LOCUS       NM_009343               2447 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PHD finger protein 1 (Phf1), transcript variant 1,
            mRNA.
ACCESSION   NM_009343 XM_914892 XM_923452
VERSION     NM_009343.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2447)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2447)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2447)
  AUTHORS   Dong,C., Nakagawa,R., Oyama,K., Yamamoto,Y., Zhang,W., Dong,A.,
            Li,Y., Yoshimura,Y., Kamiya,H., Nakayama,J.I., Ueda,J. and Min,J.
  TITLE     Structural basis for histone variant H3tK27me3 recognition by PHF1
            and PHF19
  JOURNAL   Elife 9, e58675 (2020)
   PUBMED   32869745
  REMARK    GeneRIF: Structural basis for histone variant H3tK27me3 recognition
            by PHF1 and PHF19.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2447)
  AUTHORS   Ragazzini,R., Perez-Palacios,R., Baymaz,I.H., Diop,S., Ancelin,K.,
            Zielinski,D., Michaud,A., Givelet,M., Borsos,M., Aflaki,S.,
            Legoix,P., Jansen,P.W.T.C., Servant,N., Torres-Padilla,M.E.,
            Bourc'his,D., Fouchet,P., Vermeulen,M. and Margueron,R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2447)
  AUTHORS   Qu,Y., Wang,Y. and Qiao,J.
  TITLE     PHF1 is required for chromosome alignment and asymmetric division
            during mouse meiotic oocyte maturation
  JOURNAL   Cell Cycle 17 (21-22), 2447-2459 (2018)
   PUBMED   30382790
  REMARK    GeneRIF: PHF1 is necessary for the accurate alignment of
            chromosomes and oocyte euploidy, as well for the regulation of the
            asymmetric division of oocytes in mouse.
REFERENCE   6  (bases 1 to 2447)
  AUTHORS   Cao,R., Wang,H., He,J., Erdjument-Bromage,H., Tempst,P. and
            Zhang,Y.
  TITLE     Role of hPHF1 in H3K27 methylation and Hox gene silencing
  JOURNAL   Mol Cell Biol 28 (5), 1862-1872 (2008)
   PUBMED   18086877
REFERENCE   7  (bases 1 to 2447)
  AUTHORS   Jacquemin,P., Chen,Z., Martial,J.A. and Davidson,I.
  TITLE     Genomic structure and chromosomal mapping of the mouse
            transcription factor TEF-5 (Tead3) gene
  JOURNAL   Mamm Genome 10 (6), 632-634 (1999)
   PUBMED   10341100
REFERENCE   8  (bases 1 to 2447)
  AUTHORS   Kawakami,S., Mitsunaga,K., Kikuti,Y.Y., Ando,A., Inoko,H.,
            Yamamura,K. and Abe,K.
  TITLE     Tctex3, related to Drosophila polycomblike, is expressed in male
            germ cells and mapped to the mouse t-complex
  JOURNAL   Mamm Genome 9 (11), 874-880 (1998)
   PUBMED   9799836
REFERENCE   9  (bases 1 to 2447)
  AUTHORS   Yeom,Y.I., Abe,K., Bennett,D. and Artzt,K.
  TITLE     Testis-/embryo-expressed genes are clustered in the mouse H-2K
            region
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 773-777 (1992)
   PUBMED   1731353
REFERENCE   10 (bases 1 to 2447)
  AUTHORS   Ha,H., Howard,C.A., Yeom,Y.I., Abe,K., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Several testis-expressed genes in the mouse t-complex have
            expression differences between wild-type and t-mutant mice
  JOURNAL   Dev Genet 12 (4), 318-332 (1991)
   PUBMED   1718647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK139088.1, AK133474.1 and
            AC144621.3.
            
            On Oct 22, 2014 this sequence version replaced NM_009343.2.
            
            Summary: The protein encoded by this gene belongs to the
            polycomb-like protein family, which is a component of polycomb
            repressive complex-2. This complex represses gene expression by
            catalyzing the trimethylation of histone H3 lysine 27 and is
            required for the regulation of developmental genes including
            homeotic genes. The gene is expressed primarily in testis tissue.
            Small interfering RNA-mediated knockdown in cultured cell lines
            results in changes in homeotic gene expression coincident with
            alterations in promoter methylation. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139088.1, U81490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1787              AK139088.1         2-1788
            1788-2429           AK133474.1         1540-2181
            2430-2447           AC144621.3         168442-168459
FEATURES             Location/Qualifiers
     source          1..2447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.6 cM"
     gene            1..2447
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /note="PHD finger protein 1"
                     /db_xref="GeneID:21652"
                     /db_xref="MGI:MGI:98647"
     exon            1..408
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            409..583
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..2104
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polycomb-like protein 1; t-complex testis-expressed 3"
                     /codon_start=1
                     /product="PHD finger protein 1 isoform 1"
                     /protein_id="NP_033369.2"
                     /db_xref="CCDS:CCDS37518.1"
                     /db_xref="GeneID:21652"
                     /db_xref="MGI:MGI:98647"
                     /translation="MAQLPRLSRLGAPSLWDPASPAPTSGPRPRLWEGQDVLARWTDG
                     LLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGN
                     RLVSCEKCRHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAM
                     LGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQC
                     LSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDRE
                     ILPFTSENWDSLLLGELSDTPKGERSSQLLSALNSHKDRFISGREIKKRKCLFGLHAR
                     TPPPVELLTGDGAPTSFPSGQGPGGGVSRPLGKRWRSEPEPLRRRQKGKVEELGPPTA
                     AHSRHGSREQRALQASVSPPPPSPNQSYEGSSGYNFRPTDARCLPSSPIRMFASFHPS
                     ASTAGTSGDSEPPDRSPLGLHIGFPTDTPKSSPHSVTASSSSVPALTPGFSRHSPPSP
                     LCRSLSPGTGGGVRGGVSYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF"
     exon            584..665
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..761
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..862
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1011
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1107
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1176
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1300
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1368
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1473
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1642
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1737
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1818
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2447
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2421..2426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /note="hexamer: AATAAA"
     polyA_site      2430
                     /gene="Phf1"
                     /gene_synonym="D17Ertd455e; Pcl1; Phf2; Tctex3"
                     /note="major polyA site"
ORIGIN      
        1 agaaggttat ttcctgctga cccagagcaa gcctcccatc cgaaaaaggg gctgcaggga
       61 tttcctcgac ctccgcgacc ggccgcgccc ccaacagcgc agcgccctcc gggcccgctg
      121 gaggtgaggg aggtgctgcc tgcccgtccc tctgtcgtct cctccccctg gtgctcccca
      181 ccctccactc tcctccctcc ttctgtcgac tcctcctgcc gctgctgctg ctttggctgc
      241 tgcgtcatac gccccagagc cgccaggacg gaggggctgg gcccggggac cccctggcct
      301 ccgcctgcac gccccccggc gctcacactc agtcttcccg caccggagac tcatccaggt
      361 ctcttgagtc tgaccctacc tggcttccag ctgccccggc tgtcaccggc ccccccagga
      421 tgcaatggcg cagctccccc ggctgagccg tttgggtgcc ccctctctct gggatccagc
      481 ttcccctgct cccacctcag gccccagacc tcggctttgg gaaggccaag atgtgctggc
      541 cagatggact gatgggctgc tgtacttggg taccatcaaa aaggtggaca gtgctcgaga
      601 ggtgtgtctg gtccagtttg aggacgattc ccagtttctg gttctatgga aggatatcag
      661 cccagctgcc ctccctgggg aggagctgct ctgttgtgtg tgtcgctctg agaccgtggt
      721 acctgggaac cggctggtca gctgtgagaa gtgtcgccat gcttatcacc aggactgtca
      781 cgttcccagg gccccggccc ctggagaagg agagggcgca tcctgggtat gccgccagtg
      841 tgtctttgca atcgccacta agaggggagg cgcactgaag aaaggtccct atgcccgggc
      901 catgctgggc atgaagctct ccctgccata cggattaaaa gggctggact gggatgctgg
      961 acatttgagc aacagacagc agagctactg ctactgtgga ggccctggag agtggaacct
     1021 gaaaatgctg cagtgccgga gctgcctcca gtggttccat gaggcctgca cccagtgtct
     1081 gagcaagccc ctcctctacg gagacagatt ctatgaattt gagtgctgtg tgtgccgggg
     1141 cggccctgag aaggtccgga ggttacagct tcgctgggtg gatgtggccc atcttgtcct
     1201 ctaccacctc agcgtttgct gtaagaagaa atattttgat tttgaccgag agatcctccc
     1261 cttcacctct gagaattggg acagtctgct cctgggggag ctctcagata ctcccaaggg
     1321 agagcgctct tcccagctcc tttctgctct taacagccac aaggaccgtt tcatttcagg
     1381 gagggagatt aaaaagcgaa aatgtctttt tggtctccat gctcggaccc ctcctcctgt
     1441 ggagcttctc actggagatg gagcccccac cagcttccct tcagggcagg gccctggggg
     1501 aggggtctca cgtcccctgg ggaaacgatg gaggtcggag ccagaaccct taaggaggag
     1561 gcagaagggg aaagtggagg aactggggcc acccacggca gcacacagtc ggcatgggtc
     1621 ccgggagcag agggccctgc aggcctcggt gtctccacca ccccccagcc ctaaccagag
     1681 ctatgagggc agcagcggct acaacttccg gcccacagac gcccgctgtc tgcccagcag
     1741 ccctatccgg atgttcgcct ccttccaccc ttctgccagc actgcaggga cctctgggga
     1801 cagtgaaccc ccagataggt cacctctggg acttcacatt ggcttcccca cagacacccc
     1861 taaaagttca ccccactcag tgacggcctc atcttcctcg gtcccagccc tgaccccagg
     1921 cttttccaga cattcacccc cttctccctt gtgccgtagt ctgtctccgg ggactggggg
     1981 aggagtccga ggtggggtta gctacctgtc ccgaggggac cctgtgaggg tccttgctcg
     2041 aagagtgcgg cctgacggct ctgtgcagta cctagttgag tggggagggg ggggcatctt
     2101 ctgacagcct gcttctgctc ccctccccat tcacacactg gcactttcat gccctgacct
     2161 ctgacctcac ctacagctgg gatgtacctg gagagatggg gagtggttct ccctcctgcc
     2221 caggctggaa tccaggggag tgaagaggtc ctcttctctg ccccttcatg actcctaatg
     2281 ccccccctca tttcctttga tgttattttg ttacagcttt tgagataatt ttttaagact
     2341 atttaacccc tgggattaga gattgggggg gggggtttgg gtggtccagg attccagact
     2401 gtatgactgt aataaagata aataaaccta gtaggcatga gtcattt
//
