LOCUS       NM_001362829            6721 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus PHD finger protein 21A (Phf21a), transcript variant 5,
            mRNA.
ACCESSION   NM_001362829 XM_006498974
VERSION     NM_001362829.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6721)
  AUTHORS   Porter,R.S., An,S., Gavilan,M.C., Nagai,M., Murata-Nakamura,Y.,
            Zhou,B., Bonefas,K.M., Dionne,O., Manuel,J.M., St-Germain,J.,
            Gascon,S., Kim,J., Browning,L., Laurent,B., Cho,U.S. and Iwase,S.
  TITLE     Coordinated neuron-specific splicing events restrict nucleosome
            engagement of the LSD1 histone demethylase complex
  JOURNAL   Cell Rep 44 (1), 115213 (2025)
   PUBMED   39817906
REFERENCE   2  (bases 1 to 6721)
  AUTHORS   Nagai,M., Porter,R.S., Miyasato,M., Wang,A., Gavilan,C.M.,
            Hughes,E.D., Wu,M.C., Saunders,T.L. and Iwase,S.
  TITLE     Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A,
            prevents excessive synaptogenesis
  JOURNAL   J Biol Chem 300 (11), 107881 (2024)
   PUBMED   39395799
REFERENCE   3  (bases 1 to 6721)
  AUTHORS   Najas,S., Pijuan,I., Esteve-Codina,A., Usieto,S., Martinez,J.D.,
            Zwijsen,A., Arbones,M.L., Marti,E. and Le Dreau,G.
  TITLE     A SMAD1/5-YAP signalling module drives radial glia
            self-amplification and growth of the developing cerebral cortex
  JOURNAL   Development 147 (13) (2020)
   PUBMED   32541003
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6721)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 6721)
  AUTHORS   Yin,F., Lan,R., Zhang,X., Zhu,L., Chen,F., Xu,Z., Liu,Y., Ye,T.,
            Sun,H., Lu,F. and Zhang,H.
  TITLE     LSD1 regulates pluripotency of embryonic stem/carcinoma cells
            through histone deacetylase 1-mediated deacetylation of histone H4
            at lysine 16
  JOURNAL   Mol Cell Biol 34 (2), 158-179 (2014)
   PUBMED   24190971
REFERENCE   6  (bases 1 to 6721)
  AUTHORS   Iwase,S., Shono,N., Honda,A., Nakanishi,T., Kashiwabara,S.,
            Takahashi,S. and Baba,T.
  TITLE     A component of BRAF-HDAC complex, BHC80, is required for neonatal
            survival in mice
  JOURNAL   FEBS Lett 580 (13), 3129-3135 (2006)
   PUBMED   16684532
  REMARK    GeneRIF: Bhc80 is indispensable for the survival of neonatal pups.
REFERENCE   7  (bases 1 to 6721)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 6721)
  AUTHORS   Iwase,S., Januma,A., Miyamoto,K., Shono,N., Honda,A., Yanagisawa,J.
            and Baba,T.
  TITLE     Characterization of BHC80 in BRAF-HDAC complex, involved in
            neuron-specific gene repression
  JOURNAL   Biochem Biophys Res Commun 322 (2), 601-608 (2004)
   PUBMED   15325272
  REMARK    GeneRIF: Presumably serves as a scaffold protein in BHC in neuronal
            as well as non-neuronal cells. Possible role in spermatogenesis.
REFERENCE   9  (bases 1 to 6721)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6721)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691462.12 and AL731709.19.
            
            On Apr 28, 2018 this sequence version replaced XM_006498974.3.
            
            Transcript Variant: This variant (5), as well as variant 6, encodes
            isoform 5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.25237.1,
                                           SRR13422591.489666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AL691462.12        25270-25440
            172-212             AL691462.12        55137-55177
            213-324             AL691462.12        56552-56663
            325-468             AL731709.19        3250-3393
            469-501             AL731709.19        10227-10259
            502-567             AL731709.19        12437-12502
            568-798             AL731709.19        102007-102237
            799-1047            AL731709.19        108694-108942
            1048-1137           AL731709.19        110090-110179
            1138-1431           AL731709.19        112293-112586
            1432-1530           AL731709.19        126322-126420
            1531-1582           AL731709.19        129774-129825
            1583-1662           AL731709.19        130656-130735
            1663-1723           AL731709.19        131166-131226
            1724-1887           AL731709.19        133479-133642
            1888-2043           AL731709.19        138642-138797
            2044-2119           AL731709.19        140472-140547
            2120-2223           AL731709.19        140884-140987
            2224-6721           AL731709.19        141947-146444
FEATURES             Location/Qualifiers
     source          1..6721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.8 cM"
     gene            1..6721
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /note="PHD finger protein 21A"
                     /db_xref="GeneID:192285"
                     /db_xref="MGI:MGI:2384756"
     exon            1..171
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..212
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..324
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..468
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..2478
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     BRAF35/HDAC2 complex; BRAF35-HDAC complex protein BHC80;
                     Braf35/HDAC complex (Bhc)"
                     /codon_start=1
                     /product="PHD finger protein 21A isoform 5"
                     /protein_id="NP_001349758.1"
                     /db_xref="GeneID:192285"
                     /db_xref="MGI:MGI:2384756"
                     /translation="MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKI
                     TALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLSQSENKLQTAQQQPLQPLQQQQPQQ
                     PQQQQQQQQQHAQQSAAAPPSLTASQTVTTASMITTKTLPLVLKAATATMPASVVGQR
                     PTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPP
                     QPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTK
                     FTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLPGPQTVQLSKP
                     SLEKQTVKSHPEAEEKQAESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQ
                     SKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGA
                     LTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQL
                     LMCDTCSRVYHLDCLEPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAY
                     KAAKEEEKQKLLKWSSDLKQEREQLEQKVKELSSSISKCMEMKSSILARQKEMRSSLD
                     KVKRLIRLVHGVDLCRPVDSEATAGALSNGPDCTPPANAASTPAPSPSSQSCTANCNQ
                     GEETK"
     exon            469..501
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..567
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..798
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1047
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1137
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1431
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1530
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1582
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1662
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1723
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1887
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2043
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2119
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2223
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..6721
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3863..3868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /note="hexamer: ATTAAA"
     polyA_site      3885
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /note="major polyA site"
     regulatory      6701..6706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
                     /note="hexamer: AATAAA"
     polyA_site      6721
                     /gene="Phf21a"
                     /gene_synonym="80kDa; Bhc; Bhc80; BHC80a; D030065N23Rik;
                     mBHC80; PFTF1"
ORIGIN      
        1 ctaaaaagtg cgagaggccc agagcagcag cagcagaagc agcagcggca gctccagcct
       61 cttccctccc tccccatgaa gaagagttcc ctcctcctcc tcctcctgct tctcctgctc
      121 agagttcctg cctccagctg ccagggggga cagccagcca gcagcaggag ggggactgga
      181 gagctgaagg agcgccagct tctccagaat tggacttctc agaaccttta atatgctaat
      241 gtgcattgtg aatctccaag atggggatat gatatgcagc attcttgaat acttctaatg
      301 acagggagcc cactacctca taagctgcag caacaagagg agcttgtaat tttaaacgga
      361 ggctgaagac actgtagaat tagcagacat aagagagcgt ggagaaggca gaggatggag
      421 ttgcagactc tacaggaggc tcttaaagtg gaaattcagg ttcaccagaa actggttgcc
      481 caaatgaagc aggatccaca gaatgctgac ttaaagaaac agcttcatga actccaagcc
      541 aaaatcacag ctttgagtga gaaacagaaa agagtagttg agcagctgcg caagaacctg
      601 atagtcaaac aagagcagcc ggacaagttc cagatacagc cattgtcaca gtctgaaaac
      661 aaactacaaa cagcacagca gcagccacta cagccactgc agcagcagca accgcagcaa
      721 ccgcagcagc agcagcagca gcagcagcag cacgcccagc agtcagcagc agcaccgcct
      781 agtctaactg catcacagac tgtaactaca gcttctatga ttaccacaaa gacactacct
      841 ctcgtcttga aagcagcaac tgcgaccatg cctgcctctg ttgtgggcca gagacctacc
      901 attgctatgg tgaccgccat caacagccag aaggctgtgc tcagcactga tgtgcagaac
      961 acaccagtca acctccagac gtctagtaag gtcactgggc ctggggcaga ggctgtccaa
     1021 attgtggcaa aaaacacagt cactctgcag gttcaagcaa cacctcctca gcccatcaaa
     1081 gtaccacagt ttatccctcc tcctagactc actccacgcc caaacttcct tccacaggtt
     1141 cgacccaagc ctgtggccca gaataacatt cctatcgctc cagcgcctcc tcccatgctt
     1201 gcagctcctc agcttatcca gaggcctgtc atgctgacca agtttacacc cacaaccctc
     1261 cccacatccc agaattccat ccaccctgtc cgtgttgtca atggacagac tgcaaccata
     1321 gccaaaacgt tccccatggc ccagctcacc agcattgtca tagctactcc agggaccaga
     1381 ctccctggac ctcagactgt acagcttagc aaaccaagcc tggagaaaca gacagttaaa
     1441 tcccacccag aagcagagga aaaacaagca gagagccgta ccgttacccc acctgctgca
     1501 ccaaaaccaa aacgagaaga gaaccctcag aaacttgcct tcatggtgtc tctagggttg
     1561 gtaacacatg accatctaga agaaatccaa agcaagaggc aggaaagaaa gagaagaaca
     1621 acagcaaacc cggtgtacag tggggctgtc tttgagccag agcgtaagaa gagtgcagtc
     1681 acttacctta acagcacaat gcatcctggg acgcggaaga gaggtcgtcc tccaaaatac
     1741 aatgcggtgc tggggtttgg agcccttacc ccaacatccc ccccatccag tcatcccgac
     1801 tcccctgaaa atgaaaagac agagaccaca ttcactttcc ctgcacctgt tcagcctgtg
     1861 tctttgccca gccccacctc cacagacggt gatatccatg aggatttttg cagtgtttgc
     1921 agaaaaagtg gccagttgct gatgtgtgac acgtgttccc gtgtgtatca tctggactgc
     1981 ttagagccgc ccctgaaaac aattcccaag ggcatgtgga tctgtcccag atgtcaggac
     2041 cagatgctaa agaaggaaga agcaattcct tggcctggaa ccttagccat tgttcattcc
     2101 tacatcgcct acaaagcagc aaaagaagag gagaaacaga agctacttaa gtggagttca
     2161 gatttaaaac aggagcggga acaactggag cagaaggtca aagagctcag cagttctata
     2221 agtaaatgta tggagatgaa gagcagcatc ctggcgcggc agaaggagat gcgcagctcc
     2281 ctggacaagg tgaagcggct catccgcctt gtgcatggcg tcgacctctg cagacctgtg
     2341 gactcagagg ccacggcggg ggccctctcc aatggcccag actgcactcc ccctgccaac
     2401 gccgcctcca cacccgcccc ttccccctcc tcgcagagct gcacagcgaa ctgtaaccag
     2461 ggggaagaga ctaaataaca gagccctcga ggcggacatg ccacagtcct ggtggcgagg
     2521 agacgctaga agagcaaagc cggatttctt ctggaaagta cagagttctt ttggttcttt
     2581 ggttccagag agagagaaga tgcttgtgcc aggtggcacc cgagtttgcc aattgattct
     2641 tgttattctg tgtgtacatg caaagactgg accatgttac atgaaatagt gccagctgga
     2701 ggttctttgc cagcaccatg ccaagtgaca taatatatta ctctctctat tatacaccag
     2761 tgtgtgcctg cagcagcctc cacagccacg gtgggttcgt ttttgttttg ttgggtgggg
     2821 agcagggacg ggcggaggga ggagagcagg tttcagatcc ttactgggag ccgtttgttt
     2881 aggtagaaag acaagtccaa agagtgtgtg ggctttcctg ttcctaaact tttcactacc
     2941 ataaaaccaa aaaacgaaaa aaaaagaaaa aaagataaaa aaggaaatag agatttaact
     3001 aacccagtgc ccagaagagg gacgggaagg gctgggaggg ggcaagggtg ggaaagtata
     3061 tgacataagc agtatttaac gttcctggag gggccgaagt gcaagaggag agccccgccc
     3121 ctccctagct cgccccgccc acagcctcca gcagcccctc ccctctgctt ggtgtagtgc
     3181 agagcccggg tggttctagg ccttgttaag cagggaaggg agggtgcgag gggtccggag
     3241 ggagaaaggc ggatcagagg tttacttgaa aacaagctcc atcccttttc tatatttata
     3301 agaagagaag gttctaagca gagcagcacg acccaggtgt gtgtgaatgg agacaaccct
     3361 tttctcttct tcaagtttat tttgtttctg ttcttgtttt gtttaaacaa agttttgttt
     3421 tgttgtttat ttttcctttc tttctttctt tctttctttc tttctttctt tttaacaaga
     3481 actaaaataa gaaatagaaa agctgttttt tcaggctgac ggtcctgttg agggtagcgg
     3541 agaccttgca tgatagagta ggcgtcatag tgtcaagtga ggtcggtgag tctgtgtgcg
     3601 tcctgtgtca tcagtcaggc actgttctgg tttgtttgtt ttgtttttta ctttctggtt
     3661 ttgttttctg gttttgtttt ttgttttttc atgcaagggc aaaaaaaaaa atctttgtac
     3721 ctggggaaaa caactttttt tttattaaaa aggaaaataa aagatattga ggtcttccta
     3781 gtgttactta aattaagatc aaggtaagaa acattgtaaa aattacaaaa gtgctatttg
     3841 tttcctaaaa acagtgattt ttattaaaaa ggtgtcagaa ctggagaaaa cgctgtgtag
     3901 tgacagtttt ttagcacaga gcctactgat cctgatgaca ttttactgtg ttgtatctct
     3961 agactggtgt gccagtttcc tgcagggccg ggtccgcccc ctcctcgctc ctccctactc
     4021 agacttgctg tctccttggt acagggatct catctcctgt ttgaagccaa aatggaatgt
     4081 gcatagtgtc agggcgttcc cacggtctca gaccttgcta gaacgcaggc tggtgcccac
     4141 ctagcccttc ccttggtgct gctctgtctt acagccacca gcattactta tgcctcgggg
     4201 gccccttggg ggactgacca gtgaggctcc tcactgcctg tatacttggc ctccaggagg
     4261 gtataggatg caggctggct gcatcaggga ggaaatgctt tgagagtccg tatgtctcta
     4321 agagcccagg tagccttcaa gtccatcttg cgttaaagag agaaatctga agctctaggg
     4381 ggtctctgcc tgcccgcccc aaggtcagag ttcactccca ttccactcac tcacatgctt
     4441 cctgggtgtt cctgggctag aatcactatg cttgccttgt gtggcctagt gtagactttt
     4501 cttcttggaa aaatggggtt ctgaaaggct ctctactcat ctccccgaca ataccatagg
     4561 gaacataact ctacgagacg catgctccca gtggaaatct ttatctgatc catgtccttg
     4621 agtgaaggga cagagaccta ggctctaccc ccaggtctga aagcagcatc tctctgagcc
     4681 cgccaggctc ccaagtctag gagtagcagg aaagacccct ttgcttcttc cttgcccagt
     4741 taggtccatg gaaaatgagc tggatcctga ctgaaactac agcagacaag aggtgcttgt
     4801 gagagtgagc caggcccatc cacaccagcc acccattcac ttcccagcgt ttgagaagag
     4861 ggcaggtagt ctggccacac aggcctcagc ttcaggcctc tggcttcagg ttgactgagg
     4921 ggagcagaga aaagccctct tttcttattt aggaactaag gtgctgtcta gttagcgggc
     4981 gttggagatg cctggactag ttggatcttt ggcagaggat cagagaccag ctgcaggctg
     5041 atatcctgtc tcagctcccc caacctgcca accccctgtt ggacttgtct gggcccatag
     5101 gctggggctt ggcacatact acctacctgt gatgggaaga ggttgacaag ccatcaacaa
     5161 tcactacagg cctttgctcc agaagagctg ctggtggcag cacgagaccc gagcagcata
     5221 gactcccatc ttctgatgtt tggaaatgag ttgctttgag tcaactggag tgaagtaaaa
     5281 aaatgtagcc ctgctccaag cctccactgt gggtcctgcc ccttccgtct acttgccctt
     5341 acctctgtca gcacaaagct cttctctgtc cctttagacc tgtgcgtacc tgggaccacc
     5401 tgggacatac acacacactg ccccttcaga gccgcttcca agctcccatc ctccctcccc
     5461 tacctgcgtg tgttgctctt gtagccacat gtgtaaggct cgctagcatg gcagtcactt
     5521 tggagggcct tggactggga gtccccttgt ccccagggtc aggctggcag gtgtaggcca
     5581 tagaggtcag caccatcgcc ttcctcccct aaagggtcct ctctctttct gagccactgt
     5641 cttgtctgcc tccgctgagc ttaaccagtt ctcgtttttt cccttgcttg tctggctttg
     5701 ggaggtaagg ctgctgatga cgtccttcaa gaaagtctca gaagcagtcc ccgatggctt
     5761 tacctgagta gggcctgcct ctataggcag taacagccac aggcagcctc cagctggccc
     5821 ccatcttagt gactggcatc ctcttagggg cacctctcct gctgctgctt cttgtctcat
     5881 gcccatcagg cagtggtaag gtacatgtgt acccagcact gcccaagcga ctgtgtctcc
     5941 agctgtctgt ctacacctac agctgcctct ctgccgcctc tctgatgctt cctcttgggg
     6001 cttgacttct tgactctccc taccagcccc ctccctccag ctcacaacct ttaaatggtc
     6061 tcttcccttt aggccctcct ttggtatgga ccttacctaa ctaaagggct gaactcttga
     6121 ggacattcct cccaggggca ggagtaggac ggaccagttg gtccttctct ggacactggg
     6181 ttctccagac cccatggctt ctgttgaatg caggctactt tgctctgtgt aaatgattgt
     6241 ggaccttgtc ccaccccaca tcccagcacc cctggcagaa aacaggagta tcacttctca
     6301 tcctaccttt agccggtgct cctggtcagc tcctccccga gaaggaattg ggtgacccct
     6361 agggaagatt ccactggtcc tccccaggga atgaagagtc ccacctggca gccttggccc
     6421 ctgcacccct ctccagtgtt cttgctctta gcccagggtg agttgcagtc aggtgggtgg
     6481 gctgagcaga ccagaagtca gcaagctcca ccacgcatac agccagccag acccagtcct
     6541 gtctgtgtcc atgccctttg tgatttcagt cttggtagaa tttgtatttg gagttttgtg
     6601 cttcaaagtt tctgtttcat ttgttcggtt tttgtttcga gggggtgggg ggtacagagc
     6661 agccgatcaa tttgtattta tttattttaa cattttacta aataaagcca aatgaagcct
     6721 c
//
