LOCUS       NM_026888               1644 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphorylase kinase, gamma 2 (testis) (Phkg2),
            transcript variant 1, mRNA.
ACCESSION   NM_026888 XM_133769
VERSION     NM_026888.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Gibson,R.A., Lim,J.A., Choi,S.J., Flores,L., Clinton,L., Bali,D.,
            Young,S., Asokan,A., Sun,B. and Kishnani,P.S.
  TITLE     Characterization of liver GSD IX gamma2 pathophysiology in a novel
            Phkg2-/- mouse model
  JOURNAL   Mol Genet Metab 133 (3), 269-276 (2021)
   PUBMED   34083142
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Yang,Y., Liu,S., Lei,Z., Chen,G., Huang,L., Yang,F., Lei,Y.,
            Liu,Y., Yang,L., Liu,W., Lai,L. and Guo,J.
  TITLE     Circular RNA profile in liver tissue of EpCAM knockout mice
  JOURNAL   Int J Mol Med 44 (3), 1063-1077 (2019)
   PUBMED   31524221
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Amemiya,T., Honma,M., Kariya,Y., Ghosh,S., Kitano,H., Kurachi,Y.,
            Fujita,K.I., Sasaki,Y., Homma,Y., Abernethy,D.R., Kume,H. and
            Suzuki,H.
  TITLE     Elucidation of the molecular mechanisms underlying adverse
            reactions associated with a kinase inhibitor using systems
            toxicology
  JOURNAL   NPJ Syst Biol Appl 1, 15005 (2015)
   PUBMED   28725458
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Cheong,H., Wu,J., Gonzales,L.K., Guttentag,S.H., Thompson,C.B. and
            Lindsten,T.
  TITLE     Analysis of a lung defect in autophagy-deficient mouse strains
  JOURNAL   Autophagy 10 (1), 45-56 (2014)
   PUBMED   24275123
REFERENCE   7  (bases 1 to 1644)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079680.1, AK005277.1, AA198694.1 and BQ176174.1.
            
            On May 14, 2008 this sequence version replaced NM_026888.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005277.1, BC138913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AK079680.1         11-66
            57-904              AK005277.1         2-849
            905-1093            AA198694.1         319-507
            1094-1543           AK005277.1         1039-1488
            1544-1644           BQ176174.1         1-101               c
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.6 cM"
     gene            1..1644
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /note="phosphorylase kinase, gamma 2 (testis)"
                     /db_xref="GeneID:68961"
                     /db_xref="MGI:MGI:1916211"
     exon            1..109
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            110..222
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1348
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /EC_number="2.7.11.19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PHK-gamma-T; phosphorylase kinase subunit gamma-2;
                     serine/threonine-protein kinase PHKG2; PHK-gamma-LT"
                     /codon_start=1
                     /product="phosphorylase b kinase gamma catalytic chain,
                     liver/testis isoform isoform 1"
                     /protein_id="NP_081164.2"
                     /db_xref="CCDS:CCDS21869.1"
                     /db_xref="GeneID:68961"
                     /db_xref="MGI:MGI:1916211"
                     /translation="MTLDVGPEDELPDWAAAKEFYQKYDPKDIIGRGVSSVVRRCVHR
                     ATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSF
                     MFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENIL
                     LDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWA
                     CGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKDLISKLLQVDP
                     EARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTILAAGRVALSSHRLRPLTKN
                     ALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPRLFPIAATELEGD
                     SGAITEDEATLVRS"
     exon            223..398
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            399..453
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            454..519
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..683
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            684..774
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            775..928
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1054
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1626
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1619
                     /gene="Phkg2"
                     /gene_synonym="1500017I02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggccattg gctgcaatga tgggggcggt gccttaggtc gctgtgggag ccttacaggt
       61 taaagcaaag gaacaaacat aaaccaagca gctgagggtc tttgcgcagg cccccacatc
      121 cctcagaatg acgttggacg tggggccgga ggatgaactc cctgactggg ctgcggccaa
      181 agagttttac cagaagtacg accctaagga catcattggc agaggagtga gctctgtggt
      241 ccgccgctgt gtccatcgag ctaccggtga tgagttcgca gtgaagatca tggaggtgtc
      301 agctgagcgg ctgagtcttg agcagctgga ggaggtgcgg gatgccacac ggcgagagat
      361 gcacattctt cgccaggtcg ctggccaccc ccatatcatc accctcatcg attcctacga
      421 gtcttctagc ttcatgttcc tggtgtttga cctgatgcgg aaaggagagc tgtttgacta
      481 tctcaccgag aaagtggccc tctcagaaaa ggaaaccagg tccatcatga ggtctctact
      541 ggaagcagtg agctttctcc atgccaacaa cattgtacat cgagacctga agcctgagaa
      601 tattctccta gatgacaata tgcagatacg cctttcagat tttgggttct cctgccattt
      661 ggaagctggc gagaagcttc gagaactgtg cgggactcca gggtatctag caccagagat
      721 ccttaaatgc tccatggatg aaacccaccc aggctatggc aaggaagttg atctctgggc
      781 ttgtggggtg atcctgttca cacttctggc tggctcacca ccattctggc accggcgcca
      841 aatcctgatg ctacgcatga tcatggaagg ccaatatcag tttacttcac ctgagtggga
      901 tgatcgttca aacaccgtca aagacctgat ctccaagctg ctgcaggtgg atcctgaagc
      961 gcgcctgaca gctgagcaag ccctgcagca ccccttcttt gagcgctgtg aaggcagcca
     1021 accttggaac ctcacgcctc gccagcggtt ccgggtggca gtgtggacaa tactggctgc
     1081 cggacgagtg gccttaagca gtcaccgttt acggccacta actaagaatg cactattgag
     1141 agacccctat gcactgcggc cagtacggcg cctcatcgac aactgtgcct tccggctcta
     1201 tgggcactgg gtaaagaagg gtgagcagca gaaccgggca gccctcttcc agcaccagcc
     1261 tcctaggctg ttccccattg ctgccactga actcgaagga gactccggtg ccatcacaga
     1321 ggatgaggct acactggtac ggagctaggg ccgtatccct gggcaagcca gaaagaagga
     1381 ctctccagga ggacattttt ttttctatca ttccaactgt ttgggactca gaccttagcc
     1441 ctgccttgcc aagcctacaa ctgagaatgc tgcttgtcac agaaaccagc cctttacccc
     1501 tactactctg gacttggaga tcagggcaga gatggaaggg agcctcttcg agggttgtgc
     1561 ctggcctagc tatcgccacc tgcgctgcat ctgaaataaa acctgccaca agcctgggag
     1621 agccagaaaa aaaaaaaaaa aaaa
//
