LOCUS       NM_011079               2369 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphorylase kinase gamma 1 (Phkg1), mRNA.
ACCESSION   NM_011079 XM_993479
VERSION     NM_011079.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2369)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2369)
  AUTHORS   Firulli,B.A., George,R.M., Harkin,J., Toolan,K.P., Gao,H., Liu,Y.,
            Zhang,W., Field,L.J., Liu,Y., Shou,W., Payne,R.M., Rubart-von der
            Lohe,M. and Firulli,A.B.
  TITLE     HAND1 loss-of-function within the embryonic myocardium reveals
            survivable congenital cardiac defects and adult heart failure
  JOURNAL   Cardiovasc Res 116 (3), 605-618 (2020)
   PUBMED   31286141
REFERENCE   3  (bases 1 to 2369)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2369)
  AUTHORS   Amemiya,T., Honma,M., Kariya,Y., Ghosh,S., Kitano,H., Kurachi,Y.,
            Fujita,K.I., Sasaki,Y., Homma,Y., Abernethy,D.R., Kume,H. and
            Suzuki,H.
  TITLE     Elucidation of the molecular mechanisms underlying adverse
            reactions associated with a kinase inhibitor using systems
            toxicology
  JOURNAL   NPJ Syst Biol Appl 1, 15005 (2015)
   PUBMED   28725458
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2369)
  AUTHORS   Ma,J., Yang,J., Zhou,L., Ren,J., Liu,X., Zhang,H., Yang,B.,
            Zhang,Z., Ma,H., Xie,X., Xing,Y., Guo,Y. and Huang,L.
  TITLE     A splice mutation in the PHKG1 gene causes high glycogen content
            and low meat quality in pig skeletal muscle
  JOURNAL   PLoS Genet 10 (10), e1004710 (2014)
   PUBMED   25340394
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2369)
  AUTHORS   Maichele,A.J. and Chamberlain,J.S.
  TITLE     The gamma phosphorylase kinase gene, Phkg, maps to mouse chromosome
            5 near Gus
  JOURNAL   Mamm Genome 5 (1), 15-18 (1994)
   PUBMED   8111123
REFERENCE   7  (bases 1 to 2369)
  AUTHORS   Bender,P.K., Wang,Z. and Carlson,G.M.
  TITLE     Two exons encode the calmodulin-binding domain in the mouse
            phosphorylase kinase catalytic subunit gene
  JOURNAL   Genet Anal Tech Appl 10 (3-4), 99-101 (1993)
   PUBMED   8110484
REFERENCE   8  (bases 1 to 2369)
  AUTHORS   Maichele,A.J., Farwell,N.J. and Chamberlain,J.S.
  TITLE     A B2 repeat insertion generates alternate structures of the mouse
            muscle gamma-phosphorylase kinase gene
  JOURNAL   Genomics 16 (1), 139-149 (1993)
   PUBMED   8486349
REFERENCE   9  (bases 1 to 2369)
  AUTHORS   Bender,P.K. and Emerson,C.P. Jr.
  TITLE     Skeletal muscle phosphorylase kinase catalytic subunit mRNAs are
            expressed in heart tissue but not in liver
  JOURNAL   J Biol Chem 262 (18), 8799-8805 (1987)
   PUBMED   3597394
REFERENCE   10 (bases 1 to 2369)
  AUTHORS   Chamberlain,J.S., VanTuinen,P., Reeves,A.A., Philip,B.A. and
            Caskey,C.T.
  TITLE     Isolation of cDNA clones for the catalytic gamma subunit of mouse
            muscle phosphorylase kinase: expression of mRNA in normal and
            mutant Phk mice
  JOURNAL   Proc Natl Acad Sci U S A 84 (9), 2886-2890 (1987)
   PUBMED   3472241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC242408.2 and BC055102.1.
            
            On Jan 19, 2017 this sequence version replaced NM_011079.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055102.1, J03293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC242408.2         8241-8245
            6-2365              BC055102.1         1-2360
            2366-2369           AC242408.2         23895-23898
FEATURES             Location/Qualifiers
     source          1..2369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.26 cM"
     gene            1..2369
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /note="phosphorylase kinase gamma 1"
                     /db_xref="GeneID:18682"
                     /db_xref="MGI:MGI:97579"
     exon            1..158
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            159..275
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1359
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.19"
                     /EC_number="2.7.11.26"
                     /note="phosphorylase kinase subunit gamma-1;
                     serine/threonine-protein kinase PHKG1"
                     /codon_start=1
                     /product="phosphorylase b kinase gamma catalytic chain,
                     skeletal muscle/heart isoform"
                     /protein_id="NP_035209.1"
                     /db_xref="CCDS:CCDS19701.1"
                     /db_xref="GeneID:18682"
                     /db_xref="MGI:MGI:97579"
                     /translation="MTRDDALPDSHSAQTFYENYEPKEILGRGVSSVVRRCIHKPTCQ
                     EYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKDTYETNTFFFL
                     VFDLMKRGELFDYLTEKVTLTEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDD
                     NMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMDDGHPGYGKEVDMWSTGV
                     IMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSDTVKDLVSRFLVVQPQDR
                     CSAEEALAHPFFQEYVVEEVRHFSPRGKFKVICLTVLASVKIYYQYRRVKPVTREIVI
                     RDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEEDF"
     exon            276..454
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            455..509
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            510..575
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            576..739
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            740..830
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            831..984
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1110
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..2369
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1614..1619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /note="hexamer: AATAAA"
     polyA_site      1638
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /note="major polyA site"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /note="hexamer: AATAAA"
     regulatory      1698..1703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /note="hexamer: AATAAA"
     regulatory      1702..1707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
                     /note="hexamer: AATAAA"
     polyA_site      1710
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
     polyA_site      1714
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
     polyA_site      1719
                     /gene="Phkg1"
                     /gene_synonym="Phkg"
ORIGIN      
        1 accaagtacc aaagttccgc aagaggagca agacagcaac tccaataagt gtctgctcag
       61 gacacagctt cagccctttg tggtctgctg tctcccaagg gctccaggac ctttggaatt
      121 cttgtcactt ccattcaagg gcctacaagg acctcacgag gtgtttggga tccccctgag
      181 atccacgtga ccatgacccg ggatgacgcc ctccctgact cgcattctgc acagactttc
      241 tacgagaact atgagcccaa ggagatcctg ggcaggggag tcagcagtgt ggtcaggcgc
      301 tgcatccaca aacccacatg ccaggaatac gcagtgaaaa tcattgacat caccggagga
      361 ggaagcttta gctctgagga ggtacaggag cttcgggaag ccaccctgaa ggaggtggac
      421 atcctgcaga aggtctcggg acaccccaac atcatacagc tgaaggacac ttacgagacc
      481 aacactttct tcttcttggt atttgatctg atgaagagag gggaactctt tgactatctc
      541 actgagaagg tcaccttaac cgagaaggaa accagaaaga tcatgcgggc cctgctggag
      601 gtgatctgta ccctgcacaa actcaacatt gtccatcggg acctgaagcc ggagaatatc
      661 cttttggatg acaacatgaa tataaagctc acagacttcg ggttttcctg ccagctgcag
      721 ccaggagaga agctccgaga ggtttgtggg actcccagtt atctggcccc tgaaatcata
      781 cagtgctcca tggacgacgg ccatcctggc tatgggaagg aggtggacat gtggagcaca
      841 ggcgtcatca tgtacactct gctggctggc tccccgcctt tctggcaccg gaagcaaatg
      901 ctgatgttgc ggatgatcat ggacggcaaa taccagtttg gctcaccaga gtgggatgac
      961 tactctgaca cagtgaaaga cttggtgtct cgattcttgg tggtgcaacc tcaggaccgc
     1021 tgctcggcgg aagaggcctt ggcacaccct ttctttcagg agtacgtagt agaagaagta
     1081 cggcacttca gcccccgagg gaagttcaag gtgatctgtc taactgtgct ggcatcagta
     1141 aagatctact accagtaccg tcgggtgaag ccggtaacca gggagatcgt catccgagac
     1201 ccctacgccc ttcggccgct gcggaggctc attgacgcct atgctttccg tatctacggc
     1261 cactgggtga agaaagggca acagcagaac agagccgccc tcttcgagaa cacgcccaag
     1321 gctgtgctcc tctccttggc tgaggaggag gacttctgaa gggcagcggg ggcccagggg
     1381 aaagcagaca gagggacttg tgagaagagg atgccccaag tagccttctg caaaggaata
     1441 ggtggcccta ctctgtgctc tcaaaggctt gcctctagaa gcacagggtg ttcccagtaa
     1501 acagcagtaa ttacagctgg agctggatgt gctgtggcat gtgcctgttg ccccgagaca
     1561 gtaggatcac gggttctagc ccagcccggg aagtctagtg atgcttattt caaaataaaa
     1621 atgaggctgg gaatgtaacc ctgtggtgag tgtaaggtct ccaaattcaa cctctggtac
     1681 agctaaaata gataataaat aaataaataa taaatccaac gcagctgaga ccgtgatagg
     1741 cagaaatgga agggcataga gcacatgtat tctgggagct ataagccttc tggcttctct
     1801 actgtgcacc tttgttgatg tctatagttt tcttgttttt ttttttaaga tttatgcatt
     1861 ttatgtatgt tttagctgca tgcattttat gtaacccaca tgcatgcagt acctgtagag
     1921 gtcacaagaa ggcatcagaa accctgaaac tggagttgta tagatagctg agcccacctt
     1981 gtgggtggta ggaattgaac ccctcctcag caagaacagg cgctcataac tgtctagcta
     2041 aagttatgga tatttgagga agtgaaagca ggagttcaag gtcatttgtg gctacacaag
     2101 gagcttgagg ctagcctggg ctacatgaaa ccctatctca aacaacaatt atattgtgct
     2161 tcctgatata cataagaatt tattgacctc gggctggtgt gatggctcag tgggtaagag
     2221 tacccgactg ctcttccaaa ggtccagtgt tcaagtccca gcaaccacat ggtggctcac
     2281 aaccatccgt aacgagatct gatgccctct tctggtgtgt ctgaagacag ctacagtgta
     2341 cttacatata ataaataaat aaatcttaa
//
