LOCUS       NM_016966               1871 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus 3-phosphoglycerate dehydrogenase (Phgdh), mRNA.
ACCESSION   NM_016966 NM_173768 XM_001005889
VERSION     NM_016966.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Hayashi,Y., Kaneko,J., Ito-Matsuoka,Y., Takehara,A., Funakoshi,M.,
            Maezawa,S., Shirane,K., Furuya,S. and Matsui,Y.
  TITLE     Control of epigenomic landscape and development of fetal male germ
            cells through L-serine metabolism
  JOURNAL   iScience 27 (9), 110702 (2024)
   PUBMED   39262797
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Meinhold,M., Verbrugge,S., Shi,A., Schonfelder,M., Becker,L.,
            Jaspers,R.T., Zammit,P.S. and Wackerhage,H.
  TITLE     Yap/Taz activity is associated with increased expression of
            phosphoglycerate dehydrogenase that supports myoblast proliferation
  JOURNAL   Cell Tissue Res 395 (3), 271-283 (2024)
   PUBMED   38183459
  REMARK    GeneRIF: Yap/Taz activity is associated with increased expression
            of phosphoglycerate dehydrogenase that supports myoblast
            proliferation.
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Wu,Y.Q., Zhang,C.S., Xiong,J., Cai,D.Q., Wang,C.Z., Wang,Y.,
            Liu,Y.H., Wang,Y., Li,Y., Wu,J., Wu,J., Lan,B., Wang,X., Chen,S.,
            Cao,X., Wei,X., Hu,H.H., Guo,H., Yu,Y., Ghafoor,A., Xie,C., Wu,Y.,
            Xu,Z., Zhang,C., Zhu,M., Huang,X., Sun,X., Lin,S.Y., Piao,H.L.,
            Zhou,J. and Lin,S.C.
  TITLE     Low glucose metabolite 3-phosphoglycerate switches PHGDH from
            serine synthesis to p53 activation to control cell fate
  JOURNAL   Cell Res 33 (11), 835-850 (2023)
   PUBMED   37726403
  REMARK    GeneRIF: Low glucose metabolite 3-phosphoglycerate switches PHGDH
            from serine synthesis to p53 activation to control cell fate.
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Radzishevsky,I., Odeh,M., Bodner,O., Zubedat,S., Shaulov,L.,
            Litvak,M., Esaki,K., Yoshikawa,T., Agranovich,B., Li,W.H.,
            Radzishevsky,A., Gottlieb,E., Avital,A. and Wolosker,H.
  TITLE     Impairment of serine transport across the blood-brain barrier by
            deletion of Slc38a5 causes developmental delay and motor
            dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2302780120 (2023)
   PUBMED   37812701
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Yoshida,K., Furuya,S., Osuka,S., Mitoma,J., Shinoda,Y.,
            Watanabe,M., Azuma,N., Tanaka,H., Hashikawa,T., Itohara,S. and
            Hirabayashi,Y.
  TITLE     Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase
            gene causes severe neurodevelopmental defects and results in
            embryonic lethality
  JOURNAL   J Biol Chem 279 (5), 3573-3577 (2004)
   PUBMED   14645240
  REMARK    GeneRIF: the Phgdh-dependent phosphorylated pathway is essential
            for normal embryonic development, especially for brain
            morphogenesis
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Sakai,K., Shimizu,H., Koike,T., Furuya,S. and Watanabe,M.
  TITLE     Neutral amino acid transporter ASCT1 is preferentially expressed in
            L-Ser-synthetic/storing glial cells in the mouse brain with
            transient expression in developing capillaries
  JOURNAL   J Neurosci 23 (2), 550-560 (2003)
   PUBMED   12533615
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Yamasaki,M., Yamada,K., Furuya,S., Mitoma,J., Hirabayashi,Y. and
            Watanabe,M.
  TITLE     3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine
            biosynthesis, is preferentially expressed in the radial
            glia/astrocyte lineage and olfactory ensheathing glia in the mouse
            brain
  JOURNAL   J Neurosci 21 (19), 7691-7704 (2001)
   PUBMED   11567059
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Cho,H.M., Jun,D.Y., Bae,M.A., Ahn,J.D. and Kim,Y.H.
  TITLE     Nucleotide sequence and differential expression of the human
            3-phosphoglycerate dehydrogenase gene
  JOURNAL   Gene 245 (1), 193-201 (2000)
   PUBMED   10713460
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Miller,I.J. and Bieker,J.J.
  TITLE     A novel, erythroid cell-specific murine transcription factor that
            binds to the CACCC element and is related to the Kruppel family of
            nuclear proteins
  JOURNAL   Mol Cell Biol 13 (5), 2776-2786 (1993)
   PUBMED   7682653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290664.1, AK076815.1 and AW545294.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001005889.1, NM_016966.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076815.1, AK147946.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY290664.1         1-45
            46-1476             AK076815.1         2-1432
            1477-1488           AW545294.1         384-395             c
            1489-1871           AK076815.1         1445-1827
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.74 cM"
     gene            1..1871
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /note="3-phosphoglycerate dehydrogenase"
                     /db_xref="GeneID:236539"
                     /db_xref="MGI:MGI:1355330"
     exon            1..275
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            276..427
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            428..493
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            494..548
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            549..647
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            648..780
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            781..929
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1082
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1215
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1346
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1584
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1871
                     /gene="Phgdh"
                     /gene_synonym="3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGD;
                     PGDH; SERA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaggaggg ggaggataaa gggggagcgg gagatcgaga accctgccca gtcaccggag
       61 ccagccctgc ttgcagtttc ctgaactaag tgcttctgcc cacccacagc aactgattct
      121 aaggcctgac tctagcaatg gccttcgcaa atctgcgcaa agtactcatc agtgacagcc
      181 tggacccctg ctgccggaag atcctgcaag atggagggct gcaggtggtg gagaagcaga
      241 acttgagcaa ggaggagctg atagctgaac tccaggactg tgaaggcctc attgtccggt
      301 ctgctactaa ggtcactgct gatgtcatca atgcagcaga gaagctccag gtggtgggca
      361 gggctggcac aggtgtggac aatgtggatc tggaggctgc cacgaggaag ggcatcctag
      421 tcatgaacac ccccaacggg aacagcctca gtgctgcgga gctcacctgt gggatgatca
      481 tgtgcctggc caggcagatt ccccaggcaa cagcttcgat gaaagatggc aaatgggacc
      541 ggaagaagtt catggggaca gaactgaacg ggaagacact gggaattctt ggcctcggca
      601 gaattggaag agaggtggcc acccgaatgc aatcctttgg aatgaagact gtaggctatg
      661 accccatcat ctctcctgaa gtcgccgcct cctttggtgt tcagcagctg ccgctggagg
      721 agatctggcc tctctgtgac tttataactg tccatacccc actcctgccc tctaccacag
      781 gcttgctgaa tgacagcacc tttgctcagt gcaagaaagg tgtgcgagta gtgaactgtg
      841 ctcgaggagg cattgtggat gaaggtgccc tgctgcgtgc cctgcagtct ggtcagtgtg
      901 ctggggctgc actggatgtg tttacagaag agccaccacg ggaccgggcc ttagtggacc
      961 acgagaatgt catcagctgt ccccacctgg gtgccagcac caaggaagcc cagagccgct
     1021 gtggggagga aatcgcagtc cagtttgtgg acatggtgaa ggggaaatct ctaacaggcg
     1081 ttgtgaacgc ccaggccctc accagtgcct tctctccaca caccaagcct tggattggtc
     1141 tggcagaagc aatgggcacg ctgatgcacg cctgggctgg ctcccctaaa gggaccatcc
     1201 aggtggttac acaaggaaca tctctgaaga atgctgggac ctgcctgagc cctgcagtca
     1261 ttgtcggcct tctgagagaa gcatctaagc aggcagacgt gaacttggtg aacgctaagc
     1321 tactggtgaa agaggctggc ctcaatgtca ccacctccca caaccctggg gttccagggg
     1381 agcagggtag cggggaatgc ctcctgactg tggccctggc aggtgctccc taccaagccg
     1441 tgggcttggt ccagggcacc acaccaatgc tgcagatgct caacggagct gtcttcagac
     1501 cagaggtgcc actacgcagg ggccaacccc tgctcgtatt ccgggctcag ccctccgacc
     1561 ctgggatgct gcccactatg attggcctcc tggcagaggc gggtgtacag ctgctgtcct
     1621 accaaacctc catggtgtct gacggagagc cctggcacgt catgggcctg tcctccctgc
     1681 tgcccagcct ggaaacatgg aagcagcatg tattggaggc tttccagttc tgcttctgac
     1741 cctggggttc agcactctca gccccacagg ctcttctgaa gaaacccgct caactgtgac
     1801 ctatagggag aggggatcgc agaaccaggg catctgcctg aactaatacc tagtaaagaa
     1861 ttcttaactc c
//
