LOCUS       NM_001168382            3364 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PHD finger protein 14 (Phf14), transcript variant 1,
            mRNA.
ACCESSION   NM_001168382
VERSION     NM_001168382.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Zhou,J., Hamdan,H., Yalamanchili,H.K., Pang,K., Pohodich,A.E.,
            Lopez,J., Shao,Y., Oses-Prieto,J.A., Li,L., Kim,W., Durham,M.A.,
            Bajikar,S.S., Palmer,D.J., Ng,P., Thompson,M.L., Bebin,E.M.,
            Muller,A.J., Kuechler,A., Kampmeier,A., Haack,T.B.,
            Burlingame,A.L., Liu,Z., Rasband,M.N. and Zoghbi,H.Y.
  TITLE     Disruption of MeCP2-TCF20 complex underlies distinct
            neurodevelopmental disorders
  JOURNAL   Proc Natl Acad Sci U S A 119 (4) (2022)
   PUBMED   35074918
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Zhang,L., Lu,Y., Wang,Y., Wang,F., Zhai,S., Chen,Z. and Cai,Z.
  TITLE     PHF14 is required for germinal center B cell development
  JOURNAL   Cell Immunol 358, 104221 (2020)
   PUBMED   33035772
  REMARK    GeneRIF: PHF14 is required for germinal center B cell development.
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Yang,B., Chen,S., Wu,M., Zhang,L., Ruan,M., Chen,X., Chen,Z.,
            Mei,C. and Mao,Z.
  TITLE     PHF14: an innate inhibitor against the progression of renal
            fibrosis following folic acid-induced kidney injury
  JOURNAL   Sci Rep 7, 39888 (2017)
   PUBMED   28045076
  REMARK    GeneRIF: PHF14 expression was upregulated in fibrotic models in
            vivo and in vitro, and the TGF-beta/smad3/PHF14 pathway acted as a
            self-limiting mechanism in the TGF-beta-dominated renal
            pro-fibrotic process by suppressing PDGFR-alpha expression.
            Erratum:[Sci Rep. 2020 Apr 2;10(1):6036. doi:
            10.1038/s41598-020-62765-7.. PMID: 32242053]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3364)
  AUTHORS   Huang,Q., Zhang,L., Wang,Y., Zhang,C., Zhou,S., Yang,G., Li,Z.,
            Gao,X., Chen,Z. and Zhang,Z.
  TITLE     Depletion of PHF14, a novel histone-binding protein gene, causes
            neonatal lethality in mice due to respiratory failure
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 45 (8), 622-633 (2013)
   PUBMED   23688586
  REMARK    GeneRIF: results indicated that PHF14 might be an epigenetic
            regulator and play an important role in the development of multiple
            organs in mouse
REFERENCE   6  (bases 1 to 3364)
  AUTHORS   Kitagawa,M., Takebe,A., Ono,Y., Imai,T., Nakao,K., Nishikawa,S. and
            Era,T.
  TITLE     Phf14, a novel regulator of mesenchyme growth via platelet-derived
            growth factor (PDGF) receptor-alpha
  JOURNAL   J Biol Chem 287 (33), 27983-27996 (2012)
   PUBMED   22730381
  REMARK    GeneRIF: Phf14 acts as a negative regulator of PDGFRalpha
            expression in mesenchymal cells undergoing normal and abnormal
            proliferation, and is a potential target for new treatments of lung
            fibrosis.
REFERENCE   7  (bases 1 to 3364)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 3364)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 3364)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 3364)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153640.6 and AC153641.3.
            
            On Apr 6, 2018 this sequence version replaced NM_001168382.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2764596.1,
                                           SRR1660813.42611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AC153640.6         57474-57885         c
            413-523             AC153640.6         56929-57039         c
            524-1290            AC153640.6         49747-50513         c
            1291-1435           AC153640.6         42192-42336         c
            1436-1595           AC153640.6         30319-30478         c
            1596-1707           AC153640.6         22105-22216         c
            1708-1845           AC153640.6         20977-21114         c
            1846-1992           AC153641.3         157861-158007       c
            1993-2263           AC153641.3         157075-157345       c
            2264-2370           AC153641.3         156667-156773       c
            2371-2466           AC153641.3         155532-155627       c
            2467-2570           AC153641.3         154217-154320       c
            2571-2702           AC153641.3         152232-152363       c
            2703-2871           AC153641.3         147155-147323       c
            2872-2922           AC153641.3         137488-137538       c
            2923-3044           AC153641.3         137243-137364       c
            3045-3162           AC153641.3         96405-96522         c
            3163-3364           AC153641.3         63151-63352         c
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.01 cM"
     gene            1..3364
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /note="PHD finger protein 14"
                     /db_xref="GeneID:75725"
                     /db_xref="MGI:MGI:1923539"
     exon            1..412
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..3237
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="PHD finger protein 14 isoform 1"
                     /protein_id="NP_001161854.1"
                     /db_xref="CCDS:CCDS51720.1"
                     /db_xref="GeneID:75725"
                     /db_xref="MGI:MGI:1923539"
                     /translation="MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGN
                     GSEDPSKDSGEGSCSDSEENILEEELNEDIQVKEEQLKNSTEEIMPSDKQLIKMEKKE
                     EEENGERPRKKKEKEKEKEKEREKDKEKATVSDSAAASAAGTTPATSPPAVTSPSVPT
                     TTTTTTEEQVSEPKKWNLRRNRPLLDFVSMEELNAMDDYDSEDDNDWRPTVVKRKGRS
                     ASQKEGSDGDNEDDDDEGSGSEEDENDEGNDEDHSSPASEAGGKKKRSKVLSRNSADD
                     EELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDN
                     CGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETD
                     AGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCIS
                     CDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQ
                     SYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSA
                     SAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMI
                     QIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNLNGKLRSEGQGIWALLGRI
                     TGQKLNVPAILRAPKERKPSKKEGGTQKTSALPTVLYSCGICKKNHDQHLLLLCDTCK
                     LHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIK
                     EPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEEEKHEERVPRERRQRQSVLQKKPK
                     AEDLRTECSTCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSS
                     SSKEDENEAEKKNASQELSMEQKTPKK"
     exon            413..523
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1290
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1435
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1595
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1707
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1845
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1992
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2263
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2370
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2466
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2570
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2702
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2871
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2922
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3044
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3162
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3364
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3344..3349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /note="hexamer: AATAAA"
     polyA_site      3364
                     /gene="Phf14"
                     /gene_synonym="1110001C23Rik; 4932409F11Rik;
                     5730446A07Rik; mKIAA0783"
                     /note="major polyA site"
ORIGIN      
        1 acttcctcct tgtcggagct gtatccgggt cgctgttctc cctattgtct ctgacagaag
       61 gccctccgct gtgcaaattc tgggtctttt gttgcttctg gtgcaggcta ataaagtttt
      121 ctttttattt ccagttttta ccggggcagt tcccctcgca gggcggccgg ttcgggccta
      181 gcgcccctgg ccggggagcg cgggggaagg ggcgccgggc gggcgggcgg gcgggcgcgg
      241 ggcgtgggga gggacagtag cccacccccg gggtcgcccc tgctcggtcg gcgcagcgcc
      301 ctgcctcggt agctgctctc cgaccggtct ccttggtcct ctgcgcgtcc ctgctgcctt
      361 gcctctcgca gccttcccta gctctccaaa cgaccacctc acggattcct tatggatcgc
      421 agctccaaga ggaggcaggt gaagcctttg gccgcttctc tcctggaagc tcttgattat
      481 gatagttcag atgacagtga ttttaaagtt ggagatgctt cagattctga agggagtggt
      541 aatggaagtg aagatccttc aaaggacagt ggagaaggtt cctgtagtga ttctgaggaa
      601 aacattttag aagaagaact gaatgaagat attcaagtaa aagaagaaca gcttaaaaat
      661 tctacagagg aaataatgcc atcagacaaa cagttaatta aaatggaaaa gaaggaagaa
      721 gaagaaaacg gagaaagacc tagaaagaaa aaggagaaag aaaaggagaa agaaaaggaa
      781 agggagaagg acaaagagaa agcaacagta tctgatagtg cagctgcttc tgctgctggc
      841 accacaccag ccacaagccc tcctgctgtc acctcccctt ctgtccctac caccactacc
      901 accaccacgg aggaacaagt cagtgagccc aagaaatgga atcttcgtcg gaaccgtccc
      961 ctgttggact ttgtatccat ggaagaactc aatgctatgg atgattatga cagtgaggat
     1021 gataatgact ggagacctac tgtagtaaag agaaaggggc gatcagcgtc tcagaaggag
     1081 ggcagtgatg gagacaatga ggatgatgac gatgagggaa gtgggagtga ggaagatgag
     1141 aatgatgagg gcaatgatga agatcatagc agccctgcta gcgaagcagg tggcaagaag
     1201 aagaggagta aagttcttag cagaaacagt gctgatgatg aggaactgac caatgatagc
     1261 ctgaccctat ctcaaagcaa gagtaatgag gactctctga ttcttgagaa gagtcaaaat
     1321 tggagttctc agaaaatgga ccacattctg atttgctgtg tttgtcttgg agataatagt
     1381 gaagatgcag atgaaataat tcagtgtgat aattgtggca ttacagttca tgaaggttgt
     1441 tatggagtcg atggggagag tgactctatt atgagttcgg cttctgaaaa ctccactgag
     1501 ccttggtttt gtgatgcctg taaatgtggt gtatctccta gctgtgaact atgtcctaat
     1561 caggatggga ttttcaagga gacggatgct ggaagatggg tccacattgt ttgtgcccta
     1621 tatgttcctg gagtggcttt tggagatatt gataaattac gaccagtaac gctaacagaa
     1681 atgaactatt ctaaatatgg tgccaaggag tgtagctttt gtgaagatcc tcgctttgct
     1741 agaactggag tttgcattag ctgtgatgca ggcatgtgta gagcctattt ccatgtcacc
     1801 tgtgcccaaa aggaaggcct gctatcagag gcagcagcag aagaggatat agcagatcca
     1861 ttttttgctt attgtaagca gcatgcagac agattagaca gaaaatggaa aagaaaaaac
     1921 tacttggctc tacaatccta ttgtaaaatg tctttgcaag agagagaaaa acagctgtcc
     1981 cctgaagcac aggcaaggat caatgcccga ctacagcaat atcgtgccaa ggcagagctg
     2041 gcgcgatcta ccagaccaca agcctgggtt ccaagggaaa agctacccag gccactgaca
     2101 agtagtgctt cggctattcg taagcttatg cgcaaagcag agctgatggg aatcagtacg
     2161 gatatctttc cagtggacaa ctcagatact agttctagtg tggatggaag gcggaagcat
     2221 aagcagcccg ctctcactgc tgattttgtg aattactatt ttgagagaaa tatgcgcatg
     2281 attcaaattc aggaaaatat ggctgaacaa aagaatataa aggataaatt agagaatgag
     2341 caagaaaagc ttcatgtaga atataataag ctctgtgaat cattagagga actgcaaaat
     2401 ctgaatggga aacttcgaag tgaagggcaa gggatatggg ccttacttgg ccgaattaca
     2461 gggcagaagt tgaatgtacc agcaatctta cgagcaccta aggaaaggaa accaagtaaa
     2521 aaagaaggag gcacacaaaa gacatctgct cttcctacag tgctttatag ttgtggaatt
     2581 tgtaagaaga accatgatca gcatcttctt ttactgtgtg acacctgtaa actgcattat
     2641 catctcggct gccttgatcc tcctcttaca aggatgccga gaaagacgaa aaacagttac
     2701 tggcaatgct cagagtgtga ccaggcaggg agcagcgaca tggaagcaga gatggccatg
     2761 gaaaccttac cagatggaac aaaacgatca aggagacaga ttaaggagcc agtgaagttt
     2821 gtgccacagg atgtcccacc agaacccaag aagattccaa taagaaacac gagaaccaga
     2881 ggacgaaagc gaagctttgt tcctgaggaa gaaaaacatg aggaaagagt tcctagggaa
     2941 aggaggcaga ggcagtctgt gttacagaag aagcccaagg ctgaggactt aagaactgag
     3001 tgttcaactt gcaaaggaac tggagataat gagaatcttg tcaggtgtga tgaatgcagg
     3061 ctgtgctacc attttggctg tttagatcct cctttgaaaa agtctcctaa acaaacaggc
     3121 tatggatgga tatgtcagga atgtgactct tcatcttcta aggaagatga aaatgaagct
     3181 gaaaagaaaa acgcatctca ggagctcagc atggagcaga aaactccaaa gaagtaaagg
     3241 attgtccagt gtgttctgaa gcgtgtacaa cttaggctca agcagataac gtttctgatt
     3301 tataaaatgt taattgtaaa atctaattta caaaactgtt ctcaataaag tccttgaaat
     3361 agga
//
