LOCUS       NM_001113354            6359 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus PHD finger protein 8 (Phf8), transcript variant 2,
            mRNA.
ACCESSION   NM_001113354
VERSION     NM_001113354.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6359)
  AUTHORS   Witucki,L. and Jakubowski,H.
  TITLE     Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy
            pathway by upregulating the expression of histone demethylase
            PHF8-targeting microRNAs in human vascular endothelial cells and
            mice
  JOURNAL   FASEB J 38 (18), e70072 (2024)
   PUBMED   39323294
  REMARK    GeneRIF: Homocysteine metabolites impair the
            PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression
            of histone demethylase PHF8-targeting microRNAs in human vascular
            endothelial cells and mice.
REFERENCE   2  (bases 1 to 6359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6359)
  AUTHORS   Witucki,L. and Jakubowski,H.
  TITLE     Homocysteine metabolites inhibit autophagy, elevate amyloid beta,
            and induce neuropathy by impairing Phf8/H4K20me1-dependent
            epigenetic regulation of mTOR in cystathionine
            beta-synthase-deficient mice
  JOURNAL   J Inherit Metab Dis 46 (6), 1114-1130 (2023)
   PUBMED   37477632
  REMARK    GeneRIF: Homocysteine metabolites inhibit autophagy, elevate
            amyloid beta, and induce neuropathy by impairing
            Phf8/H4K20me1-dependent epigenetic regulation of mTOR in
            cystathionine beta-synthase-deficient mice.
REFERENCE   4  (bases 1 to 6359)
  AUTHORS   Liu,Y., Hu,L., Wu,Z., Yuan,K., Hong,G., Lian,Z., Feng,J., Li,N.,
            Li,D., Wong,J., Chen,J., Liu,M., He,J. and Pang,X.
  TITLE     Loss of PHF8 induces a viral mimicry response by activating
            endogenous retrotransposons
  JOURNAL   Nat Commun 14 (1), 4225 (2023)
   PUBMED   37454216
  REMARK    GeneRIF: Loss of PHF8 induces a viral mimicry response by
            activating endogenous retrotransposons.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6359)
  AUTHORS   St-Germain,J., Khan,M.R., Bavykina,V., Desmarais,R., Scott,M.,
            Boissonneault,G., Brunet,M.A. and Laurent,B.
  TITLE     Functional Characterization of a Phf8 Processed Pseudogene in the
            Mouse Genome
  JOURNAL   Genes (Basel) 14 (1), 172 (2023)
   PUBMED   36672913
  REMARK    GeneRIF: Functional Characterization of a Phf8 Processed Pseudogene
            in the Mouse Genome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6359)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 6359)
  AUTHORS   Xiao,C., Sharp,J.A., Kawahara,M., Davalos,A.R.,
            Difilippantonio,M.J., Hu,Y., Li,W., Cao,L., Buetow,K., Ried,T.,
            Chadwick,B.P., Deng,C.X. and Panning,B.
  TITLE     The XIST noncoding RNA functions independently of BRCA1 in X
            inactivation
  JOURNAL   Cell 128 (5), 977-989 (2007)
   PUBMED   17350580
REFERENCE   8  (bases 1 to 6359)
  AUTHORS   Laumonnier,F., Holbert,S., Ronce,N., Faravelli,F., Lenzner,S.,
            Schwartz,C.E., Lespinasse,J., Van Esch,H., Lacombe,D., Goizet,C.,
            Phan-Dinh Tuy,F., van Bokhoven,H., Fryns,J.P., Chelly,J.,
            Ropers,H.H., Moraine,C., Hamel,B.C. and Briault,S.
  TITLE     Mutations in PHF8 are associated with X linked mental retardation
            and cleft lip/cleft palate
  JOURNAL   J Med Genet 42 (10), 780-786 (2005)
   PUBMED   16199551
  REMARK    GeneRIF: an important function of PHF8 is in midline formation and
            in the development of cognitive abilities, and may have a role in X
            linked mental retardation associated with cleft lip/palate
REFERENCE   9  (bases 1 to 6359)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   10 (bases 1 to 6359)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040969.1 and AK122447.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               AK040969.1         2-910
            910-6359            AK122447.1         1-5450
FEATURES             Location/Qualifiers
     source          1..6359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..6359
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /note="PHD finger protein 8"
                     /db_xref="GeneID:320595"
                     /db_xref="MGI:MGI:2444341"
     exon            1..766
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            767..955
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     CDS             858..3929
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /EC_number="1.14.11.27"
                     /EC_number="1.14.11.65"
                     /note="isoform b is encoded by transcript variant 2;
                     histone lysine demethylase PHF8; [histone
                     H3]-dimethyl-L-lysine(9) demethylase PHF8; [histone
                     H3]-dimethyl-L-lysine(36) demethylase PHF8"
                     /codon_start=1
                     /product="histone lysine demethylase PHF8 isoform b"
                     /protein_id="NP_001106825.1"
                     /db_xref="CCDS:CCDS53223.1"
                     /db_xref="GeneID:320595"
                     /db_xref="MGI:MGI:2444341"
                     /translation="MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAAD
                     IDLYHCPNCEVLHGPSIMKKRRGSSKGHDNHKGKPLKTGSSMFIRELRGRTFDSSDEV
                     ILKPTGSQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVI
                     DVARQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVETPRIVRKLSWVEN
                     LWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANL
                     TLFECWSSSSNQNEMFFGDQVEKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNF
                     LHSLNIEMQLKAYEIEKRLSTADLFKFPNFETICWYVGKHILDIFRGLRENRRHPASY
                     LVHGGKALNLAFRAWTKKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGK
                     TSNIFGLQRIFPAGSIPLTKPAHSTSVSMSKLSLPSKNGSKKKGLKPKDIFKKAERKG
                     KQSSALGPAGQLSYNLMDPYSHQALKTGPSQKAKFNMSGTSLNDSDDDSADMDLDGSE
                     NPLALLMANGSTKRMKSVSKSRRAKIAKKVDSARLVAEQVMGDEFDLDSDDELQIDER
                     LGKEKANLLIRSKFPRKLPRAKPCSDPNRIREPGEVEFDIEEDYTTDEDMVEGVESKL
                     GNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPAT
                     SSLQAWWTGGQERSSGSSSSGLGTVSSSPASQRTPGKRPIKRPAYWKNESEEEENASL
                     DEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQD
                     RPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNPIM
                     TMPAPTVATTPQPDTSSSPQPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPM
                     APGVFLTQRRPSVGSQSSQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL"
     exon            956..1041
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1150
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1311
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1453
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1640
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1803
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1891
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1998
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2090
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2180
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2483
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2587
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2766
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2852
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2986
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3297
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3393
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3503
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3840
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..6359
                     /gene="Phf8"
                     /gene_synonym="9830141C09Rik; mKIAA1111"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcccgagc ctcgtaagat ggcggcgggc tcgtctcttt cccagaacgc cgccactctc
       61 aatatggtag ctgtttacca tatctctcca cccctctccg cctcaactgc ctcgcgattt
      121 tgaataaact ttattgattg ctttgaatct cctacaaccc cccgagagtg gcttctcccg
      181 gcgacctctc cggcggtctt tctccagccg ccgcaagcct gtctcgcgaa gggggcagcg
      241 acaaagccac ttgccagtgc gcccggcggc cccgaccccg acccccagcc ccggctgaga
      301 cctcggtctc tagaaggctc tgagggccag acggtgggag ggctgaggtg gacactgccc
      361 gaaagccccg tcagagcccg ggcactgcgt gacgcggcat gtggtttcta ggagaaggca
      421 agtcagcttc acagtttggc agcggcaatc ccagcattca gcgcgcgccg cctcgggccg
      481 gaactgcccg gccagcctgt gcttagcgca gagctgggtt gccccggagc gagcccagcg
      541 gcaggcgagt ctctggggct gagctctgtt ccctgaggac ttgccccctg cagcctcggg
      601 catgaagaga gctctgtagc gtttgggacc gtggacattt tttatcaggt ttggggcata
      661 aaaaaggttc ctgtcagtgt gtgtgtgggg aggcgtagag agctcctcgt aagttttggg
      721 ggctgcaagc aagctgcgtt ctaatttaag acgagacgtc tgtcagccat cgtctagaga
      781 aggcgcttgt tgctgccttc agacccagta aagcttcaaa actggcacgg cgcaaaacga
      841 tccaaccccc tgtgaagatg gcctcggtgc ctgtgtattg cctctgtcga ctgccttatg
      901 atgtgacccg cttcatgatc gagtgtgaca tgtgccagga ctggtttcac ggcagttgtg
      961 ttggtgttga ggaggagaag gctgctgata ttgatcttta ccactgccct aactgtgagg
     1021 tcttacatgg accttccatt atgaaaaaac gtcgtggatc ttccaaagga catgataatc
     1081 acaaggggaa gccactgaag actggaagct ctatgtttat ccgagaactt cggggcagaa
     1141 cttttgacag ctcagatgaa gtgattctga agcccactgg aagtcagctg actgtggaat
     1201 tcttggaaga gaatagcttc agcgtgccta tccttgtctt gaagaaggat gggttgggga
     1261 tgacattacc ctctccatca ttcactgtga gggatgtgga acactatgtt ggttctgaca
     1321 aagagattga tgtgattgat gtggcccgcc aggctgactg caagatgaaa ctcggtgatt
     1381 ttgtcaaata ctattacagt gggaagaggg aaaaagtcct caatgtcatt agtttggaat
     1441 tctccgatac caggctttca aacctcgtgg aaacacccag gattgttcgc aagctgtcat
     1501 gggtggagaa cttgtggcca gaggaatgtg tctttgagag acccaatgtg cagaagtact
     1561 gcctcatgag tgtgcgggat agctatacag attttcacat tgactttggt gggacctcag
     1621 tttggtacca tgtgcttaag ggtgagaaga tcttctacct gatccgccca acaaatgcta
     1681 atctgactct ctttgagtgc tggagtagct cctccaatca gaacgagatg ttctttggtg
     1741 accaagtgga aaagtgctac aagtgttctg tgaagcaagg acaaacactg tttattccta
     1801 caggatggat acatgctgtg ttaacacccg tggactgctt agcattcgga gggaacttct
     1861 tacacagtct taacattgaa atgcaactca aggcttatga aattgagaag aggctgagca
     1921 cagcagacct tttcaagttt cccaacttcg agaccatctg ttggtatgtg ggaaaacata
     1981 ttctggacat ctttcgaggc ttacgagaaa atagaagaca ccctgcctcc tacctggtcc
     2041 atggtggtaa agctctgaac ttggcattta gagcttggac aaagaaagaa gctttgccag
     2101 accacgagga tgagatccca gagacagtgc ggactgtaca gctcattaaa gatctggcta
     2161 gggagatccg tctggttgaa gacatcttcc aacagaacgt tgggaagacg agcaatatct
     2221 ttgggctgca gaggatcttc ccagctggct ccatcccctt aaccaagcca gcccattcca
     2281 cttcagtatc catgtccaag ctgtcactgc cctccaaaaa tggttcaaag aagaaaggcc
     2341 tgaagcccaa ggatatcttc aagaaggcag agcgaaaggg caagcagagt tcagccttgg
     2401 ggcctgctgg ccagttgagc tataatctca tggacccata cagtcatcag gcactgaaga
     2461 caggcccttc ccagaaagca aagttcaaca tgagtggtac cagcttgaat gattcagatg
     2521 atgactcagc agacatggac cttgatggca gtgagaaccc tctggccctg ttgatggcta
     2581 atggcagtac gaagaggatg aagagtgtat ccaaatctcg gagagccaaa attgcaaaga
     2641 aggtagacag tgcaagactg gtagcagaac aggtcatggg agatgaattt gacttggatt
     2701 cagatgatga gctgcagatt gacgagagat tgggaaagga aaaggcgaac ctgttaataa
     2761 gatcaaaatt tccccggaag ttgccccgtg caaaaccttg ctctgacccc aaccgaattc
     2821 gtgaacctgg agaagttgag tttgacattg aggaggacta taccacagat gaggacatgg
     2881 tggaaggggt tgaaagcaag cttgggaatg ggagtggagc cggtggaatt cttgatctac
     2941 ttaaggccag caggcaggtg gggggacctg actatgctgc cctcactgag gccccagcct
     3001 cccccagcac tcaagaggcc atccagggca tgttgtgtat ggccaacctg cagtcctcat
     3061 catcctcacc agctacctcc agtctgcagg cttggtggac tggagggcaa gaaagaagca
     3121 gcgggagctc cagcagtggc ctgggcactg tgtctagtag tcctgcttcc cagcgcaccc
     3181 cagggaagcg gcccatcaag aggccagcat actggaaaaa cgagagtgaa gaggaggaga
     3241 atgccagtct tgatgagcaa gacagcttgg gagcatgctt caaggatgct gagtatatct
     3301 atccatctct ggagtctgat gatgatgacc ctgctttgaa atctcgaccc aagaaaaaga
     3361 agaattcaga tgatgctcca tggagtccta aagcccgtgt gactccaacc ctacccaagc
     3421 aggaccgtcc tgttcgtgag gggaccagag ttgcctccat tgagacaggc ttggctgcag
     3481 cagctgcaaa gcttgcccag caggagctac aaaaggccca aaagaagaaa tatatcaaga
     3541 agaagccttt gctgaaggag gtagaacagc cgcgccctca agattccaat cccatcatga
     3601 caatgcctgc accaactgtg gctacaacac cccagcctga cacctcctcc tcaccccagc
     3661 cacctcctga gcctaaacaa gaggctctgt caggaagtct tgctgaccat gagtacactg
     3721 ctcgtcccaa tgcctttggc atggctcagg caaatcgcag caccacaccc atggcccctg
     3781 gagtcttcct cacccagcgg cgcccttcag ttggttccca gagcagtcag gcaggacaag
     3841 gaaagcgtcc taaaaagggc ctggccacag caaagcagag actcggccgc atcctgaaaa
     3901 tccacagaaa tggcaagtta cttctgtgag acgagcccca tcatgtccta ctccttcatc
     3961 ccttcacccc cattgccttc ttcgttgtca actcggggca ctcctggatc ctatgagccc
     4021 cggacaaggt gcattgtcct gctttcttgg gactgaccaa aggcacggac tatctccaac
     4081 tccctttccc acttccccta tgagtatcct accttctttt tccatatcca taaatagcag
     4141 gtaaatggga gacatttcca actgacaaga accttttcct gctccaccca catatttcac
     4201 ttacaccttg tctttattct tttccactgc tcctctatat ggaaggaatg aggaggagca
     4261 acataaaggg agtctgggcc tgtcagtttc ctcagccatg gagtgagaag cccagtgctc
     4321 aacattttct gcacctccag ccctgtctct aagcctgccc acctccaccc attcctaccc
     4381 cttcctcaca accgatggat ataccctacc ttcattcttg ttcctgatag aaggttgtgg
     4441 tctttatctt cttttacctc tttttcatga caaaatgaag agggtcttta tgaccctatt
     4501 atgggacaac tccagagctg gcctagaaaa gctgacttta tctgtctttg ggggaggggg
     4561 aggagattcc ttttactttt cgaggtggga aaaaggacag atacccaagc ctttgaccat
     4621 gattgttgct tagcccacca gaggaaacta cttttgtctg actgcaaatg aaacccctat
     4681 gatgatcttc aggaatttgc ctgtattttt gaggccctgt agaacattat ccccatagct
     4741 ataactgggt tcaagcaggt acaaactcac ctcctagaaa tctgaagtac ctggcacatt
     4801 gagaactatg gcccctgcca ccccacaaag cacagcctgg accttctgaa gagggtgtgg
     4861 tgagataacc ctgaagggtc attatcagga acttccatgt ttctttcccc atctaagctt
     4921 agtctaaaga agatttcagt actaagatct tcacccctgg gactttccac ttccagacca
     4981 caggccaact attcaagcat agtacagata ggctattgaa gtctgaagtt agaaacaatg
     5041 cccatatgtg aagtagcaga tattctgatc cgcttttctc tgctttcctt tgtgattgtc
     5101 actattttcc agacaatgtc cccacctccc tcttgtcttg ccttactggc aatctgggct
     5161 tgatggagac tgccccttct gaacaaccca ttttggcact gcccaagtgg gagtgtcctc
     5221 taccttccac tcgtcctcat cccagcttgc ctagtgcttc tggggaattt aacagctatg
     5281 atgcagacca cagggaattt gtgaggcctc tgtgttatct tttatgtttg tggcttatct
     5341 ttcttttttc tatagatgta tcacctccat ccttgttggg atggggggat actttagcat
     5401 atttgctttt tctaccttgg ggacccccag gggccaagca gtcctccttt agtcacacca
     5461 aaggcaaaag gcctggctac ctccccttta gcacgtgagg tccctattcc cctcctttct
     5521 actcagcttt gcttatcttg gagatttcaa ggcagcagta gggaagtaag gggaaagcag
     5581 gagaagctcc taaccctgta tgggcaactt cctgactaaa gactgactgt tgtcaccaaa
     5641 aacaggtccc tagccctttc acccactaaa actccctctt gatctttcaa tggcagctaa
     5701 ttgctagcac cctcacccca cccattccag gcctcttttc cctctgtttc tttgttagaa
     5761 ggttctgtgg agctgaaacc cagcctctaa tggggtttgt ttagtttagt tgggttctca
     5821 gagtctcctg ttattttgtg ttgtttccaa tgaaaagcaa gtttaccctc aaagttatgc
     5881 ttttccaaag aagctagtgt gttagtggtg ttgttgctgt tgttgctgtt gttgttgttg
     5941 ttttgtttgt tttgttttta tgtttcaggt tctaagtgaa gtgaggtgga gaggagttgg
     6001 gaataaccaa ggtttagaac atggtgagat agttaacctc tgatctgcaa tccccagcag
     6061 agagttgggg taggataaga gggcagagag gatttctatt cacctttaat atatttttac
     6121 aaaaaagcaa acaatttaaa aacaaaccca ccgcttctgt acatgtctaa atatattttt
     6181 agaagtgggt aggattgtga tttctgatgc agggcctttt tataaatagg ttagagtagc
     6241 ctcatccaga tttctctgtt gtttgttccc cttgtttttt cttatgttgt gttactaatg
     6301 taatttatat attttttaga tctccctttc ctgtagagat aaaagtgatt tatcttggc
//
