LOCUS       NM_174852               4412 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PHD finger protein 12 (Phf12), mRNA.
ACCESSION   NM_174852
VERSION     NM_174852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4412)
  AUTHORS   Graveline,R., Marcinkiewicz,K., Choi,S., Paquet,M., Wurst,W.,
            Floss,T. and David,G.
  TITLE     The Chromatin-Associated Phf12 Protein Maintains Nucleolar
            Integrity and Prevents Premature Cellular Senescence
  JOURNAL   Mol Cell Biol 37 (5), e00522-16 (2017)
   PUBMED   27956701
  REMARK    GeneRIF: These data reveal an unsuspected function for the
            Pf1-associated chromatin complex in the ribosomal biogenesis and
            senescence pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4412)
  AUTHORS   Shimizu,H., Kubo,A., Uchibe,K., Hashimoto,M., Yokoyama,S.,
            Takada,S., Mitsuoka,K. and Asahara,H.
  TITLE     The AERO system: a 3D-like approach for recording gene expression
            patterns in the whole mouse embryo
  JOURNAL   PLoS One 8 (10), e75754 (2013)
   PUBMED   24146773
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4412)
  AUTHORS   Xie,T., Graveline,R., Kumar,G.S., Zhang,Y., Krishnan,A., David,G.
            and Radhakrishnan,I.
  TITLE     Structural basis for molecular interactions involving MRG domains:
            implications in chromatin biology
  JOURNAL   Structure 20 (1), 151-160 (2012)
   PUBMED   22244764
REFERENCE   4  (bases 1 to 4412)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 4412)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   6  (bases 1 to 4412)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4412)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4412)
  AUTHORS   Yochum,G.S. and Ayer,D.E.
  TITLE     Pf1, a novel PHD zinc finger protein that links the TLE corepressor
            to the mSin3A-histone deacetylase complex
  JOURNAL   Mol Cell Biol 21 (13), 4110-4118 (2001)
   PUBMED   11390640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053787.1 and BC043080.1.
            
            On Sep 10, 2008 this sequence version replaced NM_174852.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043080.1, AK155354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               AK053787.1         2-398
            398-4412            BC043080.1         1-4015
FEATURES             Location/Qualifiers
     source          1..4412
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..4412
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /note="PHD finger protein 12"
                     /db_xref="GeneID:268448"
                     /db_xref="MGI:MGI:1924057"
     exon            1..562
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..3508
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /note="PHD zinc finger transcription factor; PHD factor 1"
                     /codon_start=1
                     /product="PHD finger protein 12"
                     /protein_id="NP_777277.2"
                     /db_xref="CCDS:CCDS48855.1"
                     /db_xref="GeneID:268448"
                     /db_xref="MGI:MGI:1924057"
                     /translation="MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPE
                     KESRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRC
                     TVRRKKREQKKELGHVNGLVDKSSKRTTSPSSDTDLLDRPASKTELKAIAHARILERR
                     ASRPGTPTSNASTETPTSEHNDVDEDIVDVDEEPVAAEPDYVQPQLRRPFELLIAAAM
                     ERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKRTQHELDHNGLVPLPVKVCFT
                     CNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNLTLSNR
                     CQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPP
                     LIAPAAIRDGELICSGVPEESQTHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAK
                     QMPSPWDSEQTEKADIKPVIVTDSSITTSLQTADKAPLPSHYPLSCPSAVSTQNSLGC
                     SPPHQPPTLEDISCSSCVEKSKKAPCGTANGPVNTEIKANGPHLYSSPTDSTDPRRLP
                     GANTPLPGLTHRQGWPRPLTPPSAGGLQNHVGIIVKTENATGPSSCPQRSLVPVPSLP
                     PSIPSSCASIENTSTLHRKTVQSQIGPSSTESRPLGSPPNATRVLTPPQAAGDSILAT
                     GANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIE
                     INMLDEKLIKFLALQRVHQLFPSRVQASPGNVGTHPLASGGHHPEVQRKEVQARAVFC
                     PLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNY
                     SEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQ
                     AQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPK
                     GDASLLQDGVLAEKLSLKPHQGPVLRSNSVP"
     exon            563..744
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..817
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1211
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1332
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1465
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1630
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1789
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2582
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2708
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2852
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2951
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3034
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3173
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..4393
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3902..3907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /note="hexamer: AATACA"
     polyA_site      3924
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
     regulatory      4370..4375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /note="hexamer: TATAAA"
     polyA_site      4393
                     /gene="Phf12"
                     /gene_synonym="2410142K10Rik; F630045O13; mKIAA1523; PF1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgcgcgg cagccgggac gcagacggca gcggcggcga gaggcggagc ccggggacca
       61 ccccccatca tcctccccag agtcacctca cgaaccacaa cctcacctaa cctctcaccc
      121 ccccctccgg tcccccaagc ccgggatggc agcgcccgct agccttcccg gccggaccag
      181 cggtcgccag cgccagcttt agcctgtggg cctaggcccc cgccgaggcc tgacccccgg
      241 agccgggatc cactgtgcag ccagccgctg ggccggggct gaggggttgc tcccctctcg
      301 cggcccgtgg ggaggacgct gccgtcccag ggactggggg ccggggggtg ggggggagcc
      361 agggcgagga agtcggaacc tgtgttggga agagagaagg ggaccggggg tcagaggtgc
      421 ccccttcccc tcctcccccc tccccccggg gctggggggg ccggagcaga gagcgcccag
      481 cccgagaggt ggatgaatgt gggagaaaat ggagaccaag acgatcgtgt acgacttgga
      541 cacgtcgggg gggctgatgg agcaaatcca agctctgctg gctcccccca agacggacga
      601 ggcagaaaag cggagtcgga agcccgagaa ggagtcccgg agaagcggca gggccaccaa
      661 ccacgacagc tgcgatagct gcaaggaagg tggggatctc ttgtgctgcg atcactgccc
      721 tgccgccttc cacctccagt gctgtaaccc tccactgagt gaagagatgt tgcctcctgg
      781 ggagtggatg tgtcaccggt gtactgtccg ccgaaagaaa cgagagcaga aaaaggagct
      841 tggccatgtc aatggactgg tggacaagtc tagcaaacgg actacatccc ccagcagtga
      901 cactgacttg ttggacagac cagctagcaa aactgaactc aaggccattg cccatgcccg
      961 gatcctggaa aggagagcca gccggcctgg cacccccaca tccaacgcca gcacagagac
     1021 ccccacctct gagcataatg acgtcgatga ggacatcgtt gacgtggacg aggagccagt
     1081 cgcagcagag ccggactatg tgcagcccca gctgcggcgg ccttttgagc tgctgattgc
     1141 tgctgccatg gagcggaacc ctacccagtt tcagttgccc aacgaactga cctgtaccac
     1201 tgcactacca ggttctagca aacggagaag aaaggaagaa accacaggga agaatgtaaa
     1261 aaggacacag catgagttag accataatgg tcttgttccc ttgccggtca aagtctgctt
     1321 cacatgtaac aggagttgtc gagtggcccc cctcatccag tgtgactatt gcccgcttct
     1381 gtttcacatg gactgcctcg agcccccgct cactgccatg cccctgggca gatggatgtg
     1441 tccgaatcac atcgaacatg tggtgctgaa ccagaagaac ctgactctga gcaatcggtg
     1501 ccaggtgttt gatcggttcc aggacaccat ttcacaacat gttgtcaaag tagatttcct
     1561 gaaccgaatc cacaagaagc accctcctaa ccgccgtgtg ctccagtctg tcaaaagaag
     1621 aagcttgaag gttcctgatg ctataaaatc tcagtaccag tttccacccc cgcttattgc
     1681 acccgcggcc attcgggacg gggagctgat ctgcagtggg gtccctgagg aatcacaaac
     1741 gcaccttttg aactctgagc acttagccac tcaggcagag cagcaggagt ggctctgtag
     1801 tgttgttgcg ctccagtgca gcatattgaa acatttatct gctaagcaga tgccttcgcc
     1861 ttgggactct gaacagacag agaaggctga tattaagcct gttattgtga ctgacagctc
     1921 aatcaccacc tccctgcaaa ccgctgacaa ggcacctctt ccttcccact accctttgtc
     1981 ctgcccctca gcagtgagca cccaaaattc cctgggctgc tctccacccc accaaccccc
     2041 aaccctagaa gacatcagct gcagttcttg tgtggaaaag tccaagaaag ccccttgtgg
     2101 gactgccaat gggccggtga acacagagat aaaagccaat ggcccacacc tctacagcag
     2161 ccccactgat tccacggatc cccggcgact tcctggcgcc aacacccctt taccaggcct
     2221 cacacaccgg caaggctggc cccggcccct cacgccacca tcggctgggg gacttcagaa
     2281 ccacgtcggc atcattgtga agacagaaaa tgccactggc cccagctctt gtccccagag
     2341 gagtttggta cccgtcccaa gcctgccccc ttccattccc agctcttgtg ccagcatcga
     2401 gaacaccagc actttgcata gaaagactgt ccagtcacag ataggacctt cgtcgacaga
     2461 atcgaggcct ctgggctcac ccccaaatgc cacccgggtg ctcactcccc cccaggctgc
     2521 aggagacagt atcttggcca caggtgccaa ccaacgattc tgctcaccag cgccatcatc
     2581 agatggcaag gtcagccccg gcacgttatc cataggaagc gctttaaccg taccctcttt
     2641 cccagccaac tctactgcca tggtggacct caccaactca cttcgagcat ttatggatgt
     2701 caacggagaa atcgagataa atatgttgga tgagaagctg atcaagtttc tggccttgca
     2761 gagagtacat cagcttttcc cttcccgggt ccaagcttca ccgggcaatg ttgggacaca
     2821 tccgctggct tctggagggc accacccaga agtgcaaaga aaggaggtac aggcccgagc
     2881 tgtgttctgc cccctcttag ggttgggagg agctgtgaac atgtgctatc gaaccctcta
     2941 catcgggaca ggagctgaca tggatgtgtg ccttacaaac tatggtcact gtaactacgt
     3001 gtccgggaaa catgcctgca tattctacga tgagaatacc aaacattatg agctgttaaa
     3061 ctacagtgag catgggacaa cggtggacaa tgtgctgtat tcatgtgact tctctgagaa
     3121 gaccccgcca acccccccaa gcagtattgt tgccaaagta cagagtgtca tcaggcgccg
     3181 ccgacaccag aaacaggatg aagagccaag tgaggaggca gccatgatga gttcccaggc
     3241 ccaggggcca cagcggagac cctgcaattg caaagccagc agctcaagct tgattggggg
     3301 cagtggggcc ggctgggagg gcacagcctt actccaccat ggcagctaca tcaagctggg
     3361 ctgcctgcag tttgtcttca gcatcactga gtttgcgacc aaacagccca aaggcgatgc
     3421 cagcctgctg caggatgggg tcttggctga gaaactctct ctcaagcccc atcagggccc
     3481 tgtgctgcgc tccaactccg ttccctaggc cattggcctg gacgcccacc caagactcct
     3541 gcaatgcaaa aatgtacacg aaccaagcct gggtgttttc tataccagaa accctcaact
     3601 acaatctttg catgaaatga agaaaacctt ttgactgttt tttaagactt tttttctttt
     3661 ctcaagttct agggggcatt tgcacatata tttgtactca acatttcatg ggaaagcggc
     3721 agatccgcgc tgaggagcag cgagggcagg gacaggaggc cctggtctgg acacttcctc
     3781 cagcacaatc ccttcccccg cctcctgctc ctccccctcg accgcctgcc cactgttgta
     3841 aaataatcag aaacttgttc tattttgtgg cagtgacaat agttttatat taaaagaaaa
     3901 aaatacagtt ttcatacagc aaaatctata caatatcatt gttttattta atataaagat
     3961 cgctacccac tcctttccat ggttcccacc ctacaaggac ttcccctctc tgcagcagtt
     4021 gcactacagg tagctactgt gtatatggac aaatgagaaa tgaatccttt tttctggctg
     4081 tccatctatt ttatttcaaa taaggaaaag tgtatttgga ttttgtgtaa atacatctag
     4141 tgatggcatt ttttcaatgt ttttaaaagc tgtgtacagt acatgtggta gagtgtttct
     4201 caaattgtct attgtagcaa aggcgttttt gtcgtaaacc tgttctgtgt ccttttttgt
     4261 tcttaccact tctcttcctc ctcaccccag atacttcctc ttccccacaa ccaatgtaca
     4321 tagtaattgt aatgttttag acttgacaga aactttcctg tattctgtat ataaaaacca
     4381 aaaatacttc aaaaaaaaaa aaaaaaaaaa aa
//
