in
            vivo
  JOURNAL   Mol Cell Biol 21 (24), 8365-8370 (2001)
   PUBMED   11713273
  REMARK    Erratum:[Mol Cell Biol 2002 Feb;22(4):1276]
REFERENCE   8  (bases 1 to 1953)
  AUTHORS   Frank,D., Mendelsohn,C.L., Ciccone,E., Svensson,K., Ohlsson,R. and
            Tycko,B.
  TITLE     A novel pleckstrin homology-related gene family defined by
            Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression,
            chromosomal location, and parental imprinting
  JOURNAL   Mamm Genome 10 (12), 1150-1159 (1999)
   PUBMED   10594239
REFERENCE   9  (bases 1 to 1953)
  AUTHORS   Gomes,I., Xiong,W., Miki,T. and Rosner,M.R.
  TITLE     A proline- and glutamine-rich protein promotes apoptosis in
            neuronal cells
  JOURNAL   J Neurochem 73 (2), 612-622 (1999)
   PUBMED   10428057
REFERENCE   10 (bases 1 to 1953)
  AUTHORS   Park,C.G., Lee,S.Y., Kandala,G., Lee,S.Y. and Choi,Y.
  TITLE     A novel gene product that couples TCR signaling to Fas(CD95)
            expression in activation-induced cell death
  JOURNAL   Immunity 4 (6), 583-591 (1996)
   PUBMED   8673705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U44088.1 and BY378082.1.
            
            On Apr 9, 2009 this sequence version replaced NM_009344.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44088.1, AK158890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1918              U44088.1           1-1918
            1919-1953           BY378082.1         94-128
FEATURES             Location/Qualifiers
     source          1..1953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 58.7 cM"
     gene            1..1953
                     /gene="Phlda1"
                     /gene_synonym="DT1P1B11; Tdag; TDAG51"
                     /note="pleckstrin homology like domain, family A, member
                     1"
                     /db_xref="GeneID:21664"
                     /db_xref="MGI:MGI:1096880"
     exon            1..1363
                     /gene="Phlda1"
                     /gene_synonym="DT1P1B11; Tdag; TDAG51"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1337
                     /gene="Phlda1"
                     /gene_synonym="DT1P1B11; Tdag; TDAG51"
                     /note="PQR protein; PQ-rich protein; proline- and
                     glutamine-rich protein; T-cell death-associated gene 51
                     protein; T-cell death associated"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family A member
                     1"
                     /protein_id="NP_033370.2"
                     /db_xref="CCDS:CCDS24167.2"
                     /db_xref="GeneID:21664"
                     /db_xref="MGI:MGI:1096880"
                     /translation="MRRTPAAERLSELGFPPRRGRQEPPFPLGVTRGWGGWPIEKRRE
                     GPRPVPFSERSPEDGREQPAHGSGILWRVRTRLSLCRDPEPPPPPPPLCLLRVSLLCA
                     LRAGGRGSRWGEDGAGLLLLPPAGASGSLKAERSSSTPYAGRMLENSGCKALKEGVLE
                     KRSDGLLQLWKKKCCILTEEGLLLIPPKQLQQQQQQQQPGQGTAEPSQPSGPTVASLE
                     PPVKLKELHFSNMKTVDCVERKGKYMYFTVVMTEGKEIDFRCPQDQGWNAEITLQMVQ
                     YKNRQAILAVKSTRQKQQHLVQQQPPQTQQIQPQPQPQIQPQPQPQIQPQPQPQPQPQ
                     PQPQPQPQPQQLHSYPHPHPHPYSHPHQHPHPHPHPHPHPHPHPYQLQHAHQPLHSQP
                     QGHRLLRSTSNSA"
     exon            1364..1953
                     /gene="Phlda1"
                     /gene_synonym="DT1P1B11; Tdag; TDAG51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1927..1932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phlda1"
                     /gene_synonym="DT1P1B11; Tdag; TDAG51"
                     /note="hexamer: ATTAAA"
     polyA_site      1949
                     /gene="Phlda1"
                     /gene_synonym="DT1P1B11; Tdag; TDAG51"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcgcg ggcggccgtg ggcggtgggg cggggcgggg gcggagccgg cggcggggct
       61 ggggcggagc cggcggcggg gggcgtgtcc gcggcgggct ctgggaaggc cccaagttaa
      121 tgaggcgtac gccggctgcc gagcgcctct cggagctggg ttttcccccg cggcgcgggc
      181 gccaggagcc gccttttccg ctgggtgtca ctcgggggtg gggagggtgg cccattgaaa
      241 agcgccgcga ggggccccgg ccagtgccct tcagtgagcg ctcgccggag gacggcagag
      301 agcagcccgc tcacggctcc gggatcttgt ggcgagtcag gacgcgcctg tccctctgcc
      361 gggaccccga gccaccgccg ccgccgccac cgctctgtct cctgcgagtc agccttctct
      421 gcgcgctccg ggcgggcggc cgcggaagcc gctggggcga ggacggcgca gggctgctac
      481 tgctaccccc agccggagcg tctggaagcc tgaaggccga gcggagcagc agcacccctt
      541 atgccggaag gatgctggag aacagcggct gcaaggcgct gaaggaagga gtgctggaaa
      601 agcgaagcga cgggctgctg cagctctgga agaaaaagtg ctgcatcctc accgaggaag
      661 ggctactgct cataccgccc aagcagctac aacagcagca gcagcagcaa cagcccgggc
      721 aggggacggc cgaaccgtcc caacctagtg gccccaccgt cgccagcctt gagccaccag
      781 tcaagctgaa ggaattgcac ttttccaata tgaagactgt agactgcgtg gagcgcaagg
      841 gcaagtacat gtacttcact gtggtgatga cggagggcaa agagatcgac tttcggtgcc
      901 cccaggacca gggctggaac gccgagatca cgttgcagat ggtgcagtac aaaaatcgcc
      961 aggccatact ggcggtcaag tctaccaggc agaagcagca gcacctggtc cagcagcagc
     1021 ctccgcagac gcagcagatc caaccccagc cccagccgca gatccaaccc cagccccagc
     1081 cgcagatcca gcctcaaccc caaccccagc cccaacctca gccccaacct cagccccaac
     1141 cccaacccca acagctccac tcctacccgc atccgcatcc tcatccttac tctcacccgc
     1201 accagcaccc acacccgcac ccgcacccgc accctcaccc tcaccctcac ccgtaccaac
     1261 tccagcacgc gcaccagcct cttcactcgc agccgcaggg tcaccggctt ctccgcagca
     1321 cctccaactc tgcctgaaga gggcggcacc cgggccactc aaggttttga ggacttcgga
     1381 aagtgggaag agtgcattgc tattcagttc acttggatca aaaccaacag agtctcccca
     1441 ccccgcgcct gatcaagtag tttggacttc acccgacgga taacgcgcgc ttgcagttcc
     1501 ctcgtagttt tctgcataat gttcatcaca gttgcaggaa gcagattttg cgtcgagatg
     1561 actttattta tggacctttg gaaggatcac ctaacgtaat ggacctttgt aggaacaatt
     1621 tatgtactgt aattttattt taatgttatt ttggattatg attatttatt agttttttta
     1681 tgcctaatct aagacatttc tgaatgtagg ccacctcctc cccctcctcg ccaaaaagaa
     1741 aaagaaaaaa agaaaaaaaa aaaagaaact ttattttcag aaacagattt cttagtaagc
     1801 cctgatcttg gaagagaaaa agggaaaggg gtggtggagg ggggcaaaca tgaaaaaaaa
     1861 atgggttcag tattcccagg acattctcat aaagtcgact ctttcattgt atttgaagac
     1921 gttgaaatta aattctgata ttactttcag ttt
//
