LOCUS       NM_001418754            3807 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus PHD finger protein 19 (Phf19), transcript variant 2,
            mRNA.
ACCESSION   NM_001418754 XM_006498379
VERSION     NM_001418754.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3807)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3807)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3807)
  AUTHORS   Gu,W., Cheng,Y., Wang,S., Sun,T. and Li,Z.
  TITLE     PHD Finger Protein 19 Promotes Cardiac Hypertrophy via
            Epigenetically Regulating SIRT2
  JOURNAL   Cardiovasc Toxicol 21 (6), 451-461 (2021)
   PUBMED   33611744
  REMARK    GeneRIF: PHD Finger Protein 19 Promotes Cardiac Hypertrophy via
            Epigenetically Regulating SIRT2.
REFERENCE   4  (bases 1 to 3807)
  AUTHORS   Dong,C., Nakagawa,R., Oyama,K., Yamamoto,Y., Zhang,W., Dong,A.,
            Li,Y., Yoshimura,Y., Kamiya,H., Nakayama,J.I., Ueda,J. and Min,J.
  TITLE     Structural basis for histone variant H3tK27me3 recognition by PHF1
            and PHF19
  JOURNAL   Elife 9, e58675 (2020)
   PUBMED   32869745
  REMARK    GeneRIF: Structural basis for histone variant H3tK27me3 recognition
            by PHF1 and PHF19.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3807)
  AUTHORS   Vizan,P., Gutierrez,A., Espejo,I., Garcia-Montolio,M., Lange,M.,
            Carretero,A., Lafzi,A., de Andres-Aguayo,L., Blanco,E.,
            Thambyrajah,R., Graf,T., Heyn,H., Bigas,A. and Di Croce,L.
  TITLE     The Polycomb-associated factor PHF19 controls hematopoietic stem
            cell state and differentiation
  JOURNAL   Sci Adv 6 (32), eabb2745 (2020)
   PUBMED   32821835
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3807)
  AUTHORS   Hunkapiller,J., Shen,Y., Diaz,A., Cagney,G., McCleary,D.,
            Ramalho-Santos,M., Krogan,N., Ren,B., Song,J.S. and Reiter,J.F.
  TITLE     Polycomb-like 3 promotes polycomb repressive complex 2 binding to
            CpG islands and embryonic stem cell self-renewal
  JOURNAL   PLoS Genet 8 (3), e1002576 (2012)
   PUBMED   22438827
REFERENCE   7  (bases 1 to 3807)
  AUTHORS   Lavery,R., Lardenois,A., Ranc-Jianmotamedi,F., Pauper,E.,
            Gregoire,E.P., Vigier,C., Moreilhon,C., Primig,M. and
            Chaboissier,M.C.
  TITLE     XY Sox9 embryonic loss-of-function mouse mutants show complete sex
            reversal and produce partially fertile XY oocytes
  JOURNAL   Dev Biol 354 (1), 111-122 (2011)
   PUBMED   21466799
REFERENCE   8  (bases 1 to 3807)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   9  (bases 1 to 3807)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   10 (bases 1 to 3807)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929068.20.
            
            On Mar 23, 2023 this sequence version replaced XM_006498379.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4300142.1,
                                           SRR13422601.366257.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL929068.20        76549-76642         c
            95-283              AL929068.20        74225-74413         c
            284-365             AL929068.20        73772-73853         c
            366-461             AL929068.20        69613-69708         c
            462-562             AL929068.20        69066-69166         c
            563-711             AL929068.20        68058-68206         c
            712-807             AL929068.20        66663-66758         c
            808-876             AL929068.20        65960-66028         c
            877-997             AL929068.20        65744-65864         c
            998-1065            AL929068.20        63668-63735         c
            1066-1227           AL929068.20        62191-62352         c
            1228-1315           AL929068.20        61532-61619         c
            1316-1401           AL929068.20        60682-60767         c
            1402-1497           AL929068.20        59665-59760         c
            1498-3807           AL929068.20        56360-58669         c
FEATURES             Location/Qualifiers
     source          1..3807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 23.02 cM"
     gene            1..3807
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /note="PHD finger protein 19"
                     /db_xref="GeneID:74016"
                     /db_xref="MGI:MGI:1921266"
     exon            1..94
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            95..283
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1840
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /note="isoform a is encoded by transcript variant 2;
                     polycomb-like protein 3"
                     /codon_start=1
                     /product="PHD finger protein 19 isoform a"
                     /protein_id="NP_001405683.1"
                     /db_xref="GeneID:74016"
                     /db_xref="MGI:MGI:1921266"
                     /translation="METQALEPGTLEAFGATSPNKGGLSKTKKNFKDLMSKVTEGQFV
                     LCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCDVCMG
                     KTSGPMNEILICGKCGLGYHQQCHIPIAVDANWPLLTHWFCRRCIFALAVRKGGALKK
                     GAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWF
                     HEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLALYNLGVQSKKR
                     YFDFEEILAFVNHHWELLQLGKLTSTPMTERGPHLLNALNSYKSRFLCGKEIKKKKCI
                     FRLRIRVPPAPPGKLLPDRALMPSDKGTSELLRKKGKSKPGLLPQEPQQQKRRVYRRK
                     RSKFLLEDAIPSSDFTSAWSTDHHLASIFDFTLDEIQSLKSGSSGQTFFSDVDSTDAA
                     STSGSASTSLSYDSRWTVGSRKRKLTAKVHRPLRAKQRAAELEGRCASDSNAEGAVGP
                     EQPDEGIDSHTLESISGDDSSLSHLKSSITNYFGAAGRLACGEKYRVLARRVTPEGKV
                     QYLLEWEGTTPY"
     exon            284..365
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..461
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            462..562
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..711
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..807
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            808..876
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..997
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1065
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1227
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1315
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1401
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1497
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..3807
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3770..3775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3807
                     /gene="Phf19"
                     /gene_synonym="3110009G19Rik; 3321402G02Rik"
                     /note="major polyA site"
ORIGIN      
        1 actcggccag gcagccctgg gccgagcgca ccgccgccgc cgatgtgcct ggtggccaga
       61 ctccaagtgg gaccggctga cgcgctgcct cgcgcagaag ctaatggaga ctcaagctct
      121 ggaaccaggg actctggaag cctttggtgc caccagtcct aacaaggggg gcctgtctaa
      181 gaccaaaaag aacttcaaag acttgatgtc taaggtgaca gagggacagt tcgtgctatg
      241 caggtggaca gacgggctat attaccttgg caagatcaag cgggtcagca gtcctaagca
      301 aagctgcctt gtgacttttg aagataattc caaatactgg gtcctgtgga aggacatcca
      361 gcatgctggt gttccgggag aggagcccaa gtgtgacgtc tgcatgggga agacttcagg
      421 gcctatgaac gagatcctca tctgtgggaa gtgtggcctg ggttaccacc aacagtgcca
      481 catccccatc gcagttgatg ccaactggcc cctcctcact cattggttct gccgacgctg
      541 cattttcgca ctggctgtga ggaaaggtgg cgctttgaag aaaggcgcca tcgccaagac
      601 gctgcaggca gtgaaaatgg tgctgtccta ccagccggag gaactcgatt gggactcgcc
      661 ccatcgcact aaccagcagc aatgctactg ctactgcggc gggcctggag agtggtacct
      721 tcggatgcta cagtgctacc ggtgtaggca gtggttccat gaggcttgca cacagtgcct
      781 tagtgagcct atggtgtttg gagaccgctt ctacctgttc ttctgctccg tgtgtaacca
      841 aggcccagag tatattgaga ggctgccctt gcgatgggtg gatatagttc acctggctct
      901 ctataacttg ggagtacaga gcaagaagcg gtactttgac tttgaggaga tcctggcctt
      961 tgtcaaccat cactgggagc tcctgcagct tggcaagctc accagcaccc ccatgacaga
     1021 acgagggcca catctcctca acgctctcaa cagttacaag agccggttcc tgtgtggcaa
     1081 ggaaattaag aagaagaaat gcatcttccg actgcgcatc cgagtcccgc ctgcccctcc
     1141 aggaaaactg cttcccgaca gggcgttgat gccaagtgac aaagggacct ccgagctgct
     1201 tcgtaagaaa ggaaagagca agcctggttt gttgcctcag gaaccccagc agcagaaaag
     1261 gcgagtttat agaagaaaaa gatcaaagtt tttgctggaa gatgctattc ccagtagtga
     1321 cttcacctca gcctggagca cagaccacca cctagccagt atattcgact tcacactgga
     1381 tgaaattcag agtttaaaaa gtggcagctc aggccagacc ttcttctcag atgtggattc
     1441 taccgacgca gccagcacct cggggtctgc ctccaccagc ctctcctacg actccagatg
     1501 gacggtaggc agccgcaaga ggaagctgac agccaaagtg cacaggcccc tgcgagcaaa
     1561 gcaaagggcg gcggagctgg aggggcgctg cgcctcagac agcaatgcag agggagctgt
     1621 gggtcctgag cagccggatg aaggcatcga cagccacaca cttgaaagca tcagtggaga
     1681 cgactcgtcc ctgtcccacc tcaagtcctc tatcaccaac tactttggtg cagctgggcg
     1741 gttggcctgc ggggaaaaat atcgggtgtt ggcgcggagg gtcactccag aaggcaaggt
     1801 tcagtacctg ttggaatggg aggggaccac cccttactga ttaccctcag aggctgccca
     1861 gatccctgca aaccaaagga ggggcagaag aggccactgg gtccctgttt tcgccaggct
     1921 tggggtggtg gtggtgaaac aggacatcct gcctgtggcc cctgcctgct gcctgccagg
     1981 ccaaggcctg tgtgctgctg tacctgagtc tctgagaccc cattggtatt ctctcgttgt
     2041 caatactaca ctccacaccc ctcaaacttt ttattggttc ctctgacagt atcctggctc
     2101 caacccctgg atctgttttt tgttgtcccc aattctccat cttctgccct ctcacccctt
     2161 tcaggtgttt tgtgtggaca cacatcttcc acgggcatac acccatctgt ccctcactgg
     2221 gcatgcttca ctgggtcctc actaggacca cagtgaggga agggaacctt gggggtcttc
     2281 tgctttctca ctagtacccc tcaccccagg aaggtagggg gtgcctgaga aagtttagga
     2341 tgcctaggac ccagagtctg gggagtggtg agctgggtct ctgcagaagg gacaagaatc
     2401 agggtctttt attgaggagg ggagactaag gaagtcaggc agggccaagg tttccagaag
     2461 tttgcctgtc ccagcaacaa ccctttactg ttgtcaagga ttgggacctg gccctgctgc
     2521 atagacgtgt cttaaacaca cagatctggg aggaaaggat ggggaagaag actaagccag
     2581 attaaatccc atcccaaaca ctgtgtgtac agccaccacc tactcctgcc agggccccct
     2641 ggccccccgt ccttggcctc ttccagggat acatgctgca gttaaatgtg agaaccaaac
     2701 ccctgcctcc tctggcctgt gaagcagcct tggccccaca gagaagcaca aaatataccc
     2761 ctctcctgca tggctcctgc cttgccctgg agctgacaat cactttgggg acaggtttgg
     2821 agtttacaag ggcctgaatc gttggttccc ttcagaaagg aaggctttgt catcaatggt
     2881 acaaatagaa ttcttagaat ggtcaagctt agccgtgtct ggggagaaac caggaggtgg
     2941 gcagggagcc cttactttgc ctacagaaac agaaattgac tcactcagtt ggagaaatgg
     3001 aaagaactgc cattgaagtg ggaggcaagg gcaccagact gagactagcc tccctgactg
     3061 ctgctgtagc ttccagctgg gggtgggaag atggaccaca tggtgacatc agactatacc
     3121 aaaggtgctg atattcccat gactaggtct gaccccttca caccttcccg tgagcattaa
     3181 ggagggtccc tgcagtaggt tagatgtccc ctgccttaaa cctcagccac catggtgcct
     3241 tgcaaagaaa cctcgcctct catagacaca gctacctact tccctctgcc ttcctgtctg
     3301 ggctcaggca gggataagca gatggacact gggcccagtt gtcagtccca cagctgccgc
     3361 cactgaggtc ccaaagtggg gcctggtgga aggagagttg ggaagccaac tcctaggctt
     3421 gtgggaactg gggtcaaatt tgtggcttcc tgttggcttc agtgaacatg gcaacctcca
     3481 acacgtgttt tccaggccac tggggaagcc agagttagga tggctatctg tacatctgcc
     3541 cctcctctgc tgtgccccag aagctctggg cctgaggagc aggaaggcag gaggggtgcc
     3601 cgtcccgttg gggatcctag cacaaggcct gaccaggtcc ctggacttcc catggcagca
     3661 tttcactcct acaaaataat agctgcatta ctgccaactg atggtataac cctgtgcacc
     3721 tttgaaaaga ttttggtttt aaattgctgc ttttaataat atttgttata ttaaagttat
     3781 aattgatgtg tctggtttac aatgtaa
//
