LOCUS       NM_027949               2102 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PHD finger protein 7 (Phf7), transcript variant 1,
            mRNA.
ACCESSION   NM_027949
VERSION     NM_027949.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2102)
  AUTHORS   Kim,J.E., Park,S.G., Ka,D.B., Kim,E.K., Cho,S.M., Kim,H.R.,
            Lee,M.N., Choi,K.C., Yoon,W.K. and Nam,K.H.
  TITLE     Phf7 has impacts on the body growth and bone remodeling by
            regulating testicular hormones in male mice
  JOURNAL   Biochem Biophys Res Commun 704, 149596 (2024)
   PUBMED   38430697
  REMARK    GeneRIF: Phf7 has impacts on the body growth and bone remodeling by
            regulating testicular hormones in male mice.
REFERENCE   2  (bases 1 to 2102)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2102)
  AUTHORS   Garry,G.A., Bezprozvannaya,S., Chen,K., Zhou,H., Hashimoto,H.,
            Morales,M.G., Liu,N., Bassel-Duby,R. and Olson,E.N.
  TITLE     The histone reader PHF7 cooperates with the SWI/SNF complex at
            cardiac super enhancers to promote direct reprogramming
  JOURNAL   Nat Cell Biol 23 (5), 467-475 (2021)
   PUBMED   33941892
  REMARK    GeneRIF: The histone reader PHF7 cooperates with the SWI/SNF
            complex at cardiac super enhancers to promote direct reprogramming.
REFERENCE   4  (bases 1 to 2102)
  AUTHORS   Liang,Z.S., Cimino,I., Yalcin,B., Raghupathy,N., Vancollie,V.E.,
            Ibarra-Soria,X., Firth,H.V., Rimmington,D., Farooqi,I.S.,
            Lelliott,C.J., Munger,S.C., O'Rahilly,S., Ferguson-Smith,A.C.,
            Coll,A.P. and Logan,D.W.
  TITLE     Trappc9 deficiency causes parent-of-origin dependent microcephaly
            and obesity
  JOURNAL   PLoS Genet 16 (9), e1008916 (2020)
   PUBMED   32877400
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2102)
  AUTHORS   Kim,C.R., Noda,T., Kim,H., Kim,G., Park,S., Na,Y., Oura,S.,
            Shimada,K., Bang,I., Ahn,J.Y., Kim,Y.R., Oh,S.K., Choi,H.J.,
            Kim,J.S., Jung,I., Lee,H., Okada,Y., Ikawa,M. and Baek,S.H.
  TITLE     PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange
            during Spermiogenesis
  JOURNAL   Cell Rep 32 (4), 107950 (2020)
   PUBMED   32726616
  REMARK    GeneRIF: PHF7 Modulates BRDT Stability and Histone-to-Protamine
            Exchange during Spermiogenesis.
REFERENCE   6  (bases 1 to 2102)
  AUTHORS   Wang,X., Kang,J.Y., Wei,L., Yang,X., Sun,H., Yang,S., Lu,L.,
            Yan,M., Bai,M., Chen,Y., Long,J., Li,N., Li,D., Huang,J., Lei,M.,
            Shao,Z., Yuan,W., Zuo,E., Lu,K., Liu,M.F. and Li,J.
  TITLE     PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine
            exchange during spermiogenesis
  JOURNAL   Development 146 (13) (2019)
   PUBMED   31189663
  REMARK    GeneRIF: PHF7 is a novel E3 ligase that can specifically
            ubiquitylate H2A through binding H3K4me3/me2 prior to
            histone-to-protamine exchange.
            Erratum:[Development. 2020 Apr 27;147(8):dev191445. doi:
            10.1242/dev.191445.. PMID: 32341030]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2102)
  AUTHORS   van de Moosdijk,A.A. and van Amerongen,R.
  TITLE     Identification of reliable reference genes for qRT-PCR studies of
            the developing mouse mammary gland
  JOURNAL   Sci Rep 6, 35595 (2016)
   PUBMED   27752147
  REMARK    GeneRIF: validated as novel and reliable, tissue-specific reference
            gene in qRT-PCR studies of postnatal mammary gland development
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2102)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2102)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   10 (bases 1 to 2102)
  AUTHORS   Xiao,J., Xu,M., Li,J., Chang Chan,H., Lin,M., Zhu,H., Zhang,W.,
            Zhou,Z., Zhao,B. and Sha,J.
  TITLE     NYD-SP6, a novel gene potentially involved in regulating testicular
            development/spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 291 (1), 101-110 (2002)
   PUBMED   11829468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049113.1, AK005852.1 and BM937743.1.
            
            On Feb 8, 2018 this sequence version replaced NM_027949.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005852.1, BC132517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                BC049113.1         1-97
            98-2081             AK005852.1         1-1984
            2082-2102           BM937743.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2102
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..2102
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /note="PHD finger protein 7"
                     /db_xref="GeneID:71838"
                     /db_xref="MGI:MGI:1919088"
     exon            1..611
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..721
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             681..1604
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis development protein NYD-SP6"
                     /codon_start=1
                     /product="PHD finger protein 7 isoform 1"
                     /protein_id="NP_082225.1"
                     /db_xref="CCDS:CCDS26909.1"
                     /db_xref="GeneID:71838"
                     /db_xref="MGI:MGI:1919088"
                     /translation="MKTLKEKNKHPRLRKTIRTKKVTQRKLSSSPVCLLCLQEPGDPE
                     KLGEFLQKDNLCVHYFCLILSSRLPQKGQPNRGLHGFMPEDIKREAVRASKKICFVCK
                     KKGAAIRCQNDQCVQNFHLPCGQERGCLSQFFGEYKSYCRKHRPTQNIHQGSLGEESC
                     VLCCENLSRTSVENIQSPCCSQAIYHRKCIQKYAHTSAKHFFKCPQCNNREEFPQEML
                     RMGIHIPDRDAAWELEPGAFSELYQRYRHCDAPICLYEQGRDSFEDEGRWRLILCATC
                     GSHGTHRDCSSLRPNSKKWECNECLPASTTS"
     exon            722..774
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            775..866
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            867..968
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1093
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1253
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1360
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1477
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1623
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..2088
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2064..2069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2082
                     /gene="Phf7"
                     /gene_synonym="1700006H01Rik; 1700010P14Rik"
                     /note="major polyA site"
ORIGIN      
        1 cggtcctcgt tttggccaca gtccgcgtga ccccatcccc cctcagcacg ctcgcctcct
       61 tcgacggcgc agtcaccgcg cggggcggcc gcccgtgaag tagttaccac gtcttgtgtc
      121 aacgactaaa gctccgggac agcggcgccc tcggcgacag ctgggtgggc agcctgggct
      181 gaaagcggtg gcccgtagct tccgtgagag cgagcagcgg aagcagcctc cagcctggcc
      241 tcgccacagc cgcccggcaa gggagccctg gcatgcgcgg aatgctcctt gagccctctt
      301 ctgactgtta cctttggggg acggttgtgg ccacactgac gtattttcca aataaatcgt
      361 ttattcttgc ggcggcggga ccgaacacgt taatatattt ttaatttacc caacactttt
      421 atccagtgat acaacttggt aagcgtttcg agcgagcatc cgccgggtta ggaaatcgcg
      481 gactgagcag cttgcatttg ccacgaccgt cctcaactgt tttgaagatt ccatcttata
      541 actaccagtg tgcacagact actactcaag taacgtcgtg tcccagcgat gcaaagaact
      601 gaaatctcaa gctggaaaag cctgcattat cttcataata gcacagaaga attctagata
      661 ggaaggacag acggaaacga atgaagactt taaaagaaaa aaacaaacat ccaagattga
      721 gaaaaactat caggactaag aaggtaacac agaggaagct gtcttcaagt cctgtttgcc
      781 ttctatgcct tcaagaacct ggtgatcctg aaaaactagg agaatttctt cagaaagaca
      841 atctttgtgt ccattatttc tgtcttatcc tgtctagcag actgcctcag aagggccaac
      901 ccaacagagg tctccatgga tttatgcctg aagacatcaa aagggaggca gtacgggctt
      961 ctaagaagat ctgctttgta tgcaagaaaa aaggagctgc tatcagatgc cagaatgatc
     1021 agtgtgtcca gaacttccat ctgccttgtg gccaagaaag gggttgcctt tcacagtttt
     1081 ttggagagta caaatcatat tgtagaaaac atcgaccaac acagaacatc caccagggga
     1141 gtttggggga ggaaagctgt gtcttgtgtt gcgaaaattt atcccgaaca agtgttgaga
     1201 acatccagag cccatgctgt agtcaagcta tctatcaccg caagtgtatc cagaaatatg
     1261 cccacacatc agcaaagcac ttcttcaagt gtccccagtg caacaaccga gaagagttcc
     1321 cacaggagat gctgaggatg gggatccaca tcccagacag agatgctgcc tgggaactcg
     1381 agccaggggc tttctccgag ttgtatcagc gctatcggca ttgtgatgcc cccatctgtc
     1441 tgtatgagca aggcagagac agctttgagg atgaaggacg gtggcgcctc attttgtgtg
     1501 ctacgtgtgg atcccatgga acccaccggg actgctcctc tcttagacca aacagcaaga
     1561 aatgggaatg taatgagtgt ttgcctgctt caaccacgag ttaggctgga aggatggtct
     1621 gctattacat atctgaagac tcaggcaaca ccccctgttg cagcagcacc ttctgccccc
     1681 atgtgtattt cttaagggct ggctaccagc ctggaagaga atcccagctc ttctggactg
     1741 attggctaca aacttccctc ttagaaaagc ccgagtcctc tggtggaaga agctgcccgt
     1801 cctggtgatc caaaggattg caaaaaatcc aagtaatagc ttcagggcgg ttcctgccca
     1861 ggacagtgag atacaaaaga gcgttgctgc atcagtttgg agaggtagca ctttgaaacc
     1921 atgagactca aggggctaag tgaagaggtc tcaggggaca cggagtcttc gtgccaacag
     1981 tggaatgtaa gggcactcac tgttcaccat aatgtggctc tcatgtgctt cctccagctt
     2041 cactcactca tttgttattg acaaataaag gtcatctctc cactcgggaa aaaaaaaaaa
     2101 aa
//
