LOCUS       NM_001081166            3755 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus PHD finger protein 21B (Phf21b), transcript variant 1,
            mRNA.
ACCESSION   NM_001081166 XM_194983
VERSION     NM_001081166.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3755)
  AUTHORS   Chin,E.W., Ma,Q., Ruan,H., Chin,C., Somasundaram,A., Zhang,C.,
            Liu,C., Lewis,M.D., White,M., Smith,T.L., Battersby,M., Yao,W.D.,
            Lu,X.Y., Arap,W., Licinio,J. and Wong,M.L.
  TITLE     The epigenetic reader PHF21B modulates murine social memory and
            synaptic plasticity-related genes
  JOURNAL   JCI Insight 7 (14), e158081 (2022)
   PUBMED   35866480
  REMARK    GeneRIF: The epigenetic reader PHF21B modulates murine social
            memory and synaptic plasticity-related genes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3755)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3755)
  AUTHORS   Basu,A., Mestres,I., Sahu,S.K., Tiwari,N., Khongwir,B.,
            Baumgart,J., Singh,A., Calegari,F. and Tiwari,V.K.
  TITLE     Phf21b imprints the spatiotemporal epigenetic switch essential for
            neural stem cell differentiation
  JOURNAL   Genes Dev 34 (17-18), 1190-1209 (2020)
   PUBMED   32820037
  REMARK    GeneRIF: Phf21b imprints the spatiotemporal epigenetic switch
            essential for neural stem cell differentiation.
REFERENCE   4  (bases 1 to 3755)
  AUTHORS   Shimizu,H., Kubo,A., Uchibe,K., Hashimoto,M., Yokoyama,S.,
            Takada,S., Mitsuoka,K. and Asahara,H.
  TITLE     The AERO system: a 3D-like approach for recording gene expression
            patterns in the whole mouse embryo
  JOURNAL   PLoS One 8 (10), e75754 (2013)
   PUBMED   24146773
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3755)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 3755)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   7  (bases 1 to 3755)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046530.1, AL513352.12 and BM936475.1.
            
            On Nov 10, 2009 this sequence version replaced NM_001081166.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC172019.1, SRR7974084.28828.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               AK046530.1         2-466
            466-531             AL513352.12        103214-103279       c
            532-624             AL513352.12        56541-56633         c
            625-975             AL513352.12        53235-53585         c
            976-1107            AL513352.12        51929-52060         c
            1108-1159           AL513352.12        47118-47169         c
            1160-1236           AL513352.12        45798-45874         c
            1237-1291           AL513352.12        43555-43609         c
            1292-1314           AL513352.12        42371-42393         c
            1315-1473           AL513352.12        40258-40416         c
            1474-1549           AL513352.12        39829-39904         c
            1550-1653           AL513352.12        39540-39643         c
            1654-3357           AL513352.12        34221-35924         c
            3358-3755           BM936475.1         11-408              c
FEATURES             Location/Qualifiers
     source          1..3755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.08 cM"
     gene            1..3755
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /note="PHD finger protein 21B"
                     /db_xref="GeneID:271305"
                     /db_xref="MGI:MGI:2443812"
     exon            1..465
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..1875
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="PHD finger protein 21B isoform 1"
                     /protein_id="NP_001074635.2"
                     /db_xref="CCDS:CCDS37169.2"
                     /db_xref="GeneID:271305"
                     /db_xref="MGI:MGI:2443812"
                     /translation="MELQSRSEALAVELARHQNGDLKKQLHERQPRIAALSDKQALGS
                     TTAVPVTGPQVSSLQRLAGQGAAVLPQVRPKTLIPDSLPVTPGRDRPPKQPPTFQKAT
                     VVSIKNPSPALPTANNTVNHVPTPSSQTQALTEPTAITSPLSSAGVAYAIISTSPSNA
                     ATITPSTTVPVASDGIKVQPLLISADKKVIIIQPQVKTQPESSAEPEPPTEEPSQGAQ
                     ATKEDQPPSKENPEKIAFMVALGLVTTEHLEEIQSKRQERKRRSTANPAYSGFLETER
                     KRLASSYLHNPLFLTARANEDPCWKGEITHDEFCAACKRGASLQPCGTCSGAYHLSCL
                     DPPLKTPPKGLWVCPKCQRKALKKDEGVPWTGMLAIVHSYVTHKTVKEEEKQKLLQRG
                     SELQSEHQQLEERDRQLASAVKKCLELKTSLLARQRGTQSSLDRIRALLRLIQGEQML
                     QVAMATTSPTPLLAGPWTKPSTTTTMRTTLQHPQNHN"
     exon            466..531
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            532..624
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            625..975
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1107
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1159
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1236
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1291
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1314
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1473
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1549
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1653
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..3727
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3722
                     /gene="Phf21b"
                     /gene_synonym="A730032D07Rik"
                     /note="major polyA site"
ORIGIN      
        1 actgccgaat tagcatcgtg ccgaggcaca actttgccgc ggccccagcg agatccaggc
       61 gcgcgcgccg gaggaaatat agtccctgcc ggcggtcagc tggcgcgggc ggcgacaggg
      121 cgcgcgctgg ggggctgcgc ggggctcccg gcgcctgggg gccatgcgcc gggcggcgca
      181 ggcagcccgg gcacccggcg caacttagcg gcagccggaa gagttgggcg ccagctcgcc
      241 tttcttccct ctcgtcagcc tcctttccta tcggcgctgc aggagggaac tcgtgtctct
      301 ctgtgcccgg gacaccggat ccgagctctc ccggtctggt tcccgccgag ccgcacaact
      361 tcctgcgagc tccggccaaa gtgagcgcaa agtgctgccc aagttgcggc gatggagctg
      421 caaagccggt ccgaggcgct cgcggtggaa ctcgcgcgcc accagaacgg cgacctcaag
      481 aagcagctcc acgaaaggca gccacggatc gcagcgctca gcgacaaaca agctttggga
      541 tccaccactg cagtgcctgt cacaggtcct caggtcagct ccctgcagag gttggctggg
      601 caaggagcag cagtgctacc tcaggttagg ccaaagactc tgattccaga cagcctccct
      661 gtcaccccgg gcagggaccg gccacccaag caacccccaa cattccaaaa ggccactgtg
      721 gtcagcatca agaaccccag cccagccctc cccactgcca acaacaccgt caaccatgtg
      781 ccaacaccca gcagccagac ccaggccctc accgagccca ccgccatcac ctcacccctg
      841 agcagtgccg gggtggccta tgccatcatc tccacctccc ccagcaatgc tgccaccatc
      901 acccccagca ccactgtgcc cgtggccagc gacggcatca aagtgcagcc cctcctcatc
      961 agtgctgaca aaaaggttat catcattcag ccacaagtga agacacagcc agagagttca
     1021 gcagagcccg agccacccac ggaggagcca tctcagggag ctcaggccac caaggaagat
     1081 cagcccccca gcaaggagaa tcctgagaaa atcgccttca tggtagctct aggcctggtc
     1141 acaacggaac acctagaaga gatccagagc aagcggcagg agcggaagcg gaggagcaca
     1201 gccaaccctg cctatagcgg cttcttggag accgagagga agcggctggc ctccagttat
     1261 ctccacaacc ccttgttcct cacagcacga gccaatgagg acccctgctg gaagggtgaa
     1321 atcacccatg atgaattctg tgctgcctgc aagcgaggag ccagcctgca accctgcggc
     1381 acctgttcag gggcctacca cctcagctgc ctggacccgc cccttaagac gccacccaag
     1441 ggcctgtggg tctgccccaa gtgccagcgg aaggccttaa agaaagatga gggtgtgccc
     1501 tggactggga tgctggccat tgtacattcc tatgtcaccc acaagacagt gaaagaagag
     1561 gagaagcaga aattgttgca gcgtggcagt gaactgcagt ctgagcacca gcagctagag
     1621 gagcgggacc ggcagctggc ctcagctgtg aagaaatgct tggagctgaa gacaagcctc
     1681 ctggcccgcc aacggggcac acagtcatcg ctggaccgca tccgggccct cctcagactg
     1741 atccagggtg agcagatgct tcaggtcgct atggcaacca ccagccccac cccacttctg
     1801 gccgggccct ggaccaagcc ttccaccacc accaccatgc gcactaccct ccagcacccc
     1861 cagaatcaca actgacccca gggacctgtc taacactcat ggaaagttac tgggaccttg
     1921 ctctcaagac ctggaggatc tgtcggcctt aattcataaa ctctatgaat tttagacaaa
     1981 aataaaacta gagagtgatg agagaaagga ggagtgagat gagtgtccta gagccagaac
     2041 cagcctgagg tggacccctc caccagttgc agggtacacc cggaggccag gtgaaggtgt
     2101 ctcagatcca ggcacactag gcccacgagg ctgccagacc tccctggcct ttgggtttca
     2161 tgaccagctc tctccttgcg ttgtccccct caagacagga agactttaga ctttggagag
     2221 tgaggcagac tgggccacac accgcttgtg aggactcaag ctgacaacag gtagctggtt
     2281 agtgggggtg ggcggggtgg gcctctggtg caagagaggg tagttaacct aggtggttct
     2341 ccagtggccc tggggcttcc tgtgccccgc tggcccctaa tccatcagta ttaccatgtt
     2401 gaaaatcagt catttaactg gacaagtgac aggccagctt ctcttggggt cacccactgc
     2461 tgcatgggct gcctggcctg gcctggcctc tgcctctcct tttcccagct cacgctcttg
     2521 ttgctgccca cccacctctt cctattgcca atccctggaa ttttcctcat ggagttcagg
     2581 gctaaaggga gcagtcaccc agcaggggag gcacctggca ggtttcaact caaaaccgga
     2641 aacctttcga gcactctcct ttgcaggagc cgccaagcat cctgcccact tcatgccagt
     2701 taaagacact atgccaaaaa gagcttcaca ctttttgtat agcgttttgt ttttgttgta
     2761 tgatccgtaa tgtgaactgt gcccctgcct gccttcctct gcatctgatg gtctctgctc
     2821 cgatacagga actggtaacc tcgcctgaga gggaccagat ggagcaccca agaagggact
     2881 tagagatcca gggagaaggc agagagagtg gtgcacttgg ggccctggcc ttgggagact
     2941 ccagagccct caacgctctc ctcaaagcga tctccatatt tgcagggagt gtaggctcct
     3001 aggcaccctg ggggctcctg cacctctgtg agccatgtag cccacttccg caagcctcac
     3061 cctgtcccga gggacacagc acaacccata tgtgaccagg agccacaggg ctccccccac
     3121 ccccgagcat atcacacggt gccgaattgc agtgagcacg cacgcgtgca tgcgccaggg
     3181 ccacagacgc acacctgtgc acacagacac aggtgcagag cgggaaggct gactgggatc
     3241 ccgccaccag ctgttttccc tcttgtcatt tctcacgact ccgggagaaa ctgtgctgta
     3301 ggatacaaat ctattttaat acacattaca ctgggttgaa caagattttt tatattcttt
     3361 tattgatgaa caacgtgggc cctgcgaggc acacgccttt atatattggt tacgcggtgc
     3421 cgattatgcg ttaccgcacg gctggcgacg taactgtctt caggttcttt tgttggtttg
     3481 atttttcttc ctggatggat tgagttcgat tttgcaagaa acgtgggagg atgttggaag
     3541 gttggacccg ggagggggag ctgctgacgc gtctcgagac ttagttttga tttttttttt
     3601 cttttctttt cttttttggg accaaggggg accgtccagt ggatagtggc tagagaaagt
     3661 gtttgtctta aatattccag tgtagttttc cttctgtatg atgcattaaa tccaatttca
     3721 aagctcgaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
