LOCUS       NM_001081216           10729 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus pleckstrin homology domain interacting protein (Phip),
            mRNA.
ACCESSION   NM_001081216 XM_358384
VERSION     NM_001081216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10729)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (bases 1 to 10729)
  AUTHORS   McRae,H.M., Leong,M.P.Y., Bergamasco,M.I., Garnham,A.L., Hu,Y.,
            Corbett,M.A., Whitehead,L., El-Saafin,F., Sheikh,B.N., Wilcox,S.,
            Hannan,A.J., Gecz,J., Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles
            and altered transcription in the cortex of a mouse model of the
            Borjeson-Forssman-Lehmann intellectual disability syndrome
  JOURNAL   PLoS Genet 20 (10), e1011428 (2024)
   PUBMED   39405291
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10729)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 10729)
  AUTHORS   Appler,J.M., Lu,C.C., Druckenbrod,N.R., Yu,W.M., Koundakjian,E.J.
            and Goodrich,L.V.
  TITLE     Gata3 is a critical regulator of cochlear wiring
  JOURNAL   J Neurosci 33 (8), 3679-3691 (2013)
   PUBMED   23426694
REFERENCE   5  (bases 1 to 10729)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10729)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 10729)
  AUTHORS   Podcheko,A., Northcott,P., Bikopoulos,G., Lee,A., Bommareddi,S.R.,
            Kushner,J.A., Farhang-Fallah,J. and Rozakis-Adcock,M.
  TITLE     Identification of a WD40 repeat-containing isoform of PHIP as a
            novel regulator of beta-cell growth and survival
  JOURNAL   Mol Cell Biol 27 (18), 6484-6496 (2007)
   PUBMED   17636024
  REMARK    GeneRIF: Identification of a WD40 repeat-containing isoform of Phip
            as a novel regulator of beta-cell growth and survival.
REFERENCE   8  (bases 1 to 10729)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 10729)
  AUTHORS   Farhang-Fallah,J., Yin,X., Trentin,G., Cheng,A.M. and
            Rozakis-Adcock,M.
  TITLE     Cloning and characterization of PHIP, a novel insulin receptor
            substrate-1 pleckstrin homology domain interacting protein
  JOURNAL   J Biol Chem 275 (51), 40492-40497 (2000)
   PUBMED   11018022
REFERENCE   10 (bases 1 to 10729)
  AUTHORS   Kato,H., Chen,S., Kiyama,H., Ikeda,K., Kimura,N., Nakashima,K. and
            Taga,T.
  TITLE     Identification of a novel WD repeat-containing gene predominantly
            expressed in developing and regenerating neurons
  JOURNAL   J Biochem 128 (6), 923-932 (2000)
   PUBMED   11098134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121787.3 and AC151966.3.
            
            On Feb 6, 2007 this sequence version replaced XM_358384.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ303103.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC121787.3         79061-79298
            239-297             AC121787.3         79404-79462
            298-327             AC121787.3         79594-79623
            328-387             AC121787.3         79817-79876
            388-538             AC151966.3         5036-5186
            539-637             AC151966.3         5277-5375
            638-798             AC151966.3         18969-19129
            799-1020            AC151966.3         31820-32041
            1021-1121           AC151966.3         32301-32401
            1122-1192           AC151966.3         34513-34583
            1193-1293           AC151966.3         35812-35912
            1294-1334           AC151966.3         36018-36058
            1335-1433           AC151966.3         36689-36787
            1434-1587           AC151966.3         37699-37852
            1588-1722           AC151966.3         38356-38490
            1723-1851           AC151966.3         49463-49591
            1852-2077           AC151966.3         50974-51199
            2078-2215           AC151966.3         54963-55100
            2216-2399           AC151966.3         56013-56196
            2400-2517           AC151966.3         57829-57946
            2518-2658           AC151966.3         59098-59238
            2659-2735           AC151966.3         61687-61763
            2736-2967           AC151966.3         64034-64265
            2968-3087           AC151966.3         68746-68865
            3088-3195           AC151966.3         70546-70653
            3196-3320           AC151966.3         71238-71362
            3321-3403           AC151966.3         71482-71564
            3404-3515           AC151966.3         74415-74526
            3516-3577           AC151966.3         74712-74773
            3578-3733           AC151966.3         77218-77373
            3734-3854           AC151966.3         78145-78265
            3855-3980           AC151966.3         79929-80054
            3981-4050           AC151966.3         83148-83217
            4051-4101           AC151966.3         83516-83566
            4102-4251           AC151966.3         84626-84775
            4252-4404           AC151966.3         87545-87697
            4405-4568           AC151966.3         87998-88161
            4569-4828           AC151966.3         88619-88878
            4829-5026           AC151966.3         89400-89597
            5027-10729          AC151966.3         93026-98728
FEATURES             Location/Qualifiers
     source          1..10729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 45.18 cM"
     gene            1..10729
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /note="pleckstrin homology domain interacting protein"
                     /db_xref="GeneID:83946"
                     /db_xref="MGI:MGI:1932404"
     exon            1..238
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..5664
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /note="IRS-1 PH domain-binding protein; WD
                     repeat-containing protein 11; neuronal
                     differentiation-related protein; WD repeat domain 11"
                     /codon_start=1
                     /product="PH-interacting protein"
                     /protein_id="NP_001074685.1"
                     /db_xref="CCDS:CCDS40706.1"
                     /db_xref="GeneID:83946"
                     /db_xref="MGI:MGI:1932404"
                     /translation="MSRERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKEL
                     LPRRTDWTGKEHPRTYQNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLG
                     AGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYR
                     LERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLL
                     ATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFS
                     PLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPTKFTERPRPGVQMICSSFSAGGM
                     FLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW
                     QFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKV
                     WNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKVRSYFNM
                     IEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLI
                     RDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVT
                     SSGLNQVLSQQANQDISPLDSMIQRLQQEQDLRRSGEAGVSNASRVNRGSVSSTSEVH
                     SPPNIGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEEWR
                     TAKGEEEIKSYRSEEKRKHLTVAKENKILTVSKNHAHEHFLDLGDSKKQQANQHNYRT
                     RSALEETPRPLEELENGTSSSDEGEVLAVSGGTSEEEERAWHSDGSSSDYSSDYSDWT
                     ADAGINLQPPKKVPKHKTKKPESSSDEEEESENQKQKHIKKERKKANEEKDGPTSPKK
                     KKPKERKQKRLAVGELTENGLTLEEWLPSAWITDTLPRRCPFVPQMGDEVYYFRQGHE
                     AYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDT
                     GKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAWWFGTIESQ
                     EPLQPEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDVECRS
                     LIYKPLDGEWGANPRDEECERIVGGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPT
                     DLSTIKQRLENRFYRRFSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKD
                     QTCYNIIPLYNSMKKKVLSDSEEEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQA
                     WKKQCQELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESP
                     MELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNT
                     ISKKRKKRNRSSSLSSSAASSPERKKRILKPQLKSEVSTSPFSIPTRSVLPRHNAAQM
                     NGKPESSSVVRTRSNRVAVDPVVTEQPSTSSATKAFVSKTNTSAMPGKAMLENSVRHS
                     KALSTLSSPDPLTFSHATKNNSAKENMEKEKPVKRKMKSSVFSKASPLPKSAAVIEQG
                     ECKNNVLIPGTIQVNGHGGQPSKLVKRGPGRKPKVEVNTSSGEVTHKKRGRKPKNLQC
                     AKQENSEQNNMHPIRADVLPSSTCNFLSETNAVKEDLLQKKSRGGRKPKRKMKTHNLD
                     SELIVPTNVKVLRRSNRKKTDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSE
                     EEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW"
     exon            239..297
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            298..327
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            328..387
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            388..538
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            539..637
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            638..798
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1020
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1121
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1192
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1293
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1334
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1433
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1587
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1722
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1851
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2077
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2215
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2399
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2517
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2658
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2735
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2967
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3087
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3195
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3320
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3403
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3515
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3577
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3733
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3854
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..3980
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4050
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..4101
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4251
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4404
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4568
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            4569..4828
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..5026
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..10729
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10446..10451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /note="hexamer: AATAGA"
     polyA_site      10467
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /note="major polyA site"
     regulatory      10708..10713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
                     /note="hexamer: AATAAA"
     polyA_site      10729
                     /gene="Phip"
                     /gene_synonym="2810004D21Rik; 4632404O06Rik; Ndrp; Wdr11"
ORIGIN      
        1 ggcggccgca gccggggccg ctgcctgaga gttgttgttt cctcctcctc ctccgcctcc
       61 gccgccgttg cttgaatggt ggagccgagg ctcggctcgt gagcacacac tgacagctac
      121 agggcaggcg gcggcaccgt ccccgcgtcc cctcggcggc ggggtgtccc gccggcggcc
      181 ccgaagtgac ccgcaaacat gtctcgtgag aggaaaggcc tctcggagct gcgatcggag
      241 ctctacttcc tcatcgcccg gttcctggaa gatggaccct gtcagcaggc ggctcaggtg
      301 ctgatccgcg aagtggccga gaaggagctg ctgccccggc gcaccgactg gaccgggaag
      361 gagcacccca ggacctacca gaatctggtg aagtattata gacaccttgc acctgatcac
      421 ttgctgcaaa tatgtcatcg gctaggacct cttcttgagc aagaaattcc tcagagtgtt
      481 cctggagtac agactttact aggagctgga agacagtcct tgctacgaac aaataaaagc
      541 tgcaagcatg tggtatggaa aggatctgcc ctggctgcac tgcactgtgg gaggccgcca
      601 gagtctccag ttaactacgg tagcccacct agcattgcgg atactctgtt ttcaaggaag
      661 ctgaatggga aatacagact tgaacgactt gttccaactg cagtttatca gcacatgaag
      721 atgcataagc gaattcttgg acacttatca tcggtgtact gtgtaacttt tgatcgaact
      781 ggcaggcgga tatttactgg ttctgatgat tgtcttgtga aaatctgggc cacagacgat
      841 ggaagattgc tagctacttt aagaggacat gctgctgaaa tatcagacat ggctgtaaac
      901 tatgagaata ctatgatagc agctggaagt tgtgataaaa tgattcgtgt ctggtgtctt
      961 cgaacctgtg cacctttggc tgttcttcag ggacatagtg catctattac atcactacag
     1021 ttctcaccat tgtgcagtgg ctcaaagaga tacctgtctt ctacaggggc ggacggcact
     1081 atttgctttt ggctttggga tgctggaacc cttaaaataa atccaagacc cacaaaattt
     1141 acagagcgtc ctcggcctgg agtgcaaatg atatgttctt cgttcagtgc tggtgggatg
     1201 tttttggcca ctggaagcac tgaccatatt attagagttt atttttttgg atcaggtcag
     1261 ccagaaaaaa tatcagaatt ggagtttcat actgacaaag ttgacagtat ccagttttcc
     1321 aacactagta acaggtttgt gagtggtagt cgtgatggga cagcacgaat ttggcagttt
     1381 aaacgaaggg aatggaaaag cattttgtta gatatggcta ctcgtccagc aggccaaaat
     1441 cttcaaggca tagaagacaa aatcacaaaa atgaaagtaa ctatggtagc ttgggatcga
     1501 catgacaaca cagttataac tgcagttaat aacatgactc tgaaagtttg gaattcttat
     1561 actggtcaac tgatacatgt tctaatgggt catgaagatg aggtgtttgt tcttgagcca
     1621 cacccatttg atcctagagt tctcttctct gctggtcatg atggaaatgt gatagtgtgg
     1681 gatctagcaa gaggagtcaa agttcgatct tatttcaata tgattgaagg acaaggacat
     1741 ggtgcagtgt ttgactgcaa atgctcccct gatggtcagc actttgcatg tacagactct
     1801 catggacatc ttttaatttt tggttttggg tccagtagca agtatgacaa gatagcagat
     1861 cagatgtttt ttcacagtga ttatcggcct cttatccgtg atgcgaacaa ttttgtatta
     1921 gatgagcaga cgcagcaggc acctcacctc atgcctcccc cttttctggt tgatgttgat
     1981 ggaaatcctc atccatcaag gtaccagcga ttggttcctg gtcgggagaa ctgcagggag
     2041 gagcagctca ttcctcagat gggagtaact tcttcaggat tgaaccaagt tttgagccag
     2101 caagcaaacc aggatattag tcctttagac agcatgattc aaagactgca gcaggagcag
     2161 gacctgaggc gttcgggtga agcaggtgtt agtaatgcca gccgtgtgaa cagaggctca
     2221 gtaagttcta cctccgaagt tcattcacca ccaaatatag gattaaggcg cagtggccaa
     2281 atcgaaggtg tacggcagat gcacagcaat gctccgagaa gtgaaatagc cacagagcga
     2341 gatcttgttg cttggagtcg gagggtagta gtgcctgagc tctcggctgg tgtggctagt
     2401 agacaagaag aatggagaac tgcaaaggga gaagaggaaa taaagagtta tagatcagaa
     2461 gagaaaagga aacacttaac tgttgcaaaa gagaataaaa tacttactgt ctcaaagaat
     2521 catgctcatg agcatttcct ggatcttggg gattctaaaa agcagcaagc gaatcagcac
     2581 aattaccgta caagatctgc actggaagaa acacccaggc ccttagagga gctagaaaac
     2641 ggaactagtt cttcagatga aggtgaagta cttgctgtca gtggtgggac ttctgaggaa
     2701 gaggagcgag catggcacag tgatggcagc tccagtgact actccagtga ttattctgat
     2761 tggacagcag atgctggaat taacttgcag ccaccaaaga aagttcctaa gcataaaacc
     2821 aagaaaccag aaagtagttc agatgaagaa gaagaatctg aaaaccagaa gcaaaaacat
     2881 attaaaaagg aaagaaaaaa agcaaatgaa gaaaaagatg gaccaacatc accaaagaaa
     2941 aaaaagccca aagaaagaaa acaaaagaga ttggctgtag gagaactaac tgagaatggc
     3001 ctaacgttag aagagtggtt gccttcagct tggattacag acacacttcc caggagatgt
     3061 ccatttgtgc cacagatggg tgatgaggtt tattattttc gacaagggca tgaagcatat
     3121 gttgaaatgg cccggaaaaa taaaatttat agtatcaatc ctaaaaagca gccatggcat
     3181 aagatggaac taagggaaca agaactaatg aaaattgttg gtataaagta tgaagtgggg
     3241 ttgcctaccc tttgctgcct taaacttgct tttctagatc ctgatactgg caaactgacc
     3301 ggtggatcat ttaccatgaa ataccatgat atgcctgacg tcatagattt tctagtcttg
     3361 agacaacaat ttgatgatgc aaagtataga cgatggaata taggtgaccg cttcagatct
     3421 gtcatagatg atgcctggtg gtttggaaca attgaaagtc aagagcctct tcaacctgag
     3481 taccctgata gtttgtttca gtgttataat gtatgttggg acaatggaga tacagaaaag
     3541 atgagtcctt gggatatgga attaatacct aataatgctg tctttccaga agaactgggt
     3601 accagtgttc ctttaactga tgttgaatgt aggtcgctaa tttataaacc tcttgatgga
     3661 gaatggggag ccaatcccag ggatgaagaa tgtgaaagaa ttgttggagg aataaatcag
     3721 ctgatgacac tagatattgc gtctgcattt gttgcccctg tggaccttca agcttatccc
     3781 atgtattgca ctgtggtggc ctatccaacg gatctaagta caattaaaca aagactggag
     3841 aacaggtttt acaggcgctt ttcatcacta atgtgggaag ttcgatatat agaacataat
     3901 acacgaacat tcaatgagcc aggaagccca attgtgaaat ctgctaaatt tgtgactgat
     3961 cttctcctgc attttataaa ggatcagact tgttataaca taattccact ttacaactca
     4021 atgaagaaga aagttttgtc tgactctgag gaagaagaga aagatgctga tgttccaggg
     4081 acttctacca gaaagcgcaa ggatcatcaa cctagaagaa ggttacgcaa cagagctcag
     4141 tcttacgata ttcaggcatg gaagaaacaa tgtcaagaat tactgaatct catatttcaa
     4201 tgtgaagact cagaaccttt tcgacagcca gtggatcttc ttgaatatcc agactacaga
     4261 gacatcattg acactccaat ggactttgcc actgttagag agactttaga ggctgggaat
     4321 tatgagtcac ccatggagtt atgtaaagat gtcaggctca ttttcagtaa ttctaaagca
     4381 tacacaccaa gcaagagatc aaggatttac agcatgagtt tacgcctgtc tgctttcttt
     4441 gaagaacata ttagttcagt tttgtcagat tataaatctg ctcttcgttt tcataaaaga
     4501 aacaccataa gcaagaagag gaagaagcga aacaggagca gttccctgtc cagcagtgct
     4561 gcctcaagcc ctgaaaggaa aaaaaggatc ttaaaacccc agctaaagtc agaagtatct
     4621 acctctccat tctccatacc tacaagatca gtactaccaa gacataatgc tgcgcaaatg
     4681 aatggtaaac cagaatccag ttctgtggtt cgaactagga gcaaccgtgt agctgtagat
     4741 ccagttgtca ccgagcagcc ctctacatca tcagccacaa aagcttttgt ttcaaaaact
     4801 aatacatctg ccatgccagg aaaagcaatg ctagagaatt ctgtgagaca ttccaaagcc
     4861 ttgagcacac tttccagccc tgatccgctc acattcagcc atgctacaaa gaataattct
     4921 gcaaaagaaa acatggaaaa ggaaaagcct gtcaaacgta aaatgaagtc ttctgtgttt
     4981 tcaaaagcat ctccacttcc aaagtcagcc gcagtcatag agcaaggaga gtgtaagaac
     5041 aatgttctta taccaggaac cattcaagta aatggccatg gaggacaacc atcaaaactc
     5101 gtgaagagag gacctgggag gaagcccaag gtagaagtta acaccagcag tggtgaagtg
     5161 acacacaaga aaagaggtag aaagcccaag aatctgcagt gtgcaaagca ggaaaactct
     5221 gagcaaaata acatgcatcc catcagggct gacgtgcttc cttcttcaac atgcaacttc
     5281 ctttctgaaa ctaatgctgt caaggaggat ttgttacaga aaaagagtcg tggaggcaga
     5341 aaacccaaaa ggaagatgaa aactcacaac ctagattcag aactcatagt tcctacaaat
     5401 gttaaagtgt taaggagaag taaccggaaa aaaacagatg atcctataga tgaggaagag
     5461 gagtttgaag aactcaaagg ctctgagcct cacatgagaa ctagaaatca gggtcgaagg
     5521 acagctttct ataatgagga tgactcggag gaagaacaga gacagctgtt gttcgaggac
     5581 acctccttga catttggaac ttctagtaga ggacgagtcc gaaagttgac tgaaaaagca
     5641 aaggctaatt taattggttg gtaacttgaa gcaaaatatt gcattttaaa aaatctgtaa
     5701 cgcaggtaca gttaaggagt aagtagaact aaggtctctg cttccttgct gctatgacgg
     5761 attagggaat gttacaattt gacttgggaa aatggacaaa aacacattta gaagataatt
     5821 tacatctttg aatgaaaaaa atctatatac atatatattt caaatgtttg ctatttattg
     5881 cccttaggta ggttattcgg ttccacattc atttcatttg ctgtttgaaa ttgaggacct
     5941 gttataaatt ctggtttatt tatggaagag acagctctgc tacactatta agaaacatag
     6001 tattcctaga gataaagtat gtttcctctt aaattgagtt atttttgacc aagtgaggta
     6061 catttttact gatagcagaa ggcatgccct aggaagagag atgttacaaa gagtagcagt
     6121 acattaagaa tggcttcctc taaagataac tttccagttc ccaccatttg ttatcctgaa
     6181 aagtgttgtg aactgtaggt gttcaattac agaatatcta gaggaagctt ttgttttact
     6241 ccatttctgc caaacttagg agaaaaatgt attgatgcaa aggaaacata tccacattgg
     6301 aaaacatttg actgtctaat ttttcagacc ttgattctta tatcagtcac tctatctctg
     6361 tttattgtgc caaagactga gaatcagtgc agtggaaagc ctgtttttga ctgtcaggac
     6421 agcatacact tttcagtact ggaaaagcta tatattctaa agagcaagtt attacaaaat
     6481 tatgctgagt tatatctttt ttttggtact aaatgtagga aaataatgca ctggtgggtc
     6541 ctttgacaga gatatcttag agaaaatgtt taagtggtta aaggattcaa ggacaataca
     6601 ggaaacatgt atggaatttg atgtttactt gatctggatt aatgtcattt ttaaacttca
     6661 gacatatcca gtaggctaaa atgacttaaa aagaaccatg tctgtgtgtg tgtgtatatt
     6721 gataaatggg tgtgattgaa tatatatata caaacgcatt cttaagtact attacccagg
     6781 tataaattct tttttcagga ttttttagat agtagtagaa taaaaataat tttaaaatgt
     6841 catactttat agtttaattt taaggaaaag attggttatt ttcaattatt aaaagttaaa
     6901 aataggccaa atcacttttt atgcaatcat gttttataca gtggtctcat tgcacattgt
     6961 gttttttctg cactttttac ggtatcctta tcaagctggt atctcaatat acactctaaa
     7021 gagaatctct catttaatga ttgtgccttg tattctatta ttttttgcat cattagtaaa
     7081 attaagttgt ctattgtaaa tgataactat atgacttagg ggaatgtatt tctatatgta
     7141 ctgctgtggg aaaaggaaag cagttattta tttgtttatg gtacattagt tattttatat
     7201 cttgaaaacc aacataaatg ccatttctat tgtttaaaat tacttttttt tttttggtaa
     7261 gttttaagaa tgtagtattt tctgagaact gatatggtac aaagatgtaa ccaaatcttt
     7321 cagatactac atttttaaaa aggaaggatg gggaaaatat atatcagcat gaccctgatg
     7381 tagagaataa agtctttaat tgaaccttgg caaaatatgt aattagatta taattgtttc
     7441 cttgtttcca atacggataa atgttaactg tcagtcttga agaagaatga aaagtaatgc
     7501 atttgggctt tttagatcat ttataatgaa atttgtacag aaaccctcca gtgaaactaa
     7561 gtgaaccatt ttccagacct tgactggatt gctgtgattt tacagttaaa aaataatttc
     7621 aaaattttta ggttttttgt acatttattt ttttctaaca aatatattga actatataat
     7681 taaaattaag tagttactct tcataatgca gaaacggatg atgttataga aaaatgagtc
     7741 gatttcacca ttactgaaaa tgatagtgtg tacattggaa atttaagtca ttaaagtaat
     7801 tagttacttt tgaagggaat ctatttgaga aatgtaattt cctgatgtta tctgcattgt
     7861 agtagaaaat tagactaaaa tccattttta taaataaatg tagttataag gtgtgttcaa
     7921 tataaggaag tgcgcacagt cttagtgtgg aggacctcta gaatggggca cagagagttc
     7981 caacctctga gcagtgatct ccatctctct tataacaagg aaatagaaca tttctgtgtt
     8041 aaagacactg tgtattcatg accgtatttg gacattttta gacaatggtt tcttagtaaa
     8101 gtaaaatgac ttggattgca ttatttgtaa ctgaaaactt aagatatatt aataccagtt
     8161 acagatgtta tatttttata atttagcttc tgtacattgc agaagataaa ttatgaactt
     8221 taaatcatca tgttttggtt tgttttactg cttggaaaag tctcctcttt gcaacagtaa
     8281 catcctgtat gtactgtttg tacgtcagaa ggagttgtta gcgctcactt aggtatgcag
     8341 taagaaacat ctcgtttatc agaaaggaaa tttattatgt acatggaaca tagataccag
     8401 ttttcaggct gagttgagtg gtccatgcct ataatcccag catttgggac atggagacag
     8461 gaacatccaa gagttcaaag ttaaccttta atggcaaacc aagttcaaga ctagggctat
     8521 aaaagcagca ataccaaaaa gcctcagttt atatttctaa tattcaacca tattgttata
     8581 ctatcctgac ttcacgaagc ccaagtttag tagaagtttc agtgttgtca caggagtagt
     8641 ttaaagactc agtctaattg cagtctccca gcctttggaa gtagagatgt agcatccaaa
     8701 ggtctcaccc ctcacagtct ctctagagag gtctttgtct tctgcataaa cagataatta
     8761 agggccttat ttccattgtt gttttgcagt gtttcactac aactaaaggt tggtgggtta
     8821 ctaaagaatt gtcatactct aattagatag ctatggaaca tttgtcagat agttaggcca
     8881 catcggagat acatgattga ttgactggaa gcagtttcac ttgaaaatga cttacgtagg
     8941 acagtgaaca gcaaacattc tcatacataa tcattaacag aactgcctct tggctgtagt
     9001 gtagtagact aactggaacc ttcaagggtt attgagataa agttcagccc tgcatgatgt
     9061 tagcagcgtt cacacagtta gtttcagttg acagtgtttt attttgacat tccattttgt
     9121 atcatcatag ctatctataa gcttctctcc aatgtaagtt aaaagtatgt ggtttcaagc
     9181 tttctatcta agaaaacaaa ctgattttaa tattttgttt gcgtgaagtt tatttttgag
     9241 taggttgaaa ggaccaagat acttgagtta ctaaagggct attaccaatg ttcatcctat
     9301 atgcaggagg tgtacagtat tttaaaagtg aatagggtgg agattgcttt tatttagaat
     9361 gcattagccc catattatcc agaagatact gctaacagta gtagcttaat taggcagtaa
     9421 gttgtcttag gttaaaaatt gggaaaagta caccttttgt ttccatccaa aaaaatgatt
     9481 tttagatgac ttcaactaaa attaatgcat ctactaagaa actattttgt ttttaattat
     9541 aattatcaaa atgatccaaa tgaaaagaca ttctcaacta tgtacagtac tccaggagga
     9601 ggtctaattg agtcagaaga ctgtaagtac cactttgagc gctctggaga tcaacccaca
     9661 caagtacagt gagtagatta tctgagctat aaatatattt tttagtttca atagctctgt
     9721 tttgaaatac ttttttaatg cagataaaaa aaatcaggaa attaacctta tatggcacaa
     9781 accaaataca tagtagtata tggatgagtt tctacattta aagaactaag aagataggtt
     9841 caggattgta ttatagtaca tgcacttaca tgcagataca catgctgatt actttcaagg
     9901 atgtgtgtgt tggtttatca caacaataaa tttaaaagta agatacaatg ttacattttt
     9961 agaccatatt gaaacagcaa gaagagacag gtcttaaaaa gttattaaga aaactactta
    10021 atcccaccat gggatattta gaggtctaaa tatagctcaa ttttaaaaag caactgacct
    10081 aaagggttaa tgttgtaact gacacatttc aaattaaaat tatgtttatt ttgtacagaa
    10141 agcaatgtta aacacaagca gatctgttgt atgtaataag tgacagagtt tttaaaatta
    10201 tttagcttta cggatgttgt tttatttctt ctagacctgg agcaccgtgt cataagtggc
    10261 agccttgctc cacggtagca ggctctttct tttgtacata ctgatcggac cttctttact
    10321 gttccgtgga cactttctat gttagttttg atgcataatt cttggaatcc ttttatacaa
    10381 actagaatgt atgtgtaaga attcctgtcc ctgcaatgta gtaactataa acttattttt
    10441 aaataaatag aaaacttgtt tttctaagcc attttgtaga gcctcatgat ttctttgctt
    10501 ttctgtttat tttgattagt tttggacagc ataaagcact tggtacgtac tcagtaggca
    10561 gcttaccaaa gcaattgtga aatagaagcc attatgtaaa ttctggtttg ttagaggttc
    10621 cacttttctg tctatttgtg aaatgttaaa atcattatca aagatttcaa tcacctaatg
    10681 taattccaga gtgactgaag gttaaaaaat aaagatgcct ttgcctttc
//
