LOCUS       NM_027642               4420 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus PHD finger protein 6 (Phf6), transcript variant 1,
            mRNA.
ACCESSION   NM_027642
VERSION     NM_027642.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4420)
  AUTHORS   McRae,H.M., Leong,M.P.Y., Bergamasco,M.I., Garnham,A.L., Hu,Y.,
            Corbett,M.A., Whitehead,L., El-Saafin,F., Sheikh,B.N., Wilcox,S.,
            Hannan,A.J., Gecz,J., Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles
            and altered transcription in the cortex of a mouse model of the
            Borjeson-Forssman-Lehmann intellectual disability syndrome
  JOURNAL   PLoS Genet 20 (10), e1011428 (2024)
   PUBMED   39405291
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4420)
  AUTHORS   Jalnapurkar,S.S., Pawar,A.S., George,S.S., Antony,C., Somers,P.,
            Grana,J., Feist,V.K., Gurbuxani,S. and Paralkar,V.R.
  TITLE     PHF6 suppresses self-renewal of leukemic stem cells in AML
  JOURNAL   Leukemia 38 (9), 1938-1948 (2024)
   PUBMED   39004675
  REMARK    GeneRIF: PHF6 suppresses self-renewal of leukemic stem cells in
            AML.
REFERENCE   3  (bases 1 to 4420)
  AUTHORS   Mittal,P., Myers,J.A., Carter,R.D., Radko-Juettner,S., Malone,H.A.,
            Rosikiewicz,W., Robertson,A.N., Zhu,Z., Narayanan,I.V.,
            Hansen,B.S., Parrish,M., Bhanu,N.V., Mobley,R.J., Rehg,J.E., Xu,B.,
            Drosos,Y., Pruett-Miller,S.M., Ljungman,M., Garcia,B.A., Wu,G.,
            Partridge,J.F. and Roberts,C.W.M.
  TITLE     PHF6 cooperates with SWI/SNF complexes to facilitate
            transcriptional progression
  JOURNAL   Nat Commun 15 (1), 7303 (2024)
   PUBMED   39181868
  REMARK    GeneRIF: PHF6 cooperates with SWI/SNF complexes to facilitate
            transcriptional progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4420)
  AUTHORS   Rasool,D., Burban,A., Sharanek,A., Madrigal,A., Hu,J., Yan,K.,
            Qu,D., Voss,A.K., Slack,R.S., Thomas,T., Bonni,A., Picketts,D.J.,
            Soleimani,V.D., Najafabadi,H.S. and Jahani-Asl,A.
  TITLE     PHF6-mediated transcriptional control of NSC via Ephrin receptors
            is impaired in the intellectual disability syndrome BFLS
  JOURNAL   EMBO Rep 25 (3), 1256-1281 (2024)
   PUBMED   38429579
  REMARK    GeneRIF: PHF6-mediated transcriptional control of NSC via Ephrin
            receptors is impaired in the intellectual disability syndrome BFLS.
REFERENCE   5  (bases 1 to 4420)
  AUTHORS   Hou,S., Wang,X., Guo,T., Lan,Y., Yuan,S., Yang,S., Zhao,F.,
            Fang,A., Liu,N., Yang,W., Chu,Y., Jiang,E., Cheng,T., Sun,X. and
            Yuan,W.
  TITLE     PHF6 maintains acute myeloid leukemia via regulating NF-kappaB
            signaling pathway
  JOURNAL   Leukemia 37 (8), 1626-1637 (2023)
   PUBMED   37393343
  REMARK    GeneRIF: PHF6 maintains acute myeloid leukemia via regulating
            NF-kappaB signaling pathway.
REFERENCE   6  (bases 1 to 4420)
  AUTHORS   Zhang,C., Mejia,L.A., Huang,J., Valnegri,P., Bennett,E.J.,
            Anckar,J., Jahani-Asl,A., Gallardo,G., Ikeuchi,Y., Yamada,T.,
            Rudnicki,M., Harper,J.W. and Bonni,A.
  TITLE     The X-linked intellectual disability protein PHF6 associates with
            the PAF1 complex and regulates neuronal migration in the mammalian
            brain
  JOURNAL   Neuron 78 (6), 986-993 (2013)
   PUBMED   23791194
  REMARK    GeneRIF: As part of a cell-intrinsic transcriptional pathway, PHF6
            regulates neuronal migration in the brain.
REFERENCE   7  (bases 1 to 4420)
  AUTHORS   Mavrakis,K.J., Van Der Meulen,J., Wolfe,A.L., Liu,X., Mets,E.,
            Taghon,T., Khan,A.A., Setty,M., Rondou,P., Vandenberghe,P.,
            Delabesse,E., Benoit,Y., Socci,N.B., Leslie,C.S., Van
            Vlierberghe,P., Speleman,F. and Wendel,H.G.
  TITLE     A cooperative microRNA-tumor suppressor gene network in acute
            T-cell lymphoblastic leukemia (T-ALL)
  JOURNAL   Nat Genet 43 (7), 673-678 (2011)
   PUBMED   21642990
  REMARK    Erratum:[Nat Genet. 2011 Aug;43(8):815. Setti, Manu [corrected to
            Setty, Manu]]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4420)
  AUTHORS   Voss,A.K., Gamble,R., Collin,C., Shoubridge,C., Corbett,M., Gecz,J.
            and Thomas,T.
  TITLE     Protein and gene expression analysis of Phf6, the gene mutated in
            the Borjeson-Forssman-Lehmann Syndrome of intellectual disability
            and obesity
  JOURNAL   Gene Expr Patterns 7 (8), 858-871 (2007)
   PUBMED   17698420
  REMARK    GeneRIF: Strongest Phf6 gene expression and nuclear localisation of
            Phf6 protein were observed in the developing central nervous
            system, the anterior pituitary gland, the primordia of facial
            structures and the limb buds.
REFERENCE   9  (bases 1 to 4420)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   10 (bases 1 to 4420)
  AUTHORS   Lower,K.M., Turner,G., Kerr,B.A., Mathews,K.D., Shaw,M.A.,
            Gedeon,A.K., Schelley,S., Hoyme,H.E., White,S.M., Delatycki,M.B.,
            Lampe,A.K., Clayton-Smith,J., Stewart,H., van Ravenswaay,C.M., de
            Vries,B.B., Cox,B., Grompe,M., Ross,S., Thomas,P., Mulley,J.C. and
            Gecz,J.
  TITLE     Mutations in PHF6 are associated with Borjeson-Forssman-Lehmann
            syndrome
  JOURNAL   Nat Genet 32 (4), 661-665 (2002)
   PUBMED   12415272
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016480.1, BC055330.1 and CJ287261.1.
            
            On Mar 14, 2014 this sequence version replaced NM_027642.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043127.1, AK141804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AK016480.1         2-58
            58-1437             BC055330.1         1-1380
            1438-4402           BC055330.1         1382-4346
            4403-4420           CJ287261.1         370-387
FEATURES             Location/Qualifiers
     source          1..4420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 29.28 cM"
     gene            1..4420
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /note="PHD finger protein 6"
                     /db_xref="GeneID:70998"
                     /db_xref="MGI:MGI:1918248"
     exon            1..223
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            224..407
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1364
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="PHD finger protein 6 isoform 1"
                     /protein_id="NP_081918.1"
                     /db_xref="CCDS:CCDS30127.1"
                     /db_xref="GeneID:70998"
                     /db_xref="MGI:MGI:1918248"
                     /translation="MSSSIEQKKGSTRQRKCGFCKSNRDKECGQLLISENQKVAAHHK
                     CMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRT
                     YHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKTKK
                     KSRKGRPRKTNLKGLPEDSRSTSSHGTDEMESSSYRDRSPHRSSPNDTRPKCGFCHVG
                     EEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGK
                     RMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDE
                     RDEEDEERESKSRGRVAIDQQLTQQQLNGN"
     exon            408..509
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            510..643
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            644..687
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            688..854
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            855..998
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1103
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1237
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1364
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..4420
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /note="hexamer: AATAAA"
     polyA_site      4402
                     /gene="Phf6"
                     /gene_synonym="2700007B13Rik; 4931428F02Rik; mKIAA1823"
                     /note="major polyA site"
ORIGIN      
        1 agagtgcccg gcgcgctcga gacgtctcaa cgtcctgtgg gtcgtgtgcg tacggaggga
       61 ggcaacgtaa gggcgctcgg cgagcccgtc tctcctcgaa tgaaaggaaa ctacccctgg
      121 cgacagagcc ccgctcttcg gcagtgccgg agaaccgact cccgccttcc ccgtcttccc
      181 tcgtgggcgc tgtcctccct tcgcccagcc gtgagcccca ctgcatttct tgaggcttaa
      241 agtggcagtc tctaaacact ttaaaaatca tgtcaagctc aattgaacag aaaaaagggt
      301 ctacgagaca gcgtaaatgt ggcttttgta agtcaaatag agacaaggaa tgtggacagt
      361 tactgatatc tgaaaaccag aaggtggcag cacaccacaa gtgcatgctg ttttcgtctg
      421 ctttggtgtc ctcacattct gataatgaga gtcttggtgg attttctatt gaagatgttc
      481 aaaaggaaat taaaagaggc acaaagctga tgtgttctct ttgtcattgt cctggagcaa
      541 ccattggctg tgatgtgaaa acctgccaca ggacatacca ctaccactgt gcattgcatg
      601 ataaagctca gatccgagag aaaccttcgc aagggattta catggtttat tgtcgaaaac
      661 acaagaaaac tgcacataac tcggaagctg atttagaaga aagttttaat gagcatgaac
      721 tggagccctc atctccaaag actaagaaga aaagtcgcaa aggaagaccg agaaaaacta
      781 accttaaagg cttgccagaa gacagcaggt ccacatcctc ccatggaaca gatgaaatgg
      841 aaagtagctc ctaccgagat aggtctccac acaggagcag tcctaatgat accaggccta
      901 aatgtggatt ttgccatgta ggggaggaag aaaatgaagc aagagggaaa ttgcatatat
      961 ttaatgccaa gaaggcagcc gcacattaca agtgcatgtt gttttcttct ggcactgttc
     1021 agctcacaac aacatcaaga gcagaatttg gagatttcga tattaaaact gtacttcagg
     1081 agattaagcg aggaaaaagg atgaaatgta cactttgcag tcagcctggt gctactattg
     1141 gatgcgaaat aaaagcctgt gttaaaacct accattacca ctgtggtgta caagacaagg
     1201 caaaatacat tgaaaatatg tcacgaggaa tttacaaact ctattgtaaa aaccatagtg
     1261 gaaatgatga gcgagatgaa gaagatgagg agcgagagag taaaagccgt ggaagagtag
     1321 cgattgatca gcagctaacc cagcagcagc ttaatggaaa ctaggttcgt gggacagaga
     1381 gagttagaaa actgagaaaa aacaactata actcctgtgc ttcttttcca cttttttcta
     1441 aaataaaggg tttgtaactt tttactgccc gactcttaga tccttcattg aactgcctaa
     1501 atcaccttgt tagttttctg agccttcagt agacggccga atttgacata ttgatattac
     1561 gtagctgtag tttgcagttt ctgggaagca gtcaaaacac tattagccct gtgtatactg
     1621 tcagcagtta aaacagacat tgaatgaagt aaactgtatt tctggacaga acaaagttgt
     1681 actgtttaga gtatgtaagt ttgtgtagta gatccacgct caaaggaaac cagaagcaag
     1741 ttgtactcca ccttgcaaac atgcctctgg tagcaacacc tggcaatttg ggcaatggaa
     1801 acgacaaatg aagagactct tctttttgtc ttggctttga cagcacatgc tctaaccatt
     1861 tctttcacga agcgtgctga agcctacctg tggtcctttt tagagttatt ctcactgagc
     1921 agcatggact ctgggcgact ggtgatgata agctctgagc tccagtgctt ctgccaaaac
     1981 tctggacagt acacctttct gtgctgtaca gagagcttct ggcaaaataa tggaatcgta
     2041 tcaagatcaa aataatgttt ggcaacatca gattaaacct ctttgaaatt caagaggtca
     2101 gcaatgcgct aaaggacttt ggacatcatg tctgaaacca gcttctctca agtgccctgt
     2161 tgtgtggaac acttcacata ttggcccagc atatataagg aggtcttata tgctaacatt
     2221 ttttttaaag gaaccatctt tgtgcaaaac agtatttctt tttgactctg tgaccactat
     2281 tttagaaaca ttatttaatg ctttcagtca tcagtttgct tacagattga ataagctttt
     2341 gtgccctgtt tttcttcgag ggctcggaag tgttttctca atcaccagat ttttagaaag
     2401 gctttctttc cactggcatt tctcactcgt gacacacatc cacttacctg ctgaagcaca
     2461 tttacatatt tctttatggc aaaaccaaaa aagttagttg tggtctgcct aatattacca
     2521 tagcacctca gtatgaaagg taaggattct gagttccaca tcattagtta acctcccata
     2581 gtgaatcaga tttgcaaata agaaataacg tactaacttg actgtacatc catctattct
     2641 gtagctggta gaacagcgtt ttgaaatgta acaggtggaa aattacactg tgcttattga
     2701 ctgaattttt aaactgcttg tcccttaaga tcatgtttgt taaggtgtgt atttacacat
     2761 ttacttaaat caagggactc aatgcttgct ttcttttaac catcttttat tgttatttta
     2821 gaaggaaact agctttagtg gattgccttg tgcgtcttct cctttcgctc ttaatatgcc
     2881 atgatgtgta tgtgattaat tttcaaggtt catcatgact tgaagtgcaa ggacagatct
     2941 cagtttgttt accaagcgat gcgacttttc ccaaaggatc tgtactttat ttccttataa
     3001 cagcttgaaa accattcttt tttaaatctt taaatcactg tgtctaggta atttttccat
     3061 tgtgtgccat agaacttacc catggagaaa tggagcccct tcatttttgg acaactactg
     3121 taatgatttt ttttaagaaa aatggaaggt gccaggggta attatggcca gtcaataatt
     3181 atataaagga cttcaaatac tatagccgtc agttgatgga tttgatatgt agtacatgta
     3241 tgattttgta tgggtttctt cagccctttc tctgccacta gcaaccagaa aagcacttta
     3301 ccttttggtt ggttagataa gtggctaact acctgttttt ctcactgtgg tgtgattggc
     3361 tagataacct tcatttaaag ttgaaatgta aactgaagtc acattaaaca ctcacgtttg
     3421 gctgtaaact tccaatagtt tgattctttg ttcctgtttt cattctatgc tgagtaaaag
     3481 tgccttacaa tgtaaaaatt gtacagtact tacgttccca agtagcagct tcaccatctg
     3541 gctaggcgtc acattgtggt aggagtatta gatcaataga cctcagcagt gtatttactg
     3601 tacaactctt aagtccttaa ctgtagtttt aataagcatg acattatttg gcaaatatat
     3661 ggcatttaca tcatttccaa aaatactgcc attgctgtct actgcgtatt tttagcctga
     3721 aattttgatg cgtctttttt tcttgttttt ttttctttat ttcttttgtt cccttttgtc
     3781 attattaata ttaaaccgtg taatctttgc aagcgtatat tgaagattat tctggagcat
     3841 ttattgcctt accagaaatg ttagtaagaa atgttcttta gagtagaagg gtagacttga
     3901 gtttctatac tttaataaga cctctttgtt cctgggggga ggggggagtt ttgctttcat
     3961 ctcattgttt taaagcccac acaagaaatt aatttcatgt caaggatcag cagttttcaa
     4021 acttgaggtg gttcttagta cacacgactc aagatactaa cagagtaaca tgatctacag
     4081 atctgctatt gaatcgaatc tatgtacttg aacaaatgtg tgaatctcaa atatctcaaa
     4141 gcaaaagtgt tgtagaatgt tgttgctttt tgaaaaagca ctgaagttag accaaggcac
     4201 agttttgttt tagcagacat ttaagttaat tgtaaagata aggaatgcat catgggtcaa
     4261 aaatcaaaca ttcctcaatg ttatgtatat tttgttcctg ttatattggc tttattttca
     4321 aaattgtagt ttgtagtatt agtttccttt taatggtatt cttgcatata ctattcattc
     4381 aataaatgag ttctggattt caggtctgtg tctgctttgt
//
