LOCUS       NM_030064               2019 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus PHD finger protein 23 (Phf23), transcript variant 1,
            mRNA.
ACCESSION   NM_030064
VERSION     NM_030064.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Chen,M., Chen,X., Li,S., Pan,X., Gong,Y., Zheng,J., Xu,J., Zhao,C.,
            Zhang,Q., Zhang,S., Qi,L., Wang,Z., Shi,K., Ding,B.S., Xue,Z.,
            Chen,L., Yang,S., Wang,Y., Niu,T., Dai,L., Lowe,S.W., Chen,C. and
            Liu,Y.
  TITLE     An Epigenetic Mechanism Underlying Chromosome 17p Deletion-Driven
            Tumorigenesis
  JOURNAL   Cancer Discov 11 (1), 194-207 (2021)
   PUBMED   32978226
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Gough,S.M., Lee,F., Yang,F., Walker,R.L., Zhu,Y.J., Pineda,M.,
            Onozawa,M., Chung,Y.J., Bilke,S., Wagner,E.K., Denu,J.M., Ning,Y.,
            Xu,B., Wang,G.G., Meltzer,P.S. and Aplan,P.D.
  TITLE     NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide
            array of leukemias sensitive to inhibition of PHD histone reader
            function
  JOURNAL   Cancer Discov 4 (5), 564-577 (2014)
   PUBMED   24535671
  REMARK    GeneRIF: Data show that NP23 and NJL belong to a subset of
            chromatin-modifying fusion oncoproteins causing leukemia.
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12, CA750740.1, AY099326.1, AK031159.1 and BY632579.1.
            
            On Mar 26, 2014 this sequence version replaced NM_030064.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031159.1, AK019135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL596185.12        107411-107430
            21-254              CA750740.1         1-234
            255-1460            AY099326.1         1-1206
            1461-2016           AK031159.1         1210-1765
            2017-2019           BY632579.1         403-405
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.95 cM"
     gene            1..2019
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /note="PHD finger protein 23"
                     /db_xref="GeneID:78246"
                     /db_xref="MGI:MGI:1925496"
     exon            1..288
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1460
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /note="isoform a is encoded by transcript variant 1; PHD
                     zinc finger containing protein JUNE1; novel PHD-finger
                     protein JUNE1"
                     /codon_start=1
                     /product="PHD finger protein 23 isoform a"
                     /protein_id="NP_084340.2"
                     /db_xref="CCDS:CCDS24929.1"
                     /db_xref="GeneID:78246"
                     /db_xref="MGI:MGI:1925496"
                     /translation="MLEAMAEPSPEDPPPTLKPETQPPEKRRRTIEDFNKFCSFVLAY
                     AGYIPPSKEESDWPASGSSSPLRGESAADSDGWDSAPSDLRTIQTFVKKAKSSKRRAV
                     QSGPTQPGPPRSTFSRLQAPDSATLLEKMKLKDSLFDLDGPKVASPLSPTSLTHTSRP
                     PAALAPVPLSQGDLSQPRKKDRKNRKLGPGGGAGFGVLRRPRPAPGDGEKRSRIKKSK
                     KRKLKKADRGDRLPPPGPPRAPPSDTDSEEEEEEEEEEDDEEEMTVGGGVPAPVLPTP
                     PEAPRPPVTVHSEGAPPTDSEGKDVGSTETSQDGDASSSEGEMRVMDEDIMVESGDDS
                     WDLITCYCRKPFAGRPMIECSLCGTWIHLSCAKIKKTNVPDFFYCQKCKELRPEARRL
                     GGLPKSGEP"
     exon            289..320
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..413
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..1245
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..2019
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="Phf23"
                     /gene_synonym="JUNE-1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcagaag ggagggagga gagaggagga ggaggaggag ggagcaggcg gccggcggtg
       61 cggggggagg gggcccggtc cgggagtgcg ggaggcagtg gtggagggag gtggcggtag
      121 cggagtggag tctcaaccgc gccaagcgga cacttcggtg gagcgaggcg gtagaaacac
      181 ggagcactca aggcagcacc gggaatcccg gcttcgagga gggggtcgcc ggaccgggtg
      241 gaggggaggg ggcgatgctg gaagccatgg cggagcccag tcccgaagat ccgcctccga
      301 ctcttaaacc agagactcag ccaccggaga aaaggcggag aaccattgag gattttaaca
      361 aattctgcag ttttgtcttg gcctatgctg gttacatccc ccctagcaaa gaggaaagcg
      421 attggccagc ctctggctct agctctccat tgcgaggtga gagtgcagca gacagtgatg
      481 gctgggactc ggccccgtcg gaccttcgaa ctatccagac ttttgttaag aaagcaaagt
      541 catcaaagag aagggcagtt caatcaggtc ctacccagcc aggaccccca aggtccactt
      601 tttctcgtct gcaggctcct gacagtgcta ctctgcttga gaagatgaag ctcaaggact
      661 ctctttttga tctggatggg cccaaagtgg catctccact ctctcccaca tcattgacgc
      721 atacttcccg gccccccgct gctctcgccc cagtgccgct gtcccagggg gacctctccc
      781 agcctcgaaa gaaggaccga aagaatagaa agttgggacc aggaggtggg gctggctttg
      841 gggtgcttcg gagacctcga ccagctcctg gggatgggga aaagcggtct cgaatcaaga
      901 agagcaagaa gcggaagttg aaaaaggcag atcggggaga tagactccca cctcctggcc
      961 ctcctagggc tcctcccagt gatacagact ctgaagagga ggaggaagag gaagaagagg
     1021 aagatgatga ggaagagatg acagtggggg gtggagtccc agcccctgtg ctcccaacac
     1081 cccctgaggc ccccaggccc cctgttacag tgcactctga aggtgctccc cctactgaca
     1141 gtgaaggcaa agatgtgggc agcacagaaa caagccaaga tggagatgct agctccagtg
     1201 aaggcgagat gcgggtcatg gatgaggaca tcatggtaga atcaggtgac gactcctggg
     1261 atctgatcac gtgttactgc agaaagccct ttgcggggcg gcccatgatt gagtgcagcc
     1321 tctgtgggac gtggatccac ctctcctgtg ctaagattaa gaagaccaac gttcccgact
     1381 tcttttattg ccagaaatgc aaggaacttc ggccagaggc ccggcggtta gggggtctcc
     1441 ccaaatctgg agaaccctga catcactaag gctggaactt gtgacattac ttgggaactg
     1501 agcctcaggg tccccagcct tcccttggag tgaggaggct gtccccactt gagggccaca
     1561 attcccaagg gagacgtatt tggaaatgag tgtcttctac tctgtccttc ctgctccatg
     1621 gacttgaagt tgaccccatt acagttgggt cggggaggct ggatctgtag acagaatctc
     1681 tgtccagtca accctgtacc cttttcactt gcaggtccag ggctcaaact gggatgtaat
     1741 gggatagttg tctataaaac tgtagtgtaa atacagcact cccctcatgt ttcttctctc
     1801 tcccgtttac tttcttttac accggatgta tttttaattt ggggctcccc catttgagcg
     1861 aggttgctca gaggtggagt accaaagcct gtggagtgag gaaggaaaga aaaaggtgtc
     1921 aattagcact cgcctcgttt ttaatactgt tggccggctg ctcagacaga cggcctgcgt
     1981 gttgtaaata aagcagagtg ggctcttgtg ttttacagc
//
